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Adipose-derived stem cells : Methods and protocols
Discusses of the latest technology and advancements in the field of human-derived ASC and SVF. The chapters in this book are organized into four parts. Part One focuses on human ASC’s isolation, characterization, and differentiation. Part Two describes the isolation and characterization of ASC and SVF from canine, feline, and murine tissues. Part Three looks at hydrogels, scaffolds, and microphysiological systems, and Part Four talks about the new assays and applications using ASC. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Adaptive dynamic programming for chemotherapy drug delivery
Focuses on the practical application of Adaptive Dynamic Programming (ADP) in chemotherapy drug delivery, taking into account clinical variables and real-time data. ADP's ability to adapt to changing conditions and make optimal decisions in complex and uncertain situations makes it a valuable tool in addressing pressing challenges in healthcare and other fields. As optimization technology evolves, we can expect to see even more sophisticated and powerful solutions emerge.
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
About Life : Concepts in Modern Biology
This book uses modern biological knowledge to tackle the question: "What distinguishes living organisms from the non-living world?" In the first few chapters, the authors draw on recent advances in cell and molecular biology to develop an account of the "living state" that applies to all organisms, but only to organisms. Subsequent chapters use this account to explore questions about evolution, the origin of life and the possibility of extraterrestrial life. Towards the end of the book the authors consider human evolution, intelligence and the extent to which our species can be regarded as biologically unique. About Life is written as far as possible in non-technical language; all scientific terms are explained straightforwardly when they are introduced. It is aimed at the general, non-specialist reader, but the novel approach that it takes to general issues in biology will also interest students of the life sciences.
A Sea Change: The Exclusive Economic Zone and Governance Institutions for Living Marine Resources
A Sea Change in a Changing Sea The oceans, seas and coastal areas encompass over 70% of the earth’s surface. They are a critical driver of the earth’s hydrologic cycle and climate system, important for c- merce, transport, and tourism, a source of economically important living marine resources, minerals such as hydrocarbons, as well as new pharmaceutical compounds. The marine environment provides essential habitats for thousands of marine living 1 2 resources, which in turn contribute significantly to global food security, employment, 3 and trade. Overall, the sea’s contribution to human welfare, in terms of market and non-market resources and environmental services, has been estimated at US$21 trillion/year (Costanza, 2000). However, despite the importance of the ocean realm to humans, there is a growing sense that human impacts are destabilizing this system. Some experts believe that current fishing levels are approaching or exceeding the total 4 productivity of the ocean ecosystem (National Research Council, 1999).
A Reappraisal of the Ascending Systems in Man, with Emphasis on the Medial Lemniscus
Based on material assembled by Dr Jaap HR Schoen who was one of the few neuroanatomists to apply the Nauta method to human material. Gaining insight in the consequences of longitudinal damage to the human spinal cord is necessary before reimplantation of the avulsed rootlets or an autologous transplant can be performed in man.
A Legacy for Living Systems : Gregory Bateson as Precursor to Biosemiotics
This book represents a major attempt to revise this deficiency. Scholars from ecology, biochemistry, evolutionary biology, cognitive science, anthropology and philosophy discuss how Bateson's thinking might lead to a fruitful reframing of central problems in modern science. Most important perhaps, Bateson's bioanthropology is shown to play a key role in developing the set of ideas explored in the new field of biosemiotics. The idea that organismic life is indeed basically semiotic or communicative lies at the heart of the biosemiotic approach to the study of life.The only book of its kind, this volume provides a key resource for the quickly-growing substratum of scholars in the biosciences, philosophy and medicine who are seeking an elegant new approach to exploring highly complex systems.
A History of Atmospheric CO2 and Its Effects on Plants, Animals, and Ecosystems
The authors address the future role of atmospheric CO2 and its likely effects on ecosystems. This book incorporates the advances of various earth science, environmental, and ecological fields into an overall account of global change and the changing dynamics of life on Earth.
A Changing World : Challenges for Landscape Research
Written primarily for researchers and advanced students in environmental and social sciences, this latest book in Springer’s Landscape Series looks at some of the emerging fields and new challenges in landscape research. These include: the role of value systems in perceiving, appreciating, and managing landscapes the ‘space’ and ‘place’ concept in landscape research GIS and remote sensing techniques for gathering and processing spatially and temporally explicit land cover, vegetation, and land use data methods of landscape history landscape genetics and genetic methods to test landscape connectivity and dispersal of plant and animal species
3D printing of pharmaceutical and drug delivery devices progress from bench to bedside
Discover the latest, fast-developing technology to help move towards more cost-effective, small-batch, decentralized manufacturing of personalized systems . 3D printing has revolutionized manufacturing. Its precision and flexibility have enabled the large-scale production of materials and devices too complex for conventional industrial manufacturing. This has been particularly revolutionary in the field of pharmaceutical production, where 3D printing is being integrated into the manufacture of both drugs and drug delivery devices. It has never been more important for industry professionals to understand this form of production.
3D cell culture : Methods and protocols
Expands on the previous edition with discussions about the latest organoid models developed for many more organs; new hydrogels and devices for 3D culture; and the organoid systems that have been improved by incorporating more components of tissue microenvironments in the in vitro culture. The chapters in this book are organized into five parts and cover topics such as biofabrication, organoids, microfluidic systems, bioprinting, and image analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Linked Democracy : Foundations, Tools, and Applications
This book shows the factors linking information flow, social intelligence, rights management and modelling with epistemic democracy, offering licensed linked data along with information about the rights involved. This model of democracy for the web of data brings new challenges for the social organisation of knowledge, collective innovation, and the coordination of actions. Licensed linked data, licensed linguistic linked data, right expression languages, semantic web regulatory models, electronic institutions, artificial socio-cognitive systems are examples of regulatory and institutional design (regulations by design). The web has been massively populated with both data and services, and semantically structured data, the linked data cloud, facilitates and fosters human-machine interaction. Linked data aims to create ecosystems to make it possible to browse, discover, exploit and reuse data sets for applications. Rights Expression Languages semi-automatically regulate the use and reuse of content.
Liberal Democracy : Prosperity through Freedom
Aims to show which factors have been decisive in the rise of successful countries. Never before have so many people been so well off. However, prosperity is not a law of nature; it has to be worked for. A liberal economy stands at the forefront of this success – not as a political system, but as a set of economic rules promoting competition, which in turn leads to innovation, research and enormous productivity.
Comparative and international criminal justice systems : policing, judiciary, and corrections
The Nature of Comparative and International Criminal JusticeThe Purpose of Comparative and International Criminal Justice Systems; Crime and Criminal Law: Global PerspectiveCrime: International and Comparative;Overview of Model Criminal Justice Systems
Children in Tort Law Part II : Children as Victims
Since children are not as capable as adults to perceive the risks involved in many situations of daily life, they are at a high risk of suffering personal injuries, mainly resulting from home, school and traffic accidents. From the tort law perspective, this requires a specific treatment of children as victims. For the last few decades some legal systems have been trying to find new solutions for a better protection of children, while other legal systems still follow more traditional rules. After having tackled the problems concerning the position of children as tortfeasors in a previous book, in this book the same working team deals with the problems related to the position of children as victims. This book analyses both the traditional solutions found in some legal systems and the newer solutions offered by others and devotes specific attention to damage issues, apportionment of damage and insurance problems when the victim is a child.
Anti-bribery laws in common law jurisdictions
The legal regimes adopted and being implemented by parties to the OECD Convention flow from a common framework. Yet even when the anti-bribery legal regimes are virtually identical, the differences can still be significant in the context of a range of factors that are unique to each legal system.
An assessment framework for compliance with international space law and norms : Promoting equitable access and Use of space for emerging actors
proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance.
AI and law : How automation is changing the law
Provides insights into how AI is changing legal practice, government processes, and individuals’ access to those processes, encouraging each of us to consider how technological advances are changing the legal system. Particularly, and distinct from current debates on how to regulate AI, this books focuses on how the progressive merger between computational methods and legal rules changes the very structure and application of the law itself.
African Land Reform Under Economic Liberalisation: States, Chiefs, and Rural Communities
This book offers unique in-depth, comprehensive, and comparative analyses of the motivations, context, and outcomes of recent land reforms in Africa. Whereas a considerable number of land reforms have been carried out by African governments since the 1990s, no systematic analysis on their meaning has so far been conducted. In the age of land reform, Africa has seen drastic rural changes. Analysing the relationship between those reforms and change, the chapters in this book reveal not only their socio-economic outcomes, such as accelerated marketisation of land, but also their political outcomes, which have often been contrasting.
