الصفحة 12
الصفحة 12
Genetic control of neuronal migrations in human cortical development
Introduction Cortical development is a complex, tightly regulated process that eventually leads to the six-layered adult human neocortex, the substrate of the unique cognitive, emotional, and social abilities of our species. The basic mechanisms of early cortical development are believed to be very similar among mammals, which has led to a tendency of extrapolating experimental data from rodents on humans.
Genetic basis of oral health conditions
This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies.
Genetic Basis for Respiratory Control Disorders
The objective of the book is to supply state-of-the-art contributions about all aspects of respiratory control genetics, from the molecular to the system level. The book aims to review the full spectrum of available knowledge, which starts with early physiological studies in health and disease in humans and studies in rodents that suggested a hereditary component to respiratory control. The spectrum extends to recent work elucidating crucial molecular aspects of respiratory control development, from early embryonic specifications in the neural tube to the function of respiratory rhythm generators.
Genetic algorithms: theory, design and programming
We present a series of scientific contributions that delve into the intricate theoretical foundations and practical nuances of genetic algorithms (GAs). Beyond the academic realm, GAs have demonstrated profound applications in societal decision-making and engineering optimization, showcased through real-world examples and case studies. A dedicated section on programming principles offers a thorough guide for implementing GAs across diverse languages. This edition, tailored for researchers and academics, serves as a testament to the scientific advancements within the field, inviting readers to explore the nuanced journey from theoretical constructs to pragmatic applications in the dynamic landscape of GAs.
Genes, development, and cancer : The life and work of Edward B. Lewis
Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume.
Genes on the Menu : Facts for Knowledge-Based Decisions
Only little more than a decade ago the term "genetic engineering" was hardly known outside research laboratories. Today it regularly makes headlines in the news. Supporters and opponents as well tell us that it could change our lives more than any other technological advance. This book delivers the state-of-the-art facts in order to empower the public to make knowledge-based decisions about plant biotechnology and GM crops and GM food, in particular. It discusses the hot topics of the present debate in a neutral manner and will function as a personal reference book for the interested public, for decision maker, and managers of consumer organisations.
Gene Therapy of Autoimmune Disease
Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene Therapy and Gene Delivery Systems
Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, micro-biology, genetics, chemical engineering and computer science
Gene drives at tipping points : Precautionary technology assessment and governance of new approaches to genetically modify animal and plant populations
This book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.
Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Gene delivery systems : nano delivery technologies
Gene therapy involves altering the genes in the body's cells in an effort to treat or stop disease, instead of using drugs or surgery. This book discusses the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing.
GDPR and biobanking : Individual rights, Public interest and research regulation across Europe
This book focuses on the discrepancies in biobank research regulations that are among the most significant hurdles to effective research collaboration.
Gastroesophagal reflux disease (GERD)
Gastroesophageal reflux disease (GERD) is a common disease with a high prevalence worldwide and a great socioeconomic burden. GERD is a multifactorial disease in which anatomical and functional factors both play a pathogenetic role. The disease can manifest in various symptoms which can be grouped into typical, atypical and extra-esophageal symptoms. The pathophysiology of GERD is complex and not completely understood. An abnormal LES pressure and increased reflux during transient LES relaxations are believed to be key etiologic factors. Prolonged exposure of the esophagus to acid is another. Heartburn and acid regurgitation are the most common symptoms of GERD, although pathologic reflux can result in a wide variety of clinical presentations.
Gaming, simulations and society : Research scope and perspective
The Japan Association of Simulation & Gaming (JASAG) and the Science Council of Japan (SCJ) hosted ISAGA 2003, the 34th annual conference of the International Simulation and Gaming Association (ISAGA), at Kazusa Akademia Park in Kisarazu, Japan,August 25–29, 2003. About 450 participants and guests attended,with 330 from Japan and 101 from 34 other countries. The number of submitted papers and reports exceeded 210, and in addition, many poster presentations and experiential sessions were held. This book is made up of 30 papers submitted to ISAGA 2003 and provides a good example of the diverse scope and standard of research achieved in simu- tion and gaming today.The theme of ISAGA 2003 was “Social Contributions and Responsibilities of Simulation and Gaming.”
Galactose Regulon of Yeast : From Genetics to Systems Biology
The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed.
Fuzzy-Neuro Approach to Agent Applications : From the AI Perspective to Modern Ontology
The book provides a full explanation of the concepts and theories of intelligent agents and agent-based systems. Providing a comprehensive theoretical background, the author covers modern artificial intelligence topics such as ontologies, neural networks, chaos theory, fuzzy logics and genetic algorithms. Finally, the author details how the iJADK toolkit (intelligent Java agent development kit for intelligent e-business applications) can be used in the design and implementation phases of real applications.
Fuzzy Logic with engineering applications
Latest advances in the field including material on expansion of the MLFE method using genetic algorithms, cognitive mapping, fuzzy agent-based models and total uncertainty. Redundant or obsolete topics have been removed, resulting in a more concise yet inclusive text that will ensure the book retains its broad appeal at the forefront of the literature.
Fuzzy Logic and Applications ; Vol. 2955 ; 5th International Workshop, WILF 2003, Naples, Italy, October 9-11, 2003, Revised Selected Papers
This volume constitutes the thoroughly refereed post-workshop proceedings of the 5th International Workshop on Fuzzy Logic and Applications held in Naples, Italy, in October 2003. The 40 revised full papers presented have gone through two rounds of reviewing and revision. All current issues of theoretical, experimental and applied fuzzy logic and related techniques are addressed with special attention to rough set theory, neural networks, genetic algorithms and soft computing.
Fuzzy Logic : A Spectrum of Theoretical & Practical Issues
This book exclusively surveys the active on-going research of the current maturity of fuzzy logic over the last four decades. Many world leaders of fuzzy logic have enthusiastically contributed their best research results into five theoretical, philosophical and fundamental sub areas and nine distinctive applications, including two PhD dissertations from two world class universities dealing with cutting-edge research areas of bioinformatics and geological science. Beyond the scope of survey and collection of the book, one important spin off is the emerging and recognition of a major scientific paradigm shift from the conventional mathematics to the mathematics of uncertainty, which arguably holds the key to solving very difficult and complex problems in biological and social sciences alike. The book, loaded with historical perspective, creative thinking, critical reviewing, and uniquely constructed strategy for future growth of this dynamic research area, is an invaluable resource for active researchers at all levels, university administrators, foundation directors, funding agency program chiefs, research & development planners and technological assessors.
