الصفحة 1
الصفحة 1
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Omega-3 fatty acids : Keys to nutritional health
Argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health.
Object-Oriented Technology. ECOOP 2007 Workshop Reader ; ECOOP 2007 Workshops, Berlin, Germany, July 30-31, 2007, Final Reports
Contains the reports from the workshopsheld at the 21st European Conference on Object-Oriented Programming - ECOOP 2007 - at Technische Universit] at Berlin. Nineteen workshops were heldin the courseofthis conference on July 30 and July 31, 2007, covering a large spectrum of hot research topics. As in previous editions of ECOOP, numerous scientists from academia and industry took the chance to present innovative and topical ideas in an environment ofering optimal conditions for exciting discussions and fruitful interactions. The Workshop Reader which contains the reports from the workshops has been a substantial part of the ECOOP conference for more than10 years
Nutrition, diet and healthy aging
Over the last 100 years, the numerous advances in science, the improved sanitary conditions and a decline in poverty have led to an increase in life expectancy. As a result, in the coming years, the number of over-65s will triple, and the over-80s will be the fastest growing portion of the population. However, an increased lifespan is associated with an increase in chronic diseases, such as cardiovascular disease, diabetes, cancer, sarcopenia, and degenerative disorders. Therefore, ideally, increased lifespan should be associated to a better healthspan, which is the period one individual is living in good health
Nutrition and Rheumatic Disease
It is difficult, if not impossible, for health care providers to remain at the forefront of knowledge for all aspects of nutrition and rheumatic diseases. In Nutrition and Rheumatic Disease, experts provide a comprehensive review of current knowledge regarding nutrition and dietary management for the complex set of rheumatic conditions. Within the disease-specific chapters, the authors present a historical perspective, a discussion of the major clinical features, current management and treatment, a review of the literature related to nutritional status and diet, and dietary recommendations, based on current scientific evidence. The field of rheumatic diseases includes a wide variety of pathologic processes. Adequate reviews of the scientific literature on each of the rheumatic diseases in Nutrition and Rheumatic Disease alleviate the inherent confusion surrounding the risks and benefits of various dietary therapies.
Nutrigenomics and nutraceuticals
Provides an authoritative and comprehensive overview of the field of nutraceuticals and genomics—also called nutrigenomics, a rapidly growing field. It discusses both nutrigenomic and nutrigenetic techniques to investigate the nutritional basis of several health disorders because scientists have found that diet can affect gene expression. The book covers the nutrigenomic tools for the prevention of disease conditions such as cancer, viral infection, microbial infection, COVID-19, HIV/AIDS, tuberculosis, hypertension, neurodegenerative disease, obesity, baldness, and anemia. Some nutrigenomic tools that can also be used for brain health, weight loss, human nutrition, skin care, and maintaining health during pregnancy are also explored.
Numerical Methods and Applications ; 6th International Conference, NMA 2006, Borovets, Bulgaria, August 20-24, 2006, Revised Papers
This book constitutes the thoroughly refereed post-proceedings of the 6th International Conference on Numerical Methods and Applications, NMA 2006. The papers are organized in topical sections on numerical methods for hyperbolic problems, robust preconditioning solution methods, Monte Carlo and quasi-Monte Carlo for diverse applications, metaheuristics for optimization problems, uncertain/control systems and reliable numerics, interpolation and quadrature processes, large-scale computations in environmental modelling, and contributed talks.
Number Theory ; Vol.15 : Tradition and Modernization
This book appears varied, they are unified by two underlying principles:first, making everything readable as a book, and second, making a smooth transition from traditional approaches to modern ones by providing a rich array of examples. The chapters are presented in quite different in depth and cover a variety of descriptive details.The book emphasizes a few common features such as functional equations for various zeta-functions, modular forms, congruence conditions, exponential sums, and algorithmic aspects.
Nuclear Science and Safety in Europe
Recent results on the nature of low-, intermediate- and high-energy nuclear forces as well as on the internal structure of nucleons and atomic nuclei are presented. This book Prospects to find a new state of the nuclear matter at extreme conditions that existed in the early Universe and the utilisation of the nuclear energy are discussed.
Novel drug delivery systems : Fundamentals and applications
Serves as a unique resource on the field of novel drug delivery systems (NDDSs). The evolving nature of diseases and the emergence of new health complications have driven a significant shift in drug therapy. Coupled with changes in human lifestyles and economic conditions, these factors have compelled the pharmaceutical industry to develop novel, efficient, and affordable drug products. The rise of promising technologies aimed at enhancing therapeutic performance further underscores the importance of novel drug delivery systems (NDDSs), making this field one of the most dynamic in pharmaceutical sciences today.
Novel Developments for Sustainable Hydropower
This book presents (selected) new and innovative developments for sustainable and fish-friendly hydropower. It offers unique insights into the challenges, practices and policies of hydropower developments across 8 European countries, providing examples from on-site studies and European-wide analyses. The case studies throughout the book are practical “real-world” examples, which are intended to serve as inspiration for anyone who would like to know more about how solutions for more sustainable hydropower production can be designed and implemented. Hydropower is an important renewable energy source, which, however, can also impact aquatic ecosystems, fish populations and hydro-morphology. EU and national water, environmental and energy legislation strive for sustainable energy and water resource management as well as the protection of important habitats and species. These have an effect on the requirements and decision making processes for hydropower planning, commissioning and operation. With a high variety of measures existing and site-specific conditions as well as national and EU level legal requirements to consider, it can be difficult to determine, what issues to address and which measures to implement.
Notions of Convexity
The first two chapters of this book are devoted to convexity in the classical sense, for functions of one and several real variables respectively. This gives a background for the study in the following chapters of related notions which occur in the theory of linear partial differential equations and complex analysis such as (pluri-)subharmonic functions, pseudoconvex sets, and sets which are convex for supports or singular supports with respect to a differential operator. In addition, the convexity conditions which are relevant for local or global existence of holomorphic differential equations are discussed, leading up to Trépreau’s theorem on sufficiency of condition (capital Greek letter Psi) for microlocal solvability in the analytic category.
Nonlinear Dynamics of Structures Under Extreme Transient Loads
Covers model building for different engineering structures and provides detailed presentations of extreme loading conditions. A number of illustrations are given quantifying; a plane crash or explosion induced impact loading, the effects of strong earthquake motion, and the impact and long-duration effects of strong stormy winds—along with a relevant framework for using modern computational tools. The book considers the levels of reserve in existing structures, and ways of reducing the negative impact of high-risk situations by employing sounder design procedures.
Next generation probiotics from novel drugs to future therapeutics
Provides a comprehensive and cutting-edge exploration of probiotics as powerful therapeutic agents. With the rapid advancements in the field, this book offers a deep dive into how probiotics are evolving beyond traditional uses, addressing complex health conditions and diseases in modern medicine. By combining the latest scientific research with practical applications, this book equips researchers, clinicians, and healthcare professionals with the knowledge needed to incorporate probiotics into clinical practice and future therapeutic strategies.
Newman and Carranza's Clinical Periodontology and Implantology
Provides detailed, up-to-date information on the etiology and pathogenesis of periodontal disease. Basic and advanced evidence-based information on the various treatment modalities employed in periodontics and implantology is presented in an easy-to-read format, with callout boxes throughout the text highlighting the clinical relevance of foundational basic science information. Full-color photos and radiographic images depict periodontal conditions and procedures, and the Atlas of Periodontal Pathology is one of the most comprehensive ever compiled in a periodontal textbook. Written by a team of leading experts led by Michael G. Newman, this text not only demonstrates how to perform periodontal procedures but explains the evidence supporting each treatment and provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud.
New Trends in Optimal Filtering and Control for Polynomial and Time-Delay Systems
0. 1 Introduction Although the general optimal solution of the ?ltering problem for nonlinear state and observation equations confused with white Gaussian noises is given by the Kushner equation for the conditional density of an unobserved state with respect to obser- tions (see [48] or [41], Theorem 6. 5, formula (6. 79) or [70], Subsection 5. 10. 5, formula (5. 10. 23)), there are a very few known examples of nonlinear systems where the Ku- ner equation can be reduced to a ?nite-dimensional closed system of ?ltering eq- tions for a certain number of lower conditional moments.
New product development : An empirical approach to study of the effects of innovation strategy, organization learning and market Conditions
New product development (NPD) is considered as a process of learning. Successful NPD projects typically rely on knowledge and experience of multi-function teams. In addition to corporate strategy and organization learning, the external factors such as, market and competitive conditions also play a big role in driving business strategies.
New perspectives in critical data studies: the ambivalences of data power
Examines the ambivalences of data power. Firstly, the ambivalences between global infrastructures and local invisibilities challenge the grand narrative of the ephemeral nature of a global data infrastructure. They make visible local working and living conditions, and the resources and arrangements required to operate and run them. Secondly, the book examines ambivalences between the state and data justice. It considers data justice in relation to state surveillance and data capitalism, and reflects on the ambivalences between an “entrepreneurial state” and a “welfare state”. Thirdly, the authors discuss ambivalences of everyday practices and collective action, in which civil society groups, communities, and movements try to position the interests of people against the “big players” in the tech industry.
New Directions in Cognitive Information Retrieval
New Directions in Cognitive Information Retrieval presents an exciting new direction for research into cognitive oriented information retrieval (IR) research, a direction based on an analysis of the user’s problem situation and cognitive behavior when using the IR system. This contrasts with the current dominant IR research paradigm which concentrates on improving IR system matching performance. The chapters describe the leading edge concepts and models of cognitive IR that explore the nexus between human cognition, information and the social conditions that drive humans to seek information using IR systems. Chapter topics include: Polyrepresentation, cognitive overlap and the boomerang effect, Multitasking while conducting the search, Knowledge Diagram Visualizations of the topic space to facilitate user assimilation of information, Task, relevance, selection state, knowledge need and knowledge behavior, search training built into the search, children’s collaboration for school projects, and other cognitive perspectives on IR concepts and issues.
Neurosurgery : Principles and Practice
This book provides coverage of a broad range of topics in the ?eld of neurosurgery, 5 for residents and registrars in training and for recent graduates of training programs. 6 As neurosurgical training incorporates expertise from centers worldwide, there is a 7 need to have input from specialists in neurosurgery from various countries. This text 8 is a compilation by expert authors in the USA and the UK to provide information on 9 the basic knowledge and clinical management required for optimal care of neuro- 2011 surgical patients. 1 The text is an up-to-date synopsis of the ?eld of neurosurgery from American and 2 British perspectives, which covers the most common clinical conditions encountered 3 by neurosurgeons. The chapters are organized under broad topics, including inves- 4 tigative studies, perioperative care, the role of newer techniques and the management 5 of tumors, vascular and traumatic lesions. Additional topics are then covered, includ- 6 ing pediatrics, spine and peripheral nerve lesions, as well as functional neurosurgery 7 and infections. We anticipate that trainees will ?nd this information useful for certi?- 8 cation examinations and recent graduates of neurosurgical training programs can 9 utilize this text as an update of the most important neurosurgical topics.
