الصفحة 14
الصفحة 14
Drug Discovery and Evaluation
The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.
Drug discovery and development
Presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.
Distributed computing and Internet Technology ; 1st International Conference, ICDCIT 2004, Bhubaneswar, India, December 22-24, 2004, Proceedings
Taming the Dynamics of Disributed Data - DISTRIBUTED COMPUTING -- Data in Your Space -- Enabling Technologies for Harnessing Information Explosion -- Fair Leader Election by Randomized Voting -- An Efficient Leader Election Algorithm for Mobile Ad Hoc Networks -- Distributed Balanced Tables: A New Approach - Performance Evaluation of Gigabit Ethernet and SCI in a Linux Cluster -- Performance Evaluation of a Modified-Cyclic-Banyan Based ATM / IP Switching Fabric -- A Scalable and Robust QoS Architecture for WiFi P2P Networks -- NEC: Node Energy Based Clustering Protocol for Wireless Sensor Networks with Guaranteed Connectivity,and other
Distributed and Parallel Systems : In Focus : Desktop Grid Computing
In this book contributors investigate parallel and distributed techniques, algorithms, models and applications; present innovative software tools, environments and middleware; focus on various aspects of grid computing; and introduce novel methods for development, deployment, testing and evaluation.
Digital Libraries : Research and Development; 1st International DELOS Conference, Pisa, Italy, February 13-14, 2007, Revised Selected Papers
This book presented similarity search, architectures, personalization, interoperability, evaluation, miscellaneous, preservation, video data management, 3D objects, and peer to peer.
Differential Optical Absorption Spectroscopy : Principles and Applications
This book reviews the basics of atmospheric chemistry, radiation transport, and optical spectroscopy before detailing the principles underlying DOAS. The second part of the book describes the design and application of DOAS instruments as well as the evaluation and interpretation of spectra. The recent expansion of DOAS application to the imaging of trace gas distributions by ground, aircraft, and satellite-based instruments is also covered.
Diarrhea : Causes. diagnosis. Treatment
Diarrhea is a common condition that that affects most individuals at some point in their lives and can be thought of as both a symptom and a sign which varies in severity and etiology. The evaluation of diarrhea varies depending on duration, severity, and presence of certain concurrent symptoms. Treatment also varies, though rehydration therapy is an important aspect of the management of any patient with diarrhea...
Developments in demographic forecasting
This book presents new developments in the field of demographic forecasting, covering both mortality, fertility and migration. For each component emerging methods to forecast them are presented. Moreover, instruments for forecasting evaluation are provided.
Development Policies and Policy Processes in Africa : Modeling and Evaluation
Examines the methodological challenges in analyzing the effectiveness of development policies. It presents a selection of tools and methodologies that can help tackle the complexities of which policies work best and why, and how they can be implemented effectively given the political and economic framework conditions of a country. The contributions in this book offer a continuation of the ongoing evidence-based debate on the role of agriculture and participatory policy processes in reducing poverty. They develop and apply quantitative political economy approaches by integrating quantitative models of political decision-making into existing economic modeling tools, allowing a more comprehensive growth-poverty analysis.
Development and evaluation of setup strategies in printed circuit board assembly
The last decade has seen a rapid extension of electronic control devices for various types of technical products. In modern electronics manufacturing, highly automated assembly systems are used to mount the electronic components onto the printed circuit boards (PCBs). Maintaining high production flexibility in order to meet the desired product variety and, at the same time, achieving high utilization rates of the capital-intensive production equipment can only be achieved by applying highly sophisticated planning and control strategies for the operation of modern placement machines. Ihsan Onur Yilmaz develops a novel group setup strategy which integrates multiple problems of the PCB assembly, especially in a medium-variety production environment. At the core of his principle approach are the identification of similarities between different types of PCBs and the generation of PCB clusters upon which group setup strategies are based. The developed setup strategies are also innovative in the sense that they integrate the optimization of detailed machine operations. This integration has not been achieved in the classical approaches which primarily rely on statistical clustering techniques.
Designing human interface in speech technology
Designing Human Interface in Speech Technology bridges a gap between the needs of the technical engineer and cognitive researchers working in the multidisciplinary area of speech technology applications. The approach is systematic and the focus is on the utility of developing and designing speech related products. Included is coverage of topics such as neuroscience on the multimodal cortex, cognitive theories on multi-task performance, stress and workload, as well as human information process theory and ecological interface design theory for evaluating speech-related human-system interfaces.
Designing a school library media center for the future ; 2nd ed.
In this hands-on guidebook, school library construction and media specialists Rolf Erikson and Carolyn Markuson share their experiences of working on more than 100 media center building projects around the country, using conceptual plans from actual school libraries.Combining all aspects of design for the school library media center—floor plans, furniture, technology, bidding, and evaluation—this newly updated edition addresses
Design of Observational Studies
This book introduction to statistical inference in observational studies and a detailed discussion of the principles that guide the design of observational studies. An observational study is an empiric investigation of effects caused by treatments when randomized experimentation is unethical or infeasible. Observational studies are common in most fields that study the effects of treatments on people, including medicine, economics, epidemiology, education, psychology, political science and sociology. The quality and strength of evidence provided by an observational study is determined largely by its design. Design of Observational Studies is organized into five parts. Chapters 2, 3, and 5 of Part I cover concisely many of the ideas discussed in Rosenbaum’s Observational Studies. Part II discusses the practical aspects of using propensity scores and other tools to create a matched comparison that balances many covariates, and includes an updated chapter on matching in R. In Part III, the concept of design sensitivity is used to appraise the relative ability of competing designs to distinguish treatment effects from biases due to unmeasured covariates. Part IV discusses evidence factors and the computerized construction of more than one comparison group. Part V discusses planning the analysis of an observational study, with particular reference to Sir Ronald Fisher’s striking advice for observational studies: "make your theories elaborate."
Der junge Carnap in historischem kontext : 1918–1935 = Young Carnap in an historical context: 1918–1935
This volume is based on the 'Early Carnap in Context’ workshop that took place in Konstanz in 2017 and looks at Rudolf Carnap’s philosophy, documented in his recently released diaries, from a combination of historical, cultural and philosophical perspectives. It enables further evaluation of the diaries and traces newly found interrelationships and their systematic definition. From a cultural and historical point of view, Logical Empiricism and Carnap’s pivotal opus, The Logical Structure of the World, did not evolve in a vacuum
Dependable computing ; 3rd Latin-American Symposium, LADC 2007, Morelia, Mexico, September 26-28, 2007, Proceedings
This book presented fault-tolerant algorithms, software engineering of dependable systems, networking and mobile computing, experimental dependability evaluation, as well as intrusion tolerance and security.
Dependable computing ; 2nd Latin-American symposium, LADC 2005, Salvador, Brazil, October 25-28, 2005 : proceedings
Contains the proceedings of the 'Second Latin-American Symposium' on Dependable Computing, LADC 2005. This book comprises 16 papers presented together with 3 invited talks. The papers are organized in topical sections on evaluation, certification, modelling, embedded systems, time, and distributed systems algorithms.
Dental Ultrasound in Periodontology and Implantology : Examination, Diagnosis and Treatment Outcome Evaluation
This book presents up-to-date information on promising indications for ultrasound in contemporary periodontics and implant therapy with the aim of assisting researchers and dental practitioners to use this novel imaging modality to advance research and patient care.
Dental pulp derived mesenchymal stromal cells
Presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration. In this thoroughly updated and expanded second edition, the author covers mesenchymal stem cell (MSC) biology, various sources of MSCs, and the therapeutic potential of MSCs. Tooth regeneration, dental pulp-derived MSC, and the therapeutic potential of dental pulp derived stem cells is also covered.
Demystifying Climate Models : A Users Guide to Earth System Models
This book demystifies the models we use to simulate present and future climates, allowing readers to better understand how to use climate model results. In order to predict the future trajectory of the Earth’s climate, climate-system simulation models are necessary. When and how do we trust climate model predictions? The book offers a framework for answering this question. It provides readers with a basic primer on climate and climate change, and offers non-technical explanations for how climate models are constructed, why they are uncertain, and what level of confidence we should place in them. It presents current results and the key uncertainties concerning them. Uncertainty is not a weakness but understanding uncertainty is a strength and a key part of using any model, including climate models.
Decision Support for Forest Management
While earlier books concerning forest planning have tended to focus on linear programming, economic aspects, or specific multi-criteria decision aid tools, this book provides a much broader range of tools to meet a variety of planning situations. The methods themselves cover a range of decision situations – from cases involving single decision makers, through group decision making, to participatory planning. They include traditional decision support tools, from optimization to utility functions, as well as methods that are just gaining ground in forest planning – such as problem structuring methods and social choice theory. Including examples which illustrate the application of each technique to specific management planning problems, the book offers an invaluable resource for both researchers and advanced students specializing in management and planning issues relating to forestry.
