الصفحة 2
الصفحة 2
Mucosal Immune Defense : Immunoglobulin A
This book, authored by international experts in the field of IgA immunology, presents a comprehensive and timely overview of current knowledge of IgA structure and function. Topics include the basic science of IgA biochemistry and molecular biology, general and tissue-specific aspects of IgA function, and the clinical relevance of IgA in infection, autoimmunity, immunodeficiency and cancer.
MRI in Clinical Practice
The book covers the basic Physics behind MRI, quality assurance, up-to-date safety guidelines and a useful gallery of image artefacts. Part of the book focuses on the specific areas of the body in which MRI is currently exploited, describing how MRI is performed in practice. In each of these sections, a common theme is followed with illustrations of MR images acquired with clinically relevant settings and typical imaging protocols are also explicitly stated. Additional information is provided which includes a subjective view of the strengths and weaknesses of MRI in comparison to other imaging modalities. As well as covering routine clinical techniques, the latest advanced methods (e.g. spectroscopy, fMRI, diffusion, high field MRI) are discussed and placed into the context of clinical application.
Moving Millions : Transport Strategies for Sustainable Development in Megacities
The Alliance for Global Sustainability is an international partnership among four of the leading scienti?c and technological universities worldwide: • The Massachusetts Institute of Technology (MIT-AGS); • The University of Tokyo (UT); • The Swiss Federal Institute of Technology (ETH); and • The Chalmers University of Technology. Created in 1997, the AGS today brings together hundreds of university scientists, engineers, and social scientists to address complex issues that lie at the intersection of environmental, economic, and social policy goals. Since its inception, the AGS has promoted and supported multidisciplinary research teams drawn from its partner institutions. Working on critical issues in sustainability across several ?elds encompassing energy and climate, mobility, urban systems, water and agriculture, cleaner technologies, public policy, and communications, these teams have developed a signi?cant body of new knowledge.
Mouse controller using electroencephalography (EEG) device
The growing technologies related to neuroscience has to lead many innovative applications, most importantly Electroencephalography, or EEG for short. This field of study has become recently a trend that many companies around the world have started to enter the race of conquering the brain and controlling everything from a mouse controller to the whole human body. This project aims to help disabled people use a computer with ease and simplicity without needing to use their hands, or anything really, which they can achieve by wearing a headset or get someone to put it on them. The headset is designed to read brain activities and send it to a computer program to understand where the user wants to move the mouse cursor on the computer screen using an Artificial Intelligence model. This project helps further researches in this field which pushes the technology even further from where it is now. The device designed for this project can be repurposed pretty easily to serve many different applications other than controlling a mouse.
Monetary Policy and the German Unemployment Problem in Macroeconomic Models : Theory and Evidence
Having the high unemployment in Germany in mind, this book discusses how macroeconomic theory has evolved over the past forty years. It shows that in recent years a convergence has taken place, with modern models embodying a Keynesian transmission mechanism, monetarist policy implication, and modeling techniques inspired by new classical economics and real business cycle theory. It also probes in which direction models may be extended from here. Empirically, the book uses different econometric techniques to investigate the relevance and implications of different macroeconomic theories for German data. A key question this book investigates is the role of demand and supply side conditions for the increase in the German unemployment rate. On a policy level, the book relates the implications of the different theories to the ongoing debate on the appropriate roles of demand and supply side policies for curing the German unemployment problem.
Molecular Targeting in Oncology
In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice. The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.
Molecular Mimicry : Infection Inducing Autoimmune Disease
The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative fo.
Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modulated Temperature Differential Scanning Calorimetry : Theoretical and Practical Applications in Polymer Characterisation
This book provides both a basic and advanced treatment of the theory of the technique followed by a detailed exposition of its application to reacting systems, blends and semicrystalline polymers by the leaders in all of these fields. It is an essential text for anybody interested in calorimetry or polymer characterization, especially if they have found that conventional DSC cannot help them with their problems.
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics : Homogeneous and Heterogeneous Approaches
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
M-Health : Emerging Mobile Health Systems
M-health: Emerging Mobile Health Systems presents recent advances in this area and explores future trends in the applications of current and emerging wireless communication and network technologies for healthcare delivery and new wireless telemedical services. This work also evaluates the impact of the synergies between the 2.5G and 3G systems and beyond for healthcare applications and explores the augmentation of these technologies for the next generation of m-health services. M-health is commonly defined as the ‘emerging mobile communications and network technologies for healthcare systems’.
Methods of Celestial Mechanics: Vol. I: Physical, Mathematical, and Numerical Principles
G. Beutler's Methods of Celestial Mechanics is a coherent textbook for students in physics, mathematics and engineering as well as an excellent reference for practitioners. This Volume I gives a thorough treatment of celestial mechanics and presents all the necessary mathematical details that a professional would need. After a brief review of the history of celestial mechanics, the equations of motion (Newtonian and relativistic versions) are developed for planetary systems (N-body-problem), for artificial Earth satellites, and for extended bodies (which includes the problem of Earth and lunar rotation). Perturbation theory is outlined in an elementary way from generally known mathematical principles without making use of the advanced tools of analytical mechanics. The variational equations associated with orbital motion - of fundamental importance for parameter estimation (e.g., orbit determination), numerical error propagation, and stability considerations - are introduced and their properties discussed in considerable detail. Numerical methods, especially for orbit determination and orbit improvement, are discussed in considerable depth. The algorithms may be easily applied to objects of the planetary system and to Earth satellites and space debris.
Medical terminology systems : A body systems approach
Create an immersive, multimedia experience that tracks each student’s progress until they’ve mastered the language of medicine. Established record of presenting medical word building principles based on competency based curricula. Because of the pedagogical success of previous editions, this edition continues its structural design as a textbook-workbook that complements all teaching formats, including traditional lecture, distance learning, and independent or self-paced study
Medical Pharmacology and Therapeutics
Provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA. This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class. Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines.
Medical English
This book is an introduction to the vast topic of medical English. It will not only help you to improve your English, but is also an introduction to the world of medical jargon. It is intended to help health care professionals who need English for their work but do not speak the language on a day-to-day basis. It will be valuable for medical students, residents, nurses, doctors, and everybody else involved in the health care industry.
Medical data processing and analysis
Medical data can be defined as obtaining information from patients (such as signals, images, sounds, chemical components and their concentration, body temperature, respiratory rate, blood pressure, and different treatment measurements) to quantify the patient’s status and disease stage. Computer-aided diagnostic (CAD) systems use classical image processing, computer vision, machine learning, and deep learning methods for image analysis. Using image classification or segmentation algorithms, they find a region of interest (ROI) pointing to a specific location within the given image or an outcome of interest in the form of a label pointing to a diagnosis or prognosis. Computer science, with the evolution of artificial intelligence and machine learning techniques, facilitates the modeling and interpretation of results—from carrying out measurements to experiments and observations.
Medical Biometrics ; 1st International Conference, ICMB 2008, Hong Kong, China, January 4-5, 2008, Proceedings
Medical biometrics primarily refers to the usage of beh- ioral and physiological characteristics of humans for medical diagnosis and body care. Thus the goal of medical biometrics is to explore solutions to the open problems in medicine using biometric measurements, technologies and systems.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
