الصفحة 12
الصفحة 12
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Memory B-cells : Methods and protocols
Details in methods to assess memory B cell formation and function in mice and humans. Chapters guide readers through tetramer-based methods to assess antigen-specific memory B cell dynamics in humans and mice in different vaccine, next-generation deep-sequencing, single-cell techniques to assess epigenomic, VDJ landscapes, lymph node aspirates from humans, advanced imaging, murine models to determine memory B cells formation, and bioinformatic techniques and in silico modelling of memory b cell formation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Memories : Molecules and Circuits
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.
Mémento de la recherche biomédicale portant sur un médicament à usage humain = Summary of biomedical research on a medicinal product for human use
Presents the reference texts, structures and authorities that govern clinical research in France, as well as its practical aspects. It is aimed at all of its stakeholders, both caregivers and patients. It will allow the most novices to familiarize themselves with the specific vocabulary of this discipline, to answer the questions raised during the conduct or participation in a therapeutic trial, and the most experienced to consider setting up a research structure. clinic in the rules of art.
Membrane Trafficking in Viral Replication
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.
Mediterranean Island Landscapes : Natural and Cultural Approaches
Mediterranean islands exhibit many similarities in their biotic ecological, physical and environmental characteristics. There are also many differences in terms of their human colonization and current anthropogenic pressures. This book addresses in three sections these characteristics and examines the major environmental changes that the islands experienced during the Quaternary period. The first section provides details on natural and cultural factors which have shaped island landscapes. It describes the environmental and cultural changes of the Holocene and their effects on biota, as well as on the current human pressures that are now threats to the sustainability of the island communities. The second section focuses on the landscapes of the largest islands namely Sicily, Sardinia, Corsica, Cyprus, Crete, Malta and the Balearics. Each island chapter includes a special topic reflecting a particular characteristic of the island. Part three presents strategies for action towards sustainability in Mediterranean islands and concludes with a comparison between the largest islands.
Medicinal plants : From farm to pharmacy
Discuss current research on medicinal plants that connects traditionally accumulated botanical wisdom with current bioprospecting trends and (pre-clinical studies Provide an account of recent research activities on select medicinal plants from various phytogeographical regions all over the world Cater to the interest of a wide range of readers including lay enthusiasts, traditional practitioners as well as research and clinical professionals
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes features important insights into the applications of fullerenes and carbon nanotubes. It discusses the fullerene and nanotubes derivatives which are effective against viruses, cells, and bacteria and those which are able to interact and inhibit certain enzymes. Also covered in this book are the formation of complex structures between biologically active molecules and carbon materials. Furthermore, the application of fullerenes in certain medical therapies is explored, including the very recent discovery of new bio-compatible media which could be used as carriers in the delivery of fullerenes in vivo. An additional topic of this text is the formation of hybrids between nanotubes and biological molecules and their use as chemical sensors.
Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack
This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled?Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack?. The focus of this workshop was assessment of scientific concepts and practical means for management of chemical agent casualties in the area of terrorist attack with emphasis on improving the medical treatment and decontamination. These problems were analyzed from an interdisciplinary perspective. The primary objective of the ARW was to provide countries in which chemical-defense systems are currently under development with the experience and expertise of those that are more advanced and/or have already been exposed and responded to a chemical-terrorist attack. . The main areas covered were: 1. new approaches in pre-treatment and prophylaxis of nerve agent intoxication; 2. diagnosis of exposure to chemical agents ; 3. therapy of chemical agent intoxication; 4. development of personal decontamination; 5. decontamination of intoxication with chemical agents.
Medical Informatics : Knowledge Management and Data Mining in Biomedicine
Knowledge Management and Data Mining in Biomedicine covers the basic foundations of the area while extending the foundational material to include the recent leading-edge research in the field. The newer concepts, techniques, and practices of biomedical knowledge management and data mining are introduced and examined in detail. It is the research and applications in these areas that are raising the technical horizons and expanding the utility of informatics to an increasing number of biomedical professionals and researchers. These concepts and techniques are illustrated with detailed case studies.
Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 ; 11th International Conference, New York, NY, USA, September 6-10, 2008, Proceedings, Part II
The program committee carefully selected 258 revised papers from numerous submissions for presentation in two volumes, based on rigorous peer reviews. The first volume includes 127 papers related to medical image computing, segmentation, shape and statistics analysis, modeling, motion tracking and compensation, as well as registration. The second volume contains 131 contributions related to robotics and interventions, statistical analysis, segmentation, intervention, modeling, and registration.
Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 ; 11th International Conference, New York, NY, USA, September 6-10, 2008, Proceedings, Part I
The program committee carefully selected 258 revised papers from numerous submissions for presentation in two volumes, based on rigorous peer reviews. The first volume includes 127 papers related to medical image computing, segmentation, shape and statistics analysis, modeling, motion tracking and compensation, as well as registration. The second volume contains 131 contributions related to robotics and interventions, statistical analysis, segmentation, intervention, modeling, and registration.
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007; 10th International Conference, Brisbane, Australia, October 29 - November 2, 2007, Proceedings, Part II
The 10th International Conference on Medical Imaging and Computer Assisted Intervention, MICCAI2007, washeldattheBrisbaneConventionandExhibition Centre, South Bank, Brisbane, Australia from 29th October to 2nd November 2007. MICCAI has become a premier international conference in this domain, with in-depth papers on the multidisciplinary ?elds of biomedical image computing, computer assisted intervention and medical robotics.
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006 ; Vol. 4191; 9th International Conference, Copenhagen, Denmark, October 1-6, 2006, Proceedings, Part II
T MICCAI papers are of high standard and have a long lifetime. In this v- ume as well as in the latest journal issues of Medical Image Analysis and IEEE Transactions on Medical Imaging papers cite previous MICCAIs including the ?rst MICCAI conference in Cambridge, Massachusetts, 1998. It is obvious that the community requires the MICCAI papers as archive material. Therefore the proceedingsofMICCAIarefrom2005andhenceforthbeing indexedbyMedline. Acarefulreviewandselectionprocesswasexecutedinordertosecurethebest possible program for the MICCAI 2006 conference. We received 578 scienti?c papers from which 39 papers were selected for the oral program and 193 papers for the poster program.
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006 ; Vol. 4190 ; 9th International Conference, Copenhagen, Denmark, October 1-6, 2006, Proceedings, Part I
MICCAI papers are of high standard and have a long lifetime. In this v- ume as well as in the latest journal issues of Medical Image Analysis and IEEE Transactions on Medical Imaging papers cite previous MICCAIs including the ?rst MICCAI conference in Cambridge, Massachusetts, 1998. It is obvious that the community requires the MICCAI papers as archive material. Therefore the proceedingsofMICCAIarefrom2005andhenceforthbeing indexedbyMedline. Acarefulreviewandselectionprocesswasexecutedinordertosecurethebest possible program for the MICCAI 2006 conference. We received 578 scienti?c papers from which 39 papers were selected for the oral program and 193 papers for the poster program.
Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2005 ; 8th International Conference, Palm Springs, CA, USA, October 26-29, 2005, Proceedings, Part II
Robotics, Image-Guided Surgery and Interventions -- Image Registration II -- Medical Image Computing -- Atlases -- Shape I -- Structural and Functional Brain Analysis -- Model-Based Image Analysis -- Image-Guided Intervention: Simulation, Modeling and Display -- Simulation and Modeling II -- Medical Image Computing -- Shape II -- Image Segmentation and Analysis II -- Image Registration III --
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2005 ; 8th International Conference, Palm Springs, CA, USA, October 26-29, 2005, Proceedings, Part I
This paper presents a method for classification of medical images, using machine learning and deformation-based morphometry. A morphological representation of the anatomy of interest is first obtained using highdimensional template warping, from which regions that display strong correlations between morphological measurements and the classification (clinical) variable are extracted using a watershed segmentation, taking into account the regional smoothness of the correlation map which is estimated by a crossvalidation strategy in order to achieve robustness to outliers. A Support Vector Machine-Recursive Feature Elimination (SVM-RFE) technique is then used to rank computed features from the extracted regions, according to their effect on the leave-one-out error bound. Finally, SVM classification is applied using the best set of features, and it is tested using leave-one-out. The results from a group of 61 brain images of female normal controls and schizophrenia patients demonstrate not only high classification accuracy (91.8%) and steep ROC curves, but also exceptional stability with respect to the number of selected features and the SVM kernel size
Medical Decisions, Estrogen and Aging
This book is unique in that it integrates core findings from within the Decision Sciences and Evidence Based Medicine in light of the research that has been done on HT. Medical Decisions, Estrogen and Aging integrates the various components that go into medical decision making in the context of understanding the dilemmas that surround HT. Therefore this book is intended for both specialists and generalists in the field, and it is ideally suited for use by graduate and medical students, medical health care professionals, behavioral scientists, medical ethicists, gerontologists, historians of science, and endocrinologists.
Medical biotechnology, biopharmaceutics, forensic : science and bioinformatics
Covers a range of topics on exploiting Nigeria’s mega biodiversity for food security and health; DNA forensic science and its applications; medical biotechnology and biopharmaceutics; medicinal and underutilized plants; impact and mitigation of antibiotic resistance; bioinformatics applications; medical insect biotechnology; etc. The book will be useful reference material for the scientists and researchers working in the fields of nutraceuticals, molecular diagnostics and DNA forensics, biopharmaceuticals and medical biotechnology, nanotechnology, antimicrobials from indigenous plant species, bioinformatics, etc.
Medical Biometrics ; 1st International Conference, ICMB 2008, Hong Kong, China, January 4-5, 2008, Proceedings
Medical biometrics primarily refers to the usage of beh- ioral and physiological characteristics of humans for medical diagnosis and body care. Thus the goal of medical biometrics is to explore solutions to the open problems in medicine using biometric measurements, technologies and systems.
