الصفحة 13
الصفحة 13
Computational drug discovery and design
Provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery.
Computational drug discovery : methods and application
Covers a wide range of cutting-edge computational technologies and computational chemistry methods that are transforming drug discovery. The book delves into recent advances, particularly focusing on artificial intelligence (AI) and its application for protein structure prediction, AI-enabled virtual screening, and generative modeling for compound design. Additionally, it covers key technological advancements in computing such as quantum and cloud computing that are driving innovations in drug discovery.
Computational Discovery of Scientific Knowledge : Introduction, Techniques, and Applications in Environmental and Life Sciences
Advances in technology have enabled the collection of data from scientific observations, simulations, and experiments at an ever-increasing pace. For the scientist and engineer to benefit from these enhanced data collecting capabilities, it is becoming clear that semi-automated data analysis techniques must be applied to find the useful information in the data. Computational scientific discovery methods can be used to this end: they focus on applying computational methods to automate scientific activities, such as finding laws from observational data. In contrast to mining scientific data, which focuses on building highly predictive models, computational scientific discovery puts a strong emphasis on discovering knowledge represented in formalisms used by scientists and engineers, such as numeric equations and reaction pathways. This state-of-the-art survey provides an introduction to computational approaches to the discovery of scientific knowledge and gives an overview of recent advances in this area, including techniques and applications in environmental and life sciences.
Computational conflict research
This book brings together a set of original studies that use cutting-edge computational methods to investigate conflict at various geographic scales and degrees of intensity and violence.
Combinatorial pattern matching ; 19th Annual Symposium, CPM 2008, Pisa, Italy, June 18-20, 2008 Proceedings
This book constitutes the refereed proceedings of the 19th Annual Symposium on Combinatorial Pattern Matching, CPM 2008, held in Pisa, Italy, in June 2008.
Collider Physics within the Standard Model : A Primer
In 2013 the late Prof. Altarelli wrote: The discovery of the Higgs boson and the non-observation of new particles or exotic phenomena have made a big step towards completing the experimental confirmation of the standard model of fundamental particle interactions. It is thus a good moment for me to collect, update and improve my graduate lecture notes on quantum chromodynamics and the theory of electroweak interactions, with main focus on collider physics. I hope that these lectures can provide an introduction to the subject for the interested reader, assumed to be already familiar with quantum field theory and some basic facts in elementary particle physics as taught in undergraduate courses.
Cold-Water Corals and Ecosystems
Following the exciting exploration of hot vent and cold seep ecosystems, the rediscovery of cold-water coral ecosystems with high-technology instrumentation is currently another hot topic in multidisciplinary marine research. Conventionally, coral reefs are regarded as restricted to warm and well-illuminated tropical seas, not associated with cold and dark waters of higher latitudes. However, ongoing scientific missions have shed light on the global significance of this overlooked ecosystem. Cold-water coral ecosystems are involved in the formation of large seabed structures such as reefs and giant carbonate mounds, and they represent unexploited paleo-environmental archives of earth history. Like their tropical cousins, cold-water coral ecosystems harbour rich species diversity. Despite the great water depths, commercial interests overlap more and more with the coral occurrences. Human activities already impinge directly on cold-water coral reefs causing severe damage to this vulnerable ecosystem. In this volume, the current key institutions involved in cold-water coral research have contributed 62 state-of-the-art articles from geology and oceanography to biology and conservation.
Cognitive Vision ; 4th International Workshop, ICVW 2008, Santorini, Greece, May 12, 2008, Revised Selected Papers
This volume constitutes the post-conference proceedings of the 4th International Cognitive Vision Workshop, ICVW 2008, held in Santorini, Greece, on May 12, 2008.
Clocks in the Sky : The Story of Pulsars
In this book, Geoff McNamara explores the history, subsequent discovery and contemporary research into pulsar astronomy. The story of pulsars is brought right up to date with the announcement in 2006 of a new breed of pulsar, Rotating Radio Transients (RRATs), which emit short bursts of radio signals separated by long pauses. These may outnumber conventional radio pulsars by a ratio of four to one. Geoff McNamara ends by pointing out that, despite the enormous success of pulsar research in the second half of the twentieth century, the real discoveries are yet to be made including, perhaps, the detection of the hypothetical pulsar black hole binary system by the proposed Square Kilometre Array - the largest single radio telescope in the world.
Clinical Pharmacology ; 12th ed.
Balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy.
Mathematical Masterpieces : Further Chronicles by the Explorers
Experience the discovery of mathematics by reading the original work of some of the greatest minds throughout history. Here are the stories of four mathematical adventures, including the Bernoulli numbers as the passage between discrete and continuous phenomena, the search for numerical solutions to equations throughout time, the discovery of curvature and geometric space, and the quest for patterns in prime numbers. Each story is told through the words of the pioneers of mathematical thought. Particular advantages of the historical approach include providing context to mathematical inquiry, perspective to proposed conceptual solutions, and a glimpse into the direction research has taken.
Marine bioactive molecules for biomedical and pharmacotherapeutic application
Explores cutting-edge research on the discovery and application of marine bioactive molecules for biomedical and pharmacotherapeutic purposes. The book begins by delving into the bioprospection of marine sponge microbiomes for bioactive metabolites using advanced metagenomics tools. It then explores metagenome mining approaches for the discovery of marine microbial natural products. The use of marine-derived fungi as a source of anticancer secondary metabolites is also discussed. The book then turns to the biomedical applications of marine-derived biomaterials, including marine biopolymers in tissue engineering and regenerative medicine. Marine-derived pharmaceuticals and polymeric nanostructures for cancer treatment are also examined.
Marine Anthropogenic Litter
This book describes how man-made litter, primarily plastic, has spread into the remotest parts of the oceans and covers all aspects of this pollution problem from the impacts on wildlife and human health to socio-economic and political issues. Marine litter is a prime threat to marine wildlife, habitats and food webs worldwide. The book illustrates how advanced technologies from deep-sea research, microbiology and mathematic modelling as well as classic beach litter counts by volunteers contributed to the broad awareness of marine litter as a problem of global significance. The authors summarise more than five decades of marine litter research, which receives growing attention after the recent discovery of great oceanic garbage patches and the ubiquity of microscopic plastic particles in marine organisms and habitats.
Maple and Mathematica : A Problem Solving Approach for Mathematics
the history of mathematics there are many situations in which cal- lations were performed incorrectly for important practical applications. the history of computing the number began in Egypt and Babylon about 2000 years BC, since then many mathematicians have calculated (e. g. , Archimedes, Ptolemy, Vi` ete, etc. ). In modern mathematics there exist computers that can perform various mathematical operations for which humans are incapable. Therefore the computers can be used to verify the results obtained by humans, to discovery new results, to - prove the result sthatahumancanobtain without anytechnology
Making Ammonia : Fritz Haber, Walther Nernst, and the Nature of Scientific Discovery
This book discusses the progress of science and the transfer of scientific knowledge to technological application. It also identifies the factors necessary to achieve this progress. Based on a case study of the physical chemist Fritz Haber's discovery of ammonia synthesis between 1903 and 1909, the book places Haber's work in historical and scientific (physicochemical) context. The scientific developments of the preceding century are framed in a way that emphasizes the confluence of knowledge needed for Haber's success. Against this background, Haber's work is presented in detail along with the indispensable contributions of his colleague, the physical chemist, Walter Nernst, and their assistants. The detailed accounts of scientific advancement remind us of the physical basis on which our scientific theories and ideas are built. Without this reminder we often forget how complex, and how beautiful achievements in science can be.
Magnetic Resonance of Myelination and Myelin Disorders
The book has been extensively revised and expanded to do justice to the rapid advances in MR technology, molecular biochemistry, and genetics and the discovery of new disease entities with prominent white matter involvement. Forty chapters have been added, and the number of illustrations has risen considerably. The ability to confirm the presence of genetic alterations in a number of disorders allows more advantageous presentation of the phenotypic variation as expressed in differ.
Machine Learning: ECML 2007 ; 18th European Conference on Machine Learning, Warsaw, Poland, September 17-21, 2007, Proceedings
The two premier annual European conferences in the areas of machine learning and data mining have been collocated ever since the ?rst joint conference in Freiburg, 2001. The European Conference on Machine Learning (ECML) traces its origins to 1986, when the ?rst European Working Session on Learning was held in Orsay, France. The European Conference on Principles and Practice of KnowledgeDiscoveryinDatabases(PKDD) was?rstheldin1997inTrondheim, Norway.
Machine Learning: ECML 2006 ; 17th European Conference on Machine Learning, Berlin, Germany, September 18-22, 2006, Proceedings
This book constitutes the refereed proceedings of the 17th European Conference on Machine Learning, ECML 2006, held in Berlin, Germany in September 2006, jointly with PKDD 2006. The 46 revised full papers and 36 revised short papers presented together with abstracts of 5 invited talks were carefully reviewed and selected from 564 papers submitted to both, ECML and PKDD. The papers present a wealth of new results in the area and address all current issues in machine learning.
Machine Learning Techniques for Multimedia : Case Studies on Organization and Retrieval
This book provides a comprehensive coverage of the most important machine learning techniques used and their application in this domain. Arising from the EU MUSCLE network, a program that drew together multidisciplinary teams with expertise in machine learning, pattern recognition, artificial intelligence, and image, video, text and crossmedia processing, the book first introduces the machine learning principles and techniques that are applied in multimedia data processing and analysis. The second part focuses on multimedia data processing applications, with chapters examining specific machine learning issues in domains .
Machine learning for neurodegenerative disorders : advancements and applications
Explores the application of machine learning to the understanding, early diagnosis, and management of neurodegenerative disorders. With a specific focus on its role in ongoing clinical trials, the book covers essential topics such as data collection, pre-processing, feature extraction, model development, and validation techniques. It delves into the applications of neuroimaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) in the diagnosis and understanding of neurodegenerative disorders. Additionally, the book examines various machine-learning algorithms employed for biomarker discovery in neurodegenerative disorders. It highlights the role of neuroinformatics and big data analysis in advancing the understanding and management of neurodegenerative disorders. Furthermore, the book reviews future prospects and presents the ethical considerations and regulatory challenges associated with implementing machine learning approaches in the diagnosis, treatment, and prevention of neurodegenerative disorders.
