الصفحة 11
الصفحة 11
Molecular docking for computer-aided drug design : Fundamentals, techniques, resources and applications
Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery.
Molecular Diagnostic PCR Handbook
PREFACE The Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture is involved in agricultural research and development and assists Member States of FAO and IAEA in improving strategies to ensure food security through the use of nuclear techniques and related biotechnologies, where such techniques have a valuable and often unique role. In particular, molecular diagnostic methods have rapidly evolved in the past twenty years, since the advent of the Polymerase Chain Reaction (PCR). They are used in a wide range of agricultural areas such as, improving soil and water management; producing better crop varieties; diagnosing plant and animal diseases; controlling insect pests and improving food quality and safety. The uses of nucleic acid-directed methods have increased significantly in the past five years and have made important contributions to disease control country programmes for improving national and international trade. These developments include the more routine use of PCR as a diagnostic tool in veterinary diagnostic laboratories. However, there are many problems associated with the transfer and particularly, the application of this technology. These include lack of consideration of: the establishment of quality-assured procedures, the required set-up of the laboratory and the proper training of staff. This can lead to a situation where results are not assured. This book gives a comprehensive account of the practical aspects of PCR and strong consideration is given to ensure its optimal use in a laboratory environment. This includes the setting-up of a PCR laboratory; Good Laboratory Practice and standardised of PCR protocols.
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modular Forms
It provides the reader with the basic knowledge of elliptic modular forms necessary to understand the recent developments in number theory. The first part gives the general theory of modular groups, modular forms and Hecke operators, with emphasis on the Hecke-Weil theory of the relation between modular forms and Dirichlet series. The second part is on the unit groups of quaternion algebras, which are seldom dealt with in books. The so-called Eichler-Selberg trace formula of Hecke operators follows next and the explicit computable formula is given. In the last chapter, Eisenstein series with parameter are discussed following the recent work of Shimura: Eisenstein series are likely to play a very important role in the future progress of number theory, and this chapter provides a good introduction to the topic.
Modern Theatres 1950–2020
Explores in detail 30 of the most significant theatres, concert halls, opera houses and dance spaces that opened between 1950 and 2010. Each theatre is reviewed and assessed by experts in theatre buildings, such as architects, acousticians, consultants and theatre practitioners, and illustrated with full-colour photographs and comparative plans and sections. A further 20 theatres that opened from 2009 to 2020 are concisely reviewed and illustrated. An excellent resource for students of theatre planning, theatre architecture and architectural design, Modern Theatres 1950 – 2020 discusses the role of performing arts buildings in cities, explores their public and performances spaces and examines the acoustics and technologies needed in a great building. This beautifully illustrated book is also a must-read for architects, theater designers, theatre historians, and theatre practitioners.
Modern socio-technical perspectives on privacy
This book provides researchers and professionals with a foundational understanding of online privacy as well as insight into the socio-technical privacy issues that are most pertinent to modern information systems, covering several modern topics (e.g., privacy in social media, IoT) and underexplored areas (e.g., privacy accessibility, privacy for vulnerable populations, cross-cultural privacy).
Modern Operator Theory and Applications : The Igor Borisovich Simonenko Anniversary Vol.
This volume is dedicated to the eminent Russian mathematician Igor Borisovich Simonenko on the occasion of his 70th birthday. It consists of a selection of 15 original contributions written by leading experts in operator theory. The topics reflect the wide range and the rich variety of areas of interests, achievements and influence of I.B. Simonenko. The book also includes his biography, the complete list of publications and a list of his Ph.D. students.
Modern Multidimensional Scalin : Theory and Applications
The book provides a comprehensive treatment of multidimensional scaling (MDS), a family of statistical techniques for analyzing the structure of (dis)similarity data. This book may be used as an introduction to MDS for students in psychology, sociology, and marketing. The prerequisite is an elementary background in statistics. The book is also well suited for a variety of advanced courses on MDS topics. All the mathematics required for more advanced topics is developed systematically. This second edition adds some 140 pages of new material. Many chapters are revised or have sections reflecting new insights and developments in MDS. There are two new chapters, one on asymmetric models and the other on unfolding. There are also numerous exercises that help the reader to practice what he or she has learned, and to delve deeper into the models and its intricacies.
Modern Methods in the Calculus of Variations : L^p Spaces
This is the first of two books on methods and techniques in the calculus of variations. Contemporary arguments are used throughout the text to streamline and present in a unified way classical results, and to provide novel contributions at the forefront of the theory.This book addresses fundamental questions related to lower semicontinuity and relaxation of functionals within the unconstrained setting, mainly in L^p spaces. It prepares the ground for the second volume where the variational treatment of functionals involving fields and their derivatives will be undertaken within the framework of Sobolev spaces.
Modern Food Microbiology
With 30 revised and updated chapters, the new edition of this classic text brings benefits to professors and students alike who will find new sections on proteobacteria, bottled water, food sanitizers (eletrolyzed oxidating water, ozone, chlorine, activin, chitosans, endolysins, etc.), bicontrol, biosensors quorum sensing, molecular genetic methods of analysis, food safety objectives, noroviruses, and prions. The book builds on the trusted and established sections on food preservation by modified atmosphere, high pressure and pulsed electric field processing, food-borne pathogens, food regulations, fresh-cut produce, new food products, and risk assessment and analysis. In-depth references, appendixes, illustrations, index and thorough updating of taxonomies make this an essential for every food scientist.
Modern deep learning for tabular data : Novel approaches to common modeling problems
Synthesizes and presents novel deep learning approaches to a seemingly unlikely domain - tabular data. Whether for finance, business, security, medicine, or countless other domain, deep learning can help mine and model complex patterns in tabular data - an incredibly ubiquitous form of structured data. Part I of the book offers a rigorous overview of machine learning principles, algorithms, and implementation skills relevant to holistically modeling and manipulating tabular data. Part II studies five dominant deep learning model designs - Artificial Neural Networks, Convolutional Neural Networks, Recurrent Neural Networks, Attention and Transformers, and Tree-Rooted Networks - through both their 'default' usage and their application to tabular data. Part III compounds the power of the previously covered methods by surveying strategies and techniques to supercharge deep learning systems: autoencoders, deep data generation, meta-optimization, multi-model arrangement, and neural network interpretability.
Modern Circuit Placement : Best Practices and Results
This book has four unique characteristics. First, it focuses on the most recent highly scalable placement techniques used for multi-million gate circuit designs, with consideration of many practical aspects of modern circuit placement, such as density and routability control, mixed-size placement support, and area I/O support. Second the book addresses dominant techniques being used in the field. Although these tools are developed by academia, many core techniques in these tools are being used extensively in industry and represent today’s advanced placement techniques. Third, the book provides quantitative comparison among the various techniques on common benchmark circuits derived from real-life industrial designs. The book includes significant amounts of analysis on each technique, such as trade-offs between quality-of-results (QoR) and runtime. Finally, analysis of the optimality of the placement techniques is included.
Modern asset allocation for wealth management
This book provides a complete taxonomy of modern methods for constructing investment portfolios. It goes beyond the simplest models and heuristics that are commonly used today and brings advances that are otherwise buried in Ph.D.-level mathematics to the financial advisor community. It covers all aspects of creating client portfolios, including choosing asset classes to invest in, selecting securities within asset classes, client risk preference assessment, portfolio construction, and portfolio rebalancing.
Modern Aspects of Electrochemistry ; Vol. 38
Solid State Electrochemistry encompassing modern equilibria concepts, thermodymanics and kinetics of charge carriers in solids.,Electron transfer processes, with special sections devoted to hydration of the proton and its heterogeneous transfer.Electrosorption at electrodes and its relevance to electrocatalysis and electrodeposition of metals,The behavior of Pt and other alloy electrocatalyst crystallites used as the electrode materials for phosphoric acid electrolyte fuel-cells.Applications of reflexology and electron microscopy to the materials science aspect of metal electrodes.Electroplating of metal matrix composites by codeposition of suspended particles, a process that has improved physical and electrochemical properties.
Modern Anesthetics
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. in this book the very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Models, Methods and Tools for Product Service Design : The Manutelligence Project
This book summarizes research being pursued within the Manutelligence project, the goal of which is to help enterprises develop smart, social and flexible products with high value added services. Manutelligence has improved Product and Service Design by developing suitable models and methods, and connecting them through a modular, collaborative and secure ICT Platform. The use of real data collected in real time by Internet of Things (IoT) technologies underpins the design of product-service systems and makes it possible to monitor them throughout their life cycle. Available data allows costs and sustainability issues to be more accurately measured and simulated in the form of Life Cycle Cost (LCC) and Life Cycle Assessment (LCA). Analysing data from IoT systems and sharing LCC and LCA information via the ICT Platform can help to accelerate the design of product-service systems, reduce costs and better understand customer needs. Industrial partners involved in Manutelligence provide a clear overview of the project's outcomes, and demonstrate how its technological solutions can be used to improve the design of product-service systems and the management of product-service life cycles.
Models in Software Engineering ; Workshops and Symposia at MoDELS 2007, Nashville, TN, USA, September 30 - October 5, 2007, Reports and Revised Selected Papers
This book constitutes the thoroughly refereed post-workshop proceedings of 10 internationl workshops and 2 symposia held as satellite events of the 10th International Conference on Model Driven Engineering Languages and Systems, MoDELS 2007, in Nashville, TN, USA, in September/October 2007 (see LNCS 4735).The 29 revised full papers were carefully selected for inclusion in the book and are presented along with a doctoral and an educators' symposium section. The papers are organized in topical sections representing the various workshops: aspect-oriented modeling (AOM 2007), language engineering (ATEM2007), model driven development of advanced user interfaces (MDDAUI 2007), model size metrics (MSM 2007).
Models in Software Engineering ; Workshops and Symposia at MoDELS 2006, Genoa, Italy, October 1-6, 2006, Reports and Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of 11 international workshops held as satellite events of the 9th International Conference on Model Driven Engineering Languages and Systems, MoDELS 2006, in Genoa, Italy, in October 2006 (see LNCS 4199). The 32 revised full papers were carefully selected for inclusion in the book.
