الصفحة 13
الصفحة 13
The Pangenome: Diversity, Dynamics and Evolution of Genomes
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded.
The Palgrave Handbook of Family Policy
This handbook provides a multilevel view on family policies, combining insights on family policy outcomes at different levels of policymaking: supra-national organizations, national states, sub-national or regional levels, and finally smaller organizations and employers. At each of these levels, a multidisciplinary group of expert scholars assess policies and their implementation, such as child income support, childcare services, parental leave, and leave to provide care to frail and elderly family members. The chapters evaluate their impact in improving children’s development and equal opportunities, promoting gender equality, regulating fertility, productivity and economic inequality, and take an intersectional perspective related to gender, class, and family diversity
The Pain Management Workbook : Powerful CBT and Mindfulness Skills to Take Control of Pain and Reclaim Your Life
You'll find a comprehensive outline of this effective biopsychosocial approach, as well as scientifically supported interventions rooted in cognitive- behavioral therapy (CBT), mindfulness, and neuroscience to help you take control of your pain--and your life! You'll learn strategies for creating a pain plan for home and work, reducing reliance on medications, and breaking the pain cycle. Also included are tips for improving sleep, nutrition for pain, methods for resuming valued activities, and more.
The p53 Tumor Suppressor Pathway and Cancer
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signil cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.
The Nuclear Imperative : A Critical Look at the Approaching Energy Crisis
In this well documented global wake-up call, nuclear physicist Jeff Eerkens explores remedies for the impending energy crisis, when oil and natural gas are depleted. Because burning coal worsens the problem ofglobal warming, alternate energy sources must be instituted. The Nuclear Imperative demonstrates with scientific documentation that solar, wind, and biomass power, while helpful, are incapable of supplying and sustaining the enormous quantities of electricity and heat needed for manufacturing portable synthetic fuels (synfuels) to replace our current use of fossil fuels. Instead, it offers a fresh look at uranium-produced energy as the optimal affordable solution.
The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
The NMR Probe of High-Tc Materials
The NMR probe has yielded a vast array of data for the high-Tc materials, corresponding to different compounds, ionic sites, and nuclear species, as well as to a wide variety of experimental conditions. Over the twenty years, since the discovery of superconducting cuprates, ongoing analysis and discussion of cuprate NMR data have resulted in a wealth of important insights into the physics of these exotic systems. The aims of this monograph are threefold. First, it reviews NMR methodology as it has been applied to the cuprate studies. This is addressed to NMR practitioners and to physics laypersons alike. Next, it presents a review of cuprate NMR measurements and the wide variety of phenomena which they represent. The third phase is to recount the theoretical model calculations and other proposals which have been put forward to account for these data.
The new Innovation of paracetamol
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions, Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility (especially that a lot of drugs are in Class II and IV according to BCS (Biopharmaceutics Classification System) and these classes suffer from poor aqueous solubility and hence low bioavailability},dissolution rate, stability and mechanical properties of APIs and excipients...
The new in peptic ulcer
Peptic ulcer can be defined as mucosal lesions that penetrate the muscularis mucosae layer and form a cavity surrounded by acute and chronic inflammation. It continues to be a source of significant morbidity and mortality worldwide. Approximately two-thirds of patients found to have peptic ulcer disease are asymptomatic. In symptomatic patients, the most common presenting symptom of peptic ulcer disease is epigastric pain, which may be associated with dyspepsia, bloating, abdominal fullness, nausea, or early satiety.
The New Accounts Payable Toolkit
You’ll learn the key metrics and analytics needed for the accounts payable process. This comprehensive toolkit provides the best practices, tools, and internal controls that can help safeguard your company’s cash and other assets. You’ll obtain a variety of tools to create the foundation required for current internal controls and compliance to ensure that suppliers are correctly validated in the supplier master file to maintain regulatory compliance.
The Network(ed) Economy : The Nature, Adoption and Diffusion of Communication Standards
In an increasingly globalized and networked world modern communication channels and new electronic media standards are constantly changing traditional interaction patterns of humans and even machines. Communication-based interaction is of pivotal economic importance and the availability of generally accepted electronic communication standards is essential in order to decrease communication-related transaction costs.This book combines the theories of diffusion and network effects and presents a new goods classification model to explore the dissemination of IT and e-business standards. On this basis it designs two applications that support and improve firms' electronic interlaced communication by means of automation and standardization effects.
The Nature of Supply Chain Management Research : Insights from a Content Analysis of International Supply Chain Management Literature from 1990 to 2006
Julia Wolf focuses on the theoretical aspect of SCM by analyzing the evolution SCM research has undergone and by assessing the question whether SCM research can be considered a scientific paradigm as of today. A number of factors are investigated based on empirical data gathered from publications on SCM in international refereed journals from 1990 to 2006. As a result, four major periods are distinguished in the evolution of SCM research: emergence, acceptance, growth and a final phase of establishment. These periods are characterized in terms of the following factors and their alterations over time: scientific values, object of study, constructs, methods, schools of thought, and the link of research to practice.
The mystery of Tamoxifen
Selective estrogen receptor modulators (SERMs) have been shown to reduce the risk of developing estrogen-positive breast cancer. Tamoxifen, a potent SERM, has been successfully administered as adjuvant therapy for breast cancer. However, uterine pathologic changes may develop due to the effect of tamoxifen as both an agonist and antagonist of estrogen on the uterus. Here, we discuss a case of breast cancer treated with tamoxifen to clarify one of the most important complications, namely, endometrial hyperplasia.
The medical activity of salvadora persica
The human mouth is inhabited from birth by many types and numbers of microbes that are both beneficial and harmful to the health of the mouth and teeth. Either. Multiple factors in the oral environment contribute to the multiplication and diversity of microbes, including in particular the regularity of natural teeth. The cleanliness and maintenance of artificial dentures, the amount of integrity and vitality of gum tissue and ligaments around the age, as well as an important factor relates to food quality. In the mouth, saliva deposits protein-sugar compounds that form thin, transparent layers called pellicle. The surfaces of the teeth (enamels), which helps the oral microbes to adhere to these layers and thus multiply and accumulate in large quantities and in the form of thin organic layers known as microbial dental plaque on the surfaces of the teeth, above and below edge of the gum. It is scientifically proven that if the teeth are not cleaned well or regularly daily and if the accumulation of plaque continues.
The Mathematics of Arbitrage
This long-awaited book aims at a rigorous mathematical treatment of the theory of pricing and hedging of derivative securities by the principle of 'no arbitrage'. The first part presents a relatively elementary introduction, restricting itself to the case of finite probability spaces. The second part consists of an updated edition of seven original research papers by the authors, which analyse the topic in the general framework of semi-martingale theory.
The Management of Transshipment Terminals : Decision Support for Terminal Operations in Finished Vehicle Supply Chains
Multinational companies aim at strategic competitive advantages by distributing their activities around the globe. As a result, the in dividual supply chains become longer and more complex. Next to the supply chain reliability, companies try to keep supply chains cost effi cient and responsive, i.e. warrant short order fulfillment lead times (Siirie and Wagner, 2005). The above goals dictate low inventory levels at the stages of a supply chain as well as a high frequency of transports between the partners involved. Supply Chain Requirements. Detailed performance measures for a supply chain are provided by the Supply Chain Operations Refer ence (SCOR) model (Supply-Chain Council, 2002).
The Malliavin Calculus and Related Topics
In Chapter 1, the derivative and divergence operators are introduced in the framework of an isonormal Gaussian process associated with a general 2 Hilbert space H. The case where H is an L -space is trated in detail aft- s,p wards (white noise case). The Sobolev spaces D , with s is an arbitrary real number, are introduced following Watanabe’s work. Chapter 2, includes a general estimate for the density of a one-dimensional random variable, with application to stochastic integrals. Also, the c- position of tempered distributions with nondegenerate random vectors is discussed following Watanabe’s ideas. This provides an alternative proof of the smoothness of densities for nondegenerate random vectors. Some properties of the support of the law are also presented.
The Maintenance Management Framework : Models and Methods for Complex Systems Maintenance
The Maintenance Management Framework describes and reviews the concept, process and framework of modern maintenance management of complex systems; concentrating specifically on modern modelling tools (deterministic and empirical) for maintenance planning and scheduling. It presents a new perspective of maintenance management by: focusing on the course of maintenance actions; presenting a structure that ensures proper support for current maintenance managers; clarifying the functionality that is required from information technology when applied to maintenance and the functions of modern maintenance engineering; and creating a set of practical models for maintenance management planning and scheduling. The discussion of all of these issues is supported through the use of case studies.
The Longleaf Pine Ecosystem : Ecology, Silviculture, and Restoration
The longleaf pine ecosystem, once one of the most extensive ecosystems in North America, is now among the most threatened. Over the past few centuries, land clearing, logging, fire suppression, and the encroachment of more aggressive plants have led to an overwhelming decrease in the ecosystem’s size, to approximately 2.2% of its original coverage. Despite this devastation, the range of the longleaf still extends from Virginia to Texas. Through the combined efforts of organizations such as the USDA Forest Service, the Longleaf Alliance, and the Nature Conservancy, extensive programs to conserve, restore, and manage the ecosystem are currently underway.
The Logic of Logistics : Theory, Algorithms, and Applications for Logistics and Supply Chain Management
Fierce competition in today's global market provides a powerful motivation for developing ever more sophisticated logistics systems. This book, written for the logistics manager and researcher, presents a survey of the modern theory and application of logistics. The goal of the book is to present the state of the art in the science of logistics management. As a result, the authors have written a timely and authoritative survey of this field that many practitioners and researchers will find makes an invaluable companion to their work.
