الصفحة 173
الصفحة 173
An introduction to generative drug discovery
Describes the state‑of‑the‑art methods and applications for de novo design of drug candidates using generative chemistry models as well as the ethical aspects of this technology. It will provide a foundation for those new to the field as well as those that may already have some experience of its utility. With contributions from scientists in both academia and industry ‘Introduction to Generative Drug Discovery’ may represent one of the earliest if not the first book to focus on this topic.
An Introduction to Efficiency and Productivity Analysis
It is designed to be a "first port of call" for people wishing to study efficiency and productivity analysis. The book provides an accessible introduction to the four principal methods involved: econometric estimation of average response models; index numbers; data envelopment analysis (DEA); and stochastic firontier analysis (SFA). For each method, we provide a detailed introduction to the basic concepts, give some simple numerical examples, discuss some of the more important extensions to the basic methods, and provide references for further reading. In addition, we provide a number of detailed empirical applications using real-world data.
An Introduction to Difference Equations
The book integrates both classical and modern treatments of difference equations. It contains the most updated and comprehensive material, yet the presentation is simple enough for the book to be used by advanced undergraduate and beginning graduate students. This third edition includes more proofs, more graphs, and more applications. The author has also updated the contents by adding a new chapter on Higher Order Scalar Difference Equations, along with recent results on local and global stability of one-dimensional maps, a new section on the various notions of asymptoticity of solutions, a detailed proof of Levin-May Theorem, and the latest results on the LPA flour-beetle model
An introduction to description logics
Designed so that domain knowledge can be described and so that computers can reason about this knowledge. DLs have recently gained increased importance since they form the logical basis of widely used ontology languages, in particular the web ontology language OWL. Written by four renowned experts, this is the first textbook on description logics. It is suitable for self-study by graduates and as the basis for a university course. Starting from a basic DL, the book introduces the reader to their syntax, semantics, reasoning problems and model theory and discusses the computational complexity of these reasoning problems and algorithms to solve them.
An Introduction to Copulas
Copulas are functions that join multivariate distribution functions to their one-dimensional margins. The study of copulas and their role in statistics is a new but vigorously growing field. In this book the student or practitioner of statistics and probability will find discussions of the fundamental properties of copulas and some of their primary applications. The applications include the study of dependence and measures of association, and the construction of families of bivariate distributions.
An Introduction to continuous-time stochastic processes : Theory, models, and applications to finance, biology, and medicine
This book is introduction to the theory of continuous-time stochastic processes. A balance of theory and applications, the work features concrete examples of modeling real-world problems from biology, medicine, industrial applications, finance, and insurance using stochastic methods. No previous knowledge of stochastic processes is required. Key topics covered include: * Interacting particles and agent-based models: from polymers to ants * Population dynamics: from birth and death processes to epidemics * Financial market models: the non-arbitrage principle * Contingent claim valuation models: the risk-neutral valuation theory * Risk analysis in insurance
An Introduction to Computational Micromechanics
This book presents a comprehensive introduction to computational micromechanics, including basic homogenization theory, microstructural optimization and multifield analysis of heterogeneous materials. "An Introduction to Computational Micromechanics".
An Introduction To Chemoinformatics
This, the first text written specifically for this field, aims to provide an introduction to the major techniques of chemoinformatics. The first part of the book deals with the representation of 2D and 3D molecular structures, the calculation of molecular descriptors and the construction of mathematical models. The second part describes other important topics including molecular similarity and diversity, the analysis of large data sets, virtual screening, and library design. Simple illustrative examples are used throughout to illustrate key concepts, supplemented with case studies from the literature.
An introduction to cable roof structures ; 2nd ed.
Provides structural engineers with a concise introduction to the architectural, structural and technological aspects of cable roofs, and supplies sufficient information for engineers to carry out their own designs. The improved methods for generating wind and earthquake histories have been included as the trend in modern design codes seem increasingly to require that dynamic response of other forms of non-linear structures such as guyed masts is considered at the design stage.
An Interactive Multimedia Introduction to Signal Processing
A didactic concept is undertaken for microelectronics, computer technology and communication engineering, which deals with the visualization of signals and processes in addition to graphical programming of signal processing systems. Through the utilization of a professional and globally supported software for metrology and control engineering, DasyLab, useful applications can be developed, modified and optimized. Computer supported processing of real signals is made possible over the sound card and the parallel port. Over two hundred pre-programmed signal engineering systems and design transparencies are provided. Pictures also play a dominant rule in this book: there are numerous introduction-videos, one for every chapter, more than 250 high-quality pictures and - most important – all the "living" experiments and their results are visualized. With this learning system, readers can now make use of "equipment" and software, which was practically unaffordable for individuals in the past. What's more, here is a very new concept for learning Signal Processing, not only from the physically-based scientific fundamentals, but also from the didactic perspective, based on modern results of brain research.
An Illustrated Guide to Furniture History
Provides upper-level students and instructors with an alternative visual analytical approach to learning about furniture history from Antiquity to Postmodernism. Following an immersive teaching model, it presents a Nine-Step Methodology to help students strengthen their visual literacy and quickly acquire subject area knowledge. Moving chronologically through key periods in furniture history and interior design, such as the Renaissance, the Arts and Crafts Movement, and Modernism, it traverses Europe to America to present a comprehensive foundational guide to the history of furniture design.
Amplification of Chirality
Amplification of Chirality presents critical reviews of the present position and future trends in modern chemical research. The book contains short and concise reports on chemistry. Each is written by the world renowned experts. Still valid and useful after 5 or 10 years, more information as well as the electronic version of the whole content available at: springerlink.com.
Amino acids and the asymmetry of life : Caught in the act of formation
This book describes how the basic building blocks of life, the amino acids, formed. After a comprehensible introduction into stereochemistry, the author addresses the inherent property of amino acids in living organisms, namely the preference for left-handedness. What was the cause for violation of parity of amino acids in the emergence of life on Earth? All the fascinating models proposed by physicists, chemists and biologist are vividly presented including the scientific conflicts.
Americanization of the European Economy : A compact survey of American economic influence in Europe since the 1800s
Provides a comprehensive yet compact survey of the growth of American economic influence in Europe since the 1880s. Three distinct but cumulative waves of Americanization are identified. Americanization was (and still is) a complex process of technological, political, and cultural transfer, and this overview explains why and how the USA and the American model of industrial capitalism came to be accepted as the dominant paradigm of political economy in today's Europe. Americanization of the European Economy summarizes the ongoing discussion by business historians, sociologists, and political scientists and makes it accessible to all types of readers who are interested in political and economic development.
Ambisonics : A Practical 3D Audio Theory for Recording, Studio Production, Sound Reinforcement, and Virtual Reality
Provides a concise explanation of the fundamentals and background of the surround sound recording and playback technology Ambisonics. It equips readers with the psychoacoustical, signal processing, acoustical, and mathematical knowledge needed to understand the inner workings of modern processing utilities, special equipment for recording, manipulation, and reproduction in the higher-order Ambisonic format. The book comes with various practical examples based on free software tools and open scientific data for reproducible research. The book includes an extensive mathematical appendix. The book offers readers a deeper understanding of Ambisonic technologies, and will especially benefit scientists, audio-system and audio-recording engineers.
Ambiguities in Decision-oriented Life Cycle Inventories: The Role of Mental Models and Values
Shows for the first time how mental models and values influence this attribution in the life cycle inventory step of LCA. One of the key findings is that the different management rules for a sustainable use of materials must be taken into account for the attribution of material and energy flows to a product. Otherwise, improvement options recommended by an LCA might turn out to even worsen the environmental situation if reassessed from a meta-perspective. As a consequence of this book, the claim of unambiguitiy (‘objectivity’) of the life cycle inventory must be abandoned. A group-model building process for LCA is developed that allows one to grasp the decision makers' mental models and values in the inventory analysis on a case- and situation-specific basis. Only by this, LCA results will become relevant in a decision-making process. Two case studies on the modelling of recycling and other end-of-life options of aluminium windows and beech wood railway sleepers in LCA complement the methodological part.
Ambient Intelligence ; European Conference, AmI 2008, Nuremberg, Germany, November 19-22, 2008. Proceedings
This book constitutes the refereed proceedings of the Second European Conference on Ambient Intelligence, AmI 2008, held in Nuremberg, Germany, in November 2008.
Amartya Sens Capability Approach: Theoretical Insights and Empirical Applications
Kuklys examines how Nobel Prize-winning economist Amartya Sen’s approach to welfare measurement can be put in practice for poverty and inequality measurement in affluent societies such as the UK. Sen argues that an individual’s welfare should not be measured in terms of her income, but in terms what she can actually do or be, her capabilities. In Chapters 1 and 2, Kuklys describes the capability approach from a standard welfare economic point of view and provides a comprehensive literature review of the empirical applications in this area of research. In the remaining chapters, novel econometric techniques are employed to operationalise the concepts of functionings and capability to investigate inequality and poverty in terms of capability in the UK. Kuklys finds that capability measurement is always a useful complement to traditional monetary analysis, and particularly so in the case of capability-deprived disabled individuals.
Alvar Aalto Houses
Finnish architect and designer Alvar Aalto (1898-1976) designed nearly one hundred single-family houses. Aalto, who is also known for his furniture and glassware, worked in a unique style that blended modernism and traditional vernacular architecture. Authors Jari and Sirkkaliisa Jetsonen (Finnish Summer Houses) present twenty-six of Aalto's innovative residences—from small summer homes and postwar standardized housing to large housing complexes for industrial commissions—built between the 1920s to the 1960s.
Alvar Aalto and the future of architecture
Exposes dialogue between history, theory, design, construction, technology, and sensory experience by means of digital simulations that enhance the assessment and values of our material choices. It offers a critical look to the past to inspire the future. This new edition looks to Alvar Aalto as the primary protagonist for channeling discussions related to these topics. Architects like ALA, Shigeru Ban, 3XN, Peter Zumthor, and others also play the role of contemporary guides in this review. The work of Aalto and selected contemporary architects, along with computer modeling software, showcase the importance of comprehensive design.
