الصفحة 15
الصفحة 15
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Environments for Multi-Agent Systems ; 1st International Workshop, E4MAS, 2004, New York, NY, July 19, 2004, Revised Selected Papers
The modern ?eld of multiagent systems has developed from two main lines of earlier research. Its practitioners generally regard it as a form of arti?cial intelligence (AI). Some of its earliest work was reported in a series of workshops in the US dating from1980,revealinglyentitled,“DistributedArti?cialIntelligence,”andpioneers often quoted a statement attributed to Nils Nilsson that “all AI is distributed. ” The locus of classical AI was what happens in the head of a single agent, and much MAS research re?ects this heritage with its emphasis on detailed modeling of the mental state and processes of individual agents. From this perspective, intelligenceisultimatelythepurviewofasinglemind,thoughitcanbeampli?ed by appropriate interactions with other minds. These interactions are typically mediated by structured protocols of various sorts, modeled on human conver- tional behavior. But the modern ?eld of MAS was not born of a single parent. A few - searchershavepersistentlyadvocatedideasfromthe?eldofarti?ciallife(ALife). These scientists were impressed by the complex adaptive behaviors of commu- ties of animals (often extremely simple animals, such as insects or even micro- ganisms). The computational models on which they drew were often created by biologists who used them not to solve practical engineering problems but to test their hypotheses about the mechanisms used by natural systems. In the ar- ?cial life model, intelligence need not reside in a single agent, but emerges at the level of the community from the nonlinear interactions among agents. - cause the individual agents are often subcognitive, their interactions cannot be modeled by protocols that presume linguistic competence.
Environmental Photochemistry ; Part II
Photochemical reactions play a major role in the environment including a wide range of reactions in the atmosphere, natural waters, soil and living organisms. This new volume on Environmental Photochemistry up-dates the previous edition with chapters on basic aspects including concepts of photochemical transformations and mechanistic photochemical processes in the atmosphere and water. In addition a range of applications are also detailed such as advanced photochemical oxidation processes for water and air treatment as well as applications of photocatalysis for surface treatment and nuclear fuel reprocessing. The new edition provides a critical up to date overview of the most important research in the field of environmental photochemistry.
Environmental Issues in Latin America and the Caribbean
This book is a non-technical interdisciplinary collection of 12 essays, each of which uses natural or social science methods. The essays analyze a representative set of environmental issues in Latin America and the Caribbean. They consider problems at international, regional, national, and local levels and examine current and historical environmental policy. The essays are organized according to theme and approach into five parts: -conservation challenges; -national policies, local communities, and rural development; -market mechanisms for protecting public goods; -public participation and environmental justice; -the effects of development policies on the environment. Contributors are researchers from Canada, Europe, Latin America, and the United States
Environmental Chemistry : Green Chemistry and Pollutants in Ecosystems
Environmental chemistry is a new, fast developing science aimed at deciphering fundamental mechanisms ruling the behaviour of pollutants in ecosystems. Applying this knowledge to current environmental issues leads to the remediation of environmental media, and to new, low energy, low emission, sustainable processes. This book describes the state-of-the-art advances regarding the pollution of water, soils, atmosphere, food and living organisms by toxic metals, fossil fuels, pesticides and other organic pollutants. Furthermore, the eco-toxicology section presents novel bio-assays to assess the toxicity of various pollutants such as dioxins and endocrine disrupters within complex media. The green chemistry section highlights novel chemical reactions based upon environmentally friendly conditions. The analytical chemistry section describes very sensitive methods which trace the fate of pollutants in complex ecosystems.
Environmental and Microbial Relationships
After the publication of Volume IV in 1997, the introduction of molecular methods into ecology led to significant new findings. Emphasizing these advances, the chapters for the second edition have been completely updated and revised. This volume provides insight into current research on fungal populations and communities. It focuses on fungal responses to the physical environment, interactions with other fungi, microorganisms and invertebrates, the role of fungi in ecosystem processes such as decomposition and nutrient cycling, and aspects of biogeography and conservation. Several chapters deal with various applications in, e.g. biological pest control, natural products discovery, and the degradation of toxic organic compounds. This is an invaluable source of information both for scientists who wish to update their knowledge of current progress and for graduate students interested in obtaining a first overview of this field of research.
Entry Inhibitors in HIV Therapy
The introductory chapters of this book present an overview of entry inhibitors, review current knowledge of how Env mediates entry, and discuss the challenge of genetic diversity in this region of the viral genome. Subsequent chapters feature current information on individual classes of entry inhibitors that target each step of the virus entry pathway, from attachment to membrane fusion. There is an emphasis on the complex determinants of entry inhibitor susceptibility, resistance mechanisms, the need for clinical phenotyping, and how these issues create new challenges for antiretroviral therapy. Encouraging pre-clinical studies of entry inhibitors as microbicidesare also discussed. The final chapters highlight the current status of entry inhibitors in clinical studies, the major milestone achieved with FDA approval of enfuvirtide, and review drug development, past and present.
English for Everyone Junior Beginner's Practice Book : Look, Listen, Learn, and Practise
Featuring hundreds of exercises, this practice book tests all the vocabulary and grammar structures taught in the English for Everyone Junior: Beginner's Course, making use of a range of both familiar and new exercise mechanisms.
End-to-End Quality of Service Over Heterogeneous Networks
The book presents mechanisms, protocols, and system architectures to achieve end-to-end Quality-of-Service (QoS) over heterogeneous wired/wireless networks in the Internet. Particular focus is on measurement techniques, traffic engineering mechanisms and protocols, signalling protocols as well as transport protocol extensions to support fairness and QoS. It shows how those mechanisms and protocols can be combined into a comprehensive end-to-end QoS architecture to support QoS in the Internet over heterogeneous wired/wireless access networks. Finally, techniques for evaluation of QoS mechanisms such as simulation and emulation are presented.
Endophytic microbes: Isolation, identification, and bioactive potentials
Provides basic insight and protocols relating to endophytic microbes. Chapter are divided into five major sections detailing basic isolation, bioactive metabolites production. endophytism, isolation and identification of endophytes, bioactive potentials, and screening of metabolites.
Endocrinology : Basic and Clinical Principles
For this new edition of Conn & Melmed's Endocrinology: Basic and Clinical Principles, a panel of distinguished scientists and clinicians has completely rewritten every chapter to reflect the latest advances in our understanding of the endocrine system. Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, the authors have succinctly summarized in 450 pages the latest findings on hormone secretion and hormone action, as well as all of the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in humans and the lower species, and the mechanisms subserving hormone secretion.
Endocrine-Disrupting Chemicals : From Basic Research to Clinical Practice
This book presents a translational approach to EDC research, spanning both basic biology and clinical applications, and provides a critical link between the laboratory and the physicians’ office. Scientists and physicians engaged in EDC studies or practice will find that this volume offers insight across all areas of EDC research, including clarifying the mechanisms for EDC effects, understanding the adverse affects of EDCs on humans and wildlife, and offering solutions to the problems created by exposures to EDCs.
Encyclopedia of Molecular Pharmacology
It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Encyclopedia of Molecular Pharmacology
Covers all aspects of pharmacology, from the chemistry of drugs and the biochemistry of drug targets to the clinical application of drugs, with emphasis on molecular mechanisms. It also includes techniques for describing the effects of drugs and characterizing drug targets. With over 2,000 entries and 350 detailed essays by leading experts, this book is also an up-to-date and important reference for scientists in fields outside pharmacology, students, health care workers, teachers, physicians, and laypersons.
Emerging Organic Pollutants in Waste Waters and Sludge
Over the past fifteen years regulatory agencies have relied on their approaches to characterise and control the release of toxic substances into the aquatic environment: a GC/MS analysis for U.S. EPA designated 126 priority pollutants and 132 dangerous substances according to the European 76/464/CEE Directive and on the bioassays with aquatic bioorganisms. "Emerging Contaminants" correspond in most cases to irregulated contaminants, e.g. surfactants, pharmaceuticals and personal care products (PPCP), or gasoline additives. These two volumes, 5/I and 5/O, of this Handbook deal with the analytical, toxicological and environmental issues of these toxicants. Based on results of up-to-date research they give the reader a balanced view on this rapidly developing and complex subject.
Emergence of Communication and Language
This volume brings together studies from diverse disciplines, showing how they can inform and stimulate each other. It includes work in linguistics, psychology, neuroscience, anthropology and computer science. New empirical work is reported on both human and animal communication, using some novel techniques that have only recently become viable. A principal theme is the importance of studies involving artificial agents, their contribution to the body of knowledge on the emergence of communication and language, and the role of simulations in exploring some of the most significant issues. A number of different synthetic systems are described, demonstrating how communication can emerge in natural and artificial organisms. Theories on the origins of language are supported by computational and robotic experiments. Worldwide contributors to this volume include some of the most influential figures in the field, delivering essential reading for researchers and graduates in the area, as well as providing fascinating insights for a wider readership.
Elliptic Theory and Noncommutative Geometry : Nonlocal Elliptic Operators
This comprehensive yet concise book deals with nonlocal elliptic differential operators, whose coefficients involve shifts generated by diffeomorophisms of the manifold on which the operators are defined. The main goal of the study is to relate analytical invariants (in particular, the index) of such elliptic operators to topological invariants of the manifold itself. This problem can be solved by modern methods of noncommutative geometry. This is the first and so far the only book featuring a consistent application of methods of noncommutative geometry to the index problem in the theory of nonlocal elliptic operators. Although the book provides important results, which are in a sense definitive, on the above-mentioned topic, it contains all the necessary preliminary material, such as C*-algebras and their K-theory or cyclic homology.
Electronic Postage Systems : Technology, Security, Economics
This book introduces a taxonomy of electronic postage systems and explains their security risks and countermeasures. The underlying cryptographic mechanisms are introduced and explained, and the industrial-scale electronic postage systems existing worldwide, are sorted out with respect to this taxonomy. The author also discusses privacy and anonymous mail, the state of standardization of electronic postage, and the process of security evaluation and testing of electronic postage systems. This volume including electronic postage designers of postal operators and standardization bodies, software and test engineers, software vendors integrating electronic postage solutions into their applications, security engineers and cryptography experts, and accredited test laboratories evaluating electronic postage systems.
Electronic Noise and Interfering Signals
Electronic Noise and Interfering Signals" is a comprehensive reference book on noise and interference in electronic circuits, with particular focus on low-noise design. The first part of the book deals with mechanisms, modeling, and computation of intrinsic noise which is generated in every electronic device. The second part analyzes the coupling mechanisms which can lead to a contamination of circuits by parasitic signals and provides appropriate solutions to this problem. The last part contains more than 100 practical, elaborate case studies
Electronic Irradiation of Foods : An Introduction to the Technology
Electronic Irradiation of Foods describes all the key aspects of electron accelerator technology in detail. It emphasizes the physical science and technology aspects of food irradiation using machine sources of ionizing radiation. The book provides significant technical depth for interested workers and present descriptive, introductory material that should help demystify technology for businessmen to make informed choices regarding important investments decisions.Introductory chapters summarize the effects of ionizing radiation on biological organisms and the organic compounds comprising foods, and give an overview of the food irradiation process. Subsequent chapters cover the details of the electron beam and x-ray energy deposition, electron accelerator technologies, beam scanning systems, material handling systems, shielding design, and process control considerations. Important appendices cover radiation dosimetry, induced radioactivity, and ozone generation.
