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Advances in Bioactivation Research
This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.
Advanced chemical biology : chemical dissection and reprogramming of biological systems
Organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.
Adhesion Molecules : Function and Inhibition
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya
This book complements “Halophilic Microorganisms”, edited by A. Ventosa and published by Springer-Verlag (2004), “Halophilic Microorganism and their Environments” by A. Oren (2002), published by Kluwer Academic Publishers as volume 5 of “Cellular Origins, Life in Extreme Habitats and Astrobiology” (COLE), and “Microbiology and Biogeochemistry of Hypersaline Environments” edited by A. Oren, and published by CRC Press, Boca Raton (1999).
Acute Promyelocytic Leukemia : Molecular Genetics, Mouse Models and Targeted Therapy
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Actin Monomer Binding Proteins
The actin cytoskeleton plays a central role in many cellular processes including cell motility, cytokinesis, endocytosis and phagocytosis. The structure and dynamics of the actin cytoskeleton is regulated by a large number of proteins that interact with monomeric and/or filamentous actin. Actin monomer binding proteins provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin.
Acceleration and Improvement of Protein Identification by Mass Spectrometry
this book is presenting a review of basic proteomic techniques. The second part of the book is related to the novel high throughput protein identification technique called the 'molecular scanner'
Abl Family Kinases in Development and Disease
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.
Abeta Peptide and Alzheimers Disease : Celebrating a Century of Research
Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry.the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases.
25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
Bioinformatics technologies
Solving modern biological problems requires advanced computational methods. Bioinformatics evolved from the active interaction of two fast-developing disciplines, biology and information technology. The central issue of this emerging field is the transformation of often distributed and unstructured biological data into meaningful information. This book describes the application of well-established concepts and techniques from areas like data mining, machine learning, database technologies, and visualization techniques to problems like protein data analysis, genome analysis and sequence databases. Chen has collected contributions from leading researchers in each area. The chapters can be read independently, as each offers a complete overview of its specific area, or, combined, this monograph is a comprehensive treatment that will appeal to students, researchers, and R&D professionals in industry who need a state-of-the-art introduction into this challenging and exciting young field.
Algorithmic Aspects of Bioinformatics
Advances in bioinformatics and systems biology require improved computational methods for analyzing data, while progress in molecular biology is in turn influencing the development of computer science methods. This book introduces some key problems in bioinformatics, discusses the models used to formally describe these problems, and analyzes the algorithmic approaches used to solve them. After introducing the basics of molecular biology and algorithmics, Part I explains string algorithms and alignments; Part II details the field of physical mapping and DNA sequencing; and Part III examines the application of algorithmics to the analysis of biological data. Exciting application examples include predicting the spatial structure of proteins, and computing haplotypes from genotype data. This book describes topics in detail and presents formal models in a mathematically precise, yet intuitive manner, with many figures and chapter summaries, detailed derivations, and examples. It is well suited as an introduction into the field of bioinformatics, and will benefit students and lecturers in bioinformatics and algorithmics, while also offering practitioners an update on current research topics.
Advancement of Deep Learning and its Applications in Object Detection and Recognition
In just the past five years, deep learning has taken the world by surprise, driving rapid progress in fields as diverse as computer vision, natural language processing, automatic speech recognition, etc. This book presents an introduction to deep learning and various applications of deep learning such as recommendation systems, text recognition, diabetic retinopathy prediction of breast cancer, prediction of epilepsy, sentiment, fake news detection, software defect prediction and protein function prediction.
Advances in gingival diseases and conditions
Offers a comprehensive overview of the latest research and clinical innovations in periodontology. Divided into two sections, the book explores the etiology, clinical aspects, and diagnosis of gingival diseases, including biomarkers, metalloproteinases, and the impact of stress. The second section presents cutting-edge treatments, from curcumin therapy and muco-gingival surgery to guided tissue engineering and peri-implant disease management.
Mathematical Modelling of Biosystems
This volume is an interdisciplinary book, which introduces, in a very readable way, state of the art research in the fundamental topics of mathematical modelling of Biosystems. These topics include: the study of Biological Growth and its mechanisms, the coupling of pattern to form via theorems of Differential Geometry, the human immunodeficiency virus dynamics, the inverse folding problem and the possibility of analysing true protein backbone flexibility, the Biclustering techniques for the organization of microarray data, the analytical approach to the modelling of biomolecular structure via Steiner trees, the action of biocides on resistance mechanisms of mutated and phenotypic bacteria strains, a description of the fundamental processes for the distribution and abundances of species towards a unified theory of Ecology, and a special introduction to Protein Physics aiming to explain the all-or-none first order phase transitions from native to denatured states.
Life - As a Matter of Fat : The Emerging Science of Lipidomics
Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.
Chemistry and Safety of Acrylamide in Food
Specifically covered are the following aspects: exposure from the environment and the diet; biomarkers of exposure; risk assessment; epidemiology; mechanism of formation in food; biological alkylation of amino acids, peptides, proteins, and DNA by acrylamide and its epoxide metabolite glycidamide; neurotoxicity, reproductive toxicity, and carcinogenicity; protection against adverse effects; and possible approaches to reducing levels in food. Cross-fertilization of ideas among several disciplines in which an interest in acrylamide has developed, including food science, pharmacology, toxicology, and medicine, will provide a better understanding of the chemistry and biology of acrylamide in food, and can lead to the development of food processes to decrease the acrylamide content of the diet.
Chemical Evolution and the Origin of Life
Up to now, we do not have a generally accepted theory about the origin of life and about the process of development of life, we only have a great number of - to some extent even contradictory – hypotheses. Meanwhile there came up some scientific findings beyond thought only a few years ago.Horst Rauchfuss is comparing the different theories from the view of the latest results and is giving an exciting and easy understandable insight into the present state of research.
Cellulose : Molecular and Structural Biology : Selected Articles on the Synthesis, Structure, and Applications of Cellulose
Cellulose: Molecular and Structural Biology is an up-to-date treatise on the most advanced and provocative research into the biosynthesis, structure, and applications of nature’s most abundant macromolecule and renewable resource, cellulose.Molecular, biochemical, and evolutionary aspects of cellulose biosynthesis are reviewed in a variety of living organisms, including cyanobacteria, eubacteria, (Acetobacter, Salmonella, and E. coli), vascular plants (including Arabidopsis, forest trees, and maize), and tunicates.
