الصفحة 17
الصفحة 17
DNA Conformation and Transcription
the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Distributed Event-Based Systems
Event-based architectures inherently decouple system components. Event-based components are not designed to work with specific other components in a traditional request/reply mode, but separate communication from computation through asynchronous communication mechanisms via a dedicated notification service.
Discovering Biomolecular Mechanisms with Computational Biology
In this anthology, leading researchers present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation. Discovering Biomolecular Mechanisms with Computational Biology is essential reading for life science researchers and higher-level students that work on biomolecular mechanisms and wish to understand the impact of computational biology for their success.
Direct Democracy in Europe : Developments and Prospects
The initiative and referendum process offers extra channels of participation and can serve as an important supplementary institution in representative democratic systems. This first volume of the new series Direct Democracy in Modern Europe features sixteen systematic and broadly empirical approaches to the study of modern direct democracy within the context of European politics including - system contexts and effects of the initiative and referendum process - theoretical approaches and basic values in modern direct democracy - the quality and institutional design of direct democratic mechanisms - aspects of information and communication - institutional performance and economic effectiveness - transnational challenges and the development of direct democracy in Europe
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Diffuse matter from star forming regions to active galaxies : A volume honouring John Dyson
In this volume dedicated to him, introductory reviews to a number of the key processes and to the sources themselves are given by leading experts. The mechanisms in which the multi-component natures of media affect their dynamics receive particular attention, but the roles of hydromagnetic effects are also highlighted.
Diastolic Heart Failure
This book addresses the epidemiology, pathophysiologic mechanisms, diagnostic methods, treatment and prognosis. It also gives an analysis of specific problems, related to coronary artery disease, arterial hypertension, diabetes, hypertrophic and restrictive cardiomyopathies, and constrictive pericarditis.
Diagnosis of pathogenic microorganisms : Causing infectious diseases
Infectious diseases are caused by the pathogenic microbial organisms. These microbes can multiply and can cause an infection, once they enter the body. Infectious diseases are transmissible, and may cause mild to life-threatening illnesses. It can be airborne, waterborne, foodborne, and soilborne. It can be spread through direct contact (human to human, animal to human). It has also been one of the leading causes of human deaths. Therefore, there is a need to have rapid diagnostic methods to prevent and control these diseases. This book titled “Diagnosis of Pathogenic Microorganisms Causing Infectious Diseases” will help the scientific community to understand the transmission dynamics of some infectious diseases of public health importance.
Designing Organizations : 21st Century Approaches
The design of organizations has been an ongoing concern of management theory and practice over the past several decades. Over this time, there has been little change in the fundamental theory, principles and concepts of Organization Design (OD). Recently organizational life has changed dramatically with the advent of: new communication systems, adaptive mechanisms, information technology, knowledge management systems, innovation processes and more. This book systemically examines these developments and their impact on OD with contributions from leading scholars in the area. Also featured in the book are the practical issues with implementing OD in organizations. The individual chapters are organized into five sections: (1) Putting Contingency Theory in its Place, (2) Focus on Individuals Who Make up the Organization, (3) Innovation Processes and Organization Design, (4) Adaptation and Technology, and (5) Design for Performance. Each chapter examines aspects of the book’s threefold theme: (1) core issues in organization design, (2) emerging theoretical perspectives in OD, and (3) new developments and directions in OD. A special feature of each chapter is: 1) implications for theory, and 2) implications for practice.
Design of Hybrid Structures : Where Steel Profiles Meet Concrete
Focuses on design approaches for concrete structures reinforced in an unconventional way by steel profiles. It explains force transfer mechanisms of steel profiles and oncrete interfaces, and an analysis of the characteristics of hybrid structures, including slendercomponents. Several types of hybrid designs are addressed: walls and columns with several embedded steel profiles, connections strengthened by steel profiles between steel and composite or reinforced concrete components, including the specific case of shear keys connecting deep beams or flat slabs to columns. The transition zones in partly reinforced concrete and partly composite columns are also covered.
Dermatopathology
The book describes the principles of histopathologic patterns in selected acquired skin diseases, together with short clinical descriptions and case reports. The underlying, or possible underlying, mechanisms are elucidated, and controversial concepts are discussed. To facilitate the understanding of underlying mechanisms, the first chapters of the book comprise summaries of basic histology of lymphatics and blood vessels, relevant parts of general pathology, immunology, and molecular cell biology.
Deployment and operation of complex software in heterogeneous execution environments : The SODALITE approach
This book provides an overview of the work developed within the SODALITE project, which aims at facilitating the deployment and operation of distributed software on top of heterogeneous infrastructures, including cloud, HPC and edge resources. The experts participating in the project describe how SODALITE works and how it can be exploited by end users. While multiple languages and tools are available in the literature to support DevOps teams in the automation of deployment and operation steps, still these activities require specific know-how and skills that cannot be found in average teams. The SODALITE framework tackles this problem by offering modelling and smart editing features to allow those we call Application Ops Experts to work without knowing low level details about the adopted, potentially heterogeneous, infrastructures. The framework offers also mechanisms to verify the quality of the defined models, generate the corresponding executable infrastructural code, automatically wrap application components within proper execution containers, orchestrate all activities concerned with deployment and operation of all system components, and support on-the-fly self-adaptation and refactoring.
Dental neuroimaging: the role of the brain in oral functions
Provides an up-to-date overview of neuroimaging research on the neural mechanisms underlying mastication, swallowing, sensory processing, and other oral topics.
Dental Hard Tissues and Bonding : Interfacial Phenomena and Related Properties
This book comprehensively reviews bonding to enamel, dentin and cementum and analyses relevant adhesion mechanisms. Emphasis is placed on the characterization of material interfaces with dental tissues in situ. The volume also stresses the importance of appropriate experimental protocol design in facilitating clinically-relevant research methods, clarifies the mechanisms of adhesion of polymeric materials to hard dental tissues and furnishes a handy reference for routine clinical procedures in restorative and prosthetic dentistry as well as orthodontics. The book introduces important aspects of the chemistry of dental materials and their adaptation to dental hard tissues. It also analyses interfacial phenomena occurring during application of materials, including mechanical properties, and structural-compositional alterations. The text presents the current instrumental approaches in studying related issues and a summary of the current status of theories concerning bonding to dental tissues.
Dental caries
Provides information on the etiology, prevention, and treatment of tooth decay. Chapters cover such topics as dental biofilms, dietary factors, the association of Candida with early colonization of cariogenic microorganisms, oral diseases, the use of fluoride, and dental caries in disabled children.
Defending Life : The Nature of Host-Parasite Relations
Defending Life discusses the relationship between hosts and parasites. A major contention of the book is that the immune system depends ontologically on the ecosystem in which it is embedded; it would not have the features it has if it was not related in one way or other to parasitic agents and to the host’s own cells and tissues. To sustain the argument, life is investigated at all layers – from molecules up through cells, organisms and ecosystems. Together with the inverse course, which goes from ecological contingencies down to gene-expression profiles, the approach facilitates an advanced understanding of immunocompetence as well as its converse, immunoincompetence. The emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations, and thus increases the understanding of why we observe what we observe. The book contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications.
Deep Learning, Machine Learning and IoT in Biomedical and Health Informatics : Techniques and Applications
Examines and demonstrates state-of-the-art approaches for IoT and Machine Learning based biomedical and health related applications. This book aims to provide computational methods for accumulating, updating and changing knowledge in intelligent systems and particularly learning mechanisms that help us to induce knowledge from the data. It is helpful in cases where direct algorithmic solutions are unavailable, there is lack of formal models, or the knowledge about the application domain is inadequately defined. In the future IoT has the impending capability to change the way we work and live. These computing methods also play a significant role in design and optimization in diverse engineering disciplines. With the influence and the development of the IoT concept, the need for AI (artificial intelligence) techniques has become more significant than ever.
Deciphering Growth
Growth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. In mammals, the major factors involved in the regulation of body growth are known. The combined knowledge concerning the endocrine and paracrine aspects of growth have led to the introduction of treatment regimens, most effective in GH-deficient children.
Datatype-Generic Programming ; International Spring School, SSDGP 2006, Nottingham, UK, April 24-27, 2006, Revised Lectures
A leitmotif in the evolution of programming paradigms has been the level and extent of parametrisation that is facilitated — the so-called genericity of the paradigm. The sorts of parameters that can be envisaged in a programming language range from simple values, like integers and fioating-point numbers, through structured values, types and classes, to kinds (the type of types and/or classes).Datatype-generic programming is about parametrising programsby the structure of the data that they manipulate. To appreciate the importance of data type genericity,one need look no further than the internet. The internet is a massive repository of structured data, but the structure is rarely exploited. For example, compression of data can be much more efiective if its structure is known, but most compression algorithms regard the input data as simply a string of bits, and take no account of its internal organisation. Datatype-generic programming is about exploiting the structure of data when it is relevant and ignoring it when it is not. Programming languages most c- monly used at the present time do not provide efiective mechanisms for do- menting and implementing datatype genericity.
Cytokines and Cancer
This volume provides a comprehensive review of the current knowledge on cytokines and cancer. Cytokines play a variety of roles in cancer, both as components of pathogenetic mechanisms, as well as agents used in the treatment of certain malignancies.The volume is divided in two sections. Section one focuses on current developments in the basic science field with particular emphasis on novel mechanisms of cytokine actions in malignant cells. The second section deals with translational and clinical research in the field, and many of the chapter authors were among the first to introduce several cytokines in the treatment of certain tumors.
