الصفحة 2
الصفحة 2
Neutrinos and Explosive Events in the Universe
“Neutrinos and Explosive Events in the Universe” brought together experts from diverse disciplines to offer a detailed view of the exciting new work in this part of High Energy Astrophysics. Sponsored by NATO as an Advanced Study Institute, and coordinated under the auspices of the International School of Cosmic Ray Astrophysics (14th biennial course), the ASI featured a full program of lectures and discussion in the ambiance of the Ettore Majorana Centre in Erice, Italy, including visits to the local Dirac and Chalonge museum collections as well as a view of the cultural heritage of southern Sicily. Enri- ment presentations on results from the Spitzer Infrared Space Telescope and the Origin of Complexity complemented the program. This course was the best attended in the almost 30 year history of the School with 121 participants from 22 countries. The program provided a rich ex- rience, both introductory and advanced, to fascinating areas of observational Astrophysics Neutrino Astronomy, High Energy Gamma Ray Astronomy, P- ticle Astrophysics and the objects most likely responsible for the signals - plosions and related phenomena, ranging from Supernovae to Black Holes to the Big Bang. Contained in this NATO Science Series volume is a summative formulation of the physics and astrophysics of this newly emerging research area that already has been, and will continue to be, an important contributor to understanding our high energy universe.
Neuromuscular Disease : Evidence and Analysis in Clinical Neurology
Through a series of questions and answers concerning specific neuromuscular disorders, each chapter critiques the best available evidence to illustrate strengths and weaknesses of the data and make the reader aware of the quality of clinical research studies in general. Introductory chapters facilitate this learning process by elucidating the epidemiological and biostatistical issues pertinent to diagnosis, treatment, and prognosis. A broad range of disorders of the anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, and muscle are critically appraised and discussed.
Neuroacanthocytosis Syndromes II
Awareness of neuroacanthocytosis disorders has increased significantly in recent years. There have been a number of important developments in the field since the publication of the first volume, Neuroacanthocytosis Syndromes. This book contains the latest research in this area. Recent advances have identified the range of mutations in the causative genes, shedding light on potential phenotypegenotype correlations. Studies of the proteins affected in these disorders have resulted in increased understanding of their functions and distribution. In vitro studies have identified potential protein interactions, which have important implications for pathophysiology. Work on erythrocyte membranes suggests mechanisms for the generation of acanthocytes. Animal models are being generated which will greatly facilitate understanding the role of gene mutations in humans, and provide the foundation for possible therapeutic interventions. In addition, advances in other neurodegenerative disorders, such as Huntington’s and Parkinson’s diseases, have implications for neuroacanthocytosis.
Nature by Design : The Practice of Biophilic Design
Describes the basic principles, practices, and options for successfully implementing biophilic design. He shows us what is—and isn’t—good biophilic design using examples of workplaces, healthcare facilities, schools, commercial centers, religious structures, and hospitality settings. This book will to appeal to architects, designers, engineers, scholars of human evolutionary biology, and—with more than one hundred striking images of designs—anyone interested in nature‑inspired spaces.
Natural Language Processing and Text Mining
Natural Language Processing and Text Mining not only discusses applications of certain NLP techniques to certain Text Mining tasks, but also the converse, i.e., use of Text Mining to facilitate NLP. It explores a variety of real-world applications of NLP and text-mining algorithms in comprehensive detail, placing emphasis on the description of end-to-end solutions to real problems, and detailing the associated difficulties that must be resolved before the algorithm can be applied and its full benefits realized.
Nanopharmaceuticals ; Vol.1 : Expectations and realities of multifunctional drug delivery systems
Reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.
Multiwavelength Mapping of Galaxy Formation and Evolution ; Proceedings of the ESO Workshop Held at Venice, Italy, 13-16 October 2003
The possibilities of astronomical observation have dramatically increased over the last decade. Major satellites, like the Hubble Space Telescope, Chandra and XMM Newton, are complemented by numerous large ground-based observatories, from 8m-10m optical telescopes to sub-mm and radio facilities. As a result, observational astronomy has access to virtually the whole electromagnetic spectrum of galaxies, even at high redshifts. Theoretical models of galaxy formation and cosmological evolution now face a serious challenge to match the plethora of observational data. In October 2003, over 170 astronomers from 15 countries met for a 4-day workshop to extensively illustrate and discuss all major observational projects and ongoing theoretical efforts to model galaxy formation and evolution. This volume contains the complete proceedings of this meeting and is therefore a unique and timely overview of the current state of research in this rapidly evolving field.
Multiscale Optimization Methods and Applications
One general strategy for dealing with a large or difficult problem is to partition it into smaller ones, which are hopefully much easier to solve, and then work backwards towards the solution of original problem, using a solution from a previous level as a starting guess at the next level.The topics of the chapters selected for this volume are focused on the development of new solution methodologies, including general multilevel solution techniques, for tackling difficult, large-scale optimization problems that arise in science and industry. Applications presented in the book include but are not limited to the circuit placement problem in VLSI design, a wireless sensor location problem, optimal dosages in the treatment of cancer by radiation therapy, and facility location.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Multiple Abstraction Hierachies for Mobile Robot Operation in Large Environments
This book focuses on the efficient performance of mobile robots through the use of multi-hierarchical symbolic representations of the environment. A mobile robot intended to perform deliberative actions must possess some symbolic representation of its workspace, but such representations of real environments usually become so large that should be conveniently arranged in order to facilitate and, in some cases, make possible their use. This book addresses all these issues considering symbolic multi-hierarchical structures. Such structures, based on the concept of abstraction, allow a robot to speed up its operation in large environments. Practical solutions tested on real robots (for instance, a robotic wheelchair for elder people) are provided.
Multiphase Flow Dynamics 3 : Turbulence, Gas Absorption and Release, Diesel Fuel Properties
Volume 3 is devoted to selected Chapters of the multiphase fluid dynamics that are important for practical applications. The state of the art of the turbulence modeling in multiphase flows is presented. As introduction, some basics of the single-phase boundary layer theory including some important scales and flow oscillation characteristics in pipes and rod bundles are presented. Then the scales characterizing the dispersed flow systems are presented. The description of the turbulence is provided at different level of complexity: simple algebraic models for eddy viscosity, algebraic models based on the Boussinesq hypothesis, modification of the boundary layer share due to modification of the bulk turbulence, modification of the boundary layer share due to nucleate boiling. Then the role of the following forces on the matematical description of turbulent flows is discussed: the lift force, the lubrication force in the wall boundary layer, and the dispersion force.
Multidetector-Row Computed Tomography : Scanning and Contrast Protocols
Multidetector-row computed tomography (MDCT) has advanced the approach to diagnostic assessment of many pathologies and now plays an integral role in imaging of both abdominal and cardiovascular diseases. The possibility to acquire diagnostic images with shorter scan duration, longer scan ranges, and/or thinner sections, MDCT has facilitated the opening of new horizons, such as interventional MDCT and functional imaging in stroke and oncology. In addition, advanced postprocessing techniques now permit high quality volumetric imaging in combination with maximum intensity projections, volume rendering, curved planar reformations and multiplanar reconstructions. This volume gathers contributions by internationally renowned specialists in the field who, through presenting their clinical experience, provide a thorough overview not only of MDCT and its practical applications, but also of workflow management in everyday clinical practice. Focussing on scanning and contrast protocols, the current advantages and disadvantages of non-enhanced vs. enhanced MDCT are discussed, along with insights into likely future developments. The volume represents an up-to-date source of technical and practically-oriented clinical information which should prove of great benefit to all who wish to improve or consolidate their knowledge and expertise in MDCT.
Multi-Agent Programming : Languages, Platforms and Applications
Part I describes four approaches that are based on computational logic or process algebra--Jason, 3APL, IMPACT, and CLAIM/SyMPA. These programming languages have formal semantics and use heavy machinery based on formal methods, but also provide working platforms for the development of multi-agent systems. Part II presents agent languages and platforms that extend or are based on Java--JADE, Jadex, and JACKTM. Although these have no formal semantics, the languages are well documented and the platforms provide a variety of tools that have been extensively used in practice. Part III provides two significant industry specific applications--The DEFACTO System for coordinating human-agent teams for the future of disaster response, and the ARTIMIS rational dialogue agent technology. The book also features seven appendices, summarising each of the agent programming languages, hence facilitating comparison of the approaches. In particular, Appendix A describes the criteria used for comparing the agent languages and platforms.
Monograph of the Urostyloidea (Ciliophora, Hypotricha)
This monograph is the second of a series treating the hypotrichs, a major part of the spirotrichous ciliates. The urostyloids are characterised by a zigzag-arrangement of the ventral cirri. Like the first part of the series, the Oxytrichidae, it summarises the morphological, morphogenetic, faunistic, and ecological data from the past 230 years, scattered in more than 1300 references from all over the world. Dichotomous keys lead to 36 genera and subgenera comprising 153 species illustrated by more than 2100 figures, including original ones. The treatise offers taxonomists, cell biologists, and ecologists a thorough and up-to-date revision because for each species a detailed list of synonyms, a discussion of the nomenclature and systematics, and an extensive description of the morphology and ecology, including almost all published faunistic records, are provided. With the monographs of the Urostyloidea and the Oxytrichidae the interested scientist can identify more than 320 species of hypotrichs, which are an important component of the eukaryotic microbial life in limnetic, marine, and terrestrial habitats.
Monograph of the Spathidiida (Ciliophora, Haptoria) ; Vol. I : Protospathidiidae, Arcuospathidiidae, Apertospathulidae
The present monograph carefully revises the taxonomy, nomenclature, and ecology of all nominal species and shows that spathidiid diversity has been greatly underestimated. Based on the reinvestigation of described species with modern methods (silver impregnation, scanning electron microscopy) and the first description of over 50 new species, the family Spathidiidae is split into four families and 20 genera. Each species is described and figured in detail, making it unnecessary to go back to the original literature often difficult to obtain. Two identification keys are provided, viz., one for taxonomists and another, simple key for users not specifically trained in ciliate taxonomy.
Money and debt : The public role of banks
This book from the Netherlands Scientific Council for Government Policy explains how money creation and banking works, describes the main problems of the current monetary and financial system and discusses several reform options. This book systematically evaluates proposals for fundamental monetary reform, including ideas to separate money and credit by breaking up banks, introducing a central bank digital currency, and introducing public payment banks. By drawing on these plans, the authors suggest several concrete reforms to the current banking system with the aim to ensure that the monetary system remains stable, contributes to the Dutch economy, fairly distributes benefits, costs and risks, and enjoys public legitimacy. This systematic approach, and the accessible way in which the book is written, allows specialized and non-specialised readers to understand the intricacies of money, banking, monetary reform and financial innovation, far beyond the Dutch context.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modern pharmaceutics
Covers the curriculum and syllabus developed by the Pharmacy Council of India, providing students with the necessary knowledge and skills required in the field of pharmaceutical services
Modern Mathematical Statistics with Applications
This book tries to strike a balance between mathematical foundations and statistical practice. The book provides a clear and current exposition of statistical concepts and methodology, including many examples and exercises based on real data gleaned from publicly available sources. The main focus of the book is on presenting and illustrating methods of inferential statistics used by investigators in a wide variety of disciplines, from actuarial science all the way to zoology. It begins with a chapter on descriptive statistics that immediately exposes the reader to the analysis of real data. The next six chapters develop the probability material that facilitates the transition from simply describing data to drawing formal conclusions based on inferential methodology. Point estimation, the use of statistical intervals, and hypothesis testing are the topics of the first three inferential chapters. The remainder of the book explores the use of these methods in a variety of more complex settings.
Modern Developments in X-Ray and Neutron Optics
This volume describes modern developments in reflective, refractive and diffractive optics for short wavelength radiation as well as recent theoretical approaches to modelling and ray-tracing the X-ray and neutron optical systems. It is based on the joint research activities of specialists in X-ray and neutron optics from 11 countries, working together under the framework of the European Programme for Cooperation in Science and Technology (COST, Action P7) in the period 2002--2006. The chapters are written by leading specialists from European laboratories, universities and large facilities. In addition to new ideas and concepts, the contents provide a large amount of practical information about recently implemented devices and methods.
