Colchicine: A review on Chemical Structure and Clinical Usage

  • 27 Mar 2019
  • Recently published Research - Pharmacy

Researchers

Hourieh Alkadi,  Rajwa Jbeily and Mohamad Jowad Khubeiz

Published in

Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders), Volume 18, Issue 2, 2018


Abstract

For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C22H25NO6, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it. The therapeutic use of colchicine has been mainly documented in Gout, Familial Mediterranean Fever, and many other diseases such as atrial fibrillation and some researchers have been interested in the possibility of using colchicine and its analogs as an anticancer agent. This review summarizes the history of chemical structure of colchicine and presents some of its analogues. Furthermore, it shows binding mechanism with target protein when colchicine is used as a therapeutic drug, and it gives a light spot on some studies that discuss the safe use of colchicine.

Key words: Colchicine, colchicine`s analogues, Familial Mediterranean fever, Gout, Tubulin, Atrial fibrillation.

Link to read full paper

https://doi.org/10.2174/1871526517666171017114901