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Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontology Management : Semantic Web, Semantic Web Services, and Business Applications
This volume describes relevant tasks, practical and theoretical challenges, limitations and methodologies, plus available software tools. The editors discuss integrating the conceptual and technical dimensions with a business view on using ontologies, by stressing the cost dimension of ontology engineering and by providing guidance on how up-to-date tooling helps to build, maintain, and use ontologies. Also included is a one-stop reference on all aspects of managing ontological data and best practices on ontology management for a number of application domains.
On the Uniqueness of Humankind
Europäische Akademie organized the conference "The Uniqueness of Humankind – Über die Sonderstellung des Menschen". The proceedings of the conference documented in this volume approached the theoretical and practical concept of the "Sonderstellung" against the background of present day knowledge in biosciences.
On Line Citizenship : Emerging Technologies for European Cities
The book presents e-government issues from an institutional as well as a practical point of view through the contributions of distinguished authors representative of the European Union, the European network of cities (Telecities) and the Italian Government. On Line Citizenship offers an innovative approach in the analysis of technology's evolutionary paths in e-government through a comparison with e-business trends.
Odell's clinical problem solving in dentistry
Explores care planning and treatment alternatives and evaluates their advantages and disadvantages as well as medico-legal implications Integrates material from all the dental disciplines in order to cover an extensive range of clinical problems which will be encountered in daily practice A practical approach to learning - includes a large number of real-life clinical cases including those relevant to new techniques and issues such as implantology, use of CAD-CAM, CBCT (cone beam computed tomography) Designed to help the reader use the knowledge gained in a clinically useful, practically applied format Highly visual guide with more than 350 colour illustrations, artwork and tables presenting clinical, diagnostic and practical information in an easy-to-follow structure
Oculoplastics and Orbit
This book have been provided throughout each chapter. evidence-based medicine into clinical practice.It is reasonable to now update our With the start of the second cycle of subspecialty readers with what has been achieved. coverage, the dissemination of practical inform- a Te immediate goal was to transfer inform- a tion will be continued as we learn more about tion through a high quality quarterly publication the emerging advances in various ophthalmic in which ophthalmology would be represented by subspecialties that can be applied to obtain the eight subspecialties.
Ocular Traumatology
All aspects of ophthalmic trauma from the lid to the optic nerve of both mechanical and nonmechanical trauma are covered in this unique book. The focus is on practical issues and incorporates cutting-edge approaches, such as temporary keratosprosthesis, artificial iris diaphragm, and prophylactic retinectomy. This book explains and answers not simply the “when”, the “what”, and the “how”, but also the “why” questions. The information is based on epidemiologic and clinical data from evaluation to management.
Ocean Waves Breaking and Marine Aerosol Fluxes
This book presents a comprehensive study on the breaking of surface waves induced by wind and the relationship of breaking rate with marine aerosol fluxes. The book draws attention to the theoretical and experimental achievements in the study of wave breaking phenomena in deep water seas. In particular, it deals with the important problems of energy dissipation and the estimation of energy loss due to wave breaking in deep waters. The rationale behind existing methods and practical outcomes for the estimation of whitecap coverage of the sea surface and energy dissipation rate are given in detail.The book also focuses on the fundamentals of marine aerosols and their generation. The text provides a comprehensive overview of the currently available experimental data on marine aerosol fluxes and presents theoretical methodology of the estimation of the intensity of sea aerosol production. The systematic analysis leads to a novel approach in the development of links between aerosol production with sea state parameters and its seasonal variation in deep water seas.
Ocean Wave Energy : Current Status and Future Prespectives
The authors of this reference provide an updated and global view on ocean wave energy conversion for wave energy developers as well as for students and professors. The book is orientated to the practical solutions that this new industry has found so far and the problems that any device needs to face. It describes the actual principles applied to machines that convert wave power in electricity. Additionally, an historical review, state of the art of modern systems, a full scale prototype experience, and future perspectives are given.
Occlusal splints for painful craniomandibular dysfunction
Bridges that gap, presenting a practical guide for the treatment of craniomandibular dysfunction (CMD)—a functional disorder that affects the muscles of mastication, temporomandibular joints, and/or occlusion—in patients with related pain. The first half of the book provides detailed but simple clinical instructions and examples of occlusal splint therapy, including splint fabrication and coordinative training for painful CMD, based entirely on a high level of evidence. The second half delves deeper into the etiology, advanced diagnostic techniques, neurobiology, and pathophysiology of painful CMD and splint therapy.
Obstetrics in Family Medicine : A Practical Guide
The key points for each topic are summarized in tabular form for quick reference, and diagnostic flow charts illuminate all aspects of the decision-making process. Expert advice based on years of experience is also presented concerning physical and ultrasound examinations, laboratory tests, drug toxicities, and screening techniques.
Obstetric Anesthesia Handbook
As the field of obstetric anesthesia continues to change rapidly, both in technique and in specific pharmaceutical agents used, it is essential for all practitioners caring for the pregnant patient to be familiar with current anesthetic protocols and general concepts in obstetric anesthesia. The Handbook appeals to a wide audience, as it was written with the practicing anesthesiologists in mind, as well as nurse anesthetists, obstetricians, housestaff, and residents. The Obstetric Anesthesia Handbook supplies expert advice on every facet of anesthesia for childbirth and related obstetric procedures. The text is authoritative, succinct, and highly practical. It is accompanied by over 100 illustrations and tables making the text a convenient reference to the busy practitioner.
Objects, Components, Models and Patterns ; 46th International Conference, TOOLS EUROPE 2008, Zurich, Switzerland, June 30 - July 4, 2008. Proceedings
This book constitutes the thoroughly refereed proceedings of the 46th International Conference on Objects, Components, Models and Patterns, TOOLS EUROPE 2008, held in Zurich, Switzerland, in June/July 2008.TOOLS played a major role in the spread of object-oriented and component technologies. It has now broadened its scope beyond the original topics of object technology and component-based development to encompass all modern, practical approaches to software development.
Object-Oriented Software Engineering Using UML Patterns and Java
Shows students how to use both the principles of software engineering and the practices of various object-oriented tools, processes, and products. Using a step-by-step case study to illustrate the concepts and topics in each chapter, Bruegge and Dutoit emphasize learning object-oriented software engineer through practical experience: students can apply the techniques learned in class by implementing a real-world software project. The third edition addresses new trends, in particular agile project management (Chapter 14 Project Management) and agile methodologies (Chapter 16 Methodologies).
Object-oriented metrics in practice : Using software metrics to characterize, Evaluate, and Improve the design of object-oriented systems
The combination of theoretically sound results and practically tested procedures and solution paths makes this book an ideal companion for professional software architects, developers and quality engineers. The pattern-oriented description of disharmonies offers easy access to detecting shortcomings and applying solution strategies. "This well-written book is an important piece of work that takes the seemingly forgotten art of object-oriented metrics to the next level in terms of relevance and usefulness."
Objective information theory
Objective Information Theory (OIT) is proposed to represent and compute the information in a large-scale complex information system with big data in this monograph. To formally analyze, design, develop, and evaluate the information, OIT interprets the information from essential nature, measures the information from mathematical properties, and models the information from concept, logic, and physic. As the exemplified applications, Air Traffic Control System (ATCS) and Smart Court SoSs (System of Systems) are introduced for practical OITs.
Nutrition and Gastrointestinal Disease
Nutritional support of people with gastrointestinal impairment is critical to treatment and ultimately successful management. As such, gastroenterologists should be experts in nutrition and knowledgeable about the affects of nutrition on disease management. Nutritional and Gastrointestinal Disease fulfills that need, serving as a hands-on, practical reference in nutrition support for the clinical gastroenterologist and other clinicians with similar interests. The volume offers expert nutritional knowledge and management ideas as well as methodology for combating problems such as short bowel syndrome, inflammatory bowel disease, celiac disease and obesity. Renowned authorities also investigate nutrition’s influence on such issues as liver failure and acute pancreatitis. While gastroenterology training programs around the world remain deficient in their nutrition curriculum, Nutritional and Gastrointestinal Disease provides a comprehensive and groundbreaking support for clinical gastroenterologists.
Numerical partial differential equations for environmental scientists and engineers : A first practical course
This book concerns the practical solution of Partial Differential Equations (PDEs). It reflects an interdisciplinary approach to problems occurring in natural environmental media: the hydrosphere, atmosphere, cryosphere, lithosphere, biosphere and ionosphere. It assumes the reader has gained some intuitive knowledge of PDE solution properties and now wants to solve some for real, in the context of practical problems arising in real situations. The practical aspect of this book is the infused focus on computation. It presents two major discretization methods - Finite Difference and Finite Element. The blend of theory, analysis, and implementation practicality supports solving and understanding complicated problems. It is divided into three parts. Part I is an overview of Finite Difference Methods. Part II focuses on Finite Element Methods, including an FEM tutorial. Part III deals with Inverse Methods, introducing formal approaches to practical problems which are ill-posed.
Numerical Optimization : Theoretical and Practical Aspects
This book starts with illustrations of the ubiquitous character of optimization, and describes numerical algorithms in a tutorial way. It covers fundamental algorithms as well as more specialized and advanced topics for unconstrained and constrained problems. Most of the algorithms are explained in a detailed manner, allowing straightforward implementation. Theoretical aspects of the approaches chosen are also addressed with care, often using minimal assumptions. It's contains computational exercises in the form of case studies which help understanding optimization methods beyond their theoretical, description, when coming to actual implementation. Besides, the nonsmooth optimization part has been substantially reorganized and expanded.
Numerical Optimization
Numerical Optimization presents a comprehensive and up-to-date description of the most effective methods in continuous optimization. It responds to the growing interest in optimization in engineering, science, and business by focusing on the methods that are best suited to practical problems.The book has been thoroughly updated throughout. There are new chapters on nonlinear interior methods and derivative-free methods for optimization, both of which are used widely in practice and the focus of much current research. Because of the emphasis on practical methods, as well as the extensive illustrations and exercises.
