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Lagomorph Biology : Evolution, Ecology, and Conservation
Lagomorphs are a mammalian order which includes rabbits, hares and pikas. They are distributed throughout the world and are of both scientific and public interest as they are classified between endangered and pest species. In addition, some have a high economic value as important game species. In the last few decades, a huge amount of information was made available to the scientific community and resulted in remarkable advances on all aspects of Lagomorph biology. However, this information is dispersed in multiple scientific and non-scientific journals. This book provides an updated synthesis of the current knowledge on Lagomorph biology.
La scuola dell’atopia = The school of atopy
The need to clarify the current concepts of atopy, which for too long have oscillated between a primitive purely clinical vision and a subsequent purely immunological one, had been ripe for some time. Understanding that the role of immunoglobulins E is not exhaustive and accepting the Solomonic division between intrinsic and extrinsic atopy were the first two fundamental steps. Recent discoveries of the role of innate immunity, and therefore of antimicrobial peptides, have opened fundamental spaces for understanding in atopy and beyond. What now appears clear is that atopy is not the disease of an organ but rather a defect in the membranes that delimit our "self". The fact that these membranes are called skin, intestines, conjunctiva, bronchi or whatever has artificially fragmented the understanding and treatment of a unitary phenomenon. This book seeks to summarize the different experiences but above all to be a stimulus to ensure that medicine focuses constructively on the same target. If this is the case, we will no longer see "religious wars" between scientists and practicing doctors or, even worse, between the different specialists vying for the patient. If atopy, as we believe, is a global problem, it can only be adequately addressed in a multidisciplinary context and in a collaborative atmosphere, not only between doctor and doctor but also between doctor and patient.
La gonarthrose : Traitement chirurgical : De l´arthroscopie à la prothèse = Knee osteoarthritis : Surgical treatment : from arthroscopy to prosthesis
The aim of this work is to take stock in a clear and didactic way on all the current knowledge on osteoarthritis of the knee and its treatment. It successively addresses the diagnosis and the medical treatment, then the surgical treatments then finally the various aspects of the total knee prosthesis. This book is designed to be read at several levels: basic information is intended particularly for non-specialist or trainee surgeons, rheumatologists, rehabilitation physicians, radiologists and physiotherapists. More specialized aspects are discussed in a second part of the book concerning the future of medical treatment (biology, gene therapy) and certain complex problems of surgical techniques. The points of controversy concerning the total knee replacement are discussed in the last part of the book, of interest to physicians and surgeons.
L’insuffisance rénale aiguë = Acute renal failure
The aim of this book is to make current data from the experimental and clinical literature accessible to readers. More than a thousand articles are published each year on the theme and the authors aim to synthesize this information. These data relate in particular to the identification of early markers of renal dysfunction without which screening, recognition of the main pathophysiological determinants and prevention remain uncertain. This book focuses attention on clinical situations characterized by the renal impact of the main dysfunctions of vital functions, the prognosis of which is worsened by the occurrence of this renal failure. The following will be treated in particular: the renal consequences of oxidative stress, the renal consequences of respiratory dysfunction, cardiac dysfunction, hepatic dysfunction, alterations in hemostasis, septic shock and hemorrhagic shock. Finally, the physiopathological data from experimental models are gradually finding their echo in the clinical field, opening up therapeutic avenues whose recent evaluations will be analyzed.
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Katzung & Trevor's pharmacology : Examination & board review
Excellent Q & A and rationales for course exams and USMLE Step 1. With 1,000+ board-style questions/answers and fully up-to-date content, this is the most popular review in pharmacology. Organized to reflect the syllabi in pharmacology courses, Katzung & Trevor's Pharmacology Exam and Board Review covers all current drugs and retrovirals, immunologic agents, and chemotherapies. Each chapter begins with 20 pages of informative text, followed by questions and answers, and includes concise discussions of the concepts underlying basic principles or specific drug groups. Edited by the world leading figures in pharmacology and medicine, this high-yield text focuses on basic principles, autonomic drugs, cardiovascular-renal drugs, and drugs with actions on smooth muscle, central nervous system drugs, and drugs used to treat chemotherapeutic drugs, and toxicology.
Computational and Statistical Approaches to Genomics
Computational and Statistical Approaches to Genomics, 2nd Edition, aims to help researchers deal with current genomic challenges. During the three years after the publication of the first edition of this book, the computational and statistical research in genomics have become increasingly more important and indispensable for understanding cellular behavior under a variety of environmental conditions and for tackling challenging clinical problems. In the first edition, the organizational structure was: data à analysis à synthesis à application. In the second edition, the same structure remains, but the chapters that primarily focused on applications have been deleted.
Compendium of Surface Microscopic and Dermoscopic Features
This unique guide provides a comprehensive, current, and accurate A-Z encyclopaedia to clarify the meaning of surface microscopic and dermoscopic terminology including a broad range of both melanocytic and non-melanocytic skin lesions.
Common Surgical Diseases : An Algorithmic Approach to Problem Solving
Common Surgical Diseases: An Algorithmic Approach to Problem Solving, provides surgical residents and house staff with a current, concise and algorithmic approach to frequently encountered clinical challenges.
Clinical decision support systems : Theory and practice
Writes the editor, "If used properly, CDSS have the potential to change the way medicine has been taught and practiced." As clinical decision support systems (CDSS) gain an increasingly central role in the delivery of high quality health care, it becomes more important for the health care community to understand their use. This text is designed as a resource for practicing clinicians, informaticians, teachers and students alike, and provides the most current, comprehensive look a the development and evaluation of clinical decision support systems.
Clinical Cardiac Electrophysiology in the Young
This volume focuses on the practical aspects of clinical electrophysiology of cardiac arrhythmias in the young as practiced by current and former faculty and fellows in the Department of Pediatric Cardiology at the University of Michigan.
Classic Papers in Modern Diagnostic Radiology
The subject of diagnostic radiology is now very large and radiology depa- ments are involved in all areas of modern patient care.The defining event in m- ern radiology,and arguably the most significant development in radiology since Wilhelm Röntgen discovered X-rays, was the invention of the CT scanner in the 1970s.The CT scanner introduced modern cross-sectional imaging and also di- tal imaging.We now have MRI and ultrasound and these techniques are replacing many traditional X-ray procedures.The developments in radiology have been the result of a fruitful interaction between the basic sciences, clinical medicine and the manufacturers. This can be seen by looking at the various sources of these publications. Change is produced by the interactions between the various dis- plines. The editors have had a very difficult task in selecting the key discoveries and descriptions.The radiological literature is very large.Medical imaging continues to develop rapidly and these papers are the foundations of our current practice.
Chronic Prostatitis / Chronic Pelvic Pain Syndrome
In Chronic Prostatitis / Chronic Pelvic Pain Syndrome, the author provides today’s most current information covering the four categories of prostatitis (acute, chronic bacterial, CPPS and asymptomatic inflammation).
Chromatin Dynamics in Cellular Function
This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.
Choices in Palliative Care : Issues in Health Care Delivery
Keeping up with these statistics means improving on traditional concepts of palliative care to meet growing demands. Choices in Palliative Care brings together 31 leading experts to spotlight core issues in the field, identify ways PC can fill gaps in current care systems, and demonstrate state-of-the-art care that is both cost-effective and clinically appropriate. This far-sighted volume redefines palliative care as interdisciplinary and integrative, providing liaisons between patients, families, and doctors; minimizing loved ones’ care burdens; bridging acute and long-term care to respond to clients’ evolving needs; adaptable to non-fatal (and possibly curable) chronic illnesses.
Chlamydia pneumoniae infection and disease : Infection and disease
This volume, part of the Infectious Agents and Pathogenesis series, is a complete portrait of C. pneumoniae and what is currently known about it
Chlamydia Atherosclerosis Lesion : Discovery, Diagnosis, and Treatment
This book presents current understanding on the specific pathological features of the C. pneumoniae arterial lesion and the unique morphological features and life cycle of C. pneumoniae in atheromatous arteries. It is important for every medical practitioner to be aware of this disease. All internal medicine physicians, intensivists, family medicine practitioners, infectious disease and immunology physicians should be aware of the impact of C. pneumoniae, the specific pathological features, and methods of diagnosing the lesion. This book presents a unique review of this important
Chitosan-based nanocomposite materials : fabrication, characterization and biomedical applications
Discovery in the use of chitosan-based nanocomposites in biomedical applications, including the scope to which these novel materials have been incorporated by the community. It provides an exceptional insight into the strategies for the synthesis and chemical modifications of chitosan, characterization techniques, their use as anticancer agents, antimicrobial, antiviral, and antifungal agents, their role in the biomedical field, and applications in drug delivery, gene therapy, dentistry, orthopedics, etc. This book will also emphasize the challenges with previous signs of progress and way for further research, details relating to the current pioneering technology, and future perspectives with a multidisciplinary approach. Furthermore, it presents up-to-date information on the economics, toxicity, and regulations related to these novel materials.
Chitosan : properties and applications in bioengineering
Presents a review of chitosan, including information regarding its structure, main properties, available sources, extraction, and processing techniques. It presents the different applications of chitosan as a biomaterial in fields such as medicine and the agricultural, cosmetology, pharmaceutical, and food industries to have readers obtain a more technical vision of the current use of this biopolymer.
Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
