الصفحة 18
الصفحة 18
An overview of systemic lupus erythematosus (SLE) : Pathogenesis, classification, and management
Systemic lupus erythematosus (SLE), commonly referred to as lupus, is a complex and chronic autoimmune disorder that poses significant challenges to patients and healthcare providers alike. Affecting predominantly women of childbearing age, over 90% of those diagnosed are female, resulting in a striking female-to-male ratio of approximately 9:1. This condition exemplifies the intricate interplay between immune dysregulation and tissue damage, influenced by a combination of genetic predispositions, environmental triggers, hormonal factors, and immunological aberrations
Alzheimer's disease : Peptide vaccine and immunotherapy
Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) the ẞ-amyloid peptide (Aẞ) and tau are promising therapeutic avenues against AD. Two decades of effort has led to the controversial United States Food and Drug Administration (FDA) approval of the monoclonal antibody Aducamumab (Aduhelm), which has subsequentially sparked the revival and expedited review of promising monoclonal antibody immunotherapies that target Aẞ.
Alzheimers Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors).
Alzheimer’s and new horizon
Alzheimer's disease (AD) is characterized by progressive loss of memory and other cognitive functions. This study aims to discuss Alzheimer's disease (AD) and its increasing incidence and related huge fund to take care of such patients and will understand the pathophysiology in order to successfully fight this enigmatic illness and the goal of is the treatment for individuals with AD. Our study will also focus on the mutualistic relationship between AD and SARS- COV-2 infection and its correlation with cancer will be also discussed...
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
AIDS-Associated Viral Oncogenesis
AIDS-associated viral oncology is a significant healthcare problem. Since the identification of human immunodeficiency virus (HIV)-associated acquired immune disease syndrome (AIDS), the role of viruses in human cancers has become acutely apparent over the past twenty years. The understanding and treatment of AIDS-associated cancers has become a major concern among healthcare organizations. Human cancers that were once rare in the population have now become common within the HIV infected population.
Ageing : The Paradox of Life : Why We Age
For centuries people have been puzzled by the inevitability of human aging. For most of the second half of the twentieth century aging remained a mystery, or an unsolved biological problem. At the end of the 20th century a remarkable scientific discovery emerged. It was not a single discovery in the usual sense, because it was based on a series of important interconnected insights over quite a long period of time. These insights made it possible for the very first time to understand the biological reasons for aging in animals and man. It can already be said, however, that the many observations and insights that explain aging will not be accepted as established knowledge for a long time.
Advances in Targeted Cancer Therapy
This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed.
Advances in Bioactivation Research
This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.
Advances in Artificial Life ; 9th European Conference, ECAL 2007, Lisbon, Portugal, September 10-14, 2007, Proceedings
This book is organized in topical sections on conceptual articles, morphogenesis and development, robotics and autonomous agents, evolutionary computation and theory, cellular automata, models of biological systems and their applications, ant colony and swarm systems, evolution of communication, simulation of social interactions, self-replication, artificial chemistry, and posters.
Advances in artificial life ; 8th European Conference, ECAL 2005 , Canterbury, UK, September 5-9, 2005, Proceedings
The Artificial Life term appeared more than 20 years ago . Since then the area has developed dramatically, many researchersjoining enthusiastically and research groups sprouting everywhere.a conceptual track, where papers were judged on criteria like importance and/or novelty of the concepts proposed rather than the experimental / theoretical results, has been introduced this year. A conference on a theme as broad as Artificial Life is bound to be very di-verse, but a few tendencies emerged. First, fields like ‘Robotics and Autonomous Agents’ or ‘Evolutionary Computation’are still extremely active and keep onbringing a wealth of results to the A-Life community. Even there, however, new tendencies appear, like collective robotics, and more specifically self-assembling robotics, which represent now a large subsection. Second, new areas appear.‘Morphogenesis and Development’ which used to be the subject of only a fewpapers, is now one of the largest subsections, and seems to be on the brinkof becoming a field of its own. Finally, most classical themes of A-Life re-search like ‘Artificial Chemistry’, ‘Ant-Inspired Systems’, ‘Cellular Automata’,‘Self-Replication’, ‘Social Simulations’ or ‘Bio-realist Simulations’ are still goingstrong and are well represented within this volume.
Advances in Alzheimer’s and Parkinson’s Disease : Insights, Progress, and Perspectives
Proceedings of the 7th International Conference on Alzheimer’s Disease and Parkinson’s Disease (ADPD), held March 9-13, 2005 in Sorrento, Italy.The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, covering topics such as immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the history, epidemiology, clinical phenomenology, diagnosis, imaging, treatment ,and future perspectives of Alzheimer’s and Parkinson’s Diseases.
Advanced chemical biology : chemical dissection and reprogramming of biological systems
Organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.
Acute Promyelocytic Leukemia : Molecular Genetics, Mouse Models and Targeted Therapy
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
About Life : Concepts in Modern Biology
This book uses modern biological knowledge to tackle the question: "What distinguishes living organisms from the non-living world?" In the first few chapters, the authors draw on recent advances in cell and molecular biology to develop an account of the "living state" that applies to all organisms, but only to organisms. Subsequent chapters use this account to explore questions about evolution, the origin of life and the possibility of extraterrestrial life. Towards the end of the book the authors consider human evolution, intelligence and the extent to which our species can be regarded as biologically unique. About Life is written as far as possible in non-technical language; all scientific terms are explained straightforwardly when they are introduced. It is aimed at the general, non-specialist reader, but the novel approach that it takes to general issues in biology will also interest students of the life sciences.
Abnormal Skeletal Phenotypes : From Simple Signs to Complex Diagnoses
This book focuses on the radiographic changes of malformation syndromes and skeletal dysplasias. It is structured such that the reader can identify the radiographic changes and relate them to specific disease entities. The aim is to provide an essential, practical guideline to the recognition of the key radiographic signs for diagnosing malformation syndromes and skeletal dysplasias.
Abl Family Kinases in Development and Disease
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.
A Twenty-First Century Guide to Aldersonian Marketing Thought
The book has three major themes: glimpses into the kind of interesting character he was, key excerpts from his writings, and commentaries on the perceived current relevance of Aldersonian marketing thought. … this book is an excellent vehicle for educating people on a guru, influencer, theoretician, practitioner and leader in the development of marketing theory. … this is a valuable resource for anyone desiring to know about marketing theory and to understand the genesis of a number of concepts currently found in today’s marketing textbooks.
A theoretical and clinical study about multiple sclerosis
Multiple sclerosis is a one of those diseases such as Alzheimer in which no cure excites yet, any type of degradation in the neurological system is hard to restore, and more difficult in such a disease that it has a wide range of symptoms from the eye injury till some difficulty in walking to many other symptoms in which we will highlight in our project to increase public health awareness to consider such a relatively unknown disease in differential diagnosis...
