الصفحة 15
الصفحة 15
Climate Change Impacts for the Conterminous USA : An Integrated Assessment
In this volume, an improved Integrated Assessment methodology is used to analyse climate change impacts on agriculture, water resources, unmanaged ecosystems, irrigation, and land use in the United States and the economic implications of these impacts. This book contains a series of papers documenting the methods, models, analysis and results of this integrated assessment for a wide ranging set of scenarios describing future climate change. Innovations described include the integration of water resource and agricultural modeling and the refinement of an agriculture and land-use economics model to incorporate results from process-level ecosystem models of agriculture, water and natural ecosystem resources. Scenarios selected for this study address a range of uncertainties associated with choice of climate model, presence or absence of a ‘CO2-fertilization effect’, impacts on international trade in agricultural commodities and their consequences for producers and consumers.
Cleft and Craniofacial Orthodontics
Provides orthodontists, plastic and oral and maxillofacial surgeons, speech and language therapists, pediatric dentists, and prosthodontists with the information they need to evaluate and treat these conditions. Highlighting the multidisciplinary team approach, the book aids clinicians in developing a complete plan for their patients.
Classifying madness : A philosophical examination of the diagnostic and statistical manual of mental disorders
Classifying Madness examines the conceptual foundations of the D.S.M., the main classification of mental disorders used by psychiatrists world-wide. It will be of interest to both mental health professionals and to philosophers interested in classification in science. The D.S.M. has become extremely controversial, and the possibility that there may be philosophical difficulties with it has become a commonplace in the mental health literature. Classifying Madness offers mental health professionals an opportunity to explore suspicions that there might be conceptual problems with the D.S.M. For philosophers, this book aims to contribute to debates in the philosophy of science concerning natural kinds, the theory-ladenness of classification, and the effect of sociological factors in science. These issues are normally approached via a consideration of the natural sciences and, as will be seen, approaching them via a consideration of psychiatry helps shed new light on old problems.
Classification des Groupes Algébriques Semi-simples = The Classification of Semi-Simple Algebraic Groups
The third volume of the Collected Works of Claude Chevalley assembles his work on semi-simple algebraic groups contained, for the most part, in the notes of the famous "Sminaire Chevalley" held at the Ecole Normale Suprieure in Paris between 1956 and 1958 and written up by participants of the seminar namely, P. Cartier, A. Grothendieck, R. Lazard and J.L. Verdier. These texts have been entirely reset in TeX for this edition, and edited and annotated by Pierre Cartier. Almost 50 years after the original writing, these texts still constitute a choice reference from which to enter
Civil engineering structures according to the Eurocodes : Inspection and maintenance
This standard assumes that the structure, after completion, is used as intended in the project and subject to planned inspection and maintenance to meet the expected project lifetime and to detect any unforeseen weakness or behavior" (EN 13670 4.1)An important decision factor in the design of new structures and repairs to existing structures is the lifetime or expected service life. This concept, which is common for civil engineering works, has been extended to all engineering and building works by applying the European Structural Design Codes.
Citation Analysis in Research Evaluation
This book is written for members of the scholarly research community, and for persons involved in research evaluation and research policy. More specifically, it is directed towards the following four main groups of readers: – All scientists and scholars who have been or will be subjected to a quantitative assessment of research performance using citation analysis. – Research policy makers and managers who wish to become conversant with the basic features of citation analysis, and about its potentialities and limitations. – Members of peer review committees and other evaluators, who consider the use of citation analysis as a tool in their assessments. – Practitioners and students in the field of quantitative science and technology studies, informetrics, and library and information science. Citation analysis involves the construction and application of a series of indicators of the ‘impact’, ‘influence’ or ‘quality’ of scholarly work, derived from citation data, i.e. data on references cited in footnotes or bibliographies of scholarly research publications. Such indicators are applied both in the study of scholarly communication and in the assessment of research performance. The term ‘scholarly’ comprises all domains of science and scholarship, including not only those fields that are normally denoted as science – the natural and life sciences, mathematical and technical sciences – but also social sciences and humanities.
Characteristics Finite Element Methods in Computational Fluid Dynamics
This book details a systematic characteristics-based finite element procedure to investigate incompressible, free-surface and compressible flows. The fluid dynamics equations are derived from basic thermo-mechanical principles and the multi-dimensional and infinite-directional upstream procedure is developed by combining a finite element discretization of a characteristics-bias system with an implicit Runge-Kutta time integration. For the computational solution of the Euler and Navier Stokes equations, the procedure relies on the mathematics and physics of multi-dimensional characteristics. As a result, the procedure crisply captures contact discontinuities, normal as well as oblique shocks, and generates essentially non-oscillatory solutions for incompressible, subsonic, transonic, supersonic, and hypersonic inviscid and viscous flows.
Chance : The life of games and the game of life
With its many easy-to-follow mathematical examples, this book takes the reader on an almost chronological trip through the fascinating and amazing laws of chance, omnipresent in the natural world and in our daily lives. Along the route many fascinating topics are discussed, such as: challenging probability paradoxes; "paranormal" coincidences; game odds; causes and effects; interpretation of opinion polls; winning chances as a game proceeds; the nature of randomness; entropy and randomness; randomness in life; algorithmic complexity and the undecidability of randomness; possibilities and limitations of learning the laws of a Universe immersed in chance events. This charming book will inform and entertain the scientist and non-scientist alike.
Challenge In biologic drug delivery
Biologics are currently one of the most promising avenues for therapeutic interventions in conditions such as metabolic disease, ageing and inflammatory disorders, and for chronic ailments, oral delivery of such medicines has for years been recognised as an important goal. Despite decades of intensive research, oral delivery of biologics is only just starting to prove feasible. There has been much talk about the barriers to uptake of biologics, and indeed, one function of the intestine is to prevent, in one way or another, passage of unwanted materials across the gut, and yet, grams of biological agents both large and small pass across the intestinal cell wall every day. This review first describes the functioning of the gut under normal circumstances, then identifies the principle biological mechanisms, which have been harnessed successfully, to date, to achieve oral uptake, outlining the pros and cons of each approach.
Cerebral palsy
Cerebral palsy is a lifelong condition that affects the individual, family, and immediate community. Therefore, the goal of allowing the individual with cerebral palsy to live life with the least impact of the disability requires c- plex attention to the individual and the family. Furthermore, society needs to be sensitive and to accommodate individuals with disabilities by limiting architectural impediments and providing accessible public transportation and communication. The educational system provides the key means for helping the individual prepare to function in society to his or her maximum ability. In many ways, the medical care system probably has the least sign- icant role in preparing the child with cerebral palsy to function optimally in society. However, the medical care system is the place where parents first learn that their child has developmental issues outside the expected norm. It is almost universally the place where parents also expect the child to be made normal in our modern society. In earlier times, the parents would expect healing to possibly come from the doctor, but also they would place hope for healing in religion. As this belief in spiritual or miraculous healing has - creased, a significant font of hope has decreased for parents of young ch- dren with disabilities.
Cell volume and signaling
In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field.
Cardiac Mechanotransduction
For about hundred years the investigation of heart physiology has had one central guiding principle, the "law" of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con traction force. The "law" does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ ence of the original formulation of the Frank-Starling principle is that mechanotransduction is the central theme that leads the reader through the book. Since the discovery of the "law" the scope of topics related to this subject has broadened enormously, as can be seen easily by glancing at the contents of this book. Mechanotransduction in the heart has many faces that range from molecules to humans and their diseases.
Cancer immunotherapy
Defining Cancer as a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body, making it an enormous medical and economic burden accounting for 9.6 million deaths in 2018. Cancer treatments were being introduced for a long time. The development of specific therapies to treat cancer really depends on the continued discovery of the molecular changes that lead to the malignant progression of human cancers. More and more drugs are being developed to block cancer pathways that lead to impaired growth and survival of cancer cells. In this dissertation, the concept of cellular and immunotherapy of cancer will be discussed briefly, taking into considerations the mechanisms of action, the advantages, challenges and drawbacks of the different types of monoclonal antibodies and CAR T-Cell therapy.
Cancer : Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related.
Calcium and Phosphate Metabolism Management in Chronic Renal Disease
Calcium and Phosphate Metabolism Management in Chronic Renal Diseases provides an overview of the state-of-the-art clinical and basic science aspects of abnormal calcium and phosphate metabolism and its management.
Business Ethics : Methods and Application
Business Ethics: Methods and Application provides a new systematic approach to normative business ethics that covers the complex and various ethical challenges of modern business.
Business criminal law: A primer for management and economics
Deals with business criminal law from the perspective of Germany, Austria, Liechtenstein and Switzerland. It primarily addresses students in business and economics (master's programme) as well as business practitioners, but is also meant for lawyers and law students. As criminal law legislators exert considerable influence on economic life, raising and growing awareness in the area of criminal law seems compulsory for future managers and executives. This textbook approaches the legal field less normatively and rather in a practical and entrepreneurial way. Its contents are based on the master level class "Business Criminal Law
Brunet Saunier Architecture : Monospace and Simplexity
Discusses and analyzes this concept in detail, presenting trueto- scale floor plans, cross-sections, architectural views, and other information. The Monospace concept - which is based on a process of creative reduction down to essentials, i.e. "simplexity" - is adaptive rather than normative or prescriptive, and based on probabilities rather than determinism. It respects energy, even when it sometimes uses it. It takes the individual's experience into account, and starts from the position of the subject. It also permits changing perspectives. This design concept should attract attention far beyond the borders of France.
Brilliantguard : AI-powered healthcare prototype for mobile & automotive integration
Brilliantguard is an AI-powered healthcare and safety prototype designed to support individuals with special needs, the elderly users, and patients with chronic conditions such as alzheimer’s disease. The system integrates augmented reality (AR), an AI based chatbot, and bitcoin-based payments into a unified platform combining mobile apps, smartwatches, and automotive sensors. It enables real-time health monitoring, predictive alerts with preliminary health suggestions, medication reminders, initial fault detection, and geofencing-based tracking for alzheimer’s patients. Emergency alerts are automatically triggered in response to abnormal health readings or car crashes.
Brain and Heart Dynamics
Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling.
