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Bioactive Confirmation II
Specific binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term "bioactive conformation" usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore, the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof.
Atomic Force Microscopy, Scanning Nearfield Optical Microscopy and Nanoscratching : Application to Rough and Natural Surfaces
Making a clear distinction is made between nano- and micro-mechanical testing for physical reasons, this monograph describes the basics and applications of the supermicroscopies AFM and SNOM, and of the nanomechanical testing on rough and technical natural surfaces in the submicron range down to a lateral resolution of a few nm. New or improved instrumentation, new physical laws and unforeseen new applications in all branches of natural sciences (around physics, chemistry, mineralogy, materials science, biology and medicine) and nanotechnology are covered as well as the sources for pitfalls and errors.
Atmosphere and Climate : Studies by Occultation Methods
In this book we focus on sensors on Low Earth Orbit (LEO) satellites, which exploit solar, lunar, stellar, GNSS (Global Navi- tion Satellite Systems), and LEO-crosslink signals for observing the Earth's - mosphere and climate. The methods all share the key properties of self-calibration, high accuracy and vertical resolution, global coverage, and (if using radio signals) all-weather ca- bility. The atmospheric parameters obtained extend from the fundamental va- ables temperature, density, pressure and water vapor via trace gases, aerosols and cloud liquid water to ionospheric electron density. Occultation data are therefore of high value in a wide range of fields including climate monitoring and research, atmospheric physics and chemistry, operational meteorology, and ionospheric physics.
Astronomical sketching : A step-by-step introduction
At some time we have all gazed through the telescope eyepiece at the magnificent rings and banded globe of Saturn, or seen long shadows reaching across crater floors at the Moon’s terminator – and wondered at the sheer beauty of the sight. It seems almost anachronistic to think of sketching when CCD imaging is available, but astronomical sketching provides an entirely different and deeply personal experience. It means spending time at the eyepiece to really look at what you can see, training your eye to perceive ever greater detail to take the fullest advantage of your telescope's light grasp and resolution.
Argumentative Indicators in Discourse : A Pragma-Dialectical Study
Argumentative Indicators: A Pragma-Dialectical Study identifies and analyses English words and expressions that are crucial for an adequate reconstruction of argumentative discourse. It provides the analyst of argumentative discussions and texts with a systematic set of instruments for giving a well-founded analysis which results in an analytic overview of the elements that are relevant for the evaluation of the argumentation. In the book a systematic connection is made between linguistic insights into the characteristics of argumentative discourse and insights from argumentation theory into the resolution of differences of opinion by means of argumentation.
Applicazioni ed esercizi di modellistica numerica per problemi differenziali = Applications and exercises in numerical modeling for differential problems
Contains a collection of exercises related to typical topics in a course on analytical and numerical methods offered in a degree program in Engineering or Mathematics. Starting with exercises in functional analysis and approximation theory, the text develops problems related to the numerical resolution of elliptic, parabolic, and hyperbolic partial differential equations, scalar or vector, in one or more spatial dimensions. Pure diffusion and pure convection problems are therefore addressed, alongside diffusion-transport problems and problems in compressible and incompressible fluid dynamics. Particular emphasis is given to the finite element method for the spatial discretization of the problems considered, although exercises on the finite difference and finite volume methods are also included.
Anaphora and Type Logical Grammar
This book develops a hybrid architecture that allows to incorporate anaphora resolution into grammatical deduction while avoiding these consequences. To this end, the grammar logic is enriched with a connective that specifically deals with anaphora.After giving a self-contained introduction into Type Logical Grammar in general, the book discusses the formal properties of this connective. In the sequel, Jäger applies this machinery to numerous linguistic phenomena pertaining to the interaction of pronominal anaphora, VP ellipsis and quantification. In the final chapter, the framework is extended to indefiniteness, specificity and sluicing.
Algebraic Combinatorics : Lectures at a Summer School in Nordfjordeid, Norway, June 2003
This book is based on two series of lectures given at a summer school on algebraic combinatorics at the Sophus Lie Centre in Nordfjordeid, Norway, in June 2003, one by Peter Orlik on hyperplane arrangements, and the other one by Volkmar Welker on free resolutions.
Advances in Multiresolution for Geometric Modelling
Multiresolution methods in geometric modelling are concerned with the generation, representation, and manipulation of geometric objects at several levels of detail. Applications include fast visualization and rendering as well as coding, compression, and digital transmission of 3D geometric objects.The book contains seven survey papers, providing a detailed overview of recent advances in the various fields within multiresolution modelling, and sixteen additional research papers. Each of the seven parts of the book starts with a survey paper, followed by the associated research papers in that area.
Advances in Digital Terrain Analysis
Terrain analysis has been an active study field for years and attracted research studies from geographers, surveyors, engineers and computer scientists. With the rapid growth of Geographical Information System (GIS) technology, particularly the establishment of high resolution Digital Elevation Models (DEM) at national level, the challenge is now focused on delivering justifiable socio-economical and environmental benefits. The contributions in this book represent the state of the art of terrain analysis methods and techniques in areas of digital representation, morphological and hydrological models, uncertainty and applications of terrain analysis.
Advanced Time-Correlated Single Photon Counting Techniques
Time-correlated single photon counting (TCSPC) is a remarkable technique for recording low-level light signals with extremely high precision and picosecond-time resolution. TCSPC has developed from an intrinsically time-consuming and one-dimensional technique into a fast, multi-dimensional technique to record light signals. So this reference and text describes how advanced TCSPC techniques work and demonstrates their application to time-resolved laser scanning microscopy, single molecule spectroscopy, photon correlation experiments, and diffuse optical tomography of biological tissue. It gives practical hints about constructing suitable optical systems, choosing and using detectors, detector safety, preamplifiers, and using the control features and optimising the operating conditions of TCSPC devices. Advanced TCSPC Techniques is an indispensable tool for everyone in research and development who is confronted with the task of recording low-intensity light signals in the picosecond and nanosecond range.
Ad-Hoc Networking Towards Seamless Communications
Ad-Hoc Networking Towards Seamless Communications is dedicated to an area that attracts growing interest in academia and industry and concentrates on wireless ad hoc networking paradigm. The persistent efforts to acquire the ability to establish dynamic wireless connections from anywhere to anyone with any device without prerequisite imbedded infrastructure move the communications boundaries towards ad-hoc networks. Recently, ad hoc networking has attracted growing interest due to advances in wireless communications, and developed framework for running IP based protocols. The expected degree of penetration of these networks will depend on the successful resolution of the key features.
