الصفحة 116
الصفحة 116
25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
(R)Evolution : Organizations and the Dynamics of the Environment
Investigates the possible changes needed for industrial organizations to adapt to and remain competitive in their ever evolving environment. (R)Evolution’s main area of contribution to these very complex issues is embedded in the work’s ambitious attempt to borrow from evolutionary biology and genetics not only metaphors but also concepts and models to be adapted to the management of business organizations. The work provides us with a comprehensive vision of adaptation and variation in the business community, integrating various intellectual inputs which are based on an evolutionary vision of economic behavior. Using an extensive study of the literature in management science, and applying new models and methodologies in numerous case studies, Dekkers draws many insightful conclusions including the claim that companies often evolve slower than generally expected. Furthermore the research calls into question the effectiveness of the common practice of corporate reorganization. Embracing and merging most major contemporary developments in the theories of change into a comprehensive integrated approach, (R)Evolution is an invaluable resource for researchers specializing in the management of technological change.
