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Apoptosis, cell signaling, and human diseases : Molecular mechanisms ; Vol.2
Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphate" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.
Apoptosis, cell signaling, and human diseases : Molecular mechanisms ; Vol.1
Volume 1 is divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy.” Volume 2 follows a similar structure and is divided into sections entitled “Kinases and Phosphate” and “Molecular Basis of Cell Death.” All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.
Antisense RNA Design, Delivery, and Analysis
This volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome).
Antimicrobial peptides and human disease
Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.
Antidiabetic medicinal plants and herbal treatments
Diabetes is a chronic condition associated with metabolic disorder. Persons suffering from diabetes have shown accelerated levels of blood sugar which often harms the heart, blood vessels, eyes, kidneys, and nerves. Over the past few decades, the prevalence of diabetes has been progressively increasing. Synthetic drugs are used to treat diabetic patients to help control the disorder, but it is shown that numerous medicinal plants and herbal drugs are widely used in several traditional systems of medicine to prevent and treat diabetes. They are reported to produce beneficial effects in combating diabetes and alleviating diabetes-related complications. These plants contain phtyonutrients and phytoconstituents demonstrating protective or disease preventive properties. In many developing countries, herbal drugs are recommended by traditional practitioners for diabetes treatment because the use of synthetic drugs is not affordable.
Antibiotics as Anti-Inflammatory and Immunomodulatory Agents
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer.
Antarctic ecosystems : Environmental contamination, climate change, and human impact
This volume provides an overview of climate change data, its effects on the structure and functioning of Antarctic ecosystems, and the occurrence and cycling of persistent contaminants. It discusses the unique physico-chemical characteristics of the Antarctic environment, ecophysiological adaptations of terrestrial and marine organisms, the transfer of contaminants in pelagic and neritic food chains and the possible consequences for animals at higher trophic levels.
Anatomical Imaging : Towards a New Morphology
This book presents selected works of contemporary evolutionary morphologists and includes such topics as broad scale reconstructions of the brain and ear of dinosaurs, inference of locomotor habits from cancellous bone architecture in fossil primates, and a comparison of the independently evolved manipulating apparatuses in the lesser and giant pandas. Insight is provided into the application of modern noninvasive technologies, including digital imaging techniques and virtual 3D reconstruction, to the investigation of complex anatomical features and coherences. In combination with traditional methods, this allows for the formulation of improved hypotheses on coordinated function and evolution. The creation of virtual translucent specimens makes it possible to realize the age-old dream of the classical anatomists: looking through the skin into the inner organization of an organism. On full display here is the dramatic and promising impact that modern imaging techniques have on scientific progress in evolutionary morphology.
Analysis of Waiting-Time Data in Health Services Research
Analysis of Waiting-Time Data in Health Services Research asks critical questions linking waiting times to health care outcomes. Generously illustrated with charts and tables, the book places this type of data collection, analysis, and reporting firmly in the context of health services research, the study of outcomes of health care delivery to a population.
Analysis file of drug-induced lung injury : expert opinion for analysis of big data
Describes the pathologic conditions of drug-induced lung injuries, monitoring strategies, and guides on how to interpret the evidence. It also dives into particular drugs that caused the disorder, such as EGFR inhibitors, anti-EGFR antibodies, mTOR inhibitors, proteasome inhibitors, immune checkpoint inhibitors, neoangiogenesis inhibitors, and other molecular targeted drugs. It outlines the analysis and interpretation of the post-marketing survey on surveillance of each drug for inducing pulmonary lesions presenting diffuse haziness. The data and analysis from this survey are valuable since a guideline is yet to be established due to limited clinical evidence and cases. As new drugs are developed, establishing treatment and event management is crucial.
Anafilassi in pediatria = Anaphylaxis in pediatrics
Anaphylaxis is defined as an immediate systemic reaction due to the rapid IgE mediated release of potent mediators from tissue mast cells and peripheral blood basophils and represents a generalized clinical condition that includes skin, respiratory, cardiovascular and gastrointestinal signs and symptoms. It includes various clinical pictures, which derive from the association of symptoms such as urticaria, angioedema, vomiting, diarrhea, asthma, dyspnoea, edema of the glottis, hypotension, shock, etc., not always easy to identify, which however require a timely and correct diagnostic approach. .
Amazing numbers in biology
With hundreds of tables and over 10,000 entries anyone who works or studies in the life sciences or those with a curious mind will find exact answers to many questions requiring comparative data. This book is a clearly laid out presentation of the plain facts of life from all areas of biology. None of those figures or superlatives that might seem exotic to the layman is left out. Biology comes alive by this comprehensive references work.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Allosteric Regulatory Enzymes
This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Allelopathy in Sustainable Agriculture and Forestry
This book reports on the latest advances in allelopathy through the contributions of leading scientists in the field. The book addresses the history of allelopathy, the science of allelochemicals, and the application of allelopathy in agriculture and forestry. An emphasis on both methodology and application makes Allelopathy a truly practical reference for scientists, researchers and students of plant science, agriculture, forestry, terrestrial ecology and environmental science.
Allelopathy : A Physiological Process with Ecological Implications
This book provides the reader relevant information about actual knowledge about the process of allelopathy, covering all aspects from the molecular to the ecological level. Special relevance is given to the physiological and ecophysiological aspects of allelopathy. Several ecosystems are studied and methodological considerations are taken into account in several different chapters. The book has been written to be useful both for Ph.D. students and for senior researchers, so the chapters include all necessary information to be read by beginners, but they also include a lot of useful information and discussion for the initiated.
Alginates in drug delivery
Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field.
Algal Toxins : Nature, Occurrence, Effect and Detection
This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
Algal Toxins : Nature, Occurrence, Effect and Detection
This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
