الصفحة 13
الصفحة 13
Mechanisms of mineralization of vertebrate skeletal and dental tissues
Presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.
Mechanisms of Insulin Action
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
Mechanics of Elastic Structures with Inclined Members : Analysis of vibration, buckling and Bending of X-Braced Frames and Conical Shells
This monograph presents the mechanics of vibration, buckling and bending of elastic structures with inclined members such as x-braced high rise frames and conical shells. More than giving detailed derivations of basic equations.
Mechanics of biomaterials : Fundamental principles for implant design
Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues.
Mechanical Ventilation
This book represents a state-of-the-art review by the leading experts in this field and covers a number of important topics including epidemiology, underlying physiological concepts, and approaches to monitoring. The pros and cons of various modes of ventilation are reviewed, as are novel forms of ventilation that may play a role in the future management of patients with respiratory failure. The importance of patient-ventilator synchrony and ventilator-induced lung injury are reviewed, with a focus on recent clinical trials and the challenges of implementing the results into clinical practice.
Measuring Precipitation from Space : EURAINSAT and the Future
More than 20 years after the last book on the subject the worldwide precipitation community has produced a comprehensive overview of its activities, achievements, ongoing research and future plans. Measuring Precipitation from Space presents state-of-the-art rainfall estimation algorithms, validation strategies, precipitation modelling, and assimilation in numerical weather prediction models. Clouds and precipitation observations and modelling are addressed for the improvement of the rainfall product quality. Special attention is given to the applications to monitoring and forecasting weather events and to climate monitoring in a frame of growing public interest.
Measuring emission of agricultural greenhouse gases and developing mitigation options using nuclear and related Techniques : Applications of nuclear techniques for GHGs
This book is an outcome of the collaboration between the Soil and Water Management & Crop Nutrition Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna, Austria, and the German Science Foundation research unit DASIM (Denitrification in Agricultural Soils: Integrated control and Modelling at various scales) and other institutes.
Measure Theory and Probability Theory
The book can be used as a text for a two semester sequence of courses in measure theory and probability theory, with an option to include supplemental material on stochastic processes and special topics.Prerequisites are kept to the minimal level of an understanding of basic real analysis concepts such as limits, continuity, differentiability, Riemann integration, and convergence of sequences and series. A review of this material is included in the appendix. The book starts with an informal introduction that provides some heuristics into the abstract concepts of measure and integration theory, which are then rigorously developed. The first part of the book can be used for a standard real analysis course for both mathematics and statistics Ph.D. students as it provides full coverage of topics such as the construction of Lebesgue-Stieltjes measures on real line and Euclidean spaces, the basic convergence theorems, L^p spaces, signed measures, Radon-Nikodym theorem, Lebesgue's decomposition theorem and the fundamental theorem of Lebesgue integration on R, product spaces and product measures, and Fubini-Tonelli theorems. It also provides an elementary introduction to Banach and Hilbert spaces, convolutions, Fourier series and Fourier and Plancherel transforms.
MDCT and 3D Workstations : A Practical How-To Guide and Teaching File
Written by Scott A. Lipson, MD, an authority in the field, this book is ideal for radiologists, radiology residents, and CT technologists who are getting started in multidetector CT or who want to improve and optimize their CT service. This concise guide and teaching file is the perfect introduction to MDCT volumetric imaging and 3D workstations. Intended to serve as a practical, easy-to-read systematic learning tool, the book begins by introducing the reader to the process of image data acquisition, CT protocols, image reconstruction and review, 3D workstations, clinical workstation use, and CT workflow efficiency. The second section of this book is a volumetric imaging teaching file.
MDCT : A Practical Approach
Computed tomography (CT) is the most rapidly evolving medical imaging technology. This book describes current examination techniques and advanced clinical applications of state-of-the-art multidetector computed tomography (MDCT) scanners in chapters contributed by several distinguished radiologists and clinicians. Each chapter is written from a practical perspective so that radiologists, residents, medical physicists, and radiology technologists can obtain relevant information about MDCT applications in neuroradiology, cardiac imaging, chest, abdominal, and musculoskeletal radiology subspecialties. Each coauthor provides pertinent illustrations and tables for better understanding of current and advanced applications of MDCT scanners. Readers will benefit from the experience these authors describe in chapters on MDCT technology, contrast administration techniques, contrast adverse effects and their management, and advanced applications of MDCT.
Mayo clinic infectious disease case review : With board-style questions and answers
Addresses many of the current-day illnesses seen by primary care clinicians and infectious diseases specialists. A case presentation format is used for all 54 chapters, and this framework serves as a wonderful educational tool that mirrors, in many respects, the objectives of a “case conference” format. The dozens of authors from different areas of our specialty have ensured that a robust clinical examination of specific infection syndromes has been included. In addition, the Question and Answer section solidifies the educational benefits for all levels and types of clinicians who seek an understanding of disease diagnosis, management, and prevention. A well-recognized characteristic of infectious diseases specialists is our focus on epidemiology, and this trait has served us well in developing successful clinical careers.
Maxillofacial prosthetics and dental oncology : Practical approach from a high volume head and neck cancer centre
An assimilation of clinical and practical work done at Tata Memorial Hospital. It reflects the evolution of Dental Oncology and Maxillofacial Prosthodontics and more than 33 years of exclusive maxillofacial prosthodontic experience of Dr. Kanchan Dholam. This book covers the clinical guidelines for treatment, based on sound scientific principles and published literature. It also provides a step-by-step approach in the fabrication of commonly-indicated maxillofacial prostheses.
Iron Nutrition in Plants and Rhizospheric Microorganisms
This book uses an interdisciplinary approach to provide a comprehensive review on the status of iron nutrition in plants. International scientists discuss research on acquisition of iron by strategy I and strategy II plants. These reviews summarize a variety of plant species and include both laboratory and field observations. Topics covered in this book include: plants as a source of iron for animals and humans, iron translocation in the plants, iron-stimulated activities that influence crop yield and fruit tree productivity, iron uptake by plants as influenced by microorganisms (i.e. free living soil microorganisms, symbiotic nitrogen-fixing and pathogenic bacteria), the role of plant hormones in iron transport, iron-metal competition in phytoremediation, root zone activities involving interactions between minerals and organic matter, the role of microbial siderophores in rhizospheric iron cycling, iron storage as phytoferritin, proteomic and metabolic studies associated with iron stress response, methods for studying iron metabolism including stable isotopes, and the correction of iron deficiency through the use of synthetic or natural chelates.
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Investing in e-Health : What it Takes to Sustain Consumer Health Informatics
Investing in eHealth: What it Takes to Sustain Consumer Health Informatics examines the evolution of the IHCS and the significant changes in organizational culture and operational systems that may be required for successful and sustained implementation. This book culminates a set of general guidelines for any health care provider striving to successfully employ the model, and suggests directions for future research on the diffusion of IHCSs and related technologies. Investing in eHealth provides a principled approach to support health care managers, clinicians, and educators interested in complementing clinical services with interactive health communication systems (IHCSs).
Investigative Electrocardiography in Epidemiological Studies and Clinical Trials
It reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.
Investigation and management of soft rock cliffs
Cliff recession and coastal landsliding of soft rock cliffs present significant threats to land use and development. Investigation and management of soft rock cliffs presents state-of-the-art guidance on how eroding cliffs can best be managed, stressing the need to consider both structural and non-structural solutions to cliff recession problems. This authoritative text outlines the investigation approaches, measurement and monitoring techniques, and prediction methods available for obtaining the necessary cliff recession information.
Investigating the Body in the Victorian Asylum : Doctors, Patients, and Practices
This book explores how the body was investigated in the late nineteenth-century asylum in Britain. As more and more Victorian asylum doctors looked to the bodily fabric to reveal the ‘truth’ of mental disease, a whole host of techniques and technologies were brought to bear upon the patient's body. These practices encompassed the clinical and the pathological, from testing the patient's reflexes to dissecting the brain.
Invasive Species in Forests and Rangelands of the United States : A Comprehensive Science Synthesis for the United States Forest Sector
This book describes the serious threat of invasive species to native ecosystems. Invasive species have caused and will continue to cause enormous ecological and economic damage with ever increasing world trade.
