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Conditional Mutagenesis : An Approach to Disease Models
Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
Conceptual Modeling - ER 2005
Conceptual modeling is fundamental to any domain where one must cope with complex real-world situations and systems because it fosters communication - tween technology experts and those who would bene?t from the application of those technologies. Conceptual modeling is the key mechanism for und- standing and representing the domains of information system and database - gineering but also increasingly for other domains including the new “virtual” e-environmentsandtheinformationsystemsthatsupportthem.Theimportance of conceptual modeling in software engineering is evidenced by recent interest in “model-drivenarchitecture”and“extremenon-programming”.Conceptualm- eling also plays a prominent rolein various technical disciplines and in the social sciences. The Annual International Conference on Conceptual Modeling (referred to as the ER Conference) provides a central forum for presenting and discussing current research and applications in which conceptual modeling is the major emphasis.
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented.
Computer supported cooperative work and social computing ; 15th CCF Conference, ChineseCSCW 2020, Shenzhen, China, November 7–9, 2020, Revised Selected Papers
This book constitutes the refereed post-conference proceedings of the 15th CCF Conference on Computer Supported Cooperative Work and Social Computing, ChineseCSCW 2020, held in Shenzhen, China, in November 2020. The 40 revised full papers and 15 revised short papers were carefully reviewed and selected from 137 submissions. The papers of this volume are organized in topical sections on: crowdsourcing, crowd intelligence, and crowd cooperative computing; domain-specific collaborative applications; collaborative mechanisms, models, approaches, algorithms, and systems; social media and online communities; and short papers.
Computer Security – ESORICS 2006 ; 11th European Symposium on Research in Computer Security, Hamburg, Germany, September 18-20, 2006, Proceedings
This book constitutes the refereed proceedings of the 11th European Symposium on Research in Computer Security, ESORICS 2006. it presents original research contributions, case studies and implementation experiences addressing any aspect of computer security - in theory, mechanisms, applications, or practical experience.
Computational Mechanics of the Classical Guitar
This book performs a state-of-the-art finite-difference calculation of the complete geometry of the classical guitar as a time-stepping application. It provides insight into the overall behaviour as well as the finite structure mechanisms of this musical instrument. Fundamental problems of coupling, nonlinearities, noise or time reversion, complex modelling solutions, and modern signal processing tools are discussed. Also musicologists, musicians or instrument builders can find explanations and may also be inspired by aspects of musical timbre, the sounding and time-dependent qualities of the different guitar parts. The work helps to suggest new geometrical and timbral solutions in modern guitar performance.
Computational Maps in the Visual Cortex
For more than 30 years, the visual cortex has been the source of new theories and ideas about how the brain processes information. Understanding the computations in the visual cortex is therefore an important step toward a general theory of computational brain theory
Computational logic in multi-agent systems ; 4th International Workshop, CLIMA IV, Fort Lauderdale, FL, USA, January 6-7, 2004, Revised Selected and Invited Papers
Though multiagent systems (MASs) are being increasingly used, few methods exist to ensure survivability of MASs. All existing methods suffer from two flaws. First, a centralized survivability algorithm (CSA) ensures survivability of the MAS – unfortunately, if the node on which the CSA exists goes down, the survivability of the MAS is questionable. Second, no mechanism exists to change how the MAS is deployed when external factors trigger a re-evaluation of the survivability of the MAS. In this paper, we present three algorithms to address these two important problems. Our algorithms can be built on top of any CSA. Our algorithms are completely distributed and can handle external triggers to compute a new deployment. We report on experiments assessing the efficiency of these algorithms.
Combustion : Physical and Chemical Fundamentals, Modeling and Simulation, Experiments, Pollutant Formation
The actual fourth edition presents a completely restructured book: Mathematical Formulae and derivations as well as the space-consuming reaction mechanisms have been replaced from the text to appendix. A new chapter discusses the impact of combustion processes on the earth’s atmosphere, the chapter on auto-ignition is extended to combustion in Otto- and Diesel-engines, and the chapters on heterogeneous combustion and on soot formation appear heavily revised.
Collapsing Structures and Public Mismanagement
This book demonstrates how accidents happen, how social processes are fundamental to their occurrence, and how learning and inference about their causes is a core public management function. Along the way, Seibel masterfully musters evidence from a multitude of sources to painstakingly document both bridge and building failures and the organizational pathologies that accompany them. This is a must-read for those who want to better understand such 'black swan' events and the search for resilience.
Collagen: Structure and Mechanics
Collagen: Structure and Mechanics provides a cohesive introduction to collagen-rich tissues, such as tendon, bone, cornea or arterials walls. Written in a clear and didactic manner, this volume reviews current knowledge on hierarchical structure, mechanical properties, deformation and strengthening mechanisms, and discusses many applications in biomaterials and tissue engineering.
Collagen : Primer in Structure, Processing and Assembly
This volume of Topics in Current Chemistry is an attempt to update and compile the biochemical, molecular knowledge of the still growing family of collagenous proteins. Its intention is to provide a comprehensive summary of all mechanisms known to be involved in synthesis, processing and deposition of collagen molecules, all of which are apparently shared by any known collagen type as part of a common biosynthetic route. From the intracellular initiation of protein translation to the extracellular deposition of mature molecules into the scaffold of the preformed tissue texture, collagen biosynthesis exhibits a profile of mechanisms absolutely unique when compared to other proteins
Co-design for System Acceleration : A Quantitative Approach
This book is concerned with studying the co-design methodology in general, and how to determine the more suitable interface mechanism in a co-design system in particular. Some new trends in co-design and system acceleration are also introduced.
Clinical toxicology : Principles and mechanisms ; 2nd ed.
Addresses the current principles and mechanisms of clinical toxicology. It examines the complex interactions associated with clinical toxicological events and chemical exposure and drug administration. The author places special emphasis on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. He covers contemporary issues in clinical toxicology, such as biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, and changes in particular treatments. The chapters contain numerous drawings, figures, and tables to aid in comprehension.
Clinical Pharmacology for Prescribing
Provides key points of basic pharmacology to explain drug actions / Shows clear relationship between pathophysiology and prescribing / Illustrations explain pharmacological mechanisms / Practical prescribing boxes highlight therapies for common conditions / 'Prescribing warnings' help readers to avoid adverse reactions and minimise side effects / Clear links to current medical guidelines throughout / Clear consistent structure in every chapter helps navigation and learning
Mathematical Modelling of Biosystems
This volume is an interdisciplinary book, which introduces, in a very readable way, state of the art research in the fundamental topics of mathematical modelling of Biosystems. These topics include: the study of Biological Growth and its mechanisms, the coupling of pattern to form via theorems of Differential Geometry, the human immunodeficiency virus dynamics, the inverse folding problem and the possibility of analysing true protein backbone flexibility, the Biclustering techniques for the organization of microarray data, the analytical approach to the modelling of biomolecular structure via Steiner trees, the action of biocides on resistance mechanisms of mutated and phenotypic bacteria strains, a description of the fundamental processes for the distribution and abundances of species towards a unified theory of Ecology, and a special introduction to Protein Physics aiming to explain the all-or-none first order phase transitions from native to denatured states.
Mathematical and Computational Models for Congestion Charging
This book presents rigorous treatments of issues related to congestion pricing. The chapters describe recent advances in areas such as mathematical and computational models for predicting traffic congestion, determining when, where, and how much to levy tolls, and analyzing the impact of tolls on transporation systems. The analyses and methodologies developed in this book provide Mechanisms that aid in determining and comparing congestion pricing schemes; Methodologies for evaluating the efficiency of existing and proposed congestion pricing schemes; A means to predict the impact of pricing on urban transporation systems; and Information essential to the financial and political success of congestion pricing programs.
Materials for Springs
“Materials for springs” is basically intended for engineers related to spring materials and technologies who graduated from metallurgical or mechanical engineering courses in technical high school, or in other higher engineering schools, as well as those who are related to the purchase or sales of spring materials. The first chapter introduces into the fundamental selection processes of spring materials including the information sources on materials database. It is followed by the basic mechanisms and theories of spring failures such as fatigue fracture, creep/stress relaxation and stress corrosion cracking of metallic materials.
Marine Surface Films : Chemical Characteristics, Influence on Air-Sea Interactions and Remote Sensing
Since the late 1960s, various groups have investigated the influence of marine surface films on mechanisms dominating energy and mass transfer across the ocean/atmosphere interface. However, a compendium summarizing the state-of-the-art research in this field is still missing. The book fills this gap and transfers the accumulated knowledge to the scientific community. After a brief historical chapter basic chemical insights are presented, followed by theoretical and experimental approaches carried out in laboratory facilities. Air-sea interaction experiments are then described and finally, remote sensing applications with sea slicks and crude oil spills are presented.
March's Advanced Organic Chemistry : Reactions, Mechanisms, and Structure
The opening chapters of March's Advanced Organic Chemistry deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered.
