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الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Nuclear Import and Export in Plants and Animals
Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Nuclear fusion research : Understanding plasma-Surface interactions
It became clear in the early days of fusion research that the effects of the containment vessel (erosion of "impurities") degrade the overall fusion plasma performance. Progress in controlled nuclear fusion research over the last decade has led to magnetically confined plasmas that, in turn, are sufficiently powerful to damage the vessel structures over its lifetime. This book reviews current understanding and concepts to deal with this remaining critical design issue for fusion reactors. It reviews both progress and open questions, largely in terms of available and sought-after plasma-surface interaction data and atomic/molecular data related to these "plasma edge" issues.
NSTAR 2007 ; Proceedings of The 11th Workshop on The Physics of Excited Nucleons, 5–8 September 2007, Bonn, Germany
The excitation spectrum of the nucleon offers insights into the non-perturbative regime of QCD. The NStar workshops are a series of meetings that bring together experimenters and theoreticians working on baryon resonances and related areas. This work covers the proceedings that constitute an archival record of the progress in the field.
Novel Trends in Brain Science : Brain Imaging, Learning and Memory, Stress and Fear, and Pain
With the development of neural science, knowledge of the molecules and neurons that comprise the brain has increased exponentially in the past two decades. In Novel Trends in Brain Science, leading neuroscientists from Japan and Taiwan describe the latest and most relevant research in brain science, including state-of-the-art brain-imaging technologies such as fMRI, MR-DTI, TMS, and MEG, and also discuss learning, memory, emotions, and pain. With a wide range of contributors, the book presents valuable insights into functional neuroimaging, white matter tractography, synaptic plasticity, emoti.
Nonlinear Waves : Classical and Quantum Aspects
Leading scientists discuss the most recent physical and experimental results in the physics of Bose-Einstein condensate theory, the theory of nonlinear lattices (including quantum and nonlinear lattices), and nonlinear optics and photonics. Classical and quantum aspects of the dynamics of nonlinear waves are considered. The contributions focus on the Gross-Pitaevskii equation and on the quantum nonlinear Schrödinger equation. Recent experimental results on atomic condensates and hydrogen bonded systems are reviewed. Particular attention is given to nonlinear matter waves in periodic potential.
Non-Linear Optical Properties of Matte : From molecules to condensed phases
Non-Linear Optical Properties of Matter: From Molecules to Condensed Phases attempts to draw together both theory and application in this field. As such it will be of interest to both experimentalists and theoreticians alike. Divided into two parts, Part 1 is concerned with the theory and computing of non-linear optical (NLO) properties while Part 2 reviews the latest developments in experimentation.This book will be invaluable to researchers and students in academia and industry. It will be of particular interest to anyone involved in materials science, theoretical and computational chemistry, chemical physics, and molecular physics.
Non-Linear Dynamics and Fundamental Interactions
This volume contains the papers presented at the NATO Advanced Research Institute on "Non-Linear Dynamics and Fundamental Interactions" held in Tashkent, Uzbekistan, from Oct.10-16,2004. The main objective of the Workshop was to bring together people working in areas of Fundamental physics relating to Quantum Field Theory, Finite Temperature Field theory and their applications to problems in particle physics, phase transitions and overlap regions with the areas of Quantum Chaos. The other important area is related to aspects of Non-Linear Dynamics which has been considered with the topic of chaology. The applications of such techniques are to mesoscopic systems, nanostructures, quantum information, particle physics and cosmology. All this forms a very rich area to review critically and then find aspects that still need careful consideration with possible new developments to find appropriate solutions.
Non-Covalent Multi-Porphyrin Assemblies : Synthesis and Properties
This book presents an overview of the synthesis, structure, and properties of molecules obtained by connecting several porphyrins or metalloporphyrins through a variety of chemical linkages. This handsomely produced book gives the reader a broad introduction to this popular and important field. Much of the work encompassed in this area is inspired by the desire to obtain photochemically responsive molecules capable of mimicking various aspects of photosynthesis… As with many edited volumes of this type, there is a certain amount of duplicate coverage of some topics. Also the focus is largely on the methods used to generate the multiporphyrin arrays, and in some cases less attention is given to the properties, other than the structural properties of these arrays.
NMR-MRI, µSR and Mössbauer Spectroscopies in Molecular Magnets and magnetic nanoparticles
In this book an extensive overview on the results obtained during the last decade and on recent achievements in the study of molecular magnets by means of Nuclear Magnetic Resonance, Muon Spin Rotation, Magnetic Resonance Imaging and Mossbauer techniques is presented. The aim is to introduce the reader to these techniques and to give a general background on their application to molecular spin systems.
NMR in Biological Systems : From Molecules to Human
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.
Nitric oxide in plants : A molecule with dual roles
Studies have identified the central role of nitric oxide in stress mitigation through the modulation of physiological and biochemical pathways including germination, photosynthesis regulation, and programmed cell death. Nitric Oxide in Plants: A Molecule with Dual Roles provides a detailed account of the physio-biochemical, molecular, and omic basis of NO-mediated responses in crop plants under different stresses.
New Frontiers in Polymer Synthesis
It is generally accepted that a new material is often developed by ?nding a new synthesis method of reaction or a new reaction catalyst. Historically, a typical example may be referred to as a Ziegler–Natta catalyst, which has allowed large-scale production of petroleum-based polyole?ns since the middle of the 20th century. New polymer synthesis, therefore, will hopefully lead to creation of new polymer materials in the 21st century. This special issue contributed by three groups focuses on recent advances in polymer synthesis methods, which handle the cutting-edge aspects of the advanced technology.
New Aspects in Phosphorus Chemistry V
The use of polyphosphazenes as fluoroelastomers, flame retardants and self-extinguishing macromolecules, polymeric ionic conductors, biomaterials, and photosensitive polymeric compounds is outlined. This volume,as well as the four precedent volumes,describes only in part the huge number of original papers on phosphorus-related topics. Some further volumes will be necessary in the future to cover all aspects of this chemistry in perpetual rebirth.
Neutron Spin Echo in Polymer Systems
Neutron spin echo spectroscopy (NSE) provides the unique opportunity to unravel the molecular dynamics of polymer chains in space and time, covering most of the relevant length and time scales. This article reviews in a comprehensive form recent advances in the application of NSE to problems in polymer physics and describes in terms of examples expected future trends. The review commences with a description of NSE covering both the generic longitudinal field set-up as well as the resonance technique. Then, NSE results for homopolymers chains are presented, covering all length scales from the very local secondary J3-relaxation to large scale reptation. This overview is the core of the review. Thereafter the dynamics of more complex systems is addressed. Starting from polymer blends, diblock copolymers, gels, micelles, stars and dendrirners, rubbery electrolytes and biological macromolecules are discussed. Wherever possible the review relates the NSE findings to the results of other techniques, in particular emphasizing computer simulations.
Neutron Scattering in Biology : Techniques and Applications
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
Neuroanatomical Tract-Tracing : Molecules, Neurons, and Systems
"The content of the book also serves to emphasize that neuroanatomy is, perhaps more than ever, a thriving and important part of the neurosciences...Most contributions have in common the combination of modern tract-tracing methods with other means of characterizing neural tissue, and thus the book also serves to highlight the gradual disappearance of borders between traditional neuroanatomy and other approaches to the study of the nervous system...this book should continue to be a useful source of information, and deserves to be available in all laboratories applying or considering to apply neuroanatomical methods."
Natures Versatile Engine : Insect Flight Muscle Inside and Out
Integrates knowledge from various disciplines that study muscle function, from single molecule biophysics to flight aerodynamics. This work features information on advances in muscle research, from the molecular to the organismal. It focuses on Drosophila melanogaster, and other species of flying insects are also covered.
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Natural Product Synthesis II : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
