تحسين النتائح
ترتيب حسب
من
الى
الصفحة 7
الصفحة 7
Chromatin and Disease
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics.
Choices in Palliative Care : Issues in Health Care Delivery
Keeping up with these statistics means improving on traditional concepts of palliative care to meet growing demands. Choices in Palliative Care brings together 31 leading experts to spotlight core issues in the field, identify ways PC can fill gaps in current care systems, and demonstrate state-of-the-art care that is both cost-effective and clinically appropriate. This far-sighted volume redefines palliative care as interdisciplinary and integrative, providing liaisons between patients, families, and doctors; minimizing loved ones’ care burdens; bridging acute and long-term care to respond to clients’ evolving needs; adaptable to non-fatal (and possibly curable) chronic illnesses.
Chlamydia Atherosclerosis Lesion : Discovery, Diagnosis, and Treatment
This book presents current understanding on the specific pathological features of the C. pneumoniae arterial lesion and the unique morphological features and life cycle of C. pneumoniae in atheromatous arteries. It is important for every medical practitioner to be aware of this disease. All internal medicine physicians, intensivists, family medicine practitioners, infectious disease and immunology physicians should be aware of the impact of C. pneumoniae, the specific pathological features, and methods of diagnosing the lesion. This book presents a unique review of this important
Chitosan-based nanocomposite materials : fabrication, characterization and biomedical applications
Discovery in the use of chitosan-based nanocomposites in biomedical applications, including the scope to which these novel materials have been incorporated by the community. It provides an exceptional insight into the strategies for the synthesis and chemical modifications of chitosan, characterization techniques, their use as anticancer agents, antimicrobial, antiviral, and antifungal agents, their role in the biomedical field, and applications in drug delivery, gene therapy, dentistry, orthopedics, etc. This book will also emphasize the challenges with previous signs of progress and way for further research, details relating to the current pioneering technology, and future perspectives with a multidisciplinary approach. Furthermore, it presents up-to-date information on the economics, toxicity, and regulations related to these novel materials.
Chitin and Chitosan : Properties and Applications
Chitin and Chitosan: Properties and Applications presents a comprehensive review of the isolation, properties and applications of chitin and chitosan. These promising biomaterials have the potential to be broadly applied and there is a growing market for these biopolymers in areas such as medical and pharmaceutical, packaging, agricultural, textile, cosmetics, nanoparticles and more.
Chirurgie oncoplastique et reconstruction dans le cancer du sein: Techniques et indications L’expérience de l’Institut Curie = Oncoplastic surgery and reconstruction in breast cancer: Techniques and indications The Institut Curie experience
This book is the application of plastic surgery techniques to cancer situations that is called "oncoplastic" surgery. The Institut Curie team takes stock of these techniques and indications applied in 2007 in France.
Chirurgie esthétique et fonctionnelle de la face = Cosmetic and functional facial surgery
Cet ouvrage centré sur la chirurgie esthétique faciale repose sur une profonde connaissance de l'anatomie, de la physiologie et de l'étiopathogénie du vieillissement de la face. Les solutions thérapeutiques à visée esthétique sont développées mais en préservant toujours la fonction - gage d'un meilleur résultat immédiat et à plus long terme. Après un rappel du vieillissement cutané et de l'intérêt de l'utilisation de la toxine botulique, les aspects de la chirurgie esthétique de la face sont abordés à travers quatorze chapitres
Chirurgia toracica videoassistita = Video-assisted thoracic surgery
The work therefore represents an in-depth update of the various video-assisted thoracic surgery techniques, which concerns the branches of thoracic surgery, general surgery, pediatric surgery, and spinal surgery.
Chemolithoautotrophic Bacteria : Biochemistry and Environmental Biology
Covers in detail advances in the biochemistry and physiology of several chemolithoautotrophic bacteria as well as their relationship to certain environments. Included are recent findings regarding the oxidation mechanisms of ammonia, nitrite, sulfur compounds, and ferrous iron by special bacteria. The characteristics of many cytochromes are described to further advance the understanding of bacterial oxidation systems of inorganic compounds. Applications of bacteria, such as in sewage treatment and in biohydometallurgy, among others, are detailed, and bacteria considered closest to the origins of life are discussed in the final chapter.
Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
Chemokine biology : Basic research and clinical application ; Vol.2 : Pathophysiology of chemokines
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Chemokine biology : Basic research and clinical application ; Vol.1 : Immunobiology of chemokines
The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.
Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences
Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process.
Chemistry of natural products : phytochemistry and pharmacognosy of medicinal plants
Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques.
Chemistry of Biologically Potent Natural Products and Synthetic Compounds
Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.
Chemistry and pharmacology of drug discovery
Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines, discussing a total of 20 drugs that are all FDA-approved post 2021. Cover Infectious Disease, Cancer Drugs, CNS Drugs, and Miscellaneous Drugs. Each chapter covers background material on the drug class and/or disease indication and key aspects relevant to the discovery of the drug, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety.
Chemical product formulation design and optimization : methods, rechniques, and case studies
A team of renowned technologists and engineers delivers a practice guide to chemical product design. Offering real-world case studies for disinfectant formulation, the optimization of defined media, and the formulation of biocomposites, the book contains introduction to the current product design process. A practical approach to the essentials of product design, related statistical techniques and optimization, patents, green chemistry and gives real life case studies.
Chemical principles of nanoengineering
Nanomaterials, which possess at least one dimension lower than 100 nanometers, are increasingly at the forefront of technological and chemical innovation. The properties of these uniquely minute materials give them distinctive applications across a huge range of industries and research fields. It is therefore critical that the next generation of engineers and materials scientists understand these materials, their chemical properties, and how they form bonds
Chemical Biology and Drug Discovery
Gives the reader, through the specific selection of chemical-biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems.
Checkpoint Responses in Cancer Therapy
This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
