الصفحة 17
الصفحة 17
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Architecture of computing systems - ARCS 2006 ; 19th International Conference, Frankfurt / Main, Germany, March 13-16, 2006, Proceedings
Technological progress is one of the driving forces behind the dramatic devel- mentofcomputersystemarchitecturesoverthe pastthreedecades.Eventhough it is quite clear that this development cannot only be measured by the ma- mum number of components on a chip, Moore’s Law may be and is often taken as a simple measure for the non-braked growth of computational power over the years. The more components are realizable on a chip, the more innovative and unconventional ideas can be realized by system architects. As a result, research in computer system architectures is more exciting than ever before. This book coversthe trends that shape the ?eld of computer system archit- tures.
Aquaponics Food Production Systems : Combined Aquaculture and Hydroponic Production Technologies for the Future
This book, written by world experts in aquaponics and related technologies, provides the authoritative and comprehensive overview of the key aquaculture and hydroponic and other integrated systems, socio-economic and environmental aspects. Aquaponic systems, which combine aquaculture and vegetable food production offer alternative technology solutions for a world that is increasingly under stress through population growth, urbanisation, water shortages, land and soil degradation, environmental pollution, world hunger and climate change.
Applying the Kaizen in Africa : A New Avenue for Industrial Development
At present, how to develop industries is a burning issue in Africa, where population growth remains high and economic development has thus far failed to provide sufficient jobs for many, especially young people and women. The creation of productive jobs through industrial development ought to be a central issue in steering economic activity across the continent.The authors of this book, consisting of two development economists and five practitioners, argue that the adoption of Kaizen management practices, which originated in Japan and have become widely used by manufacturers in advanced and emerging economies, is decisively the most effective first step for industrial development in Africa.This open access book discusses what Kaizen management is, why it is applicable to Africa, and why it can provide Africa with a springboard for sustainable economic growth and employment generation.
Applications of random matrices in physics
Random matrices are widely and successfully used in physics for almost 60-70 years, beginning with the works of Dyson and Wigner. Although it is an old subject, it is constantly developing into new areas of physics and mathematics. It constitutes now a part of the general culture of a theoretical physicist. Mathematical methods inspired by random matrix theory become more powerful, sophisticated and enjoy rapidly growing applications in physics. Recent examples include the calculation of universal correlations in the mesoscopic system, new applications in disordered and quantum chaotic systems, in combinatorial and growth models, as well as the recent breakthrough, due to the matrix models, in two dimensional gravity and string theory and the non-abelian gauge theories. The book consists of the lectures of the leading specialists and covers rather systematically many of these topics.
Apoptosis, Senescence, and Cancer
Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment.
Anti Cancer medicines derived from plants
Cancer is a broad term. It describes the disease that results when cellular changes cause the uncontrolled growth and division of cells. Some types of cancer cause rapid cell growth, while others cause cells to grow and divide ata slower rate. Certain forms of cancer result in visible growths called tumors, while others, such as leukemia, do not. Most of the body’s cells have specific functions and fixed lifespans. While it may sound like a bad thing, cell death is part of a natural and beneficial phenomenon called apoptosis.
Angiogenesis : An integrative approach from science to medicine
It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor.
Anemia in the Elderly
Anemia is found in approximately 80% of elderly patients, most often caused by chronic disease and iron deficiency. Hemopoiesis is a crossroad for many aging-related events.Why do older patients become anemic When should a diagnostic work up of anemia be initiated in the older person? What are the clinical consequences of anemia? Can the treatment of anemia delay aging? Have erythropoietic growth factors played a role in age-related anemia? Who should receive an erythropoietin stimulating agent?When should the suspicion for Myelodysplastic Syndrome be ruled out and what are the clues?This book addresses these and many other important questions with a review of the most recent findings.
Analyzing the availability of fin tech and its role in enhancing the strategic : Performance of Syrian banks using the balanced scorecard
Aims to examine the role of financial technology (FinTech) in enhancing the strategic performance of Syrian banks by analyzing its impact on the four dimensions of the balanced scorecard : financial performance, customer satisfaction, internal process quality, and learning and growth. Amid economic and technological challenges, integrating fintech emerges as a strategic tool to boost operational efficiency, reduce costs, and promote financial inclusion. The study explores the experiences of several Syrian banks in implementing modern financial technologies, such as digital banking and smart payment systems, while evaluating key financial indicators like return on assets (ROA) and return on equity (ROE).
Analyse céphalométrique fonctionnelle et esthétique de profil = Functional and aesthetic cephalometric profile analysis
The complexity of the craniofacial architecture explains the multiplicity of cephalometric analyzes, too often based on points without phylogenetic, ontogenetic, anatomical or biomechanical justification. The value of a reliable and rapid analysis designed from indisputable fundamental foundations is essential. It enables the use of cephalometry in the daily practice of orthodontists, maxillofacial surgeons and facial plastic surgeons. This functional and aesthetic cephalometric analysis is carried out from fourteen anatomical points, ten bony points and four skin points, which all have in common that they are exo-basicranial. This analysis is easy to understand and use. It only takes five minutes to be learned and five minutes to be traced (fifteen seconds if it is computerized). The resulting results are reliable. The functional and aesthetic analysis is developed through four chapters. The first is devoted to the fundamental bases, the second to the analysis itself and to clinical cases, the third to the comparative study of different cephalometric analyzes, and finally the fourth chapter revisits the work of Arne Björk.
An Ottoman Era Town in the Balkans : The Case Study of Kavala
Presents the town of Kavala in Northern Greece as an example of Ottoman urban and residential development, covering the long period of Kavala’s expansion over five centuries under Ottoman rule. Kavala was part of the Ottoman Empire from 1387 to 1912. In the middle of the sixteenth century, Ibrahim Pasha, grand vizier of Suleiman the Magnificent, contributed to the town's prosperity and growth by the construction of an aqueduct. The Ottomans also rebuilt and extended the existing Byzantine fortress.
An Oral History of the Special Olympics in China ; Vol.2 : The Movement
This book contains the oral histories that were inspired by the work of the Special Olympics in conjunction with the 50th anniversary of its founding. The foreword and prefatory materials provide an overview of the Special Olympics and its growth in the People’s Republic of China.
An assessment framework for compliance with international space law and norms : Promoting equitable access and Use of space for emerging actors
proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance.
Americanization of the European Economy : A compact survey of American economic influence in Europe since the 1800s
Provides a comprehensive yet compact survey of the growth of American economic influence in Europe since the 1880s. Three distinct but cumulative waves of Americanization are identified. Americanization was (and still is) a complex process of technological, political, and cultural transfer, and this overview explains why and how the USA and the American model of industrial capitalism came to be accepted as the dominant paradigm of political economy in today's Europe. Americanization of the European Economy summarizes the ongoing discussion by business historians, sociologists, and political scientists and makes it accessible to all types of readers who are interested in political and economic development.
Ambient Networks ; 16th IFIP/IEEE international workshop on distributed systems : Operations and management, DSOM 2005, Barcelona, Spain, October 24-26, 2005, Proceedings
This volume of the Lecture Notes in Computer Science series contains all the papersacceptedforpresentationatthe16thIFIP/IEEEInternationalWorkshop on Distributed Systems: Operations and Management (DSOM 2005), which was held at the University Polit` ecnica de Catalunya, Barcelona 2005. The goal of the DSOM workshop is to bring togetherresearchersintheareasofnetworks,systems,andservicesmanagement, from both industry and academia, to discuss recent advances and foster future growth in this ?eld.
Alqadam Train Station
Aims to focuses on the redesign of the Southern Train Station of Damascus, located in the Al-Qadam area. The proposal aims to preserve the historical identity of the existing station while expanding it to meet the needs of modern urban mobility. The design balances heritage conservation with contemporary architectural expression, creating a space that respects the cultural fabric of Damascus while addressing future growth.Key elements include increasing station capacity, integrating sustainable design strategies, and enhancing passenger flow. Renewable energy use, passive ventilation, and green spaces are central to reducing environmental impact and improving user comfort. يركّز مشروع التخرج هذا على إعادة تصميم المحطة الجنوبية للقطارات في دمشق، الواقعة في منطقة القديهدف المشروع إلى الحفاظ على الهوية التاريخية للمحطة القديمة مع تطويرها وتوسيعها لتلبية احتياجات النقل الحضري المعاصر. يجمع التصميم بين صون التراث والتعبير المعماري الحديث، ليخلق فضاءً يحترم النسيج الثقافي لدمشق ويستجيب في الوقت نفسه لمتطلبات النمو المستقبلي. تشمل العناصر الأساسية زيادة القدرة الاستيعابية للمحطة، ودمج استراتيجيات التصميم المستدام، وتحسين حركة المسافرين. كما يعتمد المشروع على استخدام الطاقة المتجددة، والتهوية الطبيعية، وإضافة المساحات الخضراء لتقليل الأثر البيئي وتعزيز راحة المستخدمين.
Alicyclobacillus : Thermophilic Acidophilic Bacilli
Soft drinks with pHs lower than 4. 0 are subjected to minimum pasteuri- tion at 65 °C for 10 min as required by the Japanese Food Sanitation Law. Not only pathogenic bacteria but most spore-forming bacteria are unable to grow at this low pH condition, and thus reports of microbial spoilage in pasteurized acidic soft drinks are rare. Since 1982, when the spoilage of aseptically packed apple juice was - tributed to a new type of acidophilic spore-forming bacteria in Germany, a succession of similar complaints regarding other fruit juice concentrates and their products has been received. In the beginning, the bacteria were classified in the genus Bacillus, but later, in 1992, the new genus Ali- clobacillus was proposed owing to their characteristic cellular membranes containing omega-alicyclic fatty acids. A group of Alicyclobacillus strains, responsible for the tainting of fruit juices, was then described as A. a- doterrestris in 1999. They are acidophilic and grow preferably at around pH 4. 0. They are thermophilic and grow better at temperatures above 40 °C. This indicates that we might have been missing them by our or- nary methods of bacterial detection at pH 7. 0 and 35 °C.
Algal Toxins : Nature, Occurrence, Effect and Detection
This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
AI*IA 2005 : Advances in artificial intelligence ; 9th congress of the Italian Association for Artificial Intelligence Milan, Italy, September 21-23, 2005, Proceedings
This volume collects the papers selected for presentation at the IX Congress of the Italian Association for Arti?cial Intelligence (AI*IA), 2005 On the one hand this congress continues the tradition of AI*IA in organizing its biannual s- enti?c meeting from 1989; on the other hand, this edition is a landmark in the involvement of the international community of arti?cial intelligence (AI), directly involving a broad number of experts from several countries in the P- gramCommittee. Moreover,the peculiar nature of scienti?c researchin arti?cial intelligence (which is intrinsically international) and several consolidated int- national collaborations in projects and mobility programs allowed the collection and selection of papers from many di?erent countries, all around the world, enlarging the visibility of the Italian contribution within this research ?eld. Arti?cial intelligence is today a growing complex set of conceptual, theor- ical, methodological, and technological frameworks, o?ering innovative com- tational solutions in the design and development of computer-based systems. Within this perspective, researchers working in this area must tackle a broad range of knowledge about methods, results, and solutions coming from di?erent classical areas of this discipline. The congress was designed as a forum allowing researchers to present and discuss specialized results as general contributions to AI growth.
