الصفحة 17
الصفحة 17
Phenolic Compound Biochemistry
This book is written for researchers, instructors, advanced undergraduate students and beginning graduate students in the life sciences who wish to become more familiar with these and many other intriguing aspects of phenolic compounds. Topics covered include nomenclature, chemical properties, biosynthesis, including an up-to-date overview of the genetics controlling phenolic metabolism, isolation and characterization of phenolic compounds, phenolics used in plant defense, and the impact of phenolics on human health. The book is written in an accessible style, and assumes only basic knowledge of organic chemistry, biochemistry and cell physiology. More than 300 chemical structures and reaction schemes illustrate the text.
Pharmacokinetics and toxicokinetic considerations - Vol II ; 1st ed.
Explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.
Pharmacokinetics and pharmacodynamics of nanoparticulate drug delivery systems
Discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles.
Pharmacokinetics : Basics to applications
Covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject.
Pharmacokinetics : Basics to Applications
Covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature.
Pharmacogenitics
General principle was developed for the selection of subjects for Pharmacogenetics investigations. Depending on the particular metabolic pathway involved, studies may require that subjects be under carefully controlled, homogeneous environmental condition. Otherwise, segregation in families of some genetically transmitted traits can be concealed by effect from multiple hos factors. Therefore; in some Pharmacogenetics studies of pharmacokinetic variations, differences among subjects with respect to critical host factors can profoundly influence the results obtained and conclusions drawn.
Perspectives of Systems Informatics ; 6th International Andrei Ershov Memorial Conference, PSI 2006, Novosibirsk, Russia, June 27-30, 2006, Revised Papers
This volume contains the ?nal proceedings of the Sixth International Andrei Ershov Memorial Conference on Perspectives of System Informatics (PSI 2006), held in Akademgorodok (Novosibirsk, Russia), June 27-30, 2006. The conference was held to honour the 75th anniversary of a member of the Russian Academy of Sciences Andrei Ershov (1931–1988) and his outsta- ing contributions towards advancing informatics.
Perspectives in Modern Project Scheduling
Operations Research began with the mathematical scheduling of a massive project—logistically supplying Europe with military equipment and goods during the WWII. Today project scheduling research continues growing in a variety of its theoretical models, in its magnitude and application. As the world becomes more interrelated and complex, the wider its research is applied to an increasing number of project scheduling problems. Project Scheduling: Surveying the State-of-the-Art surveys the current state-of-the-art in operations research with chapters written by the respective leading experts on each topic. It covers the range of the key models in the field, including deterministic, probabilistic, single- and multi-mode, single- and multi-objective, and a general model on discrete-continuous resources. Recent solution algorithms are systematical examined. The book summarize sthe current developments and theoretical achievements in the field, including project uncertainty and grid resource management.
Periodontal manifestations of local and systemic diseases : Color atlas and text
Illustrates the important relationship between periodontal and systemic health and disease with a wealth of superb illustrations. The periodontium as a part of the oral tissues is of great interest to dentists and its importance extends beyond local disorders to a wide range of conditions that may affect periodontal health. The atlas covers both local and systemic disorders including inflammatory diseases, developmental disorders, metabolic disorders, endocrine disorders, cancer and a vast number of other diseases, that may present with gingival or periodontal lesions.
Periodontal disease : Diagnosis, management options and clinical features
Periodontal disease (PD), an inflammatory disease of tooth supporting tissues that leads to progressive loss of periodontal ligament and bone, with pocket formation and / or recession of the gums, is widespread among the world adult population and a serious public health issue. In this book, Chapter One reviews the literature about the use of probiotics in periodontal disease, including in vitro, in vivo and clinical studies, in order to improve the understanding of probiotics’ role in periodontal disease and discusses the effectiveness of their use as a therapy for periodontitis. Chapter Two studies the model of periodontitis induction by ligature and presents a protocol for performing it in rats and mice, based on the experience of the authors’ research group, to guide researchers who wish to develop the model. Chapter Three focuses on nutritional and systemic risk factors for periodontitis, focusing on modifiable common risk factors that also impact cardiometabolic disease, which can be targeted through oral and medical health professionals for improving periodontal and cardiometabolic health. Chapter Four discusses the main manifestations of gingivitis, chronic periodontitis, aggressive periodontitis, and periodontal disease resulting from systemic diseases.
Percutaneous Tumor Ablation in Medical Radiology
Thermal ablation has become an integral part of oncology, especially in the field of interventional oncology. This very comprehensive book encompasses the different technologies employed in thermal ablation, its indications and the results achieved in various clinical conditions. The first part of the book clearly explains the basics of thermal ablative techniques such as laser-induced thermotherapy, radiofrequency ablation, microwave ablation, cryotherapy, and localized tumor therapy. The latest developments in the application of minimally invasive therapies in localized neoplastic disease are demonstrated. In the main part of the book, techniques of guiding the applicators to the target structures by use of different imaging tools such as ultrasound, computed tomography and magnetic resonance imaging are discussed.
Percutaneous absorption : Drugs, cosmetics, mechanisms, methods
Supplies topics on: cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
People and Computers XVIII - Design for Life ; Proceedings of HCI 2004
We selected 23 full papers out of 63 submitted, which covered our interaction with computer systems in a variety of types of life situation — including games, tourism and certain types of work — and also covered a variety of stages in our lives, from the young to the elderly. These papers were complemented by others that described more traditional aspects of research in the field of human-computer interaction. In putting together the programme we followed a three-stage process. First each paper was reviewed by at least three reviewers. Then a member of the committee conducted a meta-review. Finally, all sets of reviews were considered by the technical chairs who assembled a programme that was submitted to, and approved by, the full committee. This process was greatly assisted by the use of the Precision Conference Solutions web-based submission system.
Pediatric Neuropathology : A Text-Atlas
Neuropathology is the foundation for understanding developmental neuroscience, pediatric neurology, and neurosurgery, but until now a comprehensive volume covering all aspects of pediatric neuropathology was not available. This atlas is thus a unique, comprehensive reference providing the fundamentals of developmental brain disorders of the nervous system that can affect fetuses, infants and young children, as well as the essentials of diagnosis in developmental brain pathology and neuroimaging. With an emphasis on the characteristic morphology and a concise summary of clinical features, pathogenesis, and genetics, the generously illustrated atlas presents more than 100 disorders, including the common diseases of the peripheral nervous system as well as genetically determined metabolic and storage diseases.
Pediatric dentistry : A comprehensive guide
A Comprehensive Guide is an insightful book that covers critical concepts and clinical studies in pediatric dentistry to provide a comprehensive understanding of oral health in children. Chapters address such topics as the “dental home” concept, which involves early dental visits and establishing a dental home for children to prevent oral health issues, stomatognathic dysfunction, the role of the community in promoting good oral health in children, the effects of malnutrition on pediatric oral health, and the role of metals in pediatric oral health.
Pediatric Critical Care Review
Pediatric critical care is an advancing science that requires both constant renewal of previously learned knowledge and exposure to new material. In Pediatric Critical Care Review, Board-certified pediatric critical care physicians uniquely capture the essence of the most common critical care scenarios in a series of carefully crafted questions, answers, rationales, and references. With their crisp and clear explanations, detailed references, and pertinent pictures, the authors illuminate-in an easy-to-read format-the essential facts and latest findings concerning the diagnosis and treatment of critical problems in the respiratory, cardiovascular, central nervous, endocrine, and gastrointestinal systems. Drawing on years of practical experience, they illuminate with simple, straightforward explanations the major clinical issues involved in the critical care of pediatric infectious diseases, hematology, oncology, immunology, metabolic disorders, pain management, and traumatology.
Pathogenesis of periodontal diseases : Biological concepts for clinicians
Provides clinicians with a refined understanding of the biology that underlies periodontal diseases, thereby offering a sound basis for improved clinical decision making with regard to prevention strategies, diagnosis, and therapy. All significant aspects of periodontal pathogenesis are covered, including the roles played by the oral microbiome and biofilms, bacterial virulence factors, cells of the immune system, matrix metalloproteinases, proinflammatory and osteolytic cytokines, genetic factors, and antimicrobial peptides.
Particle Metaphysics : A Critical Account of Subatomic Reality
The empirical successes of atomic, nuclear, and particle physics have not reduced -- and may never fully resolve -- the philosophical controversies about the inner constitution of matter. This book examines these debates by exploring the particle concept in physics.
Parallel processing and applied mathematics ; 7th International Conference, PPAM 2007, Gdansk, Poland, September 9-12, 2007 Revised Selected Papers
Constitutes the thoroughly refereed post-conference proceedings of the 7th International Conference on Parallel Processing and Applied Mathematics, PPAM 2007, held in Gdansk, Poland, in September 2007.The 63 revised full papers of the main conference presented together with 85 revised workshop papers were carefully reviewed and selected from over 250 initial submissions. The papers are organized in topical sections on parallel/distributed architectures and mobile computing, numerical algorithms and parallel numerics, parallel and distributed non-numerical algorithms, environments and tools for as well as applications of parallel/distributed/grid computing, evolutionary computing, meta-heuristics and neural networks.
Pancreatic Cancer
Since the first M. D. Anderson Solid Tumor Oncology Series volume on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease. Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment.
