70 Years of Levothyroxine
Presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment.
3D diagnosis and treatment planning in orthodontics : an atlas for the clinician
A wide-ranging guide to modern diagnostics and treatment planning in orthodontics, which are mandatory prior to the initiation of any type of comprehensive treatment. The importance of three-dimensional (3D) imaging techniques has been increasingly recognized owing to the shortcomings of conventional two-dimensional imaging in some patients, such as those requiring complex adult treatment and those with temporomandibular joint dysfunctions or sleep disturbances.

