الصفحة 18
الصفحة 18
Dynamic Analysis of Petri Net-Based Discrete Systems
Design of modern digital hardware systems and of complex software systems is almost always connected with parallelism. For example, execution of an object-oriented p- gram can be considered as parallel functioning of the co-operating objects; all modern operating systems are multitasking, and the software tends to be multithread; many complex calculation tasks are solved in distributed way. But designers of the control systems probably have to face parallelism in more evident and direct way. Controllers rarely deal with just one controlled object. Usually a system of several objects is to be controlled, and then the control algorithm naturally turns to be parallel. So, classical and very deeply investigated model of discrete device, Finite State Machine, is not expressive enough for the design of control devices and systems. Theoretically in most of cases behavior of a controller can be described by an FSM, but usually it is not convenient; such FSM description would be much more complex, than a parallel specification (even as a network of several communicating FSMs).
Durability of reinforced concrete structures
Reinforced concrete structures corrode as they age, with significant financial implications, but it is not immediately clear why some are more durable than others. This book looks at the mechanisms for corrosion and how corrosion engineering can be used for these problems to be minimized in future projects. Several different examples of reinforced concrete structures with corrosion problems are described and the various life enhancement solutions considered and applied are discussed. The book includes a chapter on the effectiveness of corrosion monitoring techniques and questions why the reality is at odds with current theory and standards.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug and Alcohol Abuse : A Clinical Guide to Diagnosis and Treatment
Gives professionals and students across the health and mental health disciplines a working knowledge of drug-related pathology, beginning with pharmacology, drug mechanisms, and genetic factors. This title features clinical/emergency orientation suited to both chronic misuse and acute situations.
Double-stranded RNA : Methods and protocols
Examines classical and cutting-edge methods involving double-stranded RNA (dsRNA), specifically regarding isolation, visualization, characterization, production, and application. Many protocols, such as co-immunoprecipitation-based isolation of double-stranded RNA-associated protein complexes, identification of mycoviruses by dsRNA extraction, application of dsRNA for fungi disease management (Sclerotinia sclerotiorum and Botrytis cin), and production of double-stranded RNA in plants by plant viral vectors for gene silencing, can also be easily adapted for identification of viruses from other organisms, control of other pathogens, and fundamental research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls.
DNA Methylation, Epigenetics and Metastasis
Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour
DNA Methylation and Cancer Therapy
DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
DNA Methylation : Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.
DNA Methylation : Basic Mechanisms
The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is not well understood. The stability, inheritability, and developmental flexibility of these patterns point to a major role that these patterns appear to play in determining structure and function of the genome.
DNA Conformation and Transcription
the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Distributed Event-Based Systems
Event-based architectures inherently decouple system components. Event-based components are not designed to work with specific other components in a traditional request/reply mode, but separate communication from computation through asynchronous communication mechanisms via a dedicated notification service.
Discovering Biomolecular Mechanisms with Computational Biology
In this anthology, leading researchers present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation. Discovering Biomolecular Mechanisms with Computational Biology is essential reading for life science researchers and higher-level students that work on biomolecular mechanisms and wish to understand the impact of computational biology for their success.
Direct Democracy in Europe : Developments and Prospects
The initiative and referendum process offers extra channels of participation and can serve as an important supplementary institution in representative democratic systems. This first volume of the new series Direct Democracy in Modern Europe features sixteen systematic and broadly empirical approaches to the study of modern direct democracy within the context of European politics including - system contexts and effects of the initiative and referendum process - theoretical approaches and basic values in modern direct democracy - the quality and institutional design of direct democratic mechanisms - aspects of information and communication - institutional performance and economic effectiveness - transnational challenges and the development of direct democracy in Europe
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Diffuse matter from star forming regions to active galaxies : A volume honouring John Dyson
In this volume dedicated to him, introductory reviews to a number of the key processes and to the sources themselves are given by leading experts. The mechanisms in which the multi-component natures of media affect their dynamics receive particular attention, but the roles of hydromagnetic effects are also highlighted.
Diastolic Heart Failure
This book addresses the epidemiology, pathophysiologic mechanisms, diagnostic methods, treatment and prognosis. It also gives an analysis of specific problems, related to coronary artery disease, arterial hypertension, diabetes, hypertrophic and restrictive cardiomyopathies, and constrictive pericarditis.
Diagnosis of pathogenic microorganisms : Causing infectious diseases
Infectious diseases are caused by the pathogenic microbial organisms. These microbes can multiply and can cause an infection, once they enter the body. Infectious diseases are transmissible, and may cause mild to life-threatening illnesses. It can be airborne, waterborne, foodborne, and soilborne. It can be spread through direct contact (human to human, animal to human). It has also been one of the leading causes of human deaths. Therefore, there is a need to have rapid diagnostic methods to prevent and control these diseases. This book titled “Diagnosis of Pathogenic Microorganisms Causing Infectious Diseases” will help the scientific community to understand the transmission dynamics of some infectious diseases of public health importance.
Development of breast cancer therapy and gender
Breast cancer is a disease in which abnormal cells in the breast tissues multiply and form an invasive (or malignant) tumor. Such tumors can invade and damage the tissue around them and spread to other parts of the body through the lymphatic or vascular systems. We will describe in our study several types of breast cancer, since they are classified into two main categories: “invasive” and “non-invasive,” or in situ. While invasive cancer has spread from the breast ducts or glands to other parts of the breast, non-invasive cancer has not spread from the original tissue. Our study will focus on the best tests that examine the breasts which are used to detect and diagnose breast cancer: Physical exam and health history, Clinical breast exam (CBE), Mammogram, Ultrasound exam, MRI (magnetic resonance imaging), Blood chemistry studies and Biopsy. We will include the value of such tests after breast cancer has been diagnosed, to find out if cancer cells have spread within the breast or to other parts of the body.
Designing Organizations : 21st Century Approaches
The design of organizations has been an ongoing concern of management theory and practice over the past several decades. Over this time, there has been little change in the fundamental theory, principles and concepts of Organization Design (OD). Recently organizational life has changed dramatically with the advent of: new communication systems, adaptive mechanisms, information technology, knowledge management systems, innovation processes and more. This book systemically examines these developments and their impact on OD with contributions from leading scholars in the area. Also featured in the book are the practical issues with implementing OD in organizations. The individual chapters are organized into five sections: (1) Putting Contingency Theory in its Place, (2) Focus on Individuals Who Make up the Organization, (3) Innovation Processes and Organization Design, (4) Adaptation and Technology, and (5) Design for Performance. Each chapter examines aspects of the book’s threefold theme: (1) core issues in organization design, (2) emerging theoretical perspectives in OD, and (3) new developments and directions in OD. A special feature of each chapter is: 1) implications for theory, and 2) implications for practice.
Design of Hybrid Structures : Where Steel Profiles Meet Concrete
Focuses on design approaches for concrete structures reinforced in an unconventional way by steel profiles. It explains force transfer mechanisms of steel profiles and oncrete interfaces, and an analysis of the characteristics of hybrid structures, including slendercomponents. Several types of hybrid designs are addressed: walls and columns with several embedded steel profiles, connections strengthened by steel profiles between steel and composite or reinforced concrete components, including the specific case of shear keys connecting deep beams or flat slabs to columns. The transition zones in partly reinforced concrete and partly composite columns are also covered.
