الصفحة 16
الصفحة 16
Earth Observation Open Science and Innovation
The digital transformation is revolutionizing our ability to monitor our planet and transforming the way we access, process and exploit Earth Observation data from satellites.This book reviews these megatrends and their implications for the Earth Observation community as well as the wider data economy. It provides insight into new paradigms of Open Science and Innovation applied to space data, which are characterized by openness, access to large volume of complex data, wide availability of new community tools, new techniques for big data analytics such as Artificial Intelligence, unprecedented level of computing power, and new types of collaboration among researchers, innovators, entrepreneurs and citizen scientists. In addition, this book aims to provide readers with some reflections on the future of Earth Observation, highlighting through a series of use cases not just the new opportunities created by the New Space revolution, but also the new challenges that must be addressed in order to make the most of the large volume of complex and diverse data delivered by the new generation of satellites.
Early Life Origins of Health and Disease
Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology
Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. This is assisting clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. In this book, targeted at both clinical practitioners and basic scientists, the principles of the methods, their practical implementation, and their application to specific tumor types are discussed by the leading authorities in the field today. The book will serve as an invaluable single-volume reference covering all the latest developments in contrast-enhanced oncological MRI.
Dryland Ecohydrology
By combining the analysis of biotic and abiotic components of terrestrial ecosystems, this volume provides a synthesis of material on arid and semiarid landscapes, which is currently scattered in a number of books and journal articles. The focus on water-limited ecosystems is motivated by their high sensitivity to daily, seasonal, and decadal perturbations in water availability, and by the ecologic, climatic, and economic significance of most of the world's drylands. Conceived as a tool for scientists working in the area of the earth and environmental sciences, this book presents the basic principles of eco-hydrology as well as a broad spectrum of topics and advances in this research field.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug target selection and validation
Focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug Discovery and Evaluation : Safety and Pharmacokinetic Assays
This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Diplomacy Games : Formal Models and International Negotiations
In this book, leading experts in international negotiations present formal models of conflict resolution and international negotiations. Besides the description of different models and approaches, the book answers three questions: How can the abstract concepts and results of rational choice theorists be made more understandable and plausible to political and social scientists not trained to work with formal models? What can be done to encourage practitioners to use not only simple but also mathematically advanced approaches in their analysis of real world negotiation problems? How can practitioners (e.g., politicians and diplomats) become interested in, take into account, and apply formal models of their more important problems?
Dioxygen Binding and Sensing Proteins : A Tribute to Beatrice and Jonathan Wittenberg
Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments.This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
Digital transformation of the Laboratory : A practical guide to the connected lab
Digital Transformation of the Laboratory: A Practical Guide to the Connected Lab delivers essential and transformative new insights into current and future technologies and strategies for the digitization of laboratories. Thoroughly supported and backed-up with contributions from thought and industry leaders, the book shows scientists in academia and industry how to move from paper to digital in their own labs.
Digital Mammography ; 8th International Workshop, IWDM 2006, Manchester, UK, June 18-21, 2006, Proceedings
This volume of Springer’s Lecture Notes in Computer Science series records th the proceedings of the 8 International Workshop on Digital Mammography (IWDM), which was held in Manchester, UK, June 18–21, 2006. The meetings bringtogetheradiversesetofresearchers(physicists,mathematicians,computer scientists, engineers), clinicians (radiologists, surgeons) and representatives of industry, who are jointly committed to developing technology, not just for its ownsake,but to supportclinicians inthe earlydetection andsubsequentpatient management of breast cancer.
Digital Holography and Three-Dimensional Display : Principles and Applications
Digital (or electronic) holography and its application to 3-D display is one of the formidable problems of evolving areas of high technology that has been receiving great attention in recent years. The realization of life-size interactive 3-D displays has been a seemingly unobtainable goal. Technology is not quite at that level yet, but advances in 3-D display now allow us to take important steps toward the achievement of this objective. The reader is presented with the state-of-the-art developments in both digital holography and 3-D display techniques. The book contains a large amount of research material as well as reviews, new ideas and insights that will be useful for graduate students, scientists, and engineers working in the field.
Digital Design of Nature : Computer Generated Plants and Organics
The reproduction of nature via computer has fascinated scientists in computer graphics and artists ever since synthetic imaging was thought possible. This book illustrates and exemplifies methods for the creation of artificial plant models, and the application of these methods within areas such as simulation, virtual reality, botany, landscaping, and architecture.The models are combined to create gardens, parks, and even entire landscapes.The range of creating representational forms reaches from deceptively authentic looking pictures to abstract presentations. In addition, with similar methods organic objects can be produced, changed, and animated.
Digital cities III : Information technologies for social capital: Cross-cultural Perspectives ; 3rd international digital cities workshop, Amsterdam, The Netherlands, September 18-19, 2003, Revised Selected Papers
Digital cities constitutes a multidisciplinary field of research and development, where researchers, designers and developers of communityware interact and collaborate with social scientists studying the use and effects of these kinds of infrastructures and systems in their local application context. The field is rather young. After the diffusion of ICT in the world of organizations and companies, ICT entered everyday life. And this also influenced ICT research and development. The 1998 Workshop on Communityware and Social Interaction in Kyoto was an early meeting in which this emerging field was discussed.
Diffusion in Condensed Matter : Methods, Materials, Models
Diffusion as the process of particle transport due to stochastic movement is a phenomenon of crucial relevance for a large variety of processes and materials. This comprehensive, handbook-style survey of diffusion in condensed matter gives detailed insight into diffusion as the process of particle transport due to stochastic movement. Leading experts in the field describe in 23 chapters the different aspects of diffusion, covering microscopic and macroscopic experimental techniques and exemplary results for various classes of solids, liquids and interfaces as well as several theoretical concepts and models. Students and scientists in physics, chemistry, materials science, and biology will benefit from this detailed compilation.
Differential Equations, Chaos and Variational Problems
Differential equations are a fast evolving branch of mathematics and one of the mathematical tools most used by scientists and engineers. This book gathers a collection of original articles and state-of-the-art contributions, written by highly distinguished researchers working in differential equations, delay-differential equations, differential inclusions, variational problems, Young measures, control theory, dynamical systems, chaotic systems and their relations with physical systems. The forefront of research in these areas is represented in this volume.
Difference Equations : From Rabbits to Chaos
Difference equations are models of the world around us. From clocks to computers to chromosomes, processing discrete objects in discrete steps is a common theme. Difference equations arise naturally from such discrete descriptions and allow us to pose and answer such questions as: How much? How many? How long? Difference equations are a necessary part of the mathematical repertoire of all modern scientists and engineers.The book cover the basics of difference equations and some of their applications in computing and in population biology. Each chapter leads to techniques that can be applied by hand to small examples or programmed for larger problems. Along the way, the reader will use linear algebra and graph theory, develop formal power series, solve combinatorial problems, visit Perron—Frobenius theory, discuss pseudorandom number generation and integer factorization, and apply the Fast Fourier Transform to multiply polynomials quickly.
Developments in Fish Telemetry ; Proceedings of the Sixt Conference on Fish Telemetry held in Europe
This volume includes 33 peer-reviewed papers presented at the Sixth Conference on Fish Telemetry held in Europe (Sesimbra, Portugal, 5-11 June 2005). The papers focus on the application of aquatic telemetry techniques by scientists to investigate fundamental aspects of animal biology in order to conserve and manage natural resources. The topics addressed in this issue are human impacts and fisheries, migration and behaviour, species conservation and habitat rehabilitation, and methodology and new technology. This book is aimed at scientists and engineers actively involved in aquatic telemetry projects, aquatic biologists (marine and freshwater), fisheries biologist and managers.
