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Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Advances in Network Electrophysiology : Using Multi-Electrode Arrays
This book book is an attempt to review the recent progress in both electronics and computational tools developed to analyze the functional operations of large ensembles of neurons and to provide the readers with a sense of the applications made possible by these technological tools. While considerable progress has been made over the last decades in our understanding of electrophysiological processes at the single channel, single synapse, and single neuron levels, our understanding of electrophysiological
Advances in multiple Sclerosis and Experimental Demyelinating Diseases
Challenging Charcot’s hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS.Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement.
Advances in Molecular Oncology
Proceedings of the 2nd Annual IFOM-IEO Meeting on Cancer. This is a new meeting, it has about 200 attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, Ireland, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA. The 2nd IFOM-IEO international meeting on cancer will provide a forum in which the world’s leading cancer researchers and young scientists will discuss the latest advances in molecular oncology. The impact of recent breakthroughs in basic research and of emerging technologies on molecular medicine in cancer will be highlighted.
Advances in Molecular Breeding Toward Drought and Salt Tolerant Crops
Advances in Molecular Breeding toward Drought and Salt Tolerant Crops seeks to integrate the most recent findings about key biological determinants of plant stress tolerance with modern crop improvement strategies. This volume is unique because is provides exceptionally wide coverage of current knowledge and expertise being applied in drought and salt tolerance research, spanning the scientific hierarchy from physiology, biochemistry, development, and genetics, to the newest technologies being used to manipulate drought and salinity associated traits for germplasm improvement. This book will be an invaluable reference for educators and researchers in agronomy and horticulture, crop breeding, molecular genetics, and biotechnology.
Advances in Microbiology, Infectious Diseases and Public Health ; Vol.15
Focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.
Advances in Integrated Soil Fertility Research in sub-Saharan Africa : Challenges and Opportunities
Food insecurity is a central concern and a fundamental challenge for human welfare and economic growth in Africa. Low agricultural production, results in low incomes, poor nutrition, vulnerability to risks and lack of empowerment. Land degradation and soil fertility depletion are considered the major threats to food security and natural resource conservation in sub-Saharan Africa (SSA). Investments in technology, policy and institutional reforms are needed to increase agricultural productivity to ensure food security and sustained national economies. Past research has generated numerous soil fertility management technologies which if adopted could propel the African continent out of the poverty trap. However, these technologies have had little, if any, impact due to low adoption by the smallholder farmers.
Advances in Healthcare Technology : Shaping the Future of Medical Care
This book describes valued contributions of technology for improving hospital and home healthcare, and gives a perspective on how they will influence critical aspects of future medical care. It provides an overview and discussion of trends, presents the state-of-the-art of important research areas, and highlights recent breakthrough results in selected fields, giving an outlook on game-changing developments in the coming decades.
Advances in Functional and Reparative Neurosurgery
The fourth official scientific meeting of the Neurorehabilitation and Reconstructive Neurosurgery Committee of the World Federation of Neurosurgical Societies (WFNS) was held in Seoul. This volume is the fourth in a new series of proceedings covering the most important advancements in this field.
Advances in Electromagnetic Fields in Living Systems ; Vol.4
Advances in Electromagnetic Fields in Living Systems , Volume 4 begins with fetal magnetocardiography (fMCG), a noninvasive method of detecting components of the magnetic field produced by the electrical activity of the fetal heart. FMCG is experiencing steady growth, and is expected to gain influence in diagnosing certain congenital fetal heart defects while at the same time providing optimal care for patients. FMCG provides a distinct signal, free of maternal cardiac interference, which can be detected throughout the last half of pregnancy.
Advances in Diagnostic Imaging : The Value of Contrast-Enhanced Ultrasound for Liver
Takes into account the great impact of new technology on clinical practice for mass liver lesions. Its findings reflect a consensus meeting of experts assembled in order to develop guidelines for the use of ultrasound contrast agents in the diagnosis of liver diseases.
Advances in cognitive neurodynamics ICCN 2007; Proceedings of the International conference on cognitive neurodynamics - 2007
Contains the Proceedings of the 1st International Conference on Cognitive Neurodynamics held in Shanghai, November 17-21, 2007. The participants were treated to an exciting and stimulating conference that left everyone with an enthusiastic vision for the future of the field. The latest important progress was covered by 13 mini-symposia including: Models of Mental Disorders; Cognitive Machines; Dynamics in learning and memory; Central nervous system synchronization; Neuroinformatics; Cognitive Computational Modeling of Human Language Processing; Cognitive Neurodynamics of Attention; Bottom-Up and Top-Down; Brain Networks; From Anatomy to Dynamics; Translational Cognitive Neuroimaging; K-sets; Theory and Applications; Advanced Signal Processing Techniques for Brain Data Analysis; Visual cortex: information processing and dynamics; Dynamics of Firing Patterns and Synchronization in Neuronal Systems.
Advances in Breast Cancer Management, 2nd ed.
Advances in Breast Cancer Management, Second Edition will highlight many of the important advances that have transformed our understanding of the biology and therapeutics of breast cancer.
Advances in Bioactivation Research
This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.
Advances in Alzheimer’s and Parkinson’s Disease : Insights, Progress, and Perspectives
Proceedings of the 7th International Conference on Alzheimer’s Disease and Parkinson’s Disease (ADPD), held March 9-13, 2005 in Sorrento, Italy.The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, covering topics such as immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the history, epidemiology, clinical phenomenology, diagnosis, imaging, treatment ,and future perspectives of Alzheimer’s and Parkinson’s Diseases.
Advances in Algal Biology : A Commemoration of the Work of Rex Lowe
Advances in Algal Biology: A Commemoration of the Work of Rex Lowe was written by students and colleagues of Rex Lowe to acknowledge his esteemed career that included exceptional contributions to research and teaching. Papers in the book cover a variety of topics in algal ecology, focusing on benthic algal ecology in freshwater ecosystems. The studies provide an unusual combination of small-scale experiments and large-scale regional surveys that bridge both basic and applied ecology. Ecologists, limnologists, phycologists, and environmental scientists will find valuable contributions to the development and application of algal research.
Advances and Technical Standards in Neurosurgery ; Vol. 33
This series has already become a classic. In general, one volume is published per year. The advances section presents fields of neurosurgery and related areas in which important recent progress has been made. The technical standards section features detailed descriptions of standard procedures to assist young neurosurgeons in their post-graduate training.
Advances and Technical Standards in Neurosurgery ; Vol. 30
This series, sponsored by the European Association of Neurosurgical Societies, has already become a classic. In general, one volume is published per year. The Advances section presents fields of neurosurgery and related areas in which important recent progress has been made. The Technical Standards section features detailed descriptions of standard procedures to assist young neurosurgeons in their post-graduate training. The contributions are written by experienced clinicians and are reviewed by all members of the Editorial Board.
Advances and technical standards in neurosurgery : Vol. 32
This volume of Advances and Technical Standards in Neurosurgery covers some important new developments in functional neurosurgery and endovascular therapy. In the Technical Standards section a variety of topics are considered, including optic pathway gliomas, pineal lesions, cavernous sinus meningiomas, and the eternal problem of minor and repetitive head injury. Endovascular treatment of a variety of lesions is now common practice, and the state of the art in endovascular treatment for acute ischemic stroke is reviewed. An appraisal of the evidence on whether there is a place for microsurgical vascular decompression for essential hypertension raises interesting questions.
Advanced Techniques in Soil Microbiology
"Advanced Techniques in Soil Microbiology" presents a wide range of biotechnological methods for application in soil microbiology analysis. These include all essential methods involving molecular biology, immunology, microbiology, and structural biology, such as transcriptome analysis, RNAi technology, molecular matchmaking, RAPD, T-RFLP and FT/MS. The techniques and procedures have been selected with the aim of offering practical guides for immediate use in the laboratory. The systems investigated range from individual molecules and cells to entire eukaryotic organisms, with a focus on bacteria, fungi, mycorrhiza, and higher plants. This volume of state-of-the-art, practice oriented methods will be of great use both to the first-timer and to the experienced scientist.
