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الصفحة 1
U.S. Pharmacopeia National Formulary 2018 USP 41 NF 36
Contains standards for medicines, dosage forms, drug substances, excipients, biologics, compounded preparations, medical devices, dietary supplements, and other therapeutics. Offers convenient, comprehensive information for all phases of producing quality prescription, nonprescription, and compounded medicines; excipients; biologics; medical devices; and dietary supplements. It is essential for quality control, quality assurance, regulatory/compendial affairs, research and development, method development/analytical services, and corporate management. USP–NF monographs and methods can help to: Ensure compliance with required U.S. quality standards / Work to world-recognized standards of precision and accuracy / Validate test results against proven benchmarks / Establish and validate in-house standard operating procedures, and specifications / Expedite new product development and approvals
The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes
World Health Organization data documents that infectious diseases and immunodeficiencies are the leading causes of morbidity and mortality in the world's children. In The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes, an authoritative, international panel of experts provide a succinct, up-to-date, evidence-based reference to the neurological consequences of infectious diseases and immunodeficiency syndromes in children in one readily accessible volume. Within each of its conveniently structured chapters, readers will find a general description of the disease or disorder, its epidemiology, etiology, clinical synopsis, neurological manifestations, diagnosis, differential diagnosis and therapy.
The Genetics and Molecular Biology of Neural Tumors
Collecting an extensive amount of information from thousands of publications by leading investigators in this rapidly developing field, The Genetics and Molecular Biology of Neural Tumors provides a convenient and up-to-date one volume source for research in neural tumors of various cellular origins. Each chapter, with a comprehensive list of references and many informative tables, contains clinical and epidemiologic information, as well as succinct but relevant patho-histologic and immunohistochemical descriptions facilitating the interpretation of the findings on tumor genetics and molecular biology. With over 3,500 references, 110 figures and 120 tables, this volume gathers an astonishing body of knowledge regarding human neural tumors.
The Four Pillars of Geometry
The Four Pillars of Geometry approaches geometry in four different ways, spending two chapters on each. This makes the subject accessible to readers of all mathematical tastes, from the visual to the algebraic. Not only does each approach offer a different view; the combination of viewpoints yields insights not available in most books at this level. For example, it is shown how algebra emerges from projective geometry, and how the hyperbolic plane emerges from the real projective line.The author begins with Euclid-style construction and axiomatics, then proceeds to linear algebra when it becomes convenient to replace tortuous arguments with simple calculations. Next, he uses projective geometry to explain why objects look the way they do, as well as to explain why geometry is entangled with algebra. And lastly, the author introduces transformation groups---not only to clarify the differences between geometries, but also to exhibit geometries that are unexpectedly the same.
The Evaluation of Surrogate Endpoints
Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the "true" endpoints of primary interest.This book offers a balanced account on this controversial topic. The text presents major developments of the last couple of decades, together with a unified, meta-analytic framework within which surrogates can be evaluated from several angles. Methodological development is coupled with perspectives on various therapeutic areas. Academic views are juxtaposed with standpoints of scientists working in the biopharmaceutical industry as well as of colleagues from the regulatory authorities.
The Concise Encyclopedia of Statistics
Presents the essential information about statistical tests, concepts, and analytical methods in language that is accessible to practitioners and students of the vast community using statistics in medicine, engineering, physical science, life science, social science, and business/economics. The reference is alphabetically arranged to provide quick access to the fundamental tools of statistical methodology and biographies of famous statisticians. The more than 500 entries include definitions, history, mathematical details, limitations, examples, references, and further readings. All entries include cross-references as well as the key citations. The back matter includes a timeline of statistical inventions. This reference will be an enduring resource for locating convenient overviews about this essential field of study.
Taylors Musculoskeletal Problems and Injuries : A Handbook
An essential guide to diagnosing and managing musculoskeletal problems and injuries in the primary care setting. Derived from Dr. Robert B. Taylor's widely acclaimed Family Medicine: Principles and Practice, Sixth Edition, this convenient, pocket-sized book examines problems of the skeleton and related muscles and joints. Expert contributors provide essential information on musculoskeletal injuries and illnesses geared to the needs of the busy clinician. In addition to common problems such as sprains, strains, and fractures, chapters also cover athletic injuries, arthritis, fibromyalgia, and complex regional pain syndrome. This handy reference is an ideal tool for family physicians and others who provide primary care.
Taylors Diagnostic and Therapeutic Challenges : A Handbook
With a clinician’s experienced eye, Robert B. Taylor, MD, has carefully chosen chapters from his widely trusted reference, Family Medicine: Principles and Practice, Sixth Edition, that focus on selected problems that clinicians often find a challenge to diagnose or treat. Respected contributors share their wisdom and provide readers with a sense of direction as they consider care options. Chapters address the diagnosis of a variety of difficult diseases and disorders, such as diabetes mellitus, fatigue, and chronic pain. The etiology of conditions is also highlighted to help physicians select the most effective therapeutic courses of treatment. Management strategies for complicated problems, such as alcoholism and obesity, are examined as well. By covering some of medicine’s most challenging clinical problems, this pocket-sized handbook is a convenient timesaving source. The text is invaluable for family physicians and other clinicians who provide primary care, including general internists, general pediatricians, nurse practitioners, and physician assistants.
Taylors Cardiovascular Diseases : A Handbook
Addresses the intricacies of providing cardiovascular care and consists of selected chapters from Family Medicine: Principles and Practice, Sixth Edition, the critically acclaimed and widely used reference for family physicians edited by Robert B. Taylor, MD. Internationally recognized contributors examine how to provide high-quality, ongoing care for common cardiovascular problems based on current evidence and time-tested methods in clinical practice. Chapters cover diseases of the heart and blood vessels that primary care physicians often find difficult to diagnose or treat, such as hypertension, ischemic heart disease, dyslipidemia, and venous thromboembolism. Other topics include cerebrovascular disease, cardiovascular emergencies, and medical care of the surgical patient. With a convenient, pocket-sized trim, this book is an indispensable resource for family physicians and others who provide primary care.
Source Book of Models for Biomedical Research
The collection of systems represented in the Sourcebook of Models for Biomedical Research reflect the diversity and utility of models that are used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. Some models have the advantage that the reproductive, mitotic, development or aging cycles are rapid compared with those in humans; others are utilized because individual proteins may be studied in an advantageous way and have human homologs. Other organisms are facile to grow in laboratory settings, lend themselves to convenient analyses, have defined genomes or present especially good human models of human or animal disease. The Sourcebook of Models for Biomedical Research is a comprehensive and extensive collection of these important medical parallels.
Site Investigation in Construction ; Part 3 : Specification for Ground Investigation
Includes associated Schedules and a Bill of Quantities, and is intended for general application to ground investigation work. The Bill of Quantities is presented as a preamble and a comprehensive list of work items, which conveniently cross-relate to the Specification items. This Specification may be used in conjunction with any suitable contractual agreement between the procurer and ground investigation contractor. The involvement of a Geotechnical Adviser of Geotechnical Specialist is considered essential in the planning, procurement and supervision of ground investigation work.
Radicals in Synthesis I : Methods and Mechanisms
Topics in Current Chemistry series highlights the importance of this rapidly growing area. The first volume, reviewed here, deals with development of new methods and the physical organic underpinnings of radical methodology, while the second volume addresses the applications of these methods in complex molecule synthesis. Although such a division is totally arbitrary, it provides a convenient platform to categorize this otherwise diverse area. ...A highly readable account of the generation and applications of alkene radical cations by heterolysis of ß-substituted radicals. The authors provide a detailed account of the methods of generation, kinetic and mechanistic aspects, and the eventual fate of these intermediates generated from diverse sources.
Physical Therapy of Cerebral Palsy
The book is conveniently divided into two sections. The first focuses on fundamental aspects of cerebral palsy management, from understanding motor impairment to evaluating equipment use. The second section presents specific rehabilitation techniques, including neurodevelopment therapy, hippotherapy, and assistive devices. A wealth of tables, algorithms and detailed illustrations helps the reader with the decision-making process for determining what treatment would be most beneficial.
Phase Transitions in Cell Biology
Phase transitions occur throughout nature. So "convenient" a feature is seen throughout the domains of physics and chemistry, and one is therefore led to wonder whether it might also be common to biology. Indeed, many of the most fundamental cellular processes are arguably attributable to radical structural shifts triggered by subtle changes that cross a critical threshold. These processes include transport, motion, signaling, division, and other fundamental aspects of cellular function.Largely on the basis of this radical concept, a symposium was organized in Poitiers, France, to bring together people who have additional evidence for the role of phase transitions in biology, and this book is a compendium of some of the more far-reaching of those presentations, as well as several others that seemed to the editors to be compelling.The book should be suitable for anyone interested in the nature of biological function, particularly those who tire of lumbering along well trodden pathways of pursuit, and are eager to hear something fresh. The book is replete with fresh interpretations of familiar phenomena, and should serve as an excellent gateway to deeper understanding.
Operations research : An introduction ; 8th ed.
Provides a broad focus on algorithmic and practical implementation of Operations Research (OR) techniques, using theory, applications, and computations to teach students OR basics. The book can be used conveniently in a survey course that encompasses all the major tools of operations research, or in two separate courses on deterministic and probabilistic decision-making.
Obstetric Anesthesia Handbook
As the field of obstetric anesthesia continues to change rapidly, both in technique and in specific pharmaceutical agents used, it is essential for all practitioners caring for the pregnant patient to be familiar with current anesthetic protocols and general concepts in obstetric anesthesia. The Handbook appeals to a wide audience, as it was written with the practicing anesthesiologists in mind, as well as nurse anesthetists, obstetricians, housestaff, and residents. The Obstetric Anesthesia Handbook supplies expert advice on every facet of anesthesia for childbirth and related obstetric procedures. The text is authoritative, succinct, and highly practical. It is accompanied by over 100 illustrations and tables making the text a convenient reference to the busy practitioner.
Nonparametric Monte Carlo Tests and Their Applications
A fundamental issue in statistical analysis is testing the fit of a particular probability model to a set of observed data. Monte Carlo approximation to the null distribution of the test provides a convenient and powerful means of testing model fit. Nonparametric Monte Carlo Tests and Their Applications proposes a new Monte Carlo-based methodology to construct this type of approximation Every chapter of the book includes algorithms, simulations, and theoretical deductions. The prerequisites for a full appreciation of the book are a modest knowledge of mathematical statistics and limit theorems in probability,empirical process theory.
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.
Multiple Abstraction Hierachies for Mobile Robot Operation in Large Environments
This book focuses on the efficient performance of mobile robots through the use of multi-hierarchical symbolic representations of the environment. A mobile robot intended to perform deliberative actions must possess some symbolic representation of its workspace, but such representations of real environments usually become so large that should be conveniently arranged in order to facilitate and, in some cases, make possible their use. This book addresses all these issues considering symbolic multi-hierarchical structures. Such structures, based on the concept of abstraction, allow a robot to speed up its operation in large environments. Practical solutions tested on real robots (for instance, a robotic wheelchair for elder people) are provided.
Metagraphs and Their Applications
The graph is a critical and useful concept in designing many information processing systems. Systems such as transaction processing systems, decision support systems, and workflow systems are all helped immensely by a graphical structure. Simple graphs and digraphs allow for the construction of a variety of system design tools that provide a convenient and appealing format for illustrating information infrastructures, while allowing any subsequent analyses to be performed by the user. However, the metagraph, a new graphical structure that is developed in this book, goes beyond the representational and provides Information Systems with a robust, analytical modeling graphic tool.
