الصفحة 14
الصفحة 14
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters.
Drug delivery aspects : Expectations and realities of multifunctional drug delivery systems ; Vol.4 : Expectations and realities of multifunctional drug delivery systems
Reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction.
Domain Decomposition Methods in Science and Engineering XVII
This volume contains a selection of papers presented at the 17th International Conference on Domain Decomposition Methods in Science and Engineering held at St. Wolfgang / Strobl, Austria, July 3 - 7, 2006. Domain decomposition is an active, interdisciplinary research area concerned with the development, analysis, and implementation of coupling and decoupling strategies in mathematical and computational models. Domain decomposition techniques provide efficient tools for treating problems in all Computational Sciences. The reader will become familiar with the newest domain decomposition technologies and their use for modeling and simulating of complex problems from different fields of applications.
Document Analysis Systems VII ; 7th International Workshop, DAS 2006, Nelson, New Zealand, February 13-15, 2006, Proceedings
This book constitutes the refereed proceedings of the 7th International Conference on Document Analysis Systems, DAS 2006, held in Nelson, New Zealand, in February 2006.
Do Exclusionary Rules Ensure a Fair Trial? : A Comparative Perspective on Evidentiary Rules
This publication discusses exclusionary rules in different criminal justice systems. It is based on the findings of a research project in comparative law with a focus on the question of whether or not a fair trial can be secured through evidence exclusion. Part I explains the legal framework in which exclusionary rules function in six legal systems: Germany, Switzerland, People’s Republic of China, Taiwan, Singapore, and the United States. Part II is dedicated to selected issues identified as crucial for the assessment of exclusionary rules. These chapters highlight the delicate balance of interests required in the exclusion of potentially relevant information from a criminal trial and discusses possible approaches to alleviate the legal hurdles involved.
Diverse Roles of Integrin Receptors in Articular Cartilage
Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Distributed computing and internet Technology ; Vol. 3816 ; 2nd International conference, ICDCIT 2005, Bhubaneswar, India, December 22-24, 2005, Proceedings
The opening ceremony and pre-conference tutorials on various related topics were held on December 21. The technical program started on December 22 and continued for three days. The program was arranged in single track so as to enable participants to attend sessions of di?erent tracks. Papers from the DM, IT, SE, and SS tracks were divided into two sessions, whereas DC track sessions were held on the ?rst two days of the conference. The program also included two plenary talks. The ?rst talk was delivered by S. S. Iyengar from Louisiana State University, USA. The second talk was delivered by He Jifeng from the International Institute for Software Technology (IIST) Macau. Prof. Iyenger’s talk on “The Distributed Sensor Networks — An Emerging Technology” was focused on new ideas about the use of distributed systems for emerging technology, while Prof. Jifeng’s talk on “Linking Theories of Concurrency by Retraction” dealt with semantics of concurrency.
Dilute III-V Nitride Semiconductors and Material Systems : Physics and Technology
A major current challenge for semiconductor devices is to develop materials for the next generation of optical communication systems and solar power conversion applications. Recently, extensive research has revealed that an introduction of only a few percentages of nitrogen into III-V semiconductor lattice leads to a dramatic reduction of the band gap. This discovery has opened the possibility of using these material systems for applications ranging from lasers to solar cells. Physics and Technology of Dilute III-V Nitride Semiconductors & Novel Dilute Nitride Material Systems reviews the current status of research and development in dilute III-V nitrides, with 24 chapters from prominent research groups covering recent progress in growth techniques, experimental characterization of band structure, defects carrier transport, transport properties, dynamic behavior of N atoms, device applications, modeling of device design, novel optoelectronic integrated circuits, and novel nitrogen containing III-V materials.
Digital Soil Mapping with Limited Data
This book focuses on digital soil mapping methodologies and applications for areas where data are limited, and has the following sections (i) introductory papers, (ii) dealing with limited spatial data infrastructures, (iii) methodology development, and (iv) examples of digital soil mapping in various parts of the globe (including USA, Brazil, UK, France, Czech Republic, Honduras, Kenya, Australia). The final chapter summarises priorities for digital soil mapping.
Digital Signal Processing with Field Programmable Gate Arrays
Field-Programmable Gate Arrays (FPGAs) are revolutionizing digital signal processing as novel FPGA families are replacing ASICs and PDSPs for front-end digital signal processing algorithms. So the efficient implementation of these algorithms is critical and is the main goal of this book. It starts with an overview of today's FPGA technology, devices, and tools for designing state-of-the-art DSP systems. A case study in the first chapter is the basis for more than 40 design examples throughout. The following chapters deal with computer arithmetic concepts, theory and the implementation of FIR and IIR filters, multirate digital signal processing systems, DFT and FFT algorithms, advanced algorithms with high future potential, and adaptive filters. Each chapter contains exercises. The VERILOG source code and a glossary are given in the appendices. This edition has a new chapter on microprocessors, new sections on special functions using MAC calls, intellectual property core design and arbitrary sampling rate converters, and over 100 new exercises.
Digital human modeling and applications in health, safety, ergonomics and risk management : Posture, motion and health ; 11th International Conference, DHM 2020, Held as Part of the 22nd HCI International Conference, HCII 2020, Copenhagen, Denmark, July 19–24, 2020, Proceedings, Part I
This two-volume set LNCS 12198 and 12199 constitutes the thoroughly refereed proceedings of the 11th International Conference on Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management, DHM 2020, which was supposed to be held as part of the 22st HCI International Conference, HCII 2020, in Copenhagen, Denmark, in July 2020. The conference was held virtually due to the COVID-19 pandemic.
Digital human modeling and applications in health, safety, ergonomics and risk management : Human communication, organization and work ; 11th International Conference, DHM 2020, Held as Part of the 22nd HCI International Conference, HCII 2020, Copenhagen, Denmark, July 19–24, 2020, Proceedings, Part II
This two-volume set LNCS 12198 and 12199 constitutes the thoroughly refereed proceedings of the 11th International Conference on Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management, DHM 2020, which was supposed to be held as part of the 22st HCI International Conference, HCII 2020, in Copenhagen, Denmark, in July 2020. The conference was held virtually due to the COVID-19 pandemic.
Digital cities III : Information technologies for social capital: Cross-cultural Perspectives ; 3rd international digital cities workshop, Amsterdam, The Netherlands, September 18-19, 2003, Revised Selected Papers
Digital cities constitutes a multidisciplinary field of research and development, where researchers, designers and developers of communityware interact and collaborate with social scientists studying the use and effects of these kinds of infrastructures and systems in their local application context. The field is rather young. After the diffusion of ICT in the world of organizations and companies, ICT entered everyday life. And this also influenced ICT research and development. The 1998 Workshop on Communityware and Social Interaction in Kyoto was an early meeting in which this emerging field was discussed.
Dialogue as a Means of Collective Communication
In the book, readers are introduced to five sections: Section I examines the historical and cultural perspectives of conversation. This examination helps to create a foundation for a deeper study of the emergent and salient aspects of conversation as it relates to cultural creativity and human systems design. Sections II offers the reader an examination of dialogue through different philosophical and theoretical perspectives as well as methodological ideas related to conversation. Section III explores different modalities of conversation and the application of design conversation within and across various types of design settings and human experiences. Section IV examines the field of practice as related to use of different forms of conversation.
Diagnosis and Treatment of Human Mycoses
Diagnosis and Treatment of Human Mycoses brings together globally-recognized mycoses experts to guide readers in the use of current knowledge in the field of medical mycology to manage those who suffer from fungal infections (mycoses). Often, diagnostic strategies and tests, including basic and directed culturing techniques, histopathology with standard and special stains, serological methods, and radiological studies all need to be considered and commonly combined to make the diagnosis of fungal infection. This volume first introduces and reviews these tools separately and then as they pertain to specific infections or groups of diseases. The volume consists of four parts. Parts I-III provide an overview of diagnostic and therapeutic tools, and part IV presents the human mycoses.Diagnosis and Treatment of Human Mycoses is meant to be a concise text that will provide the busy infectious disease, hematology–oncology, pulmonology, or critical care specialist a practical tool to diagnose and manage fungal infections. In addition, the depth of the material in the text will provide these and other medical specialists and trainees an excellent reference and learning resource.
Developing Tsunami-Resilient Communities : The National Tsunami Hazard Mitigation Program
Tsunamis remain an ever-present threat to lives and property along the coasts of most of the world’s oceans. Because of the geographical extent of U.S. coastlines, an earthquake in Alaska can generate a local tsunami for Alaskans and, hours later, a distant tsunami for communities in Hawaii and along the Pacific Coast . This volume chronicles the development and accomplishments of a joint State/Federal partnership that was forged to reduce tsunami hazards along U.S. coastlines – the National Tsunami Hazard Mitigation Program. By integrating hazard assessment, warning guidance, and mitigation activities, the program has created a roadmap and a set of tools to develop communities more resilient to local and distant tsunamis. Among the set of tools are tsunami forecasting, educational experiments, early alerting systems, and design guidance for tsunami-resilient communities. Part of this book has already been published in a recent journal issue.
Detection of Liquid Explosives and Flammable Agents in Connection with Terrorism
The organization of an Advanced Research Workshop with the title “Detection and Disposal of Liquid Explosives and Flammable Agents in Connection with Terrorism” was motivated by international findings about activities in this field of application. This ARW followed a meeting about the “Detection of Disposal Improvised Explosives” (St. Petersburg, 2005). Both items show the logistic problems as one of the lessons, terrorists have to overcome. These problems are connected with the illegal supply and transport of explosives and fuels and as counter-measure the detection of these materials. The invention of liquid explosives goes back to the middle of the 19th century and was used for special purposes in the commercial field of application. Because of the high sensitivity of liquid explosives against mechanical shock, caused by adiabatic compression of air-bobbles producing “hot spots” as origin of initiation the commercial application was not very successful. Because of this high risk, liquid explosives are not used in military or commercial application with some exceptions. In the commercial field explosives as slurries or emulsions consisting of suitable salts (Ammoniumnitrate etc.) and water are used to a large extend because of their high insensitivity. In many cases these slurries or emulsions were unfit for terrorist actions, because of their low sensitivity, large critical diameter and using in confinement. In the military field liquid explosives are used in World War I and II as bomb-fillings.
Design, user experience, and usability interaction design ; 9th International Conference, DUXU 2020, Held as Part of the 22nd HCI International Conference, HCII 2020, Copenhagen, Denmark, July 19–24, 2020, Proceedings, Part I
This book constitutes the refereed proceedings of the 9th International Conference on Design, User Experience, and Usability, DUXU 2020, held as part of the 22nd International Conference on Human-Computer Interaction, HCII 2020, in Copenhagen, Denmark, in July 2020. The conference was held virtually due to the COVID-19 pandemic. From a total of 6326 submissions, a total of 1439 papers and 238 posters has been accepted for publication in the HCII 2020 proceedings. The 40 papers included in this volume were organized in topical sections on UX design methods, tools and guidelines, interaction design and information visualization, and emotional design.
Design of Observational Studies
This book introduction to statistical inference in observational studies and a detailed discussion of the principles that guide the design of observational studies. An observational study is an empiric investigation of effects caused by treatments when randomized experimentation is unethical or infeasible. Observational studies are common in most fields that study the effects of treatments on people, including medicine, economics, epidemiology, education, psychology, political science and sociology. The quality and strength of evidence provided by an observational study is determined largely by its design. Design of Observational Studies is organized into five parts. Chapters 2, 3, and 5 of Part I cover concisely many of the ideas discussed in Rosenbaum’s Observational Studies. Part II discusses the practical aspects of using propensity scores and other tools to create a matched comparison that balances many covariates, and includes an updated chapter on matching in R. In Part III, the concept of design sensitivity is used to appraise the relative ability of competing designs to distinguish treatment effects from biases due to unmeasured covariates. Part IV discusses evidence factors and the computerized construction of more than one comparison group. Part V discusses planning the analysis of an observational study, with particular reference to Sir Ronald Fisher’s striking advice for observational studies: "make your theories elaborate."
Dental materials: latest advances and prospects ; Vol. II
Almost all fields of dentistry are closely related to newly developed materials, and all clinical improvements often follow or go hand in hand with the creation and development of innovative and higher-performing materials, instruments, and equipment. Thanks to the application of contemporary dental materials, the effectiveness of clinical dentistry has witnessed remarkable advances. This Special Issue contains high-quality research articles, clinical studies, review articles, and case reports focused on the latest advances and prospects of dental materials concerning all fields of dentistry.
