الصفحة 12
الصفحة 12
Contemporary Accounts in Drug Discovery and Development
Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field.
Construction materials : Their nature and behaviour
Provides an understanding of materials’ behaviour through knowledge of their chemical and physical structure. It covers the main classes of construction materials: metals, concrete, other ceramics (including bricks and masonry), polymers, fibre composites, bituminous materials, timber, and glass.
Concrete Structures : Design and Residual Capacity Assessment
Based primarily on Eurocode 2, this book offers a comprehensive exploration of theory alongside a substantial collection of solved examples. Intended for students and professionals specializing in structural engineering, the content delves into the fundamental aspects of designing and evaluating concrete structures. Discover a unique focus on both theoretical and practical aspects, empowering engineers to unearth solutions that minimize steel usage.
Concrete materials and technology : A practical guide
Demands an underlying knowledge of concrete fundamentals as well as its constituent materials, and in various formulations. Starting with the basics, Concrete Materials and Technology: A Practical Guide examines the production and chemistry of cement, as well as the different types and their applications. Quality control processes and numerous methods for testing are presented and explained in detail.
Concrete gravity and arch dams on rock foundation
Presents and analyzes the designs of erected concrete dams, which allows for a better understanding of the approaches and decision-making principles for designing dams, taking into account the specifics of natural, construction, and other conditions, and also analyzes a number of new solutions that reflect the various ways that engineering theory and practice has sought further improvement of concrete dams.
CONCREEP 10 : Mechanics and physics of creep, shrinkage, and durability of concrete and concrete structures
Contains 187 papers invited on the basis of carefully peer-reviewed abstracts. It elucidates the intricacies of concrete, linking atomistic physics to real life civil engineering design. Topics include: microstructures and micromechanics; multiscale creep, shrinkage, fracture, and durability properties; constitutive and numerical modeling; simulation and design of concrete structures; molecular- to lab-scale simulations and characterization of concrete; macroscopic material testing; creep and shrinkage of concrete under extreme conditions; monitoring of concrete structures and exploitation of measurement data; and creep and shrinkage properties of new cementitious materials.
Concepts in pharmaceutical biotechnology and drug development
Provides comprehensive coverage of the development of new pharmaceuticals and the enhancement of existing ones. It offers a comprehensive understanding of pharmaceutical biotechnology, including its underlying principles and practical applications from an industrial standpoint. While introducing the roles and applications of biotechnology in drug design and development, the book describes how developments in other fields, like genomics, proteomics, and high-throughput screening, have facilitated the discovery of novel therapeutic targets and drug development methods. It included concepts that are essential to biotechnology and apply to protein therapies. And provides a thorough overview of the ways in which biotechnology influences drug development, production, and regulation, and is a valuable resource for those seeking to enhance their understanding in this area.
Computer vision and graphics ; International Conference, ICCVG 2020, Warsaw, Poland, September 14–16, 2020, Proceedings
This book constitutes the refereed proceedings of the International Conference on Computer Vision and Graphics, ICCVG 2020, held in Warsaw, Poland, in September 2020. The 20 full papers were selected from 49 submissions. The contributions cover topics such as: modelling of human visual perception; computational geometry; geometrical models of objects and scenes; illumination and reflection models and methods; image formation; image and video coding; image filtering and enhancement; biomedical image processing; biomedical graphics; colour image processing; multispectral image processing; pattern recognition in image processing
Computer Aided Verification ; Vol. 3576 ; 17th International Conference, CAV 2005, Edinburgh, Scotland, UK, July 6-10, 2005, Proceedings
This volume contains the proceedings of the International Conference on Computer Aided Veri?cation (CAV), held in Edinburgh, Scotland, 2005. CAV 2005 was the seventeenth in a series of conferences dedicated to the advancement of the theory and practice of computer-assisted formal an- ysis methods for software and hardware systems. The conference covered the spectrum from theoretical results to concrete applications, with an emphasis on practical veri?cation tools and the algorithms and techniques that are needed for their implementation.
Computer Aided Verification ; 19th International Conference, CAV 2007, Berlin, Germany, July 3-7, 2007, Proceedings
This volume contains advancement of the theory and practice of computer-assisted formal analysis methods for software and hardware systems. covers the spectrum from theoretical - sults to concrete applications, with an emphasis on practical verification tools and the algorithms and techniques that are needed for their implementation.
Computer Aided Pharmaceutics and Drug Delivery : An Application Guide for Students and Researchers of Pharmaceutical Sciences
Examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics.
Computational Techniques for Dental Image Analysis
With the technology innovations dentistry has witnessed in all its branches over the past three decades, the need for more precise diagnostic tools and advanced imaging methods has become mandatory across the industry. Recent advancements to imaging systems are playing an important role in efficient diagnoses, treatments, and surgeries. Provides innovative insights into computerized methods for automated analysis. The research presented within this publication explores pattern recognition, oral pathologies, and diagnostic processing.
Computational Structural Concrete : Theory and Applications
Concrete is by far the most used building material due to its advantages: it is shapeable, cost-effective and available everywhere. Combined with reinforcement it provides an immense bandwidth of properties and may be customized for a huge range of purposes. Thus, concrete is the building material of the 20th century. To be the building material of the 21th century its sustainability has to move into focus. Reinforced concrete structures have to be designed expending less material whereby their load carrying potential has to be fully utilized.
Computational methods in engineering and science ; Proceedings of enhancement and promotion of computational methods in engineering and science X" Aug. 21-23, 2006, Sanya, China
Here are the printed proceedings of EPMESC X, held on August 21-23, 2006 in Sanya, Hainan Island of China. It includes 14 full papers of plenary and semi-plenary lectures and approximately 166 one-page summaries. The accompanying CD-ROM includes all 180 full papers presented at the conference.
Computational methods for nanoscale applications : Particles, plasmons and waves
Computational Methods for Nanoscale Applications: Particles, Plasmons and Waves presents new perspectives on modern nanoscale problems where fundamental science meets technology and computer modeling. This book describes well-known computational techniques such as finite-difference schemes, finite element analysis and Ewald summation, as well as a new finite-difference calculus of Flexible Local Approximation MEthods (FLAME) that qualitatively improves the numerical accuracy in a variety of problems. Application areas in the book include long-range particle interactions in homogeneous and heterogeneous media, electrostatics of colloidal systems, wave propagation in photonic crystals, photonic band structure, plasmon field enhancement, and metamaterials with backward waves and negative refraction.
Computational Mechanics of Composite Materials : Sensitivity, Randomness and Multiscale Behaviour
The Engineering Materials and Processes series focuses on all forms of materials and the processes used to synthesise and formulate them as they relate to the various engineering disciplines. The series deals with a diverse range of materials: ceramics; metals (ferrous and non-ferrous); semiconductors; composites, polymers biomimetics etc. Each monograph in the series will be written by a specialist and will demonstrate how enhancements in materials and the processes associated with them can improve performance in the field of engineering in which they are used.
Computational Materials Chemistry : Methods and Applications
As a result of the advancements in algorithms and the huge increase in speed of computers over the past decade, electronic structure calculations have evolved into a valuable tool for characterizing surface species and for elucidating the pathways for their formation and reactivity. It is also now possible to calculate, including electric field effects, STM images for surface structures. To date the calculation of such images has been dominated by density functional methods, primarily because the computational cost of - curate wave-function based calculations using either realistic cluster or slab models would be prohibitive. DFT calculations have proven especially valuable for elucidating chemical processes on silicon and other semiconductor surfaces. However, it is also clear that some of the systems to which DFT methods have been applied have large non-dynamical correlation effects, which may not be properly handled by the current generation of Kohn-Sham-based density functionals. For example, our CASSCF calculations on the Si(001)/acetylene system reveal that at some geometries there is extensive 86 configuration mixing. This, in turn, could signal problems for DFT cal- lations on these systems.
Computational Life Sciences ; Vol. 3695 ; 1st International Symposium, CompLife 2005, Konstanz, Germany, September 25-27, 2005, Proceedings
This book constitutes the refereed proceedings of the First International Symposium on Computational Life Sciences, CompLife 2005, held in Konstanz, Germany in September 2005. The integration of knowledge in the life sciences is continuing apace with ev- increasingimportancebeing placedoncomputer-basedmethodsofdata capture, analysis, and knowledge representation. Today, our many di?erent sciences are providing us with a sea of information: it is the handling of this in?ux that is becoming a key discovery and regulatory question. The solutions to these problems will result in advancements to all of the involved sciences and will be highly in?uential both in the selection of the areas scientists seek to investigate and also on their success. For this to happen, it is crucial to establish an open and lively exchange between computer scientists, biologists, and chemists. To encourage precisely this type of exchange, crossing the borders of the sciences, we organized the 1st Symposium on Computational Life Science in Konstanz, Germany(September 25 27,2005).
Computational Intelligence in Multimedia Processing : Recent Advances
This book presents a large number of interesting applications to intelligent multimedia processing of various Computational Intelligence techniques, such as rough sets, Neural Networks; Fuzzy Logic; Evolutionary Computing; Artificial Immune Systems; Swarm Intelligence; Reinforcement Learning and evolutionary computation.
Computational intelligence ; Vol. 4114 ; International conference on intelligent computing, ICIC 2006, Kunming, China, August 16-19, 2006, Proceedings, Part II
The International Conference on Intelligent Computing (ICIC) was formed to provide an annual forum dedicated to the emerging and challenging topics in artificial intelligence, machine learning, bioinformatics, and computational biology, etc. It aims to bring together researchers and practitioners from both academia and industry to share ideas, problems and solutions related to the multifaceted aspects of intelligent computing.
