الصفحة 2
الصفحة 2
Neurodegeneration and Prion Disease
This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow’s disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
Neurocutaneous Disorders : Phakomatoses and Hamartoneoplastic Syndromes
Neurocutaneous diseases are a wide group of conditions that affect the nervous system but appear as lesions of the skin. Some of the more common entities have variable forms of expression that can confuse the diagnosis; for the rare conditions it is difficult to find descriptions in the literature. Recent insights into their cellular, biochemical and molecular genetic bases have shown the essential need for a new nosology and updated genotype-phenotype correlations. The book provides an authoritative source of knowledge about these difficult problems and bridges the gap between clinical recognition and the new molecular medicine. The editors, distinguished clinicians and geneticists, assembled an internationally renowned group of collaborators, many of them the experts who first described a particular disorder or established its present accepted definition.
Natural Disasters as Interactive Components of Global-Ecodynamics
This book opens a new approach to the study of global environmental changes having unfavourable character for mankind and other living systems. The main advantage of the book consists in the accumulation of knowledge from different sciences to parametrize the global ecodynamic process. Natural catastrophes are considered as an interactive element of global natural dynamics which are described by means of simulation models of global nature/society. The realization of this approach allows the integration within a complex structure of all international and national means of environmental monitoring and provides a tool for objective evaluation of the environmental quality. The main purpose of this book is to develop a universal information technology to estimate the state of environmental subsystems functioning under various climatic and anthropogenic conditions.
Multiscale processes in the earth’s magnetosphere : From interball to cluster ; Proceedings of the NATO ARW on Multiscale Processes in the Earth's Magnetosphere: From Interball to Cluster, Prague, Czech Republic from 9 to 12 September 2003
The past forty years of space research have seen a substantial improvement in our understanding of the Earth’s magnetosphere and its coupling with the solar wind and interplanetary magnetic ?eld (IMF). The magnetospheric str- ture has been mapped and major processes determining this structure have been de?ned. However, the picture obtained is too often static. We know how the magnetosphere forms via the interaction of the solar wind and IMF with the Earth’s magnetic ?eld. We can describe the steady state for various upstream conditions but do not really understand the dynamic processes leading from one state to another. The main dif?culty is that the magnetosphere is a comp- cated system with many time constants ranging from fractions of a second to days and the system rarely attains a steady state. Two decades ago, it became clear that further progress would require multi-point measurements. Since then, two multi-spacecraft missions have been launched — INTERBALL in 1995/96 and CLUSTER II in 2000. The objectives of these missions d- fered but were complementary: While CLUSTER is adapted to meso-scale processes, INTERBALL observed larger spatial and temporal scales. However, the number of papers taking advantage of both missions simul- neously is rather small.
Multilevel Block Factorization Preconditioners : Matrix-based Analysis and Algorithms for Solving Finite Element Equations
This monograph is the first to provide a comprehensive, self-contained and rigorous presentation of some of the most powerful preconditioning methods for solving finite element equations in a common block-matrix factorization framework. Topics covered include the classical incomplete block-factorization preconditioners and the most efficient methods such as the multigrid, algebraic multigrid, and domain decomposition. Additionally, the author discusses preconditioning of saddle-point, nonsymmetric and indefinite problems, as well as preconditioning of certain nonlinear and quadratic constrained minimization problems that typically arise in contact mechanics. The book presents analytical as well as algorithmic aspects.
Multicriteria Optimization
Decision makers in many areas, from industry to engineering and the social sector, face an increasing need to consider multiple, conflicting objectives in their decision processes. In many cases these real world decision problems can be formulated as multicriteria mathematical optimization models. The solution of such models requires appropriate techniques to compute so called efficient, or Pareto optimal, or compromise solutions that - unlike traditional mathematical programming methods - take the contradictory nature of the criteria into account. This book provides the necessary mathematical foundation of multicriteria optimization to solve nonlinear, linear and combinatorial problems with multiple criteria. Motivational examples illustrate the use of multicriteria optimization in practice. Numerous illustrations and exercises as well as an extensive bibliography are provided.
MR Imaging in White Matter Diseases of the Brain and Spinal Cord
Comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.
MR Cholangiopancreatography : Atlas with Cross-Sectional Imaging Correlation
Magnetic resonance cholangiopancreatography (MRCP) is a novel non-invasive technique for diagnosis of pancreatic-biliary disease. The purpose of this book is to highlight the advantages, limitations and indications of MRCP. Specific examples have been selected to showcase the utility of this technique in a large variety of clinical conditions. Each example is purposefully used to stress important technical features, to give practical advice, or to discuss the role of MRCP in specific clinical situations. Important features of the book are the high quality of the illustrations, the reduction of the text to relevant and practically useful issues, and the simple and logic organisation of the case material. The book should show: the optimal technique in MRCP, the pitfalls and limitations.
Mortality and Maldevelopment : Part I : Congenital cardiovascular malformations
The most frequent of them all are the many types of malformations of the cardiovascular system, the heart and its blood vessels.Study of these conditions during the twentieth century took many forms, revolving about examination and analysis of their causes, genetic, nongenetic, and complex. To aid in unraveling the complexities of this causation, various influences on their frequency are considered, among them social conditions, maternal health, birthweight, newborn maturity. And of course the known and possible environmental bases of their occurrence are fully described.
Monitoring Nature Conservation in Cultural Habitats : A Practical Guide and Case Studies
Monitoring Nature Conservation in Cultural Habitats presents monitoring as an integral component of responsible conservation management and as a catalyst for decision making. The early sections of the book cover key areas in the development of a monitoring project, including: - The roles of survey and surveillance - Incorporating knowledge from existing research - Identifying the conservation priority on sites - Minimising observer error - Identifying site-specific condition indicators for habitats - Collecting monitoring data The later sections of the book comprise a series of case studies covering a wide range of habitats and species. These case studies focus mostly, though not exclusively, on sites that form part of the Natura 2000 series in Europe.
Monetary Policy and the German Unemployment Problem in Macroeconomic Models : Theory and Evidence
Having the high unemployment in Germany in mind, this book discusses how macroeconomic theory has evolved over the past forty years. It shows that in recent years a convergence has taken place, with modern models embodying a Keynesian transmission mechanism, monetarist policy implication, and modeling techniques inspired by new classical economics and real business cycle theory. It also probes in which direction models may be extended from here. Empirically, the book uses different econometric techniques to investigate the relevance and implications of different macroeconomic theories for German data. A key question this book investigates is the role of demand and supply side conditions for the increase in the German unemployment rate. On a policy level, the book relates the implications of the different theories to the ongoing debate on the appropriate roles of demand and supply side policies for curing the German unemployment problem.
Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Modern implant dentistry
A comprehensive look at the state of implant dentistry today, equipping beginners and seasoned clinicians alike to improve their skills and practice implant dentistry safely and predictably. The early chapters focus on the biology of dental implants as well as medical considerations required prior to placing them, followed by chapters dedicated to documentation, treatment planning, and digital workflow. Surgical concepts are then described in detail, from single-tooth extraction to guided All-on-X treatment, followed by detailed discussion of the prosthetic options available in implant dentistry. The final chapters include relevant topics such as soft tissue management in implant dentistry, treatment of peri-implant disease, the socket shield technique, and marketing of dental implant therapy. Written by experienced clinicians from all over the world, the book includes over 60 surgical and clinical videos (linked via QR codes) to demonstrate what the procedures and techniques and products look like in real life, not in a photograph taken in ideal conditions, so readers can be confident in their understanding.
Modern hospice design : The architecture of palliative and social care
Takes cognisance of the new conditions of social care in the 21st century, principally in the UK, Europe and North America. It does so with regard to the development of new building types, but also in response to new philosophies of palliative care and the status of the elderly and the dying. At its core is a public discussion of a philosophy of design for providing care for the elderly and the vulnerable, taking the importance of architectural aesthetics, the use of quality materials, the porousness of design to the wider world, and the integration of indoor and outdoor spaces as part of the overall care environment.
Modern Ferrite Technology
odern Ferrite Technology ; 2nd ed. offers the readers an expert overview of the latest ferrite advances as well as their applications in electronic components. This volume develops the interplay among material properties, component specification and device requirements using ferrites. Throughout, emphasis is placed on practical technological concerns as opposed to mathematical and physical aspects of the subject. The book traces the origin of the magnetic effect in ferrites from the level of the simplest particle and then increases the scope to include larger hierarchies. From the desired magnetic properties, the author deduces the physical and chemical material parameters, taking into consideration major chemistry, impurity levels, ceramic microstructures and grain boundary effects. He then discusses the processing conditions and associated conditions required for implementation. In addition to conventional ceramic techniques, he describes non-conventional methods such as co-precipitation, co-spray roasting and single crystal growth.
Modern architecture and climate design before air conditioning
explores how leading architects of the twentieth century incorporated climate-mediating strategies into their designs, and shows how regional approaches to climate adaptability were essential to the development of modern architecture. Focusing on the period surrounding World War II'before fossil-fuel powered air-conditioning became widely available'Daniel Barber brings to light a vibrant and dynamic architectural discussion involving design, materials, and shading systems as means of interior climate control. He looks at projects by well-known architects such as Richard Neutra, Le Corbusier, Lúcio Costa, Mies van der Rohe, and Skidmore, Owings, and Merrill, and the work of climate-focused architects such as MMM Roberto, Olgyay and Olgyay, and Cliff May. Drawing on the editorial projects of James Marston Fitch, Elizabeth Gordon, and others, he demonstrates how images and diagrams produced by architects helped conceptualize climate knowledge, alongside the work of meteorologists, physicists, engineers, and social scientists. Barber describes how this novel type of environmental media catalyzed new ways of thinking about climate and architectural design.
Modelling, Monitoring and Diagnostic Techniques for Fluid Power Systems
Modelling, Monitoring and Diagnostic Techniques for Fluid Power Systems covers the background theory of fluid power and indicates the range of concepts necessary for a modern approach to condition monitoring and fault diagnosis in a readable and understandable fashion. The theory is constantly leavened by 15 years' worth of practical measurements by the author, working in association with major fluid power companies, and real industrial case studies – hot-strip-mill monitoring in conjunction with Corus p.l.c. being just one example. Comprising four parts, it provides: • an introduction to component behaviour. • a guide to the modelling methods employed for circuit analysis. • methods for doing condition monitoring. • common faults and breakdowns.
Modelling community structure in freshwater ecosystems
"The book presents approaches and methodologies for predicting the structure and diversity of key aquatic communities (namely diatoms, benthic macroinvertebrates and fish), under natural conditions and under man-made disturbance. Such an approach will make it possible to: 1) set up procedures for robust and sensitive ecosystem evaluation, based on the prediction of the excepted community structure; 2) model community structure in disturbed ecosystems, taking into account all the relevant ecological variables; 3) test ecosystem sensitivity to natural and anthropic disturbance; and 4) explore specific actions to be taken for the restoration of ecosystem integrity."--Jacket.
Modeling Solid Oxide Fuel Cells : Methods, Procedures and Techniques
The volume is structured in two parts. Part one presents the basic theory, and the general equations describing SOFC operation phenomena. Part two deals with the application of the theory to practical examples, where different SOFC geometries, configurations (from single cells to hybrid systems), operating conditions (steady-state and dynamic), and different phenomena (e.g. performance, temperature and chemical species, and mechanical stress distribution) are analyzed in detail.
Modeling Solar Radiation at the Earth’s Surface : Recent Advances
Solar radiation data is important for a wide range of applications, e.g. in engineering, agriculture, health sector, and in many fields of the natural sciences. A few examples showing the diversity of applications may include: architecture and building design e.g. air conditioning and cooling systems; solar heating system design and use; solar power generation; weather and climate prediction models; evaporation and irrigation; calculation of water requirements for crops; monitoring plant growth and disease control; skin cancer research.
