الصفحة 15
الصفحة 15
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
High Order Difference Methods for Time Dependent PDE
Many books have been written on ?nite difference methods (FDM), but there are good reasons to write still another one. The main reason is that even if higher order methods have been known for a long time, the analysis of stability, accuracy and effectiveness is missing to a large extent. For example, the de?nition of the formal high order accuracy is based on the assumption that the true solution is smooth, or expressed differently, that the grid is ?ne enough such that all variations in the solution are well resolved. In many applications, this assumption is not ful?lled, and then it is interesting to know if a high order method is still effective. Another problem that needs thorough analysis is the construction of boundary conditions such that both accuracy and stability is upheld. And ?nally, there has been quite a strongdevelopmentduringthe last years, inparticularwhenit comesto verygeneral and stable difference operators for application on initial–boundary value problems.
High mountain conservation in a changing world
This book aims to provide case studies and a general view of the main processes involved in the ecosystem shifts occurring in the high mountains, and to analyse the implications for nature conservation. Although case studies from the Pyrenees are preponderant, conclusions are aimed at any mountain range surrounded by highly populated lowland areas. The chapters give emphasis to approaches from environmental geography, functional ecology, biogeography, and paleoenvironmental reconstructions. The introductory and closing chapters summarize the main challenges that nature conservation may face in mountain areas under the environmental shifting conditions.
Hidradénite suppurée = Hidradenitis suppurativa
This book is the first to deal specifically with hidradenitis suppurativa, a common but little-known condition. Many patients experience it as a painful and debilitating disease, insensitive to treatment and demoralizing for the doctors of various specialties who take care of it. This book will be an encouragement for them by showing them that there are many ways to improve a distressing disease and the quality of life of patients.
Heterogeneity, high performance computing, self-organization and the cloud
Addresses the most recent developments in cloud computing such as HPC in the Cloud, heterogeneous cloud, self-organising and self-management, and discusses the business implications of cloud computing adoption. Establishing the need for a new architecture for cloud computing, it discusses a novel cloud management and delivery architecture based on the principles of self-organisation and self-management. This focus shifts the deployment and optimisation effort from the consumer to the software stack running on the cloud infrastructure. It also outlines validation challenges and introduces a novel generalised extensible simulation framework to illustrate the effectiveness, performance and scalability of self-organising and self-managing delivery models on hyperscale cloud infrastructures. It concludes with a number of potential use cases for self-organising, self-managing clouds and the impact on those businesses.
Heterocycles from Transition Metal Catalysis : Formation and Functionalization
The book provides a representative selection of transition metal catalysed reactions, transformations that are relevant in heterocyclic chemistry. In this way, the authors provide a useful resource for members of the academic community looking for a textbook as well as industrial chemists in search of a reference book. This book is an invaluable resource for synthetic chemists, medicinal chemists, and those more generally interested in applied catalysis.
Hereditary Peripheral Neuropathies
"Hereditary Peripheral Neuropathies" deals with the Charcot-Marie-Tooth group of neuropathies and related primary hereditary neuropathies. The knowledge in this field has grown exponentially during the last ten years. The book is divided into two sections. The first section deals with the clinical presentation, electrophysiological features and differential diagnosis of these disorders as well as with the general biology of the peripheral nerve. The second section gives a detailed account of the known disease entities. The book will be interesting for both the clinician with a special interest in PNS diseases as well as for the researcher.
Hepatitis Delta Virus ; Vol. 307
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Heinz Werner and Developmental Science
This book will be of interest to developmental psychologists, sociologists and historians of science, philosophers, practitioners working in special education and neuropsychology, and for general readers interested in the history of ideas and life courses of scientists.
Hedgehog-Gli Signaling in Human Disease
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Hebrew Scholasticism in the Fifteenth Century : A History and Source Book
This book aims to respond to this need. After a historical introduction, where a "state of the art" about research on the relationship between Jewish philosophy and science and Latin Scholasticism in the thirtheenth-fifteenth centuries is given, the book consists of four chapters. Each of them offers a general bio-bibliographical survey of one or two key-authors of fifteenth-century "Hebrew Scholasticism", followed by English translations of some of their most significant "Scholastic" works or of some parts of them: Abraham Bibago’s "Treatise on the Plurality of Forms", Baruch Ibn Ya’ish’s commentaries on Aristotle’s "Nicomachean Ethics" and "De anima", Eli Habillo’s introduction to Antonius Andreas’s commentary on the "Metaphysics", Judah Messer Leon’s commentary on Aristotle’s "Physics" and questions on Porphyry’s "Isagoge".
Heat and cold storage with PCM : An up to date introduction into basics and applications
Latent heat storage with phase change materials (PCM) has the potential to improve significantly the efficiency of heat and cold storages and to reduce their size considerably. The book is an introduction into the field for researchers and students. It summarizes and explains the basics, general concepts, and applications with examples in a single text. For a better understanding, many derivations, graphs and tables are included. All aspects from materials analysis and modification, storage design, storage integration, and different application examples are covered. Special focus is on applications in buildings.
Healthy Longevity in China : Demographic, Socioeconomic, and Psychological Dimensions
China is aging at an extraordinary speed and has the largest quantity of elderly persons in the world. Scholars utilize this unprecedented living experience of human being and the unique Chinese Longitudinal Healthy Longevity Survey (CLHLS) datasets with the aim to answer in this volume the following questions critical to the aging population world wide. Is the period of disability compressing or expanding with increasing life expectancy and what factors are associated with these trends in the recent decades? Is it possible to realize morbidity compression with a prolongation of the life span in the future?The first section of the book presents the CLHLS project’s study design, sample distribution, contents of data collected, and assessments of age reporting and data quality. The remaining chapters are grouped into sections dealing with the demographic, social, economic, familial and psychological dimensions of healthy longevity.
Health research in developing countries : A collaboration between Burkina Faso and Germany
Health research in developing countries has many facets. On one side, malaria and AIDS as main causes of morbidity and mortality are a focus for clinical and epidemiological studies. On the other side, the need for improving the health care system in general cannot be overestimated. The book offers a survey of current and important topics of health research in developing countries. Special emphasis is placed to show that cooperation of different health research areas if of highest importance in future. In addition the CRSN (Burkina Faso) - University of Heidelberg collaboration is given as a model that allows high class research in remote areas of any developing country. An absolutely must for all who are working in clinical, epidemiological and health systems research for and in developing countries.
Harty’s endodontics in clinical practice
A guide to proven, current clinical endodontic practice. It is designed, primarily, with the undergraduate readership in mind but is also suitable for anyone pursuing specialist training, including extended skills in endodontics, and general dental practitioners undertaking CPD, or wishing to keep up-to-date. The seventh edition is available with an online question bank containing MCQs and Clinical Cases.
Harmonic Analysis and Rational Approximation : Their Rôles in Signals, Control and Dynamical Systems
This book - an outgrowth of a topical summer school - sets out to introduce non-specialists from physics and engineering to the basic mathematical concepts of approximation and Fourier theory. After a general introduction, Part II of this volume contains basic material on the complex and harmonic analysis underlying the further developments presented. Part III deals with the essentials of approximation theory while Part IV completes the foundations by a tour of probability theory. Part V reviews some major applications in signal and control theory. In Part VI mathematical aspects of dynamical systems theory are discussed. Part VII, finally, is devoted to a modern approach to two physics problems: turbulence and the control and noise analysis in gravitational waves measurements.
Hands-On Design Patterns with Java : Learn Design Patterns That Enable the Building of Large-Scale Software Architectures
Java design patterns are reusable and proven solutions to software design problems. This book covers over 60 battle-tested design patterns used by developers to create functional, reusable, and flexible software. Hands-On Design Patterns with Java starts with an introduction to the Unified Modeling Language (UML), and delves into class and object diagrams with the help of detailed examples. You'll study concepts and approaches to object-oriented programming (OOP) and OOP design patterns to build robust applications. As you advance, you'll explore the categories of GOF design patterns, such as behavioral, creational, and structural, that help you improve code readability and enable large-scale reuse of software. You’ll also discover how to work effectively with microservices and serverless architectures by using cloud design patterns, each of which is thoroughly explained and accompanied by real-world programming solutions. By the end of the book, you’ll be able to speed up your software development process using the right design patterns, and you’ll be comfortable working on scalable and maintainable projects of any size.
Handbook of transdisciplinary research
Transdisciplinary research (TR) is an emerging field of research in the knowledge society.This handbook provides, for the first time, a structured overview of the manifold experiences gained in these fields. Twenty-one projects from all over the world present their research approaches, structured along the three phases of a TR project.
Handbook of Spatial Logics
The aim of this handbook is to create, for the first time, a systematic account of the field of spatial logic. The book comprises a general introduction, followed by fourteen chapters by invited authors. Each chapter provides a self-contained overview of its topic, describing the principal results obtained to date, explaining the methods used to obtain them, and listing the most important open problems. Jointly, these contributions constitute a comprehensive survey of this rapidly expanding subject.
Handbook of pharmacokinetics and toxicokinetics
An effort to blend the common approaches to pharmacokinetics and toxicokinetics. It integrates the principles held in common by both fields through a logical and systematic approach, which includes mathematical descriptions of physical and physiological processes employed in approaches to PK/TK modeling. It emphasizes general principles and concepts and related isolated applications and case studies observations.The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advance courses/workshops and seminars.
