الصفحة 10
الصفحة 10
Human origins and environmental backgrounds
Human Origins and Environmental Backgrounds is a benchmark compendium of research that presents itself at a major paradigm shift in paleoanthropology. The editors offer a variety of theoretical approaches to puzzles on the place of the Hominidae, particularly Homo sapiens, among the Primates, including our unique bipedal positional behavior and social structure and the selective factors that might have been involved in our evolution in the broad context of Miocene and later environments. The contributors represent several generations of pioneering laboratory and field researchers from Japan, France and the United States, who have worked together over the past 40 years and who have trained future leaders in evolutionary anthropology and experimental primatology. This volume, compiled by the leading experts in the field, explores the interface between hominid origins and palaeoenvironments.
Human mitochondrial DNA and the evolution of homo sapiens
Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about the human past. This volume takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents the global picture of human mitochondrial DNA variation. It takes a critical look at the field, flagging the problems, as well as the successes, and always placing the mitochondrial phylogeny centre stage.
Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population
Old-age survival has considerably improved in the second half of the twentieth century. In this book, these fundamental questions are explored by experts from such diverse fields as biology, medicine, epidemiology, demography, sociology, and mathematics: they report on recent cutting-edge studies about essential issues of human longevity such as evolution of lifespan of species, genetics of human longevity, reasons for the recent improvement in survival of the elderly, medical and behavioral causes of deaths among very old people, and social factors of long survival in old age.
Human Exploitation and Biodiversity Conservation
The sustainable use of biodiversity is one of the three key objectives of the 1992 "Convention on Biological Diversity". To achieve this, sound conservation practice has to be recognized as beneficial and implemented by all who access, or use it – from subsistence farmers to skiers and pharmaceutical bioprospectors. At the same time, indigenous peoples necessarily utilize enormous numbers of plants, fungi, and fish, particularly for foods and medicines. This book gathers together a wide range of contributions addressing diverse aspects of front-line human involvement in biodiversity exploitation and conservation. Its scope is broad, the organisms explored ranging from birds, invertebrates and mammals – both terrestrial and aquatic – to crops and medicinal plants. Meanwhile, the issues addressed include land use changes, the importance of gardens, hedges and green lanes, housing developments, hunting, invasive species, local community involvement, sacred groves, socioeconomic factors and trade.
Human Ear Recognition by Computer
Human Ear Recognition by Computer is the first book on the automatic recognition of human ears. It presents an entire range of computational algorithms for recognition of humans by their ears. These algorithms have been tested and validated on the largest databases that are available today,This state-of-the-art research reference explores all aspects of 3D ear recognition, including representation, detection, recognition, indexing and performance prediction. It has been written for a professional audience of both researchers and practitioners within industry, and is also ideal as an informative text for graduate students in computer science and engineering.
Human antibody therapeutics for viral disease
The articles in this volume are definitive and comprehensive reviews written by experts who have sought to define the principles of viral neutralization by human antibodies. They explore and anticipate the obstacles and opportunities that will be encountered as the power of human antibodies is harnessed to address the vast, un-met need for effective anti-viral therapeutics.
How to engineer software : A model-based approach
The book promotes development scalability through domain partitioning and subdomain partitioning. It also explores software documentation that specifically and intentionally adds value for development and maintenance. Contains many illustrative examples of model-based software engineering, from semantic model all the way to executable code Explains how to derive verification (acceptance) test cases from a semantic model Describes project estimation, along with alternative software development and maintenance processes Shows how to develop and maintain cost-effective software that solves real-world problems
Housing Estates in the Baltic Countries : The Legacy of Central Planning in Estonia, Latvia and Lithuania
This book focuses on the formation and later socio-spatial trajectories of large housing estates in the Baltic countries—Estonia, Latvia, and Lithuania. It also explores claims that a distinctly “westward-looking orientation” in their design produced housing estates that were superior in design to those produced elsewhere in the Soviet Union. The first two parts of the book provide contextual material to help readers understand the vision behind housing estates in Estonia, Latvia, and Lithuania. These sections present the background of housing estates in the Baltic Republics as well as challenges and debates concerning their formation, evolution, and present condition and importance.
Housing Estates in Europe : Poverty, Ethnic Segregation and Policy Challenges
Explores the formation and socio-spatial trajectories of large housing estates in Europe. Are these estates clustered or scattered? Which social groups originally had access to residential space in housing estates? What is the size, scale and geography of housing estates, their architectural and built environment composition, services and neighbourhood amenities, and metropolitan connectivity? How do housing estates contribute to the urban mosaic of neighborhoods by ethnic and socio-economic status? What types of policies and planning initiatives have been implemented in order to prevent the social downgrading of housing estates?The collection of chapters in this book addresses these questions from a new perspective previously unexplored in scholarly literature. The social aspects of housing estates are thoroughly investigated (including socio-demographic and economic characteristics of current and past inhabitants; ethnicity and segregation patterns; population dynamics; etc.), and the physical composition of housing estates is described in significant detail (including building materials; building form; architectural and landscape design; built environment characteristics; etc.).
Homology modeling : Methods and protocols
It Provides state-of-the-art methodologies and reviews of important topics in the field of homology modeling. From homology modeling in the twilight zone and improving accuracy through sequence space analysis to approaches to construct multi-protein complex models, the book explores a wide variety of uses and applications of this valuable technique.
Holonic and multi-agent systems for manufacturing ; 2nd International conference on industrial applications of holonic and multi-agent systems, HoloMAS 2005, Copenhagen, Denmark, August 22-24, 2005, Proceedings
The challenge faced in today’s manufacturing and business environments is the question of how to satisfy increasingly stringent customer requirements while managing growing system complexity. For example, customers expect high-quality, customizable, low-cost products that can be delivered quickly. The systems that deliver these expectations are by nature distributed, concurrent, and stochastic, and, as a result, increasingly difficult to manage. Unfortunately, the traditional hierarchical, strictly centralized approach to control used in these domains is characteristically inflexible, fragile, and difficult to maintain. These shortcomings have led to the development of a new class of manufacturing and supply-chain decision-making approaches in recent years. Solutions based on these approaches usually explore a set of highly distributed decision-making units that are capable of autonomous operations while cooperating interactively to resolve larger problems. The units, referred to as agents in classical computer science and software engineering, or holons if physically integrated with the manufacturing hardware, interact by exchanging information. These units are motivated by arriving at local solutions as well as collaborating and sharing resources and goals in solving the overall problem in question collectively.
History of Science, History of Text
This book explores the hypothesis that the types of inscription or text used by a given community of practitioners are designed in the very same process as the one producing concepts and results. The book sets out to show how, in exactly the same way as for the other outcomes of scientific activity, all kinds of factors, cognitive as well as cultural, technological, social or institutional, conjoin in shaping the various types of writings and texts used by the practitioners of the sciences. To make this point, the book opts for a genuinely multicultural approach to the texts produced in the context of practices of knowledge
High-Resolution Approaches in Stratigraphic Paleontology
This volume delves into a spectrum of theoretical as well as applied aspects of high-resolution stratigraphic approaches in paleontology. It explores how increasingly detailed knowledge of the fossil record can enhance our understanding of the evolution of life on Earth and also allows geoscientists to address a broad range of important evolutionary and environmental questions in this arena.
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
Heterologous protein production in CHO cells : Methods and protocols
Explores the use of Chinese hamster ovary (CHO) cells in the production of therapeutic protein products. Beyond updates on earlier methodologies, the book also delves into the genetic manipulation of CHO cells for recombinant protein production, analysis of CHO cells using proteomic and metabolomic approaches, as well as methods for the characterization of recombinant protein products, such as glycosylation and host cell protein analysis.
Herbal pharmacopeia : Nanotechnology and advancing drug
Explores the intersection between traditional herbal medicine and cutting-edge nanotechnology. The chapters introduce modern techniques used in herbal extraction and analysis. The principles of drug discovery from plants are discussed, with a focus on the identification and development of bioactive compounds that have therapeutic potential. It discusses the pharmacological properties, biotechnological approaches in drug development, and challenges in the formulation and standardization of herbal medicines. Emerging trends and applications of nanotechnology in herbal pharmacotherapy, such as nanoparticle synthesis, enhanced bioavailability using nanocarriers, safety assessments, novel and targeted delivery systems, and regulatory considerations, are thoroughly discussed. Additionally, it includes a comparative analysis of traditional and nano-formulated approaches and their implementation in clinical settings. Towards the end, the book reviews the regulatory considerations for herbal products and future perspectives in herbal pharmacopeia. This book is intended for researchers, clinicians, and professionals in herbal medicine, pharmacology, and nanotechnology.
Herbal bioactive-based drug delivery systems ; 1st ed.
Provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.
Hepatitis C virus-host interactions and therapeutics : Current insights and future perspectives
The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still strive to understand virus-host interactions to map the disease’s progression along with extrahepatic manifestations and virus invasion strategies impacting the host’s immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management.
Heat transfer : Evolution, design and performance
Covers thermodynamics principles and establishes performance and evolution as fundamental concepts in thermal sciences Demonstrates how principles of physics predict a future with economies of scale, multi-scale design, vascularization, and hierarchical distribution of many small features Explores new work on conduction architecture, convection with nanofluids, boiling and condensation on designed surfaces, and resonance of natural circulation in enclosures
Healthy Minds in the Twentieth Century : In and Beyond the Asylum
This book contributes a new dimension to the study of mental health and psychiatry in the twentieth century. It takes the present literature beyond the ‘asylum and after’ paradigm to explore the multitude of spaces that have been permeated by concerns about mental well-being and illness.
