الصفحة 14
الصفحة 14
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Ion Channels
Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field.
Investment Appraisal : Methods and Models
Investment decisions are of vital importance to all companies. Getting these decisions right is crucial but, due to a complex and dynamic business environment, this remains a challenging management task. Effective appraisal methods are valuable tools in supporting investment decision-making. As organisations continue to seek a competitive edge, it is increasingly important that management accountants and strategic decision-makers have a sound knowledge of these tools. This book presents a range of investment appraisal methods and models, some of which are not widely known, or at least not well covered in other books. Each approach is thoroughly described, evaluated and illustrated using examples, with its assumptions and limitations analysed in terms of their implications for investment decision-making practice.
Investing in Movies : Strategies for Investors and Producers
Offers a broad range of guidelines on how to source interesting projects and advice on what kinds of projects to avoid, as well as numerous ways to maximize risk-adjusted returns. While focusing primarily on investments in independent films, Cohen also provides valuable insights into the studio and independent slate deals that have been marketed to the institutional investment community.
Intuitive Human Interfaces for Organizing and Accessing Intellectual Assets ; International Workshop, Dagstuhl Castle, Germany, March 1-5, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the 2004 International Workshop on Intuitive Human Interfaces for Organizing and Accessing Intellectual Assets, held in Dagstuhl Castle, Germany in March 2004. The 17 revised full papers presented together with an introductory overview have gone through two rounds of reviewing and revision. The papers are organized in topical sections on man-machine interface for intuitive knowledge access, intelligent pad and meme media, visualization and design of information access spaces, and semantics and narrative organization and access of knowledge.
Intuition and the Axiomatic Method
All of Hilbert, Gödel, Poincaré, Weyl and Bohr thought that intuition was an indispensable element in describing the foundations of science. They had very different reasons for thinking this, and they had very different accounts of what they called intuition. But they had in common that their views of mathematics and physics were significantly influenced by their readings of Kant. In the present volume, various views of intuition and the axiomatic method are explored, beginning with Kant’s own approach. By way of these investigations, we hope to understand better the rationale behind Kant’s theory of intuition, as well as to grasp many facets of the relations between theories of intuition and the axiomatic method,
Introduzione al Calcolo Scientifico : Esercizi e problemi risolti con MATLAB = Introduction to scientific computing : Exercises and problem solved with MATLAB
Introduces the fundamental concepts for the numerical modeling of partial differential problems. We consider the classic linear elliptic, parabolic and hyperbolic equations, but also other equations, such as those of diffusion and transport, of Navier-Stokes, and the conservation laws. Numerous physical examples underlying these equations are provided, their main mathematical properties are studied, then numerical resolution methods based on finite elements, finite differences, finite volumes and spectral methods are proposed and analyzed. In particular, the algorithmic and computer implementation aspects are discussed and some easy-to-use programs in C ++ language are provided. The text does not presuppose an advanced mathematical knowledge of partial differential equations: the strictly indispensable concepts in this regard are reported in the Appendix. THE VOLUME is therefore suitable for students of scientific degree courses (Engineering, Mathematics, Physics, Chemistry, Information Sciences) and recommended for researchers from the academic and extra-academic world who want to approach this interesting branch of applied mathematics.
Introduction to wine laboratory practices and procedures
winemaking was a romanticized notion of putting grape juice into a barrel and allowing time to perform its magic as you sat on the veranda watching the sunset on a Tuscan landscape. For some small wineries, this notion might still ring true, but for the majority of wineries commercially producing quality wines, the reality of winemaking is far more complex. The persistent evolution of the wine industry demands continual advan- ments in technology and education to sustain and promote quality winem- ing. The sciences of viticulture, enology, and wine chemistry are becoming more intricate and sophisticated each year. Wine laboratories have become an integral part of the winemaking process, necessitating a knowledgeable staff possessing a multitude of skills. Science incorporates the tools that new-age winemakers are utilizing to produce some of the best wines ever made in this multibillion dollar trade. A novice to enology and wine chemistry can find these subjects daunting and intimidating. Whether you are a home winemaker, a new winemaker, an enology student, or a beginning-to-intermediate laboratory technician, p- ting all the pieces together can take time.
Introduction to Systems Biology
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
Introduction to Structural Analysis
Covers the principles of structural analysis without any requirement of prior knowledge of structures or equations. Beginning with basic principles of equilibrium of forces and moments, all other subsequent theories of structural analysis have been discussed logically. Divided into two major parts, this book discusses the basics of mechanics and principles of degrees of freedom upon which the entire paradigm rests, followed by analysis of determinate and indeterminate structures. The energy method of structural analysis is also included.
Introduction to Project Management : A Source Book for Traditional PM Basics
Presents the fundamentals of project management in simple language and an easy-to-understand format. It is targeted principally at those who are learning or desiring to learn project management as well as those who are already taking project management as a course of study or as a profession
Introduction to Plane Algebraic Curves
This work treats an introduction to commutative ring theory and algebraic plane curves, requiring of the student only a basic knowledge of algebra, with all of the algebraic facts collected into several appendices that can be easily referred to, as needed.IT focuses on the purely algebraic aspects of plane curve theory, leaving the topological and analytical viewpoints in the background, with only casual references to these subjects and suggestions for further reading.
Introduction to Physics and Chemistry of Combustion : Explosion, Flame, Detonation
Most of the material covered in this book deals with the fundamentals of chemistry and physics of key processes and fundamental mechanisms for various combustion and combustion-related phenomena in gaseous combustible mixture. It provides the reader with basic knowledge of burning processes and mechanisms of reaction wave propagation
Introduction to Pharmaceutical Analytical Chemistry
Enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
Introduction to Optics
Since the discovery of the laser in 1960 and optical fibers in 1970, optics has undergone dramatic changes that accentuate its multi-disciplinary character. This text covers essential concepts and reports the key developments and progress in current knowledge in the field. Inspired by the style of Richard Feynman, the method of presentation emphasizes "telling" optics, rather than deducing it from fundamental laws, as well as tactfully using mathematical tools so as not to obscure the physical phenomena of interest. For its excellent teaching approach, the book received the Arnulf-Francon Award of the French Optical Society. The concepts are formulated in a way such that the necessary mathematical tools do not hinder comprehension of the phenomena. Global in vision, the book can also be used as a reference. In addition to the traditional aspects of optics, it includes the tools and methods currently used by researchers and engineers, as well as explanation and implications of the most recent developments.
Introduction to Logic and Theory of Knowledge : Lectures 1906/07
This course on logic and theory of knowledge fell exactly midway between the publication of the Logical Investigations in 1900-01 and Ideas I in 1913. It constitutes a summation and consolidation of Husserl’s logico-scientific, epistemological, and epistemo-phenomenological investigations of the preceding years and an important step in the journey from the descriptivo-psychological elucidation of pure logic in the Logical Investigations to the transcendental phenomenology of the absolute consciousness of the objective correlates constituting themselves in its acts in Ideas I. In this course Husserl began developing his transcendental phenomenology as the genuine realization of what had only been realized in fragmentary form in the Logical Investigations.
Introduction to Genetic Algorithms
This book is designed to provide an in-depth knowledge on the basic operational features and characteristics of Genetic Algorithms. The various operators and techniques given in the book are pertinent to carry out Genetic Algorithm Research Projects. The book also explores the different types are Genetic Algorithms available with their importance. Implementation of Genetic Algorithm concept has been performed using the universal language C/C++ and the discussion also extends to Genetic Algorithm MATLAB Toolbox. Few Genetic Algorithm problems are programmed using MATLAB and the simulated results are given for the ready reference of the reader. The applications of Genetic Algorithms in Machine learning, Mechanical Engineering, Electrical Engineering, Civil Engineering, Data Mining, Image Processing, and VLSI are dealt to make the readers understand where the concept can be applied.
Introduction to Drug Disposition and Pharmacokinetics
The application of knowledge of drug disposition, and skills in pharmacokinetics, are crucial to the development of new drugs and to a better understanding of how to achieve maximum benefit from existing ones. The book takes the reader from basic concepts to a point where those who wish to will be able to perform pharmacokinetic calculations and be ready to read more advanced texts and research papers.
Introduction to design theory : philosophy, critique, history and practice
Introduces a comprehensive, systematic, and didactic outline of the discourse of design. Designed both as a course book and a source for research, this textbook methodically covers the central concepts of design theory, definitions of design, its historical milestones, and its relations to culture, industry, body, ecology, language, society, gender and ideology.
Introduction to Data Mining and its Applications
This book explores the concepts of data mining and data warehousing, a promising and flourishing frontier in data base systems and new data base applications and is also designed to give a broad, yet in-depth overview of the field of data mining. Data mining is a multidisciplinary field, drawing work from areas including database technology, AI, machine learning, NN, statistics, pattern recognition, knowledge based systems, knowledge acquisition, information retrieval, high performance computing and data visualization.
