Artificial intelligence (AI) and machine learning (ML) will play a major role. By adopting AI software and services, businesses can create predictive strategies, enhance their capabilities, better interact with customers, and streamline their business processes. Explores novel concepts and cutting-edge research and developments towards designing these fully automated advanced digital systems. Fostered by technological advances in artificial intelligence and machine learning, such systems potentially have a wide range of applications in robotics, human computing, sensing and networking. The chapters focus on models and theoretical approaches to guarantee automation in large multi-scale implementations of AI and ML systems; protocol designs to ensure AI systems meet key requirements for future services such as latency; and optimisation algorithms to leverage the trusted distributed and efficient complex architectures.