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Ion Channels
Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field.
Investment Appraisal : Methods and Models
Investment decisions are of vital importance to all companies. Getting these decisions right is crucial but, due to a complex and dynamic business environment, this remains a challenging management task. Effective appraisal methods are valuable tools in supporting investment decision-making. As organisations continue to seek a competitive edge, it is increasingly important that management accountants and strategic decision-makers have a sound knowledge of these tools. This book presents a range of investment appraisal methods and models, some of which are not widely known, or at least not well covered in other books. Each approach is thoroughly described, evaluated and illustrated using examples, with its assumptions and limitations analysed in terms of their implications for investment decision-making practice.
Investigating Spoken English : A Practical Guide to Phonetics and Phonology Using Praat
Combining coverage of the key concepts and tools within phonetics and phonology with a systematic introduction to Praat, this textbook provides a lively and engaging 'way in' to the discipline. The author first covers the fundamentals of the articulatory and acoustic aspects of speech and introduces Praat as the main tool for examining and visualising speech. Next, the unit of analysis is gradually expanded (from syllables to words to turns and dialogues) and excerpts of real dialogues exemplify the core concepts for discovering how speech works.
Inventory Control
The strategic importance of efficient Supply Chain Management is today fully recognized by top management. The total investment in inventories is enormous, and the control of capital tied up in raw material, work-in-progress, and finished goods offers an important potential for improvement. At the same time, advances in information technology have drastically changed the possibilities to apply improved inventory control techniques. Furthermore, the recent progress in research has resulted in new and more general methods that can reduce the supply chain costs substantially.
Invariant Manifolds for Physical and Chemical Kinetics
By bringing together various ideas and methods for extracting the slow manifolds the authors show that it is possible to establish a more macroscopic description in nonequilibrium systems. The book treats slowness as stability. A unifying geometrical viewpoint of the thermodynamics of slow and fast motion enables the development of reduction techniques, both analytical and numerical. Examples considered in the book range from the Boltzmann kinetic equation and hydrodynamics to the Fokker-Planck equations of polymer dynamics and models of chemical kinetics describing oxidation reactions. Special chapters are devoted to model reduction in classical statistical dynamics, natural selection, and exact solutions for slow hydrodynamic manifolds. The book will be a major reference source for both theoretical and applied model reduction. Intended primarily as a postgraduate-level text in nonequilibrium kinetics and model reduction, it will also be valuable to PhD students and researchers in applied mathematics, physics and various fields of engineering.
Intumescent Coating and Fire Protection of Steel Structures
Introduced are the features and applications of intumescent coatings for protecting steel structures against fire. The constant effective thermal conductivity is defined and employed to simplify the quantification for the thermo-resistance of intumescent coatings. An experimental investigation into the hydrothermal aging effects on insulative properties of intumescent coatings is presented, as well as the influence of topcoat on insulation and aging of intumescent coatings. Also described is a practical method for calculating the temperature of the protected steel structures with intumescent coatings in order to evaluate the fire safety of a structure.
Intuitive Human Interfaces for Organizing and Accessing Intellectual Assets ; International Workshop, Dagstuhl Castle, Germany, March 1-5, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the 2004 International Workshop on Intuitive Human Interfaces for Organizing and Accessing Intellectual Assets, held in Dagstuhl Castle, Germany in March 2004. The 17 revised full papers presented together with an introductory overview have gone through two rounds of reviewing and revision. The papers are organized in topical sections on man-machine interface for intuitive knowledge access, intelligent pad and meme media, visualization and design of information access spaces, and semantics and narrative organization and access of knowledge.
Introduzione alla teoria della misura e all’analisi funzionale = Introduction to measurement theory and functional analysis
Presents a treatment of the theory of measure from an abstract point of view, with particular emphasis on some aspects of interest in probability. The typical arguments of the theory of integration are developed in a rather in-depth way, trying where possible to deduce classical results from the modern setting of the theory as well. The text has a modular structure, with interconnections between the parts: some chapters deal with theoretical aspects, others are dedicated to more applied topics. Alongside the numerous examples, a wide range of exercises is proposed.
Introduzione alla Teoria della elasticità : Meccanica dei solidi continui in regime lineare elastico = Introduction to the theory of elasticity : Mechanics of continuous solids in linear elastic regime
Introduces the student to the theory of elasticity through the choice of a selected number of topics of paradigmatic conceptual importance and through the performance of numerous exercises and in-depth problems. The topics range from the formal properties of stress and strain tensors, to the theory of linear elastic continuum, to the thermodynamics of deformations, to the propagation of elastic waves, to the theory of brittle fracture in a linear elastic regime.
Introduction to wine laboratory practices and procedures
winemaking was a romanticized notion of putting grape juice into a barrel and allowing time to perform its magic as you sat on the veranda watching the sunset on a Tuscan landscape. For some small wineries, this notion might still ring true, but for the majority of wineries commercially producing quality wines, the reality of winemaking is far more complex. The persistent evolution of the wine industry demands continual advan- ments in technology and education to sustain and promote quality winem- ing. The sciences of viticulture, enology, and wine chemistry are becoming more intricate and sophisticated each year. Wine laboratories have become an integral part of the winemaking process, necessitating a knowledgeable staff possessing a multitude of skills. Science incorporates the tools that new-age winemakers are utilizing to produce some of the best wines ever made in this multibillion dollar trade. A novice to enology and wine chemistry can find these subjects daunting and intimidating. Whether you are a home winemaker, a new winemaker, an enology student, or a beginning-to-intermediate laboratory technician, p- ting all the pieces together can take time.
Introduction to Systems Biology
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
Introduction to Symplectic Dirac Operators
One of the basic ideas in differential geometry is that the study of analytic properties of certain differential operators acting on sections of vector bundles yields geometric and topological properties of the underlying base manifold. Symplectic spinor fields are sections in an L^2-Hilbert space bundle over a symplectic manifold and symplectic Dirac operators, acting on symplectic spinor fields, are associated to the symplectic manifold in a very natural way. Hence they may be expected to give interesting applications in symplectic geometry and symplectic topology. These symplectic Dirac operators are called Dirac operators, since they are defined in an analogous way as the classical Riemannian Dirac operator known from Riemannian spin geometry. They are called symplectic because they are constructed by use of the symplectic setting of the underlying symplectic manifold. This volume is the first one that gives a systematic and self-contained introduction to the theory of symplectic Dirac operators and reflects the current state of the subject. At the same time, it is intended to establish the idea that symplectic spin geometry and symplectic Dirac operators may give valuable tools in symplectic geometry and symplectic topology,
Introduction to Structural Analysis
Covers the principles of structural analysis without any requirement of prior knowledge of structures or equations. Beginning with basic principles of equilibrium of forces and moments, all other subsequent theories of structural analysis have been discussed logically. Divided into two major parts, this book discusses the basics of mechanics and principles of degrees of freedom upon which the entire paradigm rests, followed by analysis of determinate and indeterminate structures. The energy method of structural analysis is also included.
Introduction to Stochastic Calculus for Finance : A New Didactic Approach
The justifcation is mainly pedagogical. These lecture notes start with an elementary approach to stochastic calculus due to Föllmer, who showed that one can develop Ito's calculus "pathwise" as an exercise in real analysis. The text opens to students interested in finance a quick (but by no means "dirty") road to the tools required for advanced finance in continuous time, including option pricing by martingale methods, term structure models in a HJM-framework and the Libor market model.
Introduction to Singularities and Deformations
This book presents the basic singularity theory of analytic spaces, including local deformation theory, and the theory of plane curve singularities. Plane curve singularities are a classical object of study, rich of ideas and applications, which still is in the center of current research and as such provides an ideal introduction to the general theory. Deformation theory is an important technique in many branches of contemporary algebraic geometry and complex analysis. This introductory text provides the general framework of the theory while still remaining concrete.
Introduction to Relativistic Continuum Mechanics
This mathematically-oriented introduction takes the point of view that students should become familiar, at an early stage, with the physics of relativistic continua and thermodynamics within the framework of special relativity. Therefore, in addition to standard textbook topics such as relativistic kinematics and vacuum electrodynamics, the reader will be thoroughly introduced to relativistic continuum and fluid mechanics. Emphasis in the presentation is on the 3+1 splitting technique, widely used in general relativity for introducing the relative observers point of view.
Introduction to Physics and Chemistry of Combustion : Explosion, Flame, Detonation
Most of the material covered in this book deals with the fundamentals of chemistry and physics of key processes and fundamental mechanisms for various combustion and combustion-related phenomena in gaseous combustible mixture. It provides the reader with basic knowledge of burning processes and mechanisms of reaction wave propagation
Introduction to Permanent Plug and Abandonment of Wells
This book offers a timely guide to challenges and current practices to permanently plug and abandon hydrocarbon wells. With a focus on offshore North Sea, it analyzes the process of plug and abandonment of hydrocarbon wells through the establishment of permanent well barriers.
Introduction to Optics
Since the discovery of the laser in 1960 and optical fibers in 1970, optics has undergone dramatic changes that accentuate its multi-disciplinary character. This text covers essential concepts and reports the key developments and progress in current knowledge in the field. Inspired by the style of Richard Feynman, the method of presentation emphasizes "telling" optics, rather than deducing it from fundamental laws, as well as tactfully using mathematical tools so as not to obscure the physical phenomena of interest. For its excellent teaching approach, the book received the Arnulf-Francon Award of the French Optical Society. The concepts are formulated in a way such that the necessary mathematical tools do not hinder comprehension of the phenomena. Global in vision, the book can also be used as a reference. In addition to the traditional aspects of optics, it includes the tools and methods currently used by researchers and engineers, as well as explanation and implications of the most recent developments.
Introduction to Modern Number Theory: Fundamental Problems, Ideas and Theories
"Introduction to Modern Number Theory" surveys from a unified point of view both the modern state and the trends of continuing development of various branches of number theory. Motivated by elementary problems, the central ideas of modern theories are exposed. Some topics covered include non-Abelian generalizations of class field theory, recursive computability and Diophantine equations, zeta- and L-functions. This substantially revised and expanded new edition contains several new sections, such as Wiles' proof of Fermat's Last Theorem, and relevant techniques coming from a synthesis of various theories. Moreover, the authors have added a part dedicated to arithmetical cohomology and noncommutative geometry, a report on point counts on varieties with many rational points, the recent polynomial time algorithm for primality testing, and some others subjects.
