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Mathematical Modelling of Biosystems

This volume is an interdisciplinary book, which introduces, in a very readable way, state of the art research in the fundamental topics of mathematical modelling of Biosystems. These topics include: the study of Biological Growth and its mechanisms, the coupling of pattern to form via theorems of Differential Geometry, the human immunodeficiency virus dynamics, the inverse folding problem and the possibility of analysing true protein backbone flexibility, the Biclustering techniques for the organization of microarray data, the analytical approach to the modelling of biomolecular structure via Steiner trees, the action of biocides on resistance mechanisms of mutated and phenotypic bacteria strains, a description of the fundamental processes for the distribution and abundances of species towards a unified theory of Ecology, and a special introduction to Protein Physics aiming to explain the all-or-none first order phase transitions from native to denatured states.

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Mathematical Modeling of Complex Biological Systems : A Kinetic Theory Approach

This book describes the evolution of several socio-biological systems using mathematical kinetic theory. Specifically, it deals with modeling and simulations of biological systems—comprised of large populations of interacting cells—whose dynamics follow the rules of mechanics as well as rules governed by their own ability to organize movement and biological functions. The authors propose a new biological model for the analysis of competition between cells of an aggressive host and cells of a corresponding immune system.Because the microscopic description of a biological system is far more complex than that of a physical system of inert matter, a higher level of analysis is needed to deal with such complexity. Mathematical models using kinetic theory may represent a way to deal with such complexity, allowing for an understanding of phenomena of nonequilibrium statistical mechanics not described by the traditional macroscopic approach. The proposed models are related to the generalized Boltzmann equation and describe the population dynamics of several interacting elements (kinetic population models).The particular models proposed by the authors are based on a framework related to a system of integro-differential equations, defining the evolution of the distribution function over the microscopic state of each element in a given system. Macroscopic information on the behavior of the system is obtained from suitable moments of the distribution function over the microscopic states of the elements involved. The book follows a classical research approach applied to modeling real systems, linking the observation of biological phenomena, collection of experimental data, modeling, and computational simulations to validate the proposed models. Qualitative analysis techniques are used to identify the prediction ability of specific models.

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Mathematical Modeling of Biological Systems ; Vol. II : Epidemiology, Evolution and Ecology,Immunology, Neural Systems and the Brain, and Innovative Mathematical Methods

This two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout both works are mathematical and computational approaches to examine central problems in the life sciences, ranging from the organizational principles of individual cells to the dynamics of large populations.

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Mathematical Modeling of Biological Systems ; Vol. I : Cellular Biophysics, Regulatory Networks, Development, Biomedicine, and Data Analysis

This two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout both works are mathematical and computational approaches to examine central problems in the life sciences, ranging from the organizational principles of individual cells to the dynamics of large populations.

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Mathematical Modeling for the Life Sciences

Proposing a wide range of mathematical models that are currently used in life sciences may be regarded as a challenge, and that is precisely the challenge that this book takes up. Of course this panoramic study does not claim to offer a detailed and exhaustive view of the many interactions between mathematical models and life sciences. This textbook provides a general overview of realistic mathematical models in life sciences, considering both deterministic and stochastic models and covering dynamical systems, game theory, stochastic processes and statistical methods. Each mathematical model is explained and illustrated individually with an appropriate biological example. Finally three appendices on ordinary differential equations, evolution equations, and probability are added to make it possible to read this book independently of other literature.

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Marine resource damage assessment : Liability and compensation for environmental damage

MARE-DASM research focused on: (i) the estimation and distribution of marine contaminants in order to assess their long term effects (ecotoxicology); (ii) the integration of these result into a Biological Effects SubModel and a mathematical model assessing the risks associated with accidental spillage of oil at sea and the damage this can cause (modelling); (iii) the assessment of the willingness to pay for ecological damage, based on the Contingent Valuation Method (economics); (iv) the development and evaluation of measures to be taken in order to guarantee a sustainable use of the Belgian part of the North Sea, taking into account the economic and social interests and values (social economics); (v) the potential to develop technical and legal procedures that allow ecological damage to the marine environment to be evaluated and compensated, taking into account constraints in national and international liability legislation (legal).

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Marine Geochemistry

Since 1980 a considerable amount of scientific research dealing with geochemical processes in marine sediments has been carried out. This textbook summarizes the state of the art in this field of research. The topics comprise the examination of sedimentological and physical properties of the sedimentary solid phase, of pore water and pore water constituents, organic matter as the driving force of most microbiological processes, biotic and abiotic redox reactions, carbonates and stable isotopes as proxies for paleoclimate reconstruction, metal enrichments in ferromanganese nodules and crusts as well as in hot vents and cold seeps on the seafloor. A new chapter describes properties, occurrence and formation of gas hydrates in marine sediments. The textbook ends with a chapter on model conceptions and computer models to quantify processes of early diagenesis.

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Manual for Soil Analysis - Monitoring and Assessing Soil Bioremediation

Reliable methods for monitoring and assessing soil quality are a prerequisite for successful soil bioremediation projects. The fifth volume of Soil Biology presents detailed descriptions of selected methods for evaluating, monitoring and assessing bioremediation treatments of soils contaminated with organic pollutants or heavy metals.

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Managing Forest Ecosystems : The Challenge of Climate Change

With climate change now charging up the political agenda, there are three issues commonly making the headlines: carbon budgets, renewable energy, and the anticipated impacts of climate change. Equally important, though currently less well covered, is the issue how these effects might be mitigated. Given the significant role that forests play in the climate system – as sources, sinks, and through carbon trading – this book discusses the current scientific evidence on the relationships between climate, forest resources and forest management practices around the world. Drawing on expertise from forest scientists from several continents, the book presents both in depth analysis of the current knowledge, and a series of case studies which assess the biological and the economic impacts of climate change. It includes sections on forest responses to climate change, monitoring and modeling changes, economic and management implications, and carbon sequestration under specific management systems.

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Management of Intentional and Accidental Water Pollution

The goals of the workshop included a discussion of the state of the science in identification of new research and approaches for water pollution events and communication of the management of water pollution and sustainability of water resources. Critical to management of accidental and intentional pollution events is the assessment of the risk, an understanding of the hazards and lessons learned from events which may lead to preventative management and control strategies. Public health protection will ultimately be improved by the ability to develop management frameworks which are flexible and adaptable to the specific region, country or watershed problems and concerns and allow for prioritization in the decision making. The integration of scientific information regarding the types of hazards the environmental fate of the chemical/biological, exposure pathways and human and ecosystem impacts may be implemented from both a qualitative or descriptive approach or using a more classical quantitative risk assessment paradigm. Thus the frameworks for assessing the risk and managing the risk may be seen as preventive, early warning and responsive.

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Longer Life and Healthy Aging

Focuses on theoretical issues and empirical findings related to trends and determinants of healthy aging, including factors related to "healthy longevity" of the oldest-old, aged 80 and over. The group is the most rapidly increasing elderly sub-population and is most likely to need assistance in daily living in all countries. Chapters include both longitudinal and cross-sectional data from North America, Europe, and Asia in country-specific studies and cross-national comparisons. Part I focuses on the definition, components, concepts, measurements, and determinants of healthy aging, and discusses the trends and patterns of disability and healthy life expectancy at the macro level. Part II addresses individual healthy aging, including its biological and socio-demographic aspects. Part III focuses on issues concerning the family and healthy aging, and Part IV explores formal and informal care for healthy aging through governmental policy interventions and community service programs.

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Links between geological processes, microbial activities & evolution of life : Microbes and geology

Microbial activities influence water-rock interaction processes and chemical transport between the major geochemical reservoirs and the formation/transformation of minerals and rocks, whereas geological processes and geochemical controls influence the microbial ecology in extreme environments. How biological activity influences geological processes and what role these processes played in the geological evolution of the Earth are fundamental questions.

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Life - As a Matter of Fat : The Emerging Science of Lipidomics

Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.

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Language Production

This comprehensive text presents an up-to-date overview of the key topics in the field, providing important theoretical and empirical challenges to the traditional and accepted modal view of language production. Each chapter explores in detail a different aspect of language production, covering traditional methods including written and signed production alongside emerging research on joint action production. Emphasizing the neurobiological underpinnings of language, chapter authors showcase research that moves from a monologue-only approach to one that that considers production in more ecologically valid circumstances.

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Killer Cell Dynamics : Mathematical and Computational Approaches to Immunology

Reviews how mathematics can be used in combination with biological data in order to improve understanding of how the immune system works. This is illustrated largely in the context of viral infections. Mathematical models allow scientists to capture complex biological interactions in a clear mathematical language and to follow them to their precise logical conclusions. This can give rise to counter-intuitive insights which would not be attained by experiments alone, and can be used for the design of further experiments in order to address the mathematical results.

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Issues in Bioinvasion Science: EEI 2003 : a Contribution to the Knowledge on Invasive Alien Species

Biological invasions are a global problem whose local impact can be of great magnitude. The prevention and minimization of the impact of invasive alien species has become a priority because of their negative impact on biodiversity, economy and public health. Issues in Bioinvasion Science contains key contributions of this conference. The themes included cut across different aspects of non-native species invasions. This volume is essential reading for anyone seeking an understanding of non-native species invasions.

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Complex Engineered Systems : Science Meets Technology

This volume examines the difficulties that arise in creating highly complex engineered systems and new approaches that are being adopted. Topics addressed range from the formal representation and classification of distributed networked systems to revolutionary engineering practices inspired by biological evolution. By bringing together the latest research in Complex Engineered Systems, this book sheds light on the current state and future course of this emerging field.

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Complex and Adaptive Dynamical Systems : A Primer

We are living in an ever more complex world, an epoch where human actions can accordingly acquire far-reaching potentialities. Complex and adaptive dynamical systems are ubiquitous in the world surrounding us and require us to adapt to new realities and the way of dealing with them. This primer has been developed with the aim of conveying a wide range of "commons-sense" knowledge in the field of quantitative complex system science at an introductory level, providing an entry point to this both fascinating and vitally important subject.

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Chernobyl - What Have We Learned? : The Successes and Failures to Mitigate Water Contamination Over 20 Years

Twenty million people have been exposed to Chernobyl radionuclides through the Dnieper River aquatic pathways. This book presents a 20-year historical overview and comprehensive study results of the aquatic environment affected by the 1986 Chernobyl nuclear accident. During this time, many water quality management practices and countermeasures were enacted. The book presents in-depth analyses of these water remediation actions, using current science and mathematical modeling, and discusses why some were successful, but many others failed. The chapter entitled Where Do We Go From Here? incorporates a comprehensive discussion of the planned New Safe Confinement (NSC) structure to cover the Chernobyl plant. The book closes with a summary and conclusions drawn from these analyses, making it a valuable reference tool for the future. This book will be of interest to engineers, scientists, decision-makers, and those involved in radiation protection and radioecology, environmental protection and risk assessment, water remediation and mitigation measures, and radioactive waste disposal. In addition, the detailed, almost day-to-day, emergency responses to the Chernobyl accident described in this book will also be useful to people developing emergency and long-term responses to accidental or intentional (by terrorists) releases of radionuclides, toxic chemicals and biological agents.

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Chemistry from First Principles

This book examines the appearance of matter in its most primitive form, from the vacuum and the diversity that results from the fusion of elementary units in the genesis of atomic matter; considers the empirical rules of chemical affinity that regulate the synthesis and properties of molecular matter; analyzes the compatibility of the theories of chemistry with the quantum and relativity theories of physics; formulates a consistent theory, based on clear physical pictures and manageable mathematics, to account for chemical concepts such as the structure and stability of atoms and molecules, the periodicity of nuclides and elements, valence states, activation and chemical reactivity, electronegativity and general covalency, the exclusion principle, electronic energy, orbital angular momentum and spin in relation to molecular shape, torsional rigidity, chirality and molecular modeling; explains the self-similarity between space-time, nuclear structure, covalent assembly, biological growth, planetary systems and galactic conformation.

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