الصفحة 15
الصفحة 15
Drug-Induced Oral Complications
Provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance.
Drug Metabolism: Current Concepts
The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development.
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug discovery and development
Presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.
Drug design : A conceptual overview
The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design" (CADD), which has profound application in RDD. The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide.
Drug Delivery Systems
Expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Drug and Biological Development : From Molecule to Product and Beyond
Drug and Biological Development: From Molecule to Product and Beyond offers a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery to product launch, continuing through life cycle management. The book is organized for optimal usefulness in the education and training of health care professionals. The text's narrative descriptions are enhanced by real-life examples, illustrations, controversies in industry, and references. Dr. Ronald Evens and his contributors are industry and research experts in a variety of disciplines.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
DNA nanotechnology for cell research : from bioanalysis to biomedicine
Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery.
DNA- and RNA-Based Computing Systems
DNA- and RNA-Based Computing Systems delivers an authoritative overview of DNA- and RNA-based biocomputing systems that touches on cutting-edge advancements in computer science, biotechnology, nanotechnology, and materials science.
Distributed applications and interoperable systems ; Vol. 3543 ; 5th IFIP WG 6.1 International conference, DAIS 2005, Athens, Greece, June 15-17, 2005, Proceedings
ThisvolumecontainstheproceedingsoftheIFIPWG6. 1InternationalWorking Conference on Distributed Applications and Interoperable Systems V held in Athens, Greece, on June 15–17, 2005. The conference program presented the state of the art in research concerning distributed and interoperable systems. The emergence of 4th-generation c- munication systems, the evolution of Internet technologies, the convergence of telecom and datacom, wireless and ?xed communication systems and appli- tions pave the path for ubiquitous service and application provision. Innovative solutions are required for the development, implementation and operation of distributed applications in complex IT environments full of diversity and h- erogeneity. Today, the emerging wide spectrum of distributed systems.
DiPiro’s pharmacotherapy : A pathophysiologic approach
It is this in-depth knowledge of pharmacotherapy, combined with the clinical experience gained through postgraduate training in direct patient care practice, that allows the pharmacist to be the "medication therapy expert" on the healthcare team and to proactively address medication-related problems.It is provides knowledge necessary to prevent, identify, and manage disease and medication-related problems
Digital transformation of the design, construction and management processes of the built environment
This book focuses on the development of methods, interoperable and integrated ICT tools, and survey techniques for optimal management of the building process.
Digital transformation in semiconductor manufacturing ; Proceedings of the 1st and 2nd European advances in digital transformation Conference, EADTC 2018, Zittau, Germany and EADTC 2019, Milan, Italy
This book reports on cutting-edge electrical engineering and microelectronics solutions to foster and support digitalization in the semiconductor industry.
Digital platforms in finance and supply chain management : Governance, ethics, and industry 5.0
A comprehensive analysis of digital platforms as the driving force of the modern economy, exploring their evolution, governance, and integration across financial and supply chain ecosystems. It presents a synthesis of theories, strategic models, and empirical insights to address the complexities of platform economies, making it an essential resource for scholars, policymakers, and industry practitioners. It is structured around core principles of digital platforms, including their definition, key features, and transformative impact on value creation. It delves into governance and ethical considerations, examining global regulatory frameworks and the emerging paradigms of Industry 5.0, where digital platforms intersect with economic, social, and environmental sustainability. The theoretical foundations are rooted in network effects, New Economic Geography, Platform Economics, Agency Theory, and Systems Theory, offering a robust analytical framework for understanding scalability, competition, and strategic decision-making in platform ecosystems. Two important areas -finance and supply chains-are explored in depth.
Digital Forensics and Internet of Things : Impact and Challenges
The book discusses applications and challenges professionals encounter in the burgeoning field of IoT forensics. IoT forensics attempts to align its workflow to that of any forensics practice—investigators identify, interpret, preserve, analyze and present any relevant data. As with any investigation, a timeline is constructed, and, with the aid of smart devices providing data, investigators might be able to capture much more specific data points than in a traditional crime.
Dietary interventions for human general and oral health and disease reduction
Nutrition is considered an integral part of health and oral health in terms of treatment and prevention. Thus, different strategies should be employed, as described in this Special Issue, including weight management and control, the incorporation of probiotics, prebiotics, and dietary supplementation. This Special Issue reprint also covers the aspects of dental and oral health impacting systemic health and quality of life. Hence, risk factors and health behaviors have been identified and discussed. The significance of this Special Issue reprint has been outlined by examining and exploring the effects of diet and nutrition on health and oral health issues that affect well-being and quality of life.
Diagrammatology : An investigation on the borderlines of phenomenology, ontology, and semiotics
Diagrammatology investigates the role of diagrams for thought and knowledge. Based on the general doctrine of diagrams in Charles Peirce's mature work, Diagrammatology claims diagrams to constitute a centerpiece of epistemology. The book reflects Peirce's work on the issue in Husserl's contemporanous doctrine of "categorial intuition" and charts the many unnoticed similarities between Peircean semiotics and early Husserlian phenomenology. Diagrams, on a Peircean account, allow for observation and experimentation with ideal structures and objects and thus furnish the access to the synthetic a priori of the regional and formal ontology of the Husserlian tradition.
Designing commercial interiors ; 3rd ed.
A practical, comprehensive resource for commercial interior design Designing Commercial Interiors is the industry standard reference, now fully revised and expanded to reflect the latest developments in commercial interior design. includes new: Sustainability concepts for a variety of commercial spaces Coverage of accessibility, security, safety, and codes—and how these factors influence commercial design Chapters on design research, project process, and project management Drawings and photographs of design applications Supplemental instructor's resources
Dependable Embedded Systems
This book introduces readers to many new techniques for enhancing and optimizing reliability in embedded systems, which have emerged particularly within the last five years.
