الصفحة 17
الصفحة 17
Immunogenicity of Biopharmaceuticals
This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.
Immune regulation and immunotherapy in autoimmune disease
Assembles the insights and experience of over twenty experts and thought leaders in the field of autoimmune disease and immunotherapy. These discussions represent some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. This book provides a wide-ranging review of two main arenas of current research: that of autoimmune mechanisms of disease and that of the latest developments in immunotherapy, with an emphasis upon multiple sclerosis.
Immobilisation of DNA on Chips II
DNA chips are gaining increasing importance in different fields ranging from medicine to analytical chemistry with applications in the latter in food safety and food quality issues as well as in environmental protection. In the medical field, DNA chips are frequently used in arrays for gene expression studies to identify diseased cells due to over- or under-expression of certain genes, to follow the response of drug treatments, or to grade cancers), for genotyping of individuals, for the detection of single nucleotide polymorphisms, point mutations, and short tandem reports, or moreover for genome and transcriptome analyses in the quasi post-genomic sequencing era. Furthermore, due to some unique properties of DNA molecules, self-assembled layers of DNA are promising candidates in the field of molecular electronics.the main focus of these two volumes is on the immobilization chemistry, considering the various aspects of the immobilization process itself, since different types of nucleic acids, support materials, surface activation chemistries and patterning tools are of key concern.
Imaging of the Temporomandibular Joint
This book is designed to meet the demand for a comprehensive yet concise source of information on temporomandibular joint (TMJ) imaging that covers all aspects of TMJ diagnostics. Readers will find clear presentation of the imaging findings in the full range of TMJ pathologies, from intrinsic pathological processes to invasion by lesions of the temporal bone and mandibular condyle.
Image Processing : Dealing with Texture ; 2nd ed.
Updates the classic work on texture analysis theory and methods without abandoning the foundational essentials of this landmark work. Like the first, the new edition offers an analysis of texture in digital images that are essential to a diverse range of applications such as: robotics, defense, medicine and the geo-sciences. Designed to easily locate information on specific problems, the text is structured around a series of helpful questions and answers. Updated to include the most recent developments in the field, many chapters have been completely revised including: Fractals and Multifractals, Image Statistics, Texture Repair, Local Phase Features, Dual Tree Complex Wavelet Transform, Ridgelets and Curvelets and Deep Texture Features. The book takes a two-level mathematical approach: light math is covered in the main level of the book, with harder math identified in separate boxes.
Image and video encryption : From digital rights management to secured personal communication
Image and Video Encryption provides a unified overview of techniques for encryption of images and video data. This ranges from commercial applications like DVD or DVB to more research oriented topics and recently published material. This volume introduces different techniques from unified viewpoint, then evaluates these techniques with respect to their respective properties (e.g., security, speed.....). Encryption of visual data is an important topic in the area of mutimedia security, applications range from digital rights management (DVD, DVB) ) to secure personal communications. Within this topic area, we face several aims which contradict each other. What we thrive on is good compression, fast compression, high security, fast encryption, bitstream compliance, little power consumption and little memory requirements. The authors experimentally compare different approaches proposed in the literature and include an extensive bibliography of corresponding published material. Image and Video Encryption is designed for a professional audience composed of researchers and practitioners in industry. The book is also suitable for graduate-level students in computer science and electrical engineering.
Image Analysis, Sediments and Paleoenvironments
This seventh volume of the DPER series examines imaging techniques for sedimentologists, paleolimnologists, paleoceanographers and microscopists working on issues related to paleoenvironmental reconstruction. It will help the researcher or graduate student to understand every step involved in the imaging process, from image acquisition to measurements.nbsp; Procedures are described to ensure that the right protocols and methodology are selected to solve a particular issue, and to evaluate the validity of scientific results. Case studies illustrate the wide range of information that can be obtained from many kinds of sediments (marine, lacustrine and aeolian) and different types of samples (cores, embedded blocks, microscopic slides) using different regions of the electromagnetic spectrum (visible, UV, IR, X-ray). The volume provides comprehensive protocols, guidelines, and recommendations for the use of low cost image analysis techniques, to facilitate intercomparisons of measurements.
Ileo meccanico dell’intestino tenue : Aspetti TC e correlazioni eco-radiografiche = Mechanical ileus of the small intestine : CT aspects and echo-radiographic correlations
Mechanical occlusion of the small intestine is a frequently encountered clinical problem, whose clinical-instrumental management is made difficult by the complexity of the mechanisms responsible for the occlusive picture. The role of the radiologist is to promptly guide the therapeutic process on the basis of a correct interpretation of the iconographic pictures. The purpose of this volume - the only one of its kind - is to relate the pathophysiology of occlusion to imaging. The rich iconography, which ranges from clinical onset to resolution, emphasizes the role of multidetector computed tomography with intravenous contrast, which is the current gold standard. However, the correlations with the echo-radiographic methods are not forgotten, which retain an effective diagnostic role, with a low biological and economic cost. The mechanical ileus of the small intestine is a striking example in support of the dream of many professionals: that, that is, to have a figure of a fine abdominal emergency radiologist, an expert in organ and disease and not only in the machine, as often unfortunately it happens.
Identifying, Assessing, and Treating Autism at School
As the rate of autism diagnosis continues to escalate, awareness and recognition of this developmental brain disorder - as well as a demand for services - are also mushrooming. School districts, already struggling under the weight of withering budgets and increasing enrollments, are now scrambling to strike a balance between the types of services and treatments parents want for their children and what the school system can afford to provide. Consequently, a broad cross-section of professionals and parents are searching for the means and methods by which to identify and address the wide-ranging.
Hypoxia and Exercise
The 14th volume in the series will focus on cutting edge research at the interface of hypoxia and exercise. The work will cover the range from molecular mechanisms of muscle fatigue and muscle wasting to whole body exercise on the world’s highest mountains. State of the art papers on training at high altitude for low altitude athletic performance will also be featured.
Hyperthermia In Cancer Treatment : A Primer
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Hypertension in the Elderly
Topics range from basic concepts, epidemiology and trials, and evaluation and management, to pharmacological treatment, special populations, and adherence, all presented with an emphasis on the optimal management of patients. The authors examine in detail the mechanisms of hypertension in the elderly, particularly age-related changes in vascular stiffness, and methodically review the lifestyle and outcomes trials that were conducted in older persons. The problems of clinical evaluation, secondary hypertension, and target organ damage are also fully addressed, and a practical approach is provided for correctly determining blood pressure, one of the most important tasks in evaluating an older patient. Extensive discussions of pharmacological therapy detail the role of individual drug classes, including diuretics and b-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium antagonists, a-1 blockers, and combination drug therapies. Additional chapters focus on special populations, such as African Americans, patients with diabetes, and patients with arthritis, as well as on the clinician's role in improving therapeutic adherence in older patients. Offers family practitioners and general internists an up-to-date, user-friendly reference on the diagnosis, treatment, and complications of hypertension in the elderly.
Hydrogels : Design, Synthesis and Application in Drug Delivery and Regenerative Medicine
Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions.
Hydrodynamics of Explosion : Experiments and Models
Hydronamics of Explosion presents the research results for the problems of underwater explosions and contains a detailed analysis of the structure and the parameters of the wave fields generated by explosions of cord and spiral charges, a description of the formation mechanisms for a wide range of cumulative flows at underwater explosions near the free surface, and the relevant mathematical models. Shock-wave transformation in bubbly liquids, shock-wave amplification due to collision and focusing, and the formation of bubble detonation waves in reactive bubbly liquids are studied in detail. Particular emphasis is placed on the investigation of wave processes in cavitating liquids, which incorporates the concepts of the strength of real liquids containing natural microinhomogeneities, the relaxation of tensile stress, and the cavitation fracture of a liquid as the inversion of its two-phase state under impulsive (explosive) loading. The problems are classed among essentially nonlinear processes that occur under shock loading of liquids and may be of interest to researchers in physical acoustics, mechanics of multiphase media, shock-wave processes in condensed media, explosive hydroacoustics, and cumulation.
Hybrid Intelligent Systems : Analysis and Design
The objective of this edited volume is to offer a general view at the recent conceptual developments of Soft Computing (SC) regarded as a general methodology supporting the design of hybrid systems along with their diversified applications to modeling, simulation and control of non-linear dynamical systems. As of now, SC methodologies embrace neural networks, fuzzy logic, genetic algorithms and chaos theory. Each of these methodologies exhibits well delineated advantages and disadvantages. Interestingly, they have been found useful in solving a broad range of problems. However, many real-world complex problems require a prudent, carefully orchestrated integration of several of these methodologies to fully achieve the required efficiency, accuracy, and interpretability of the solutions. In this edited volume, an overview of SC methodologies, and their applications to modeling, simulation and control, will be given in an introductory paper by the Editors. Then, detailed methods for integrating the different SC methodologies in solving real-world problems will be given in the papers by the other authors in the book. The edited volume will cover a wide spectrum of applications including areas such as: robotic dynamic systems, non-linear plants, manufacturing systems, and time series prediction.
Human-Like Biomechanics : A Unified Mathematical Approach to Human Biomechanics and Humanoid Robotics
The book contains six Chapters and an Appendix. The first Chapter is an Introduction, giving a brief review of mathematical techniques to be used in the text. The second Chapter develops geometrical basis of human-like biomechanics, while the third Chapter develops its mechanical basis, mainly from generalized Lagrangian and Hamiltonian perspective. The fourth Chapter develops topology of human-like biomechanics, while the fifth Chapter reviews related nonlinear control techniques. The sixth Chapter develops covariant biophysics of electro-muscular stimulation. The Appendix consists of two parts: classical muscular mechanics and modern path integral methods, which are both used frequently in the main text.
Human Exploitation and Biodiversity Conservation
The sustainable use of biodiversity is one of the three key objectives of the 1992 "Convention on Biological Diversity". To achieve this, sound conservation practice has to be recognized as beneficial and implemented by all who access, or use it – from subsistence farmers to skiers and pharmaceutical bioprospectors. At the same time, indigenous peoples necessarily utilize enormous numbers of plants, fungi, and fish, particularly for foods and medicines. This book gathers together a wide range of contributions addressing diverse aspects of front-line human involvement in biodiversity exploitation and conservation. Its scope is broad, the organisms explored ranging from birds, invertebrates and mammals – both terrestrial and aquatic – to crops and medicinal plants. Meanwhile, the issues addressed include land use changes, the importance of gardens, hedges and green lanes, housing developments, hunting, invasive species, local community involvement, sacred groves, socioeconomic factors and trade.
Human Ear Recognition by Computer
Human Ear Recognition by Computer is the first book on the automatic recognition of human ears. It presents an entire range of computational algorithms for recognition of humans by their ears. These algorithms have been tested and validated on the largest databases that are available today,This state-of-the-art research reference explores all aspects of 3D ear recognition, including representation, detection, recognition, indexing and performance prediction. It has been written for a professional audience of both researchers and practitioners within industry, and is also ideal as an informative text for graduate students in computer science and engineering.
Hughes Syndrome : Antiphospholipid Syndrome
The second edition of Hughes Syndrome: Antiphospholipid Syndrome addresses the complete range of conditions produced by this common disorder which is also known as APS or "sticky blood" syndrome. APS is one of the main causes of strokes (40%), leg deep vein thrombosis, and recurrent miscarriages in women.
Hormonal control of cell cycle
This volume reflects the proceedings of an International Workshop held in Paris in December 2006. The aim of the meeting was to undertake a high level of scholarly exchange between experts in cell biology, oncology and endocrinology interested in cell cycle control. The topics covered ranged from fundamental studies of DNA replication,chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression.
