الصفحة 11
الصفحة 11
Hedgehog-Gli Signaling in Human Disease
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Harnessing the Power of the Criminal Corpse
This book is the culmination of many years of research on what happened to the bodies of executed criminals in the past. Focusing on the eighteenth and nineteenth centuries, it looks at the consequences of the 1752 Murder Act. These criminal bodies had a crucial role in the history of medicine, and the history of crime, and great symbolic resonance in literature and popular culture. Starting with a consideration of the criminal corpse in the medieval and early modern periods, chapters go on to review the histories of criminal justice, of medical history and of gibbeting under the Murder Act, and ends with some discussion of the afterlives of the corpse, in literature, folklore and in contemporary medical ethics. Using sophisticated insights from cultural history, archaeology, literature, philosophy and ethics as well as medical and crime history, this book is a uniquely interdisciplinary take on a fascinating historical phenomenon.
Handbook on Information Technologies for Education and Training
The handbook's goal is to enable the reader to gain a deep understanding of past, current and future research and applications in the field of educational technology. The reader will gain an in-depth understanding of complex theories, strategies, concepts, and methods relating to the design, development, implementation, and evaluation of educational technologies. Because it combines both the present experience in the field and the vision of its emerging directions, the handbook will be a comprehensive guide for researchers and practitioners working with educational technologies. All the chapters of the second edition are newly written, the handbook therefore presents the latest developments in the field.
Handbook on Decision Support Systems 1 : Basic Themes
Decision support systems have experienced a marked increase in attention and importance over the past 25 years. The aim of this book is to survey the decision support system (DSS) field – covering both developed territory and emergent frontiers. It will give the reader a clear understanding of fundamental DSS concepts, methods, technologies, trends, and issues. It will serve as a basic reference work for DSS research, practice, and instruction. To achieve these goals, the book has been designed according to a ten-part structure, divided in two volumes with chapters authored by well-known, well-versed scholars and practitioners from the DSS community.
Handbook of Pathogens and Diseases in Cephalopods
The aim of this book is to facilitate the identification and description of the different organs as well as pathogens and diseases affecting the most representative species of cephalopods focussed on Sepia officinalis, Loligo vulgaris and Octopus vulgaris. These species are valuable ‘morphotype’ models and belong to the taxonomic groups Sepioidea, Myopsida and Octopoda, which include most of the species with a high market value and aquaculture potential. The study is based on photographs at macroscopic and histological level in order to illustrate the role of the most important pathogens and related diseases from the view of a pathological diagnosis. The reader is able to familiarize with functional anatomy, necropsy and general histology of adults and paralarvae, as well as with the identification of different pathogens and pathologies. This work is thus an invaluable guide for the diagnosis of cephalopod diseases. Besides including pathogens for non-European cephalopod species, it also provides a useful contribution encouraging marine pathologists, parasitologists, veterinarians and those involved in fishery sanitary assessments, aquarium maintenance and aquaculture practices aiming to increase their knowledge about the pathology of cephalopods.
Handbook of neurochemistry and molecular neurobiology : Neural Protein Metabolism and Function
This volume discusses aspects of neural protein metabolism. Although this subject is clearly very important and has numerous functional aspects, it did not always get the attention it clearly deserves. Perhaps there are many explanations for researchers hesitating in the past to focus on protein metabolism.
Handbook of neurochemistry and molecular neurobiology : Amino acids and peptides in the nervous system
It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.
Handbook of neurochemistry and molecular neurobiology : Acute Ischemic injury and repair in the nervous system
It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.
Handbook of molecular force spectroscopy
Modern materials science and biophysics are increasingly focused on studying and controlling intermolecular interactions on the single-molecule level. Molecular force spectroscopy was developed in the past decade as the result of several unprecedented advances in the capabilities of modern scientific instrumentation, and defines a number of techniques that use mechanical force measurements to study interactions between single molecules and molecular assemblies in chemical and biological systems. Examples of these techniques, which typically target a specific range of experimental systems and geometries, include atomic force microscopy, optical tweezers, surface forces apparatus, and magnetic tweezers.
Handbook of employment discrimination research : Rights and realities
this book includes original contributions from many of the legal scholars, economists, psychologists, sociologists, political scientists, and historians who are at the forefront of new research on discrimination and law. The Handbook of Employment Discrimination Research encompasses critical discussions across different social science disciplines, as well as between legal scholars and social scientists. As a collection, it suggests a broad reconsideration of employment discrimination and its treatment in law.
Handbook of cardiac anatomy, physiology, and devices
Because of rapid growth in the medical device industry-which today enjoys revenues as large as those of the automobile industry-as well as in our understanding of cardiac disease processes, biomedical engineers must cope with a rising tide of highly complex information. In Handbook of Cardiac Anatomy, Physiology, and Devices, leading experts from the University of Minnesota's renowned Lillehei Heart Institute and scientists from Medtronic, Inc. have compiled a concise-yet detailed and comprehensive-reference source on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Here, active bioengineers working on cardiac devices will find the complete critical background they need to understand cardiac pacing, defibrillation, cardiac repair using stem cell therapy, robotics, less invasive cardiac surgery, biventricular pacing, cardiac bioenergetics, and more. Insightful chapters address animal models for cardiac research, cardiac mapping systems, heart valve disease, ventricular assist devices, and genomics-based tools and technology.
Guide to RISC Processors : for Programmers and Engineers
This guidebook provides an accessible and all-encompassing compendium on RISC processors, introducing five RISC processors: MIPS, SPARC, PowerPC, ARM, and Itanium. Initial chapters explain the differences between the CISC and RISC designs and clearly discuss the core RISC design principles. The text then integrates instruction on MIPS assembly language programming, thereby enabling readers to concretely grasp concepts and principles introduced earlier. Readers need only have a basic knowledge of any structured, high-level language to obtain the full benefits here.
Guide to periodontal treatment solutions for general dentistry
A concise textbook on periodontics geared towards dental students, residents, and early career general dentists. Each chapter includes cases and evidence-based practice exercises that illustrate key concepts and enable application of these concepts through independent study or non-lecture based teaching methods. This book is arranged in a logical sequence mirroring the manner in which patients present with periodontal disease, from the initial exam to state-of-the art treatments. The opening chapters cover gingivitis and disease basics, data collection, epidemiology, classification systems, and diagnosis. Subsequent chapters encompass a wide array of nonsurgical and surgical approaches for treating issues such as gum pockets, furcation, gingival recession, mucogingival defects, and tooth mobility, as well as when to refer patients. The latest methods for controlling gingival inflammation are discussed, including scaling and root planing, systemic and local antimicrobial therapy, antiseptics, lasers, and photodynamic therapy
Guide to Deep Learning Basics : Logical, Historical and Philosophical Perspectives
This stimulating text/reference presents a philosophical exploration of the conceptual foundations of deep learning, presenting enlightening perspectives that encompass such diverse disciplines as computer science, mathematics, logic, psychology, and cognitive science. The text also highlights select topics from the fascinating history of this exciting field, including the pioneering work of Rudolf Carnap, Warren McCulloch, Walter Pitts, Bulcsú László, and Geoffrey Hinton.
Growth Dynamics of Conifer Tree Rings : Images of Past and Future Environments
Each tree ring contains an image of the time when the ring formed, projected onto the ring's size, structure, and composition. Tree rings thus are natural archives of past environments, and contain records of past climate. While dendrochronologists have investigated the impact of climate on tree-ring growth by empirical–statistical methods, this volume presents a process-based model complementing previous approaches. Basic ideas concerning the biology of tree-ring growth and its control by environmental factors are treated, especially for conifers. The use of the model is illustrated by means of several examples from widely differing environments, and possible future directions for model development and application are discussed. The volume provides an improved mechanistic basis for the interpretation of tree rings as records of past climate. It advances process understanding of the large-scale environmental control of wood growth. As forests are the main carbon sink on land, the results are of great importance for all global change studies.
Ground bearing concrete slabs : Specification, design, construction and behaviour
Ground bearing concrete floors, industrial concrete hardstandings and concrete highway pavements have not, in the past, been perceived as a single type of structural element and their construction has taken place independently of each other. This is in spite of their obvious commonality in the areas of design, materials, geotechnical appreciation and construction.
Green human resource management research : Issues, trends, and challenges
This book, engaging SDGs 4 and 8, among others, examines green HRM from a variety of perspectives. Divided into three sections, it explores the process of human resource acquisition, the connection between green HRM practice and employee behavior, and international perspectives of green HRM.
Graphic Design School : The principles and practice of graphic design ; 7th ed.
Develops design students' core competencies and provides practical advice and tips for how these fundamentals translate into new and evolving media. This Seventh Edition offers all new examples from web, app, social media, magazines, websites and books, presenting a comprehensive overview of the visual communications profession. This updated edition includes guidance and media examples using the latest in grahpic design software, and traditional printing techniques such as risograph and screen printing are revisited. Pedagogical tools throughout the text focus on the growth of interdisciplinary learning and collaborations between design specialists, as well as highlights on key players in the past and present of graphic design. Coveres : color, typographic rules and typefaces, coding requirements, information architecture, file organization, web design and layout, mobile device composition, app design, CMS, designing for social media, and SEO. Graphic Design School, 7th Edition includes full-color illustrations throughout, as well as case studies, designer biographies, and student assignments for testing skills and concepts.
Graded Ferroelectrics, Transpacitors and Transponents
The primary focus of the book is directed toward polarization-graded ferroelectrics and their active components - transpacitors; however, the findings here are quite general. The theory of graded ferroics is put on a solid foundation in Chapters 2 and 5, whereas much of the introductory material relies more heavily upon analogy. This was done so as to provide the reader with an intuitive approach to graded ferroics. Heterogeneous ferroics are shown as logical extensions of passive semiconductor junction devices such as p-n and n-p diodes and their active manifestations: transistors, to transpacitors, transductors, translastics and ultimately to the general active ferroic elements, transponents.
Good work : How to build a career that makes a difference in the world
Packed with useful tools and exercises, this step-by-step guide will help you figure out your passion and purpose, and how to effectively harness it to make real and positive change - on the world, and on your career. Whether you want to battle climate change, promote diversity and inclusion, work in sustainability - or if you're not sure, but just want to leave things a little better at the end of every work day - let this book support you in turning that passion into action.
