الصفحة 1
الصفحة 1
Z-DNA : Methods and protocols
Compiles key methods and techniques used to establish some of the structural and functional aspects of Z-form nucleic acids. Beginning with chapters on characterizing Z-DNA, the book continues by exploring structure determination techniques, gene- and genome-targeting methods and genome-wide approaches, Z-RNA study, and much more.
Yerba mate is a natural alternative of ozempic
Yerba mate (Ilex paraguariensis), a traditional South American herbal tea, has gained attention as a potential natural alternative to Ozempic (semaglutide), a pharmaceutical drug used for weight management and type 2 diabetes. Rich in bioactive compounds like caffeine, theobromine, chlorogenic acids, and saponins, yerba mate exhibits appetitesuppressing, metabolism-boosting, and glucose-regulating properties. Studies suggest that yerba mate may enhance satiety, promote fat oxidation, and improve insulin sensitivity, mimicking some effects of GLP-1 receptor agonists like Ozempic—but with fewer side effects
Wild-type Food in Health Promotion and Disease Prevention : The Columbus Concept
Wild-Type Food in Health Promotion and Disease Prevention: The Columbus Concept is one of the first books to focus on the role of omega-6/3 polyunsaturated fatty acids in unhealthy diets.
The Gut Microbiome
The gut microbiome is now becoming known for its role in metabolism, immune defense, and behavior. From in utero variations to those that rapidly occur post-partum, our gut microbiome changes with age, environment, stress, diet, and health status as well as medication exposure. The human microbiome have a greater complexity than the human genome itself and it is composed of communities of bacteria (and viruses and fungi).The human microbiome has a very important functions such as development of immunity, host nutrition including production of short-chain fatty acids important in host energy metabolism defense against pathogens, synthesis of vitamins and fat storage as well as an influence on human behaviors, making it an essential organ of the body without which we would not function in a perfect manner.
The Genetic Code and the Origin of Life
Early Thoughts on RNA and the Origin of Life The full impact of the essential role of the nucleic acids in biological systems was forcefully demonstrated by the research community in the 1950s. Although Avery and his collaborators had identified DNA as the genetic material responsible for the transformation of bacteria in 1944, it was not until the early 1950s that the Hershey-Chase experiments provided a more direct demonstration of this role. Finally, the structural DNA double helix proposed by Watson and Crick in 1953 clearly created a structural frame work for the role of DNA as both information carrier and as a molecule that could undergo the necessary replication needed for daughter cells. Research continued by Kornberg and his colleagues in the mid-1950s emphasized the biochemistry and enzymology of DNA replication. At the same time, there was a growing interest in the role of RNA. The 1956 dis covery by David Davies and myself showed that polyadenylic acid and polyuridylic acid could form a double-helical RNA molecule but that it differed somewhat from DN A A large number of experiments were subsequendy carried out with synthetic polyribonucleotides which illustrated that RNA could form even more complicated helical structures in which the specificity of hydrogen bonding was the key element in determining the molecular conformation. Finally, in I960,1 could show that it was possible to make a hybrid helix.
The Codes of Life : The Rules of Macroevolution
Building on a range of disciplines – from biology and anthropology to philosophy and linguistics – this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The book’s 18 chapters present a range of experimental evidence which suggests that the genetic code was only the first in a long series of organic codes, and that it has been the appearance of new codes – organic, mental and cultural – that paved the way for the major transitions in the history of life.While the existence of many organic codes has been proposed since the 1980s, this volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution. This creates the conditions for a synthesis of biology and linguistics that finally overcomes the old divide between nature and culture.
Solid State NMR Spectroscopy for Biopolymers : Principles and Applications
When considering the biological significance and industrial and medical applications of biopolymers, it is crucial to know details of their secondary structure, dynamics and assembly. The biopolymers include globular, membrane and fibrous proteins, polypeptides, nucleic acids, polysaccharides and lipids. Solid state NMR spectroscopy has proved to be the most suitable and unrivaled means for investigations of biopolymers. The major advantage of solid state NMR spectroscopy is that the resulting line widths can be manipulated experimentally and are not influenced by motional fluctuation of proteins under consideration as a whole.
RNA Editing
The term "RNA editing" describes a diverse set of biochemical processes whereby genetic information is modulated on a post-transcriptional level i.e. on the level of ribonucleic acids (RNA). RNA editing has been demonstrated in viruses, protozoan organisms, in plants and in mammals and in many cases it has been identified as a key step in the regulation of gene expression. This book dedicates a chapter to each of the main types of RNA editing. All sections are written by experts in the various research areas and a specific focus is put on the correlation between RNA structure and function, as well as on the complex cellular machineries that catalyze the different editing reactions. This leads to a "state of the art" compendium of our current knowledge on RNA editing.
Radiation Induced Molecular Phenomena in Nucleic Acids : A Comprehensive Theoretical and Experimental Analysis
This volume presents a comprehensive overview of theoretical and experimental data on Ultraviolet radiation and low energy electron induced phenomena in nucleic acid fragments. The elucidation of possible mechanisms of these events is important for all living species and hence the technical challenges involved in the exploration of these processes are discussed. This volume will be of particular interest for those involved in understanding the photophysical and photochemical properties of nucleic acid bases, base assemblies, and also model systems related to nucleic acids. The chapter contributions assembled in Radiation Induced Molecular Phenomena in Nucleic Acids are written by theoreticians and experimentalists of international distinction.
QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
This series in heterocyclic chemistry is being introduced to collectively makeavailable critically and comprehensively reviewed literature scattered in vari-ous journals as papers and review articles. All sorts of heterocyclic compoundsoriginating from synthesis, natural products, marine products, insects, etc. willbe covered. Several heterocyclic compounds play a significant role in main-taining life. Blood constituent hemoglobin and purines as well as pyrimidines,the constituents of nucleic acid (DNA and RNA) are also heterocyclic com-pounds. Several amino acids, carbohydrates, vitamins, alkaloids, antibiotics,etc. are also heterocyclic compounds that are essential for life. Heterocycliccompounds are widely used in clinical practice as drugs, but all applications ofheterocyclic medicines can not be discussed in detail. In addition to such appli-cations, heterocyclic compounds also find several applications in the plasticsindustry, in photography as sensitizers and developers, and in dye industry asdyes, etc.
Protein 3D-structure prediction
Protein plays a major role in every cell it is responsible for every function in our body and every living being in their body. consisting of one or more long chains of amino acid residues. The 3D structure is responsible for the function of a protein, predicting the 3D structure it is a challenge for scientists and researchers by using AI systems and neural networks technics it's becoming a trend for reducing the time and cost, also helping scientists to understand how proteins act in real life a lot of universities around the world and institution they are competes to build a model and solution to help with predicting the proteins they invented CASP competition for this purpose it happens every two years, tomake the ability to predict protein’s 3D structure by sequences of amino acids this all happens by learning and calculating the distance between atoms and understanding the correlation between amino acids by using neural networks consists of bi directional LSTM to understand the sequence.
Prebiotic Chemistry : From Simple Amphiphiles to Protocell Models
Fve areas are covered in this special volume of Topics in Current Chemistry: The prebiotic chemistry of simple amphiphilic molecules and their selfassembly into compartmentalized structures, The prebiotic chemistry of nucleobases, nucleotides and oligonucleotides as essential elements of the hypothetical “RNA-world” and its relation to the proposed “pre-RNA-world(s), The prebiotic chemistry of amino acids and peptides; The possible prebiotic origin of homochirality; and , The possible formation of protocellular structures .
Pomegranate peel pharmacological effect and germ killer
The growing scientific interest of pomegranate is due to the functional properties produced for its Phenolic compounds. The term “functional” is understood as the potentially positive effect of a food on health beyond basic nutrition. It contains hydrolysable tannins, condensed tannins, flavonols, anthocyanins, and phenolic and organic acids. Pomegranate, being rich in bioactive compounds like polyphenols, has shown many health-related properties, such as antioxidant, anti-inflammatory and antihypertensive, through in vivo and in vitro studies. Several studies have brought up the potential contribution of pomegranate in the treatment of cancer, diabetes and heart disease.
Persistent Organic Pollutants in the Great Lakes
Brings together what is known about the major classes of these pollutants in the Great Lakes. Each chapter reviews our knowledge of the extent of contamination of the various parts of the Great Lakes ecosystem (air, water, sediment, fishes, birds, etc.), what is known about the trends over time of this contamination, and knowledge about the mechanisms by which these pollutants are mobilized in the lakes. Detailed information is presented on polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and dibenzofurans, pesticides, toxaphene, polychlorinated naphthalenes, polycyclic aromatic hydrocarbons, brominated flame retardants, and perfluoroalkyl acids. These reviews make this volume an invaluable resource for all those involved in environmental research, measurements, and decision making.
Peptide science : Chemical ligation, lead Generation, and therapeutic advances
Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. Overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it’s a must-own for anyone looking to understand a vital field of chemistry.
Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Palladium in Organic Synthesis
Presents a number of accounts and reviews on the novel Pd-catalyzed reactions discovered mainly in the last five years. The book covers Pd-catalyzed reactions that are new – entirely different from the more standard ones. Topics such as new reactions involving ß-carbon elimination and formation of palladacycles as key reactions, cross-coupling of unactivated alkyl electrophiles with organometallic compounds, arylation via C-H bond cleavage, Pd/norbornene-catalyzed aromatic functionalizations, three-component cyclizations of allenes, use of N-heterocyclic carbenes as ligands, asymmetric reactions catalyzed by Pd(II) compounds such as Lewis acids, cycloadditions of arynes and alkynes, and nucleophilic attack by Pd species are surveyed in detail by researchers who have made important contributions to these fields. The book addresses graduate students majoring in organic synthesis and researchers in academic and industrial institutes.
Oxidative Damage to Nucleic Acids
This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.
Organic Chemistry ; 9th ed.
Structure and Bonding / Polar Covalent Bonds; Acids and Bases / Organic Compounds: Alkanes and Their Stereochemistry / Organic Compounds: Cycloalkanes and Their Stereochemistry / Stereochemistry at Tetrahedral Centers / An Overview of Organic Reactions / Alkenes: Structure and Reactivity / Alkenes: Reactions and Synthesis / Alkynes: An Introduction to Organic Synthesis / Organohalides / Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations / Structure Determination: Mass Spectrometry and Infrared Spectroscopy / Structure Determination: Nuclear Magnetic Resonance Spectroscopy / Conjugated Compounds and Ultraviolet Spectroscopy / Benzene and Aromaticity / Chemistry of Benzene: Electrophilic Aromatic Substitution / Alcohols and Phenols / Ethers and Epoxides; Thiols and Sulfides / Aldehydes and Ketones: Nucleophilic Addition Reactions / Carboxylic Acids and Nitriles / Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions / Carbonyl Alpha-Substitution Reactions / Carbonyl Condensation Reactions / Amines and Heterocycles / Biomolecules: Carbohydrates / Biomolecules: Amino Acids, Peptides, and Proteins / Biomolecules: Lipids / Biomolecules: Nucleic Acids / The Organic Chemistry of Metabolic PathwaysOrbitals and Organic Chemistry: Pericyclic Reactions Synthetic / Polymers
Omega-3 fatty acids : Keys to nutritional health
Argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health.
