الصفحة 15
الصفحة 15
Teratogenicity testing : Methods and protocols
Collects laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. Beginning with a section detailing basic principles of teratogenicity, the book continues with application of in vitro models for teratogenic screening to predict toxicity in embryonic animals and humans, as well as a variety of well-established in vivo animal model tests, which offer solutions for evaluating the efficacy and the teratogenicity of compounds in preclinical trials before human safety testing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Tensor Network Contractions : Methods and Applications to Quantum Many-Body Systems
This book is intended for graduated students, but can also be used as a professional book for researchers in the related fields. To understand most of the contents in the book, only basic knowledge of quantum mechanics and linear algebra is required. In order to fully understand some advanced parts, the reader will need to be familiar with notion of condensed matter physics and quantum information, that however are not necessary to understand the main parts of the book. This book is a good source for non-specialists on quantum physics to understand tensor network algorithms and the related mathematics.
Ten Crises : The Political Economy of China’s Development (1949-2020)
This book contextualizes China’s 70 years of contemporary history against one coherent backdrop: a late developing country endeavoring at all costs to industrialize, whether it was in the name of socialism or capitalism. This path is even more complicated by China’s getting caught in the geo-political confrontation of two superpowers in the 20th century: the Soviet Union and the USA. The author argues that China could only cope with these costs by internalizing them. As one of the leading scholars of agrarian issues in China, the author emphasizes the role of rural sector having been a source of surplus extraction for industrialization and the receptor of cost of development being transferred by the urban sector.
Technology transfer : Drug product manufacturing process
Offers technology transfer solutions and guidance to the pharmaceutical industry. The chapters provide a systematic understanding of applying the technology transfer concepts in pharmaceutical manufacturing, promoting standardization within the industry. Since Stage 1b is not specified in detail within the regulations, pharmaceutical organizations are left to determine the requirementsof the stage.
Technique déquilibrage = Balancing technique
The balancing technique is part of our environment. It is present not only in industrial processes, but also in our daily life. The families of parts involved in balancing - practically everything that rotates - are so extensive, their behavior is so varied, the objectives pursued are so different, that only a solid basic knowledge and a systematic approach make it possible to tackle this task. in the best conditions. This work should provide the reader with the fundamental knowledge enabling him to solve in the rules of the art and with a view to efficiency the new problems which constantly arise.
Technetium-99m Pharmaceuticals : Preparation and Quality Control in Nuclear Medicine
Gives an account of the accomplishments related to the development of 99mTc-radiopharmaceuticals and their application in diagnostic nuclear medicine. Since radioactive drug development is a multi-disciplinary task, experts working in nuclear medicine and research institutions have contributed valuable information concerning the preparation with sterile kits, methods of quality control, and the use of 99mTc-radiopharmaceuticals in patients. In addition, the legal aspects governing production and clinical application are also considered.
Teaching : Professionalization, Development and Leadership : Festschrift for Professor Eric Hoyle
The world-wide reform movement has now been in process for thirty years and it is therefore perhaps an appropriate point to consider its implications for the work of teachers thus far and to ponder on the future. It would be widely agreed that the reform movement in general, and in relation to teachers’ work in particular, has brought advantages and disadvantages. It has stimulated teacher development and increased the accountability of teachers to clients – including the state as client. On the other hand, it has led to the intensification of teachers’ work and to the deprofessionalisation as well as professionalisation of teachers. Moreover, it has increased the power of managerialism over the influence of professionalism. This book addresses these issues from different perspectives and in relation to different contexts. It also considers possible solutions to two problems in particular: how to achieve accountability without intensification, and how to ensure that school management and leadership functions to support and enhance teachers as professionals.
Targeting the DNA damage response for cancer therapy
Discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic.
Targeted metallo-drugs : Design, development, and mode of action
Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.
Targeted drug delivery
Explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field.
Taming the Big Green Elephant: Setting in Motion the Transformation Towards Sustainability
In this publication it is shown, that sustainable low carbon development is a transformative process that constitutes the shifting from the initially chosen or taken pathway to another pathway as goals have been re-visited and revised to enable the system to adapt to changes.
Talking About Second Language Acquisition
Includes interviews with fourteen internationally-acclaimed leading figures in Second Language Acquisition (SLA), who speak on seminal issues in the field as well as their own contributions to SLA scholarship. As well as covering the contributors’ backgrounds and academic achievements, the interviews also delve into their areas of expertise, current theoretical and practical considerations, and contemporary questions, developments and challenges in SLA.
Tablet press machine supervision with scada
As technology is advancing and the needs for development in various fields become necessary, the idea of our project is born, which aspire to develop and automate a press tablet machine. The rotary tablet press machine is designed to produce tablets and capsules in different size and shape and is used widely in pharmacy and chemical industries. Quality control test for tablets depends on several parameters such as compression force, humidity and temperature. The project purpose is to add some features such us reading and saving those parameters to be used in researches and experiments for the research and development laboratory in Arab International University’s faculty of pharmacy.
Systems of Commercial Turbofan Engines : An Introduction to Systems Functions
Provides an introduction to the systems of modern commercial turbofan engines. It is made for the reader who is familiar with the basics of aircraft gas turbine engine operation and is preparing him- or herself for the first engine type training. This book also offers a basic orientation through the numerous tubes, lines and system components installed on a complex turbofan engine.Within this book you will find information on the operation of engine systems, the functions of their components and the terminology used throughout the industry. The engine systems are explained using examples selected from today’s engines. As a result, you will be made familiar with the current technology in this field.
Systems mapping : How to build and use causal models of systems
Provides a key starting point and general-purpose resource for understanding complex adaptive systems in practical, actionable, and participatory ways. The book successfully meets the growing need in a range of social, environmental, and policy challenges for a richer more nuanced, yet actionable and participatory understanding of the world. The authors provide a clear framework to alleviate any confusion about the use of appropriate terms and methods, enhance the appreciation of the value they can bring, and clearly explain the differences between approaches and the resulting outputs of mapping processes and analysis.
Systems and Virtualization Management. Standards and New Technologies ; 2nd International Workshop, SVM 2008 Munich, Germany, October, 21-22, 2008 Proceedings
Includes virtualization, key management issues, web services and SOA, new management paradigms, experience implementing and deploying management technology.
Synthesis of essential drugs
Offers a brief description of methods of synthesis, activity and implementation of different drug types. Features chapters that begin with brief definition and description of a particular group of drugs, propose their classification, and explain model of their action, followed by a description of methods for their synthesis.
Synthesis of Best-Seller Drugs
A key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field
Synthesis and Characterization of Glycosides
There is no doubt that glycoside chemistry continues to be a dynamic and exciting field related to organic chemistry. Within sugar chemistry, glycosides are of special interest not only because of the challenges represented by their synthesis and structural characterization, but also due to their important biochemical relevance, and hence their applications in a number of essential disciplines, such as pharmaceuticals, food, and biotechnology. Important biomolecules such as DNA and RNA, or cofactors such as ATP and NAD, are some of the natural glycosidic structures playing key rules at a biochemical level. Also, a considerable number and variety of natural and synthetic glycosides are being extensively used as antibiotics, antiviral, and antineoplasic agents.
Syntax and Semantics of Prepositions
This book is the first to provide an integrated view of preposition from morphology to reasoning, via syntax and semantics. It offers new insights in applied and formal linguistics, and cognitive science. It underlines the importance of prepositions in a number of computational linguistics applications, such as information retrieval and machine translation. The reader will benefit from a wide range of views and applications to various linguistic frameworks, among which, most notably, HPSG. The book is for researchers working in the fields of computational linguistics, linguistics, and artificial intelligence.
