الصفحة 14
الصفحة 14
Drug Selectivity : An Evolving Concept in Medicinal Chemistry
Provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Drug design : A conceptual overview
The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design" (CADD), which has profound application in RDD. The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide.
Distributed computing and internet Technology ; Vol. 3816 ; 2nd International conference, ICDCIT 2005, Bhubaneswar, India, December 22-24, 2005, Proceedings
The opening ceremony and pre-conference tutorials on various related topics were held on December 21. The technical program started on December 22 and continued for three days. The program was arranged in single track so as to enable participants to attend sessions of di?erent tracks. Papers from the DM, IT, SE, and SS tracks were divided into two sessions, whereas DC track sessions were held on the ?rst two days of the conference. The program also included two plenary talks. The ?rst talk was delivered by S. S. Iyengar from Louisiana State University, USA. The second talk was delivered by He Jifeng from the International Institute for Software Technology (IIST) Macau. Prof. Iyenger’s talk on “The Distributed Sensor Networks — An Emerging Technology” was focused on new ideas about the use of distributed systems for emerging technology, while Prof. Jifeng’s talk on “Linking Theories of Concurrency by Retraction” dealt with semantics of concurrency.
Distributed applications and interoperable systems ; Vol. 3543 ; 5th IFIP WG 6.1 International conference, DAIS 2005, Athens, Greece, June 15-17, 2005, Proceedings
ThisvolumecontainstheproceedingsoftheIFIPWG6. 1InternationalWorking Conference on Distributed Applications and Interoperable Systems V held in Athens, Greece, on June 15–17, 2005. The conference program presented the state of the art in research concerning distributed and interoperable systems. The emergence of 4th-generation c- munication systems, the evolution of Internet technologies, the convergence of telecom and datacom, wireless and ?xed communication systems and appli- tions pave the path for ubiquitous service and application provision. Innovative solutions are required for the development, implementation and operation of distributed applications in complex IT environments full of diversity and h- erogeneity. Today, the emerging wide spectrum of distributed systems.
Dissipative Solitons
This volume is devoted to the exciting topic of dissipative solitons, i.e. pulses or spatially localised waves in systems exhibiting gain and loss. Examples are laser systems, nonlinear resonators and optical transmission lines. The physical principles and mathematical concepts are explained in a clear and concise way, suitable for students and young researchers. The similarities and differences in the notion of a soliton between dissipative systems and Hamiltonian and integrable systems are discussed, and many examples are given. The contributions are written by the world's leading experts in the field, making it a unique exposition of this emerging topic.
Discrete-Time Markov Chains : Two-Time-Scale Methods and Applications
The motivation stems from existing and emerging applications in optimization and control of complex hybrid Markovian systems in manufacturing, wireless communication, and financial engineering. Much effort in this book is devoted to designing system models arising from these applications, analyzing them via analytic and probabilistic techniques, and developing feasible computational algorithms so as to reduce the inherent complexity. This book presents results including asymptotic expansions of probability vectors, structural properties of occupation measures, exponential bounds, aggregation and decomposition and associated limit processes, and interface of discrete-time and continuous-time systems. One of the salient features is that it contains a diverse range of applications on filtering, estimation, control, optimization, and Markov decision processes, and financial engineering.
Discrete Differential Geometry
Discrete differential geometry is an active mathematical terrain where differential geometry and discrete geometry meet and interact. It provides discrete equivalents of the geometric notions and methods of differential geometry, such as notions of curvature and integrability for polyhedral surfaces. Current progress in this field is to a large extent stimulated by its relevance for computer graphics and mathematical physics. This collection of essays, which documents the main lectures of the 2004 Oberwolfach Seminar on the topic, as well as a number of additional contributions by key participants, gives a lively, multi-facetted introduction to this emerging field.
Digital twin : Architectures, networks, and applications
Offers comprehensive, self-contained knowledge on digital twin (DT), which is a very promising technology for achieving digital intelligence in the next-generation wireless communications and computing networks. DT is a key technology to connect physical systems and digital spaces in Metaverse. The objectives of this book are to provide the basic concepts of DT, to explore the promising applications of DT integrated with emerging technologies, and to give insights into the possible future directions of DT. For easy understanding, this book also presents several use cases for DT models and applications in different scenarios. The book starts with the basic concepts, models, and network architectures of DT. Then, we present the new opportunities when DT meets edge computing, Blockchain and Artificial Intelligence, and distributed machine learning (e.g., federated learning, multi-agent deep reinforcement learning).
Digital transformation management : Challenges and futures in the Asian digital economy
Addresses key topics related to organization design and knowledge management in the digital economy with organizational context, particularly in Asia. the book conceptualizes organization design into three dimensions, people, information, and technology, and offers readers a unique valued insight, bringing new perspectives to understanding emerging business opportunities and challenges in Asia. it presents a valuable collection of 14 chapters with empirical studies from leading researchers. the book addresses digital transformation in companies and organizations in Asia, analysing how disruptive technologies can help them to have more efficient organization processes, create innovative products and services, be more resilient and achieve sustainable goals in post-pandemic time.
Digital Sketching : Computer-Aided Conceptual Design
Delivers a comprehensive and insightful examination of how architects and other design professionals can best use digital design technology to become better designers. Celebrated professional, professor, and author John Bacus provides readers with practical and timely information on emerging digital design technologies and their effect on professional practice.
Digital platforms in finance and supply chain management : Governance, ethics, and industry 5.0
A comprehensive analysis of digital platforms as the driving force of the modern economy, exploring their evolution, governance, and integration across financial and supply chain ecosystems. It presents a synthesis of theories, strategic models, and empirical insights to address the complexities of platform economies, making it an essential resource for scholars, policymakers, and industry practitioners. It is structured around core principles of digital platforms, including their definition, key features, and transformative impact on value creation. It delves into governance and ethical considerations, examining global regulatory frameworks and the emerging paradigms of Industry 5.0, where digital platforms intersect with economic, social, and environmental sustainability. The theoretical foundations are rooted in network effects, New Economic Geography, Platform Economics, Agency Theory, and Systems Theory, offering a robust analytical framework for understanding scalability, competition, and strategic decision-making in platform ecosystems. Two important areas -finance and supply chains-are explored in depth.
Digital innovation management : People, process, platforms and policy
Shows how digital innovation management practices can facilitate project coordination aimed at business success while prioritizing environmental and social responsibility. structured around the four pillars of digital innovation (people, process, platforms, and policy), the book illustrates how digital and physical elements of innovation management can be integrated to create new marketing offerings, organizational processes, and business models that align with sustainability and human centric ideals. the book supports a theoretical framing of digital innovation management with case studies of creative digital ecosystems such as smart cities, which leverage integrated digital systems to advance research, innovation, and education. finally, the book provides an analysis of emerging technologies, such as artificial intelligence and blockchain, that may introduce significant digital innovations to make smarter organizations and territories.
Digital Human Modeling : Trends in Human Algorithms
The emerging information technologies have given rise to new human patterns in terms of both physiological and psychological interactions. Human Algorithms aim to model human forms, interactions, and dynamics in this new context.
Digital Fabrication in Interior Design : Body, Object, Enclosure
Draws together emerging topics of making that span primary forms of craftsmanship to digital fabrication in order to theoretically and practically analyze the innovative and interdisciplinary relationship between digital fabrication technology and interior design. The history of making in interior design is aligned with traditional crafts, but a parallel discourse with digital fabrication has yet to be made evident.
Digital cities III : Information technologies for social capital: Cross-cultural Perspectives ; 3rd international digital cities workshop, Amsterdam, The Netherlands, September 18-19, 2003, Revised Selected Papers
Digital cities constitutes a multidisciplinary field of research and development, where researchers, designers and developers of communityware interact and collaborate with social scientists studying the use and effects of these kinds of infrastructures and systems in their local application context. The field is rather young. After the diffusion of ICT in the world of organizations and companies, ICT entered everyday life. And this also influenced ICT research and development. The 1998 Workshop on Communityware and Social Interaction in Kyoto was an early meeting in which this emerging field was discussed.
Digital Anatomy : Applications of Virtual, Mixed and Augmented Reality
This book offers readers fresh insights on applying Extended Reality to Digital Anatomy, a novel emerging discipline. Indeed, the way professors teach anatomy in classrooms is changing rapidly as novel technology-based approaches become ever more accessible. Recent studies show that Virtual (VR), Augmented (AR), and Mixed-Reality (MR) can improve both retention and learning outcomes.
Diabetes Mellitus & Recent developments
Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from defect in insulin secretion, insulin action, or both. Symptoms of marked hyperglycemia include polyuria, polydipsia, weight loss, sometimes with polyphagia, and blurred vision. Frequency of diabetic in the world About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic Classification Of Diabetic Mellitus. 1-Type 1 diabetes: which accounts for only5–10% of those with diabetes, results from a cellular-mediated autoimmune destruction of the cells of the pancreas. 2-Type 2 diabetes: which accounts for90 –95% of those with diabetes, result from insulin resistance. The chronic complications of diabetes mellitus affect many organ systems and are responsible for the majority of morbidity and mortality. Such as, retinopathy, diabetic foot, neuropathy, and nephropathy, sexual dysfunction, and skin changes.
Developments in demographic forecasting
This book presents new developments in the field of demographic forecasting, covering both mortality, fertility and migration. For each component emerging methods to forecast them are presented. Moreover, instruments for forecasting evaluation are provided.
Developmental State Building : The Politics of Emerging Economies
This book modifies and revitalizes the concept of the ‘developmental state’ to understand the politics of emerging economy through nuanced analysis on the roles of human agency in the context of structural transformation. In other words, there is a revived interest in the ‘developmental state’ concept. The nature of the ‘emerging state’ is characterized by its attitude toward economic development and industrialization. Emerging states have engaged in the promotion of agriculture, trade, and industry and played a transformative role to pursue a certain path of economic development. Their success has cast doubt about the principle of laissez faire among the people in the developing world. This doubt, together with the progress of democratization, has prompted policymakers to discover when and how economic policies should deviate from laissez faire, what prevents political leaders and state institutions from being captured by vested interests, and what induce them to drive economic development.
Developing BIM talent : A guide to the BIM body of knowledge with Metrics, KSAs, and learning outcomes
A systematic Building Information Modeling (BIM) framework features cutting-edge use cases and competencies for students and professionals pursuing BIM careers. Offers: A solid foundation and guidelines for educators and practitioners for starting or enhancing a BIM curriculum or training program Templates, expert interviews, and case studies that provide in-depth knowledge and lessons learned that can facilitate process changes and strategic action plans Strategies for standardizing emerging BIM job tasks, descriptions, and methods for benchmarking performance
