الصفحة 18
الصفحة 18
Cyclin Dependent Kinase 5 (Cdk5)
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
Current Topics in Innate Immunity
This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.
Current Perspectives in microRNAs (miRNA)
In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.
Current Developments in Bioerosion
The book opens with papers on the evolutionary significance of bioerosion, and subsequently ventures out to explore the remarkable diversity of bioerosive biota. From microboring bacteria to grazing echinoids, the studies use a variety of techniques ranging from field observations to sophisticated micro-computed tomography to investigate the ecological and environmental role of these organisms, including symbiotic interactions and alteration of non-carbonate substrates.
Ctenophores : Methods and protocols
Explores emerging approaches and methods inspired by recent research using ctenophores or placozoans, facilitating the study of these enigmatic species and ancient animal lineages. Practical protocols are integrated with introductory chapters about general biology, summarizing the diversity, evolution, genomics, development, and neurobiology of these organisms. Special chapters outline strategies and applications for culturing, microscopy, physiology, electrical synapses, and bioluminescence, molecular and single-cell biology, transcription factors, as well as gene and protein expression analyses. The book also contains bioinformatics and computational chapters covering peptidomics and epigenomics. Written for the highly successful Methods in Molecular Biology series, chapters include detailed implementation advice that leads to dependable results in the laboratory.
CSR and Codes of Business Ethics in the USA, Austria (EU) and China and their Enforcement in International Supply Chain Arbitrations
Analyzes the implementation of CSR reporting and codes of business conduct and ethics in the legal systems of the USA, Austria and China and their enforcement in international supply chain arbitrations. demonstrates that long-term profit maximization is increasingly intertwined with corporate ethics and CSR policies. In order to prevent window-dressing and greenwashing, certain control mechanisms and legal standards are required along the entire supply chain.
Cryptography and cryptanalysis in Java : Creating and programming advanced algorithms with Java SE 17 LTS and Jakarta EE 10
Includes challenging cryptographic solutions that are implemented in Java 17 and Jakarta EE 10. It provides a robust introduction to Java 17's new features and updates, a roadmap for Jakarta EE 10 security mechanisms, a unique presentation of the "hot points" (advantages and disadvantages) from the Java Cryptography Architecture (JCA), and more. You Will Learn : Develop programming skills for writing cryptography algorithms in Java / Dive into security schemes and modules using Java / Explore “good” vs “bad” cryptography based on processing execution times and reliability / Play with pseudo-random generators, hash functions, etc. / Leverage lattice-based cryptography methods, the NTRU framework library, and more
Cryptographic Algorithms on Reconfigurable Hardware
This book covers the study of computational methods, computer arithmetic algorithms, and design improvement techniques needed to implement efficient cryptographic algorithms in FPGA reconfigurable hardware platforms. The concepts and techniques reviewed in this book will make special emphasis on the practical aspects of reconfigurable hardware design, explaining the basic mathematics related and giving a comprehensive description of state-of-the-art implementation techniques. The authors show how high-speed cryptographic algorithms implementations can be achieved on reconfigurable hardware devices without posing prohibited high requirements for hardware resources. The material in this book will be of interest to engineering professionals, programmers, hardware designers, and graduate students interested in the development of security and cryptographic mechanisms at a beginning/intermediate level.
Critical issues in head and neck oncology : Key concepts from the eighth THNO meeting
Reviews the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches.
Cough : Pathophysiology, diagnosis and treatment
This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice. The book also provides insights into cough’s features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored.
Cosmic Ray Interactions, Propagation, and Acceleration in Space Plasmas
"The book consists of four Chapters. Chapter 1 shortly describes main properties of space plasmas and primary CR, different types of CR interactions with space plasmas components Chapter 2 considers the problem of CR propagation in space plasmas described by the kinetic equation and different types of diffusion approximations ,Chapter 3 is devoted to CR non-linear effects in space plasmas caused by CR pressure and CR kinetic stream instabilities with the generation of Alfvèn turbulence In Chapter 4 different processes of CR acceleration in space plasmas are considered: the development of the Fermi statistical mechanism, acceleration in the turbulent plasma, Alfven mechanism of magnetic pumping, induction mechanisms, acceleration during magnetic collapse and compression, cumulative acceleration mechanism near the zero lines of a magnetic field, acceleration in shear flows, shock-wave diffusion (regular) acceleration. The book ends with a list providing more than 1,300 full references, a discussion on future developments and unsolved problems, as well as Object and Author indexes. "
Cosmeceuticals as Game Changers in the Cosmetic Industry
Objectives of this work is to compare conventional cosmetics to biotechnology derived cosmeceuticals in terms of skin anti-aging, skin color modulation and hair growth, and to find out which is of greater overall performance. Research revealed superiority of cosmeceuticals to classical cosmetics as it was found that many classical cosmetic agents used for aesthetical purposes posed a certain level of either ineffectiveness, for the reason that the effect did not treat the cause of the problem and was merely temporary and external, or harmfulness because of proposed potential health risks and adverse effects. Whereas cosmeceuticals presented promising novel mechanisms and compounds for a deeper, more thorough remedy.
Corporate Entrepreneurship and Venturing
The common theme in Corporate Entrepreneurship and Venturing is how and why corporate entrepreneurship and corporate venturing can contribute to innovation and strategic renewal in large established companies. In particular it explores ways to balance exploitation and exploration in established companies. The issue is how the locus of entrepreneurship affects the way corporate entrepreneurship addresses the exploitation/exploration challenge. One stream of research focuses on the entrepreneurial culture in large companies and how they can create an environment in which intrapreneurs (entrepreneurs within large companies) can blossom. In this view entrepreneurial initiatives can emerge throughout the organization and this type of entrepreneurship has been labelled as ‘dispersed corporate entrepreneurship’. Two related chapters fit into that stream of research. The other three chapters address the challenge of corporate venture capital programs. These programs have funds to invest in start-ups (external ventures) and the corporate parent want to benefit from the technology, new products or new competences developed in these start-ups. In this case they have separated the locus of entrepreneurship from the main line of business operations, which has been labelled ‘focused corporate entrepreneurship’. In this ‘focused corporate entrepreneurship’ stream the issue is not so much the motivational factors and supportive culture to entrepreneurial initiatives, but the creation and development of linkage mechanisms between the start-ups and the parent company in order to create new combinations based on competences from both the start-up and the parent company. Although the challenges in these two streams of literature are different, they both address the strategic issue of balancing exploitation and exploration.
Coronavirus therapeutics ; Vol. I : Basic science and therapy development
Provides the most comprehensive review on contemporary knowledge on the origin and structural biology and molecular aspects of Coronaviruses. This also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated.
Cooperation in Primates and Humans : Mechanisms and Evolution
Cooperative behavior has been one of the enigmas of evolutionary theory since the days of Darwin. The contributions to this book examine the many facets of cooperative behavior in primates and humans. Some of the world’s leading experts summarize and review the state of the art of theoretical and empirical studies of cooperation. This is the first attempt to bridge the gap between parallel research activities in primatology and studies of humans. This comparative approach highlights both common principles as well as aspects of human uniqueness with respect to cooperative behavior.
Control of Biofilm Infections by Signal Manipulation
Describes the molecular mechanisms of cell-to-cell communication among bacterial cells in a biofilm, the development of antibiofilm inhibitors, like quorum-sensing inhibitors, and the use of biofilm inhibitors to prevent and treat bacterial infections in humans and other animals.
Continental Evolution : The Geology of Morocco : Structure, Stratigraphy, and Tectonics of the Africa-Atlantic-Mediterranean Triple Junction
Morocco is one of the most fascinating lands in the world from the point of view of its geological structure and evolution. Our knowledge on the geology of the country has been greatly improved during the last decades, based on numerous seismic profiles and boreholes, seismological analysis of focal mechanisms, seismic tomography, gravimetric/geodetic modelling and, on the other hand, based on a big National Program of Geological Mapping including modern geochemical analyses (trace elements) and reliable isotopic datings (39Ar-40Ar, U-Pb zircon, Sm-Nd, etc). Moreover, a number of academic studies have been performed in relation with the increasing number of Moroccan universities.
Contextualisms in Epistemology
This comprehensive anthology collects twenty original essays and critical commentaries on different aspects of contextualism, written by leading philosophers on the topic. The editors’ introduction sketches the historical development of the contextualist movement and provides a survey and analysis of its arguments and major positions. The papers explore, inter alia, the central problems and prospects of semantic (or conversational) contextualism and its main alternative approaches such as inferential (or issue) contextualism, epistemic contextualism, and virtue contextualism. They also investigate the connections between contextualism and epistemic particularism, and between contextualism and stability accounts of knowledge.
Content Delivery Networks
Content Delivery Networks enables the readers to understand the basics, to identify the underlying technology, to summarize their knowledge on concepts, ideas, principles and various paradigms which span on broad CDNs areas.
Contemporary endodontics for children and adolescents
Describes pulp therapy from a holistic approach that highlights new developments in the field. Readers will find updates on the formation, structure and function of the dental pulp revealed by the latest single-cell technologies, and discussions on carious lesions and their impact on the pulp. The book examines clinical considerations in the decision to perform pulp treatment and emphasizes the need to integrate pupal diagnostics with patient-dependent factors such as behavior management and pulpal pain mechanisms. The second part of the book includes comprehensive descriptions of current treatments for each type of caries-inflicted tooth damage, from selective caries removal through direct pulp capping, pulpotomy, pulpectomy and root canal therapy for primary dentition to direct pulp capping and endodontic treatment of young permanent teeth.
