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Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Classic Papers in Modern Diagnostic Radiology
The subject of diagnostic radiology is now very large and radiology depa- ments are involved in all areas of modern patient care.The defining event in m- ern radiology,and arguably the most significant development in radiology since Wilhelm Röntgen discovered X-rays, was the invention of the CT scanner in the 1970s.The CT scanner introduced modern cross-sectional imaging and also di- tal imaging.We now have MRI and ultrasound and these techniques are replacing many traditional X-ray procedures.The developments in radiology have been the result of a fruitful interaction between the basic sciences, clinical medicine and the manufacturers. This can be seen by looking at the various sources of these publications. Change is produced by the interactions between the various dis- plines. The editors have had a very difficult task in selecting the key discoveries and descriptions.The radiological literature is very large.Medical imaging continues to develop rapidly and these papers are the foundations of our current practice.
Antibiotics Simplified
Designed to bridge knowledge gained in basic sciences courses with clinical practice in infectious diseases. This practical text reviews basic microbiology and how to approach the pharmacotherapy of a patient with a presumed infection. It also contains concise Drug Class Reviews with an explanation of the characteristics of various classes of antibacterial drugs and antifungal drugs.
Comprehensive applied basic sciences : For MDS students
All the questions are answered as per the type of question (long | short) and with “to the point” answers to make it more interesting. Answers are selected authentically from standard textbooks commonly referred to by the students to avoid confusion during examinations. Each answer is explained in heading and subheadings to break the continuous text. Written in a simple, well structured and point-wise format with a comprehensive examination-oriented description along with the diagrammatic representation. An indispensable book for the ‘last minute’ revision while preparing for the examinations and for quick reference throughout the course duration.
A Review on Dental Materials
A Review on Dental Materials discusses the current biomaterials used for dental applications and the basic sciences underpinning their application.
A Portrait of State-of-the-Art Research at the Technical University of Lisbon
This book contains the edited version of the invited lectures that were delivered by prominent researchers at UTL. This book brings together in a review manner a comprehensive summary of high quality research contri- tions across basic and applied sciences. The contributing papers are organized around the following major areas: – Emergent areas (Nanosciences, Quantic Computations and Infor- tion, Risk and Volatility in Financial Markets); – Basic Sciences (Mathematics, Physics, Chemistry and Materials); – Social Sciences, Economics and Management Sciences; – Life Sciences and Biotechnology; – Engineering and Technologies – Nature, Environment and Sustainability; – Public Health, Food Quality and Safety; – Health and Sport Sciences; – Urbanism, Transports, Architecture, Arts and Design.
